ライフサイエンスコーパス: intermembrane

1 of c-SWNTs, was 4.74% intramembrane and 6.3% intermembrane.

2 Intermembrane [(14)C]cholesterol transfer was strongly e

3 f thicker (7-8 nm) swelled films with weaker intermembrane adhesion ( approximately 0.13 mJ/m(2)) on

4 to form a compact film (3-4 nm) with strong intermembrane adhesion ( approximately 0.36 mJ/m(2)), in

5 Close proximity of these two classes of intermembrane bonds would require significant membrane b

6 The mechanisms regulating this retrograde, intermembrane cholesterol transfer are not well understo

7 ariability in reported values for intra- and intermembrane cholesterol transport rates.

8 nd comparative protein studies, allowing for intermembrane comparisons with high sensitivity and repr

9 two events are coordinated through a dynamic intermembrane coupling between two distinct membrane pro

10 They are fully reconstituted via intermembrane coupling of the Ca(2+)-selective Orai chan

11 annels are gated through a unique process of intermembrane coupling with the Ca(2+)-sensing STIM prot

12 e, the receptor-ligand complex spans a short intermembrane distance (15 nm) compared to long surface

13 By increasing the equilibrium intermembrane distance on binding, we show that intermem

14 espectively) is achieved for a fixed 120 mum intermembrane distance stack (without movement of the me

15 Based on crystal structures, the intermembrane distance would be approximately 15 nm for

16 This setup that fixes the intermembrane distance, and thereby the transient states

17 ein complexes to cope with variations in the intermembrane distance.

18 water and seawater compartments have a fixed intermembrane distance.

19 ange due to the high pressure drops at small intermembrane distance.

20 electrodialysis stack by varying in time the intermembrane distance.

21 to an increase in adhesion at a much-reduced intermembrane distance.

22 ed for different membrane conductivities and intermembrane distances simulating high performance memb

23 Cytochrome c (cyt c), a mitochondrial intermembrane electron shuttle between complexes III and

24 le neutron scattering to measure cholesterol intermembrane exchange and intramembrane flipping rates,

25 Although it catalyzes the intermembrane exchange of phosphatidylcholines in vitro,

26 the protein are located on the mitochondrial intermembrane-facing surface, with six membrane-spanning

27 vesicle trafficking machinery that mediates intermembrane fusion.

28 the release of cytochrome c (cyt c) from the intermembrane gap and subsequent cell death.

29 adherin forms two bound states that span two intermembrane gap distances.

30 along the entire length of the pores that no intermembrane gap is visible.

31 esence correlates with the appearance of the intermembrane gap.

32 rin interactions that occur within confined, intermembrane gaps but not in solution.

33 nd the HOPS complex, are required for stable intermembrane interactions and that the three vacuolar Q

34 ermembrane distance on binding, we show that intermembrane interactions become negligible for the bin

35 ropose a simple model that describes how the intermembrane interactions tilt the free energy landscap

36 ab proteins and effectors are sufficient for intermembrane interactions.

37 gratory and antigen recognition occurs at an intermembrane junction where the T cell physically conta

38 aterally fluid receptor-ligand complex at an intermembrane junction.

39 A dynamic-elastic model for weakly adhered intermembrane junctions is presented.

40 y for another function of Nm23-H4, selective intermembrane lipid transfer.

41 plast envelopes, respectively, necessitating intermembrane lipid transfer.

42 The intermembrane lipid transport processes play important r

43 sertional mutagenesis in the first predicted intermembrane loop eliminated MFT function, but the intr

44 e of insertion of the c-myc epitope into the intermembrane loops and of a series of site-directed mut

45 embrane-spanning regions interspersed by two intermembrane loops and three matrix-facing loops.

46 exerted by the so-called native cyt c in the intermembrane mitochondrial space of healthy cells.

47 es to determine the mechanistic basis of the intermembrane movement and identify the interactions res

48 This intermembrane movement of lipid-modified proteins is a f

49 the potential pathways for intracellular and intermembrane movement of molecules.

50 e-binding affinities and consequent rates of intermembrane movement.

51 However, tools available to evaluate the intermembrane organization of the synapse are limited.

52 that the Mla pathway constitutes a bacterial intermembrane PL trafficking system.

53 een Scythe and the apoptogenic mitochondrial intermembrane protein AIF (apoptosis-inducing factor).

54 Stable expression of the mitochondrial intermembrane protein IMS-RP was established in human br

55 the Trx1 reductant, as well as mitochondrial intermembrane proteins AIF and Mia40.

56 e proton pumping from the matrix (N-side) to intermembrane region (P-side) in mitochondria; the resul

57 n FP domains and contributes to reduction of intermembrane separation between FPs.

58 tivated channels per dyadic cleft and on the intermembrane separation, but not very sensitive to othe

59 We reconstituted this intermembrane signaling geometry between live EphA2-expr

60 how they function to mediate this remarkable intermembrane signaling process controlling Ca(2+) signa

61 encoded protein, ERIS (endoplasmic reticulum intermembrane small protein), is also shown to localize

62 luorescent protein-based redox sensor to the intermembrane space (IMS) and matrix of yeast mitochondr

63 d by misfolded proteins in the mitochondrial intermembrane space (IMS) and mediated by the estrogen r

64 tochondrial membrane translocases facing the intermembrane space (IMS) and that this interaction prom

65 Once imported, PNPase localized to the intermembrane space (IMS) as a peripheral membrane prote

66 beta-barrel fold consisting of an N-terminal intermembrane space (IMS) domain and a C-terminal 16-str

67 ner membrane, the dynamic association of its intermembrane space (IMS) domain with the outer membrane

68 The mitochondrial intermembrane space (IMS) harbors an oxidizing machinery

69 and superoxide dismutase 1 (Sod1) within the intermembrane space (IMS) in yeast.

70 ast to matrix proteins, many proteins of the intermembrane space (IMS) lack presequences and are impo

71 stitute the largest group of proteins in the intermembrane space (IMS) of mitochondria.

72 iated release of DDP/TIMM8a, a mitochondrial intermembrane space (IMS) protein , into the cytoplasm,

73 logy of the mitochondria and accumulation of intermembrane space (IMS) proteins.

74 dent sulfhydryl oxidase in the mitochondrial intermembrane space (IMS) that functions in the import o

75 hatase that is targeted to the mitochondrial intermembrane space (IMS) where it interacts with the mi

76 ause Cu,Zn-SOD is found in the mitochondrial intermembrane space (IMS), we hypothesized that mitochon

77 ied to map the proteome of the mitochondrial intermembrane space (IMS), which can freely exchange sma

78 oid dehydrogenase type 2 (3betaHSD2) via its intermembrane space (IMS)-exposed charged unstructured l

79 transacylase tafazzin, which associates with intermembrane space (IMS)-facing membrane leaflets.

80 mbrane proteins facing the matrix versus the intermembrane space (IMS).

81 nner membrane (IM) protein facing toward the intermembrane space (IMS).

82 le is known about folding of proteins in the intermembrane space (IMS).

83 mostly on the outer membrane and inside the intermembrane space (IMS).

84 m (lfALR) which resides in the mitochondrial intermembrane space (IMS).

85 phospholipid metabolism in the mitochondrial intermembrane space (IMS).

86 ria, where it localizes predominantly in the intermembrane space (IMS).

87 reduced proteins entering the mitochondrial intermembrane space (IMS).

88 may inhibit respiration directly within the intermembrane space (IMS).

89 anslocated through the inner membrane to the intermembrane space (IMS).

90 and outer mitochondrial membranes facing the intermembrane space (IMS).

91 0p and Tim8p/Tim13p protein complexes in the intermembrane space (IMS).

92 ensitive cysteine residues reside within the intermembrane space (IMS).

93 m a structural disulfide bond exposed to the intermembrane space (IMS).

94 e oxidizing environment of the mitochondrial intermembrane space (IMS).

95 al matrix (Mito-RoGFP), or the mitochondrial intermembrane space (IMS-RoGFP), allowing assessment of

96 to acidification, whereas the mitochondrial intermembrane space (trans) side barely responded to pH

97 expressed at low levels are degraded by the intermembrane space AAA (i-AAA) protease, suggesting mis

98 The presence of this peptidoglycan in the intermembrane space allows the refinement of a model for

99 localization of Prx1: a soluble form in the intermembrane space and a form in the matrix weakly asso

100 cytochrome c release from the mitochondrial intermembrane space and apoptosis.

101 rosomes, Osm1 localizes to the mitochondrial intermembrane space and assembles with Erv1 in a complex

102 motif mitochondrial protein localized in the intermembrane space and associated with the inner membra

103 ed both by their presence in the constrained intermembrane space and by the 2D environment of membran

104 tosis-inducing factor from the mitochondrial intermembrane space and can cause the cleavage of full-l

105 ive literature on proteins released from the intermembrane space and consider genetic evidence for an

106 reases in ROS signaling in the mitochondrial intermembrane space and cytosol, and it abrogated hypoxi

107 10 is a mitochondrial protein located in the intermembrane space and enriched at cristae junctions.

108 ein that exposes its carboxy-terminus to the intermembrane space and exists in several complexes of 6

109 approach to express SOD1 exclusively in the intermembrane space and found that mitochondrial SOD1 is

110 isoenzyme is expressed in the mitochondrial intermembrane space and is mutated in reticular dysgenes

111 ation-prone proteins enter the mitochondrial intermembrane space and matrix after heat shock, and som

112 y the Mia40 oxidative-folding pathway in the intermembrane space and probably stabilize the membrane

113 alization of mu-calpain to the mitochondrial intermembrane space and provides new insight into the po

114 tosis-inducing factor from the mitochondrial intermembrane space and the cleavage of full-length Bid

115 8's and Pam16's N termini interacting in the intermembrane space and the matrix, respectively.

116 er membrane, which in turn is bounded by the intermembrane space and the outer membrane.

117 When calcium levels in the intermembrane space are high, the N-terminus of the amph

118 ia demonstrated that DSP18 is located in the intermembrane space as a peripheral membrane protein of

119 ria accommodates the essential mitochondrial intermembrane space assembly (MIA) machinery that cataly

120 The mitochondrial intermembrane space assembly (MIA) pathway is generally

121 ydryl oxidase Erv1, termed the mitochondrial intermembrane space assembly (MIA) pathway.

122 the intermembrane space by the mitochondrial intermembrane space assembly pathway that couples their

123 e1 mediated translocation of PNPase into the intermembrane space but did not degrade PNPase.

124 Interestingly, PNPase is localized to the intermembrane space by a novel import pathway.

125 f DAG in the leaflets facing the chloroplast intermembrane space by DAGK impairs plant growth.

126 mbrane and is subsequently released into the intermembrane space by proteolytic removal of a hydropho

127 Mitochondrial proteins are targeted to the intermembrane space by the mitochondrial intermembrane s

128 chondrial inner membrane and consists of two intermembrane space chaperone complexes, the Tim9-Tim10

129 , to examine the in vitro degradation of two intermembrane space chaperone subunits, Tim9 and Tim10.

130 the small Tim proteins of the mitochondrial intermembrane space contain a consensus twin CX3C Zn2+-f

131 Cox19 isolated from the mitochondrial intermembrane space contains variable quantities of copp

132 in pumping protons from the matrix into the intermembrane space contributing to the proton motive fo

133 in pumping protons from the matrix into the intermembrane space contributing to the proton motive fo

134 The intermembrane space domain of Mic60 has a lipid-binding

135 Ablation of the intermembrane space domain of the translocase subunit, a

136 We report the crystal structure of the intermembrane space domain of yeast Tim50 to 1.83 A reso

137 Notably, the transmembrane and intermembrane space domains are separated from the main

138 he central region of Tim23, which enters the intermembrane space first, may serve to nucleate the bin

139 n protein translocation, indicating that the intermembrane space harbors diverse pathways for protein

140 The mitochondrial intermembrane space has an analogous pathway with the ox

141 Expression of Opa1 CTFs in the intermembrane space has no effect on mitochondria morpho

142 ane space via the redox-driven mitochondrial intermembrane space import and assembly (MIA) pathway.

143 Mitochondrial intermembrane space import and assembly protein40, a pro

144 component of a redox-sensitive mitochondrial intermembrane space import machinery.

145 , a dynamin-like GTPase of the mitochondrial intermembrane space important for maintaining cristae st

146 ls, allowing K(+) to enter the mitochondrial intermembrane space in a controlled regulated fashion.

147 3-nm particles could enter the mitochondrial intermembrane space in mitochondria of permeabilized cel

148 dative protein import into the mitochondrial intermembrane space in yeast and mammals.

149 d through these pores from the mitochondrial intermembrane space into the cytoplasm where they initia

150 otic factors including cytochrome c from the intermembrane space into the cytoplasm, where they initi

151 orine causes translocation of DSP18 from the intermembrane space into the cytosol similar to other ap

152 e release of proteins from the mitochondrial intermembrane space into the cytosol.

153 sults suggest that SOD1 in the mitochondrial intermembrane space is fundamental for motor axon mainte

154 The functional significance of SOD1 in the intermembrane space is unknown.

155 We show that Prx1 sorting into the intermembrane space likely involves the release of the p

156 mine-conjugated dextran in the mitochondrial intermembrane space of digitonin-permeabilized hepatocyt

157 sol, nucleus, peroxisomes, and mitochondrial intermembrane space of human cells.

158 The oxidative folding mechanism in the intermembrane space of human mitochondria underpins a di

159 The intermembrane space of mitochondria accommodates the ess

160 containing metalloprotein is located in the intermembrane space of mitochondria and released into bl

161 tosis, cytochrome c (cyt c) is released from intermembrane space of mitochondria into the cytosol whe

162 and biogenesis of proteins localized to the intermembrane space of mitochondria.

163 ides drives import of many proteins into the intermembrane space of mitochondria.

164 g the efficiency of oxidative folding in the intermembrane space of mitochondria.

165 trols proteostasis at the inner membrane and intermembrane space of mitochondria.

166 We found that CPS-6 relocates from the intermembrane space of paternal mitochondria to the matr

167 h a chaperone had not been identified in the intermembrane space of plastids and we propose that Tic2

168 firmed that POTRA domains are located in the intermembrane space of the chloroplast envelope.

169 osome in which m-IL-1beta resides within the intermembrane space of the double-membrane structure.

170 t, but it localizes to the cytoplasm and the intermembrane space of the mitochondria.

171 ther cellular compartments especially in the intermembrane space of the mitochondrial to avoid irreve

172 is unclear whether loss of the enzyme in the intermembrane space or cytosol is important in this resp

173 her complex I subunits as a substrate of the intermembrane space oxidoreductase CHCHD4 (also known as

174 g the potential across this membrane and the intermembrane space pH.

175 eric Tim9-Tim10 complex of the mitochondrial intermembrane space plays an important role during impor

176 sible for the transfer of disulfide bonds to intermembrane space precursor proteins, causing their ox

177 ndria, suggesting that OPA1 is cleaved by an intermembrane space protease which is regulated by activ

178 observed with knockdown of the mitochondrial intermembrane space protease Yme1.

179 x activation and pro-apoptotic mitochondrial intermembrane space protein release, which are required

180 ond is the CHCHD3 homologue, CHCH-3, a small intermembrane space protein that may act as a chaperone.

181 is a developmentally regulated mitochondrial intermembrane space protein that undergoes processive cl

182 thermore, the protease Prd1, misannotated as intermembrane space protein, could be re-assigned and ch

183 and D sphingosine potentiate the release of intermembrane space proteins by long-chain ceramide and

184 ismutase (Sod1) requires a growing number of intermembrane space proteins containing a twin Cx(9)C mo

185 ge assembly defect and emphasize the role of intermembrane space proteins for the efficient assembly

186 ability of ceramide to induce the release of intermembrane space proteins from mitochondria in vitro.

187 , the Mia40/Erv1 pathway for import of small intermembrane space proteins participates in CCS mitocho

188 The release of mitochondrial intermembrane space proteins to the cytosol is a key eve

189 membrane permeabilization and the release of intermembrane space proteins, such as cytochrome c, are

190 n the permeability transition and release of intermembrane space proteins, the mitochondrial Ca(2+)-i

191 e, we investigated the role of the conserved intermembrane space proteins, Ups1p and Ups2p, and an in

192 In this study, we report that two homologous intermembrane space proteins, Ups1p and Ups2p, control c

193 ed to the transport and oxidative folding of intermembrane space proteins.

194 sociates with the small alpha subunit on the intermembrane space side of the inner membrane.

195 d plants, Toc75 N terminus is located on the intermembrane space side, not the cytosolic side, of the

196 PNPase localization to the mitochondrial intermembrane space suggests a unique role distinct from

197 lectron acceptor couple in the mitochondrial intermembrane space that seems to function in both aerob

198 in yet another subcellular compartment: the intermembrane space that separates forespores from mothe

199 articles must have entered the mitochondrial intermembrane space through the VDAC.

200 ther apoptotic factors are released from the intermembrane space through these pores, initiating down

201 e recruitment of molecular chaperones in the intermembrane space to facilitate membrane transport.

202 nsported across two membranes and an aqueous intermembrane space to the cell surface.

203 0 and Tim23 transfer preproteins through the intermembrane space to the inner membrane.

204 cation for proteins that are targeted to the intermembrane space via the redox-driven mitochondrial i

205 ifunctional hemoprotein in the mitochondrial intermembrane space whereby its participation in electro

206 cal hexameric complexes in the mitochondrial intermembrane space with phosphotransfer activity using

207 and poly-A polymerase, in the mitochondrial intermembrane space, a location lacking resident RNAs.

208 lipid transfer proteins in the mitochondrial intermembrane space, allowing formation of PE by Psd1 in

209 e with the FAD binding domain exposed to the intermembrane space, and 3) the ability of recombinant C

210 n, a sulfhydryl oxidase of the mitochondrial intermembrane space, and a larger protein containing the

211 whose hydrophilic domains are located in the intermembrane space, and Cox20 remains associated with m

212 , localized to the cytosol and mitochondrial intermembrane space, and Grx2, localized primarily to th

213 d in the major compartments (outer membrane, intermembrane space, and the matrix) of the organelle is

214 ropose that a set of stacked rings spans the intermembrane space, as has been found for type III secr

215 g in both neuronal cytosol and mitochondrial intermembrane space, calpain I was found to be activated

216 vely reside in the cytosol and mitochondrial intermembrane space, can engage negatively charged bilay

217 interact via their C-terminal domains in the intermembrane space, consistent with their in vivo topol

218 e oxidation takes place in the mitochondrial intermembrane space, delivering electrons to the respira

219 -Tim13 complex, located in the mitochondrial intermembrane space, functions in the TIM22 import pathw

220 P-independent chaperone of the mitochondrial intermembrane space, involved in transport of polytopic

221 whose extracellular domain is located in the intermembrane space, is a substrate of StoA.

222 denine nucleotide interconversion within the intermembrane space, is markedly induced during adipocyt

223 protons from the mitochondrial matrix to the intermembrane space, it builds up an electrochemical pot

224 ompartments: outer membrane, inner membrane, intermembrane space, or matrix.

225 estined for the outer or inner membrane, the intermembrane space, or the matrix, proteins begin the i

226 locase complex, located in the mitochondrial intermembrane space, plays an essential chaperone-like r

227 eing in the mitochondrial outer membrane and intermembrane space, SOD1 is also localized in the mitoc

228 o replenish protons from the matrix into the intermembrane space, sustaining mitochondrial membrane p

229 s are by nature transient and located in the intermembrane space, this determination is generally a v

230 Two mitochondrial proteins located in the intermembrane space, Ups1p and Ups2p, have been shown to

231 the translocase of the outer membrane to the intermembrane space, where divergent pathways sort them

232 otein Opa1 is localized to the mitochondrial intermembrane space, where it facilitates fusion between

233 argeted to mitochondria and localizes in the intermembrane space, where it participates in an approxi

234 ) promotes transport of the precursor to the intermembrane space, whereas the sorting and assembly ma

235 III is also released into the mitochondrial intermembrane space, which contains a recently identifie

236 sistant fold, associates non-integrally with intermembrane space-facing membranes and assembles in a

237 ) forms the membrane anchor, which binds the intermembrane space-localized alpha-subunit (Psd1alpha).

238 s the respiratory chain to the mitochondrial intermembrane space-localized, ubiquitous, and ancient S

239 membrane with the C and N termini facing the intermembrane space.

240 which reduce i-AAA protease activity in the intermembrane space.

241 brane a second time to finally reside in the intermembrane space.

242 ner membrane, and matrix or trap them in the intermembrane space.

243 rane protease following translocation to the intermembrane space.

244 ch protein substrates into the mitochondrial intermembrane space.

245 ated by a highly conserved linker facing the intermembrane space.

246 the mitochondrial inner membrane facing the intermembrane space.

247 is a peripheral protein of the IM facing the intermembrane space.

248 freely between the cytosol and mitochondrial intermembrane space.

249 ome c and smac/DIABLO from the mitochondrial intermembrane space.

250 tase, but is also found in the mitochondrial intermembrane space.

251 isoforms were predicted to be soluble in the intermembrane space.

252 ondrial matrix and the N-terminus facing the intermembrane space.

253 ane, whereas the C-terminal domain faces the intermembrane space.

254 he small Tim proteins into the mitochondrial intermembrane space.

255 one the hydrophobic Tim23 across the aqueous intermembrane space.

256 ed in the cytoplasm and in the mitochondrial intermembrane space.

257 ugh partially localized to the mitochondrial intermembrane space.

258 tive protease localized in the mitochondrial intermembrane space.

259 te-binding site is open to the mitochondrial intermembrane space.

260 DP to AMP by adenylate kinase located in the intermembrane space.

261 brane helices, shielding it from the aqueous intermembrane space.

262 the mitochondrial inner membrane facing the intermembrane space.

263 aggregation as the preprotein traverses the intermembrane space.

264 small molecules pass between the cytosol and intermembrane space.

265 e with the beta-folded P0-cyt located at the intermembrane space.

266 mu-calpain, are present in the mitochondrial intermembrane space.

267 e, suggesting its functional role within the intermembrane space.

268 ly associated with the inner membrane in the intermembrane space.

269 e inner mitochondrial membrane and faces the intermembrane space.

270 proapoptotic factors from the mitochondrial intermembrane space.

271 mitochondria with the C-terminus facing the intermembrane space.

272 membrane with it's C-terminus exposed to the intermembrane space.

273 phobic carrier substrates across the aqueous intermembrane space.

274 l of Lyn and Syk reside in the mitochondrial intermembrane space.

275 ion or by artificially targeting XIAP to the intermembrane space.

276 ysteine-rich proteins into the mitochondrial intermembrane space.

277 cysteine-rich proteins in the mitochondrial intermembrane space.

278 arding how lipids transit across the aqueous intermembrane space.

279 e of mitochondria with its C terminus in the intermembrane space.

280 al quality control mechanisms present in the intermembrane space.

281 dase (Ccp1) is targeted to the mitochondrial intermembrane space.

282 terminal end of the protein localized to the intermembrane space.

283 study was used to reveal the relative matrix/intermembrane space/outer membrane (85:6:9) distribution

284 Here, we show that the conserved intermembrane-space dynamin-related GTPase Mgm1 is requi

285 olipid, cardiolipin (CL), is oxidized by the intermembrane-space haemoprotein, cytochrome c.

286 periplasms of bacteria and the mitochondrial intermembrane spaces of fungi.

287 e-protein adsorption mechanisms that affects intermembrane spacing and adhesion and has direct implic

288 as with planar bilayers demonstrated average intermembrane spacing of 12.8 nm with CD48-WT, 14.7 nm w

289 The relationship between intermembrane spacing, adhesion efficiency, and lateral

290 of NPC2 on the rate and kinetic mechanism of intermembrane sterol transport, to model the movement of

291 thalene-8-sulfonic acid, and (iv) glycolipid intermembrane transfer activity monitored by Forster res

292 ation of the GLTP paralogs showed glycolipid intermembrane transfer activity only for 12q24.11 GLTP.

293 lten globule-like state inhibited glycolipid intermembrane transfer by the HET-C2 GLTP fold.

294 ble proteins that selectively accelerate the intermembrane transfer of glycolipids.

295 transfer protein (GLTP) catalyzes selective intermembrane transfer of GSLs.

296 tidylcholine transfer protein) regulates the intermembrane transfer of phosphatidylcholine.

297 ansfer protein (GLTP) accelerates glycolipid intermembrane transfer via a unique lipid transfer/bindi

298 mol %) in C1P source vesicles depressed C1P intermembrane transfer.

299 inal domains, to promote STING dimerization, intermembrane translocation, and signaling.

300 Tic22 is a ubiquitous intermembrane translocon component that interacts with t