ライフサイエンスコーパス: internal motion

1 ially in the fluid phase, but not the faster internal motion.

2 and tauhf, a time constant reflecting faster internal motion.

3 mall splittings, giving further evidence for internal motion.

4 ed leucine residues, suggesting a restricted internal motion.

5 time representing helix tumbling as well as internal motion.

6 east one, and probably more than one type of internal motion.

7 ave suggested that there may be some limited internal motions.

8 dence in tumbling, in addition to other fast internal motions.

9 ameters, and effective correlation times for internal motions.

10 p CD, and the C terminus undergo significant internal motions.

11 given carbon experience identical isotropic internal motions.

12 mobile lipids and thus increase the protein internal motions.

13 a clear separation between the influence of internal motion and the influence of global rotational t

14 relation time of 0.3-3 ns representing probe internal motions and a slow component with 50-100 ns cor

15 eters provide only angular information about internal motions and are totally insensitive to translat

16 Mean-square displacements of localized internal motions and effective force constants, <k'>, de

17 bound to external regions of protein impacts internal motions and, therefore, protein function.

18 bound and free states, (2) bound water with internal motion, and (3) free diffusion.

19 sidered as dynamically active assemblies and internal motions are closely linked to function such as

20 These functional slow motions and other fast internal motions are evident from backbone (15)N spin re

21 r analyses indicates that changes in protein internal motions are expected to contribute significantl

22 Nanosecond time-scale internal motions are found for all NHs in the protein, a

23 The residues that exhibit these slow internal motions are found in regions that have been pre

24 The local internal motions are highly restricted in most of the he

25 Within the active site of the leadzyme, internal motions are observed on a wide variety of time

26 to quantitatively assess whether overall and internal motions are statistically separable.

27 -factors would be sensitive to translational internal motions as well.

28 age of these two structures confirm that the internal motion at the alpha (1,3) linkage is small and

29 The resulting order parameters indicate the internal motion at the alpha (1,3) linkage to be limited

30 namic trend and predicted the slowing of the internal motions at 10 degrees C.

31 around the bound lactose molecule, dampening internal motions at that site and increasing motions els

32 eparation has a profound effect on the local internal motions available to the DNA, supporting the id

33 n changes on both equilibrium structures and internal motions becomes accessible.

34 methods for separating overall rotation from internal motions by optimal superposition.

35 A spectral density function for internal motions can be described.

36 overall correlation time in solution, where internal motions characterized here would not be observa

37 loop, and part of the second helix, exhibit internal motions close to the time scale of the overall

38 l intrinsically flexible mRNA has all of its internal motions completely inhibited and shows mainly a

39 ssumed by classical models, but by a complex internal motion coupled to the RL.

40 fields higher than approximately 6 T due to internal motion CSA relaxation.

41 l code can be maintained solely based on the internal motion cues derived from the passive rotations.

42 The effective correlation times for internal motions do not show significant temperature dep

43 lexes, it is usual to observe the effects of internal motions due to the shallowness of the potential

44 tretches of polypeptide chain with increased internal motion, except at the extreme chain termini.

45 olypeptide chain with dramatically increased internal motion, except at the extreme N and C termini.

46 ing between overall diffusional rotation and internal motion expected to exist in TAR, here we utiliz

47 on experiments unveiled some regions of fast internal motions, faster than the overall correlation ti

48 monstrated that even with extreme amounts of internal motion, "flexible helices" of 25 residues or mo

49 (15)N relaxation analyses implied fast internal motions for the beta-domain.

50 0 MHz static magnetic fields showed that the internal motions for the residues in the H1-H3 loop (K24

51 t high fields reflects CSA relaxation due to internal motions, for which a correlation time, tau(hf),

52 sappears when we exclude the contribution of internal motion from the R(1) in the ratio.

53 Internal motions have previously been assumed to be on a

54 all show that there are differing amounts of internal motion in the different residues of the polysac

55 monitor the effects of high pressure on fast internal motion in the protein ubiquitin.

56 r cells (MDA-MB-231) exhibit more solid-like internal motions in 3D compared to 2D, and actin network

57 Internal motions in elements of the secondary structure

58 values which defines the range of rates for internal motions in GAL4(1-65).

59 a useful first-order description of complex internal motions in macromolecules despite neglecting th

60 (RDCs) has made it possible to characterize internal motions in proteins at atomic resolution and wi

61 Cu(+) binding quenches the protein's internal motions in regions linked to binding CusB, sugg

62 g a domain elongation strategy, we decoupled internal motions in RNA from overall rotational diffusio

63 two beta-strands and have similar nanosecond internal motions in several regions including the C-term

64 ), and (15)N-[(1)H] NOE indicated restricted internal motions in the helical region with NOE values b

65 om the rotary diffusion of the protein, from internal motions in the side chain, and from backbone fl

66 The magnitude of backbone internal motions in the small protein ubiquitin that nee

67 for characterizing picosecond-to-nanosecond internal motions in uniformly 13C/15N-labeled RNAs that

68 er, these observations suggest that the slow internal motions in Y35G BPTI are more independent in th

69 The effects of internal motions incorporated into these helices was mod

70 Using NMR, we characterized internal motions induced by the internal loop in an SL1

71 operative nature of protein substructure and internal motion is a critical aspect of their functional

72 Internal motion is central to protein folding, to protei

73 face) side chains, the contribution from the internal motion is sequence independent, as is that from

74 A consequence of the DNA internal motion is that protein target search may be acc

75 emperature, a novel side chain with hindered internal motion is used, along with a more commonly empl

76 binds to the internal loop and arrests these internal motions, it preserves and/or activates local mo

77 urements, indicating that the energetics for internal motions occurring on the nanosecond time-scale

78 At the heart of these devices is the internal motion of electrons through semiconductor mater

79 which are a measure of the amplitude of the internal motion of individual C-H vectors with respect t

80 be a useful tool to describe the overall and internal motion of molecules on the picosecond to nanose

81 Although the internal motion of R1 and the number of preferred rotame

82 an important consequence of the constrained internal motion of RX, spectral diffusion detected with

83 on times reflective of the time scale of the internal motion of the C-H vectors were in all cases <60

84 Changes in internal motion of the Cdc42Hs, as revealed by methyl ax

85 ontaining RX all reveal a highly constrained internal motion of the side chain.

86 han residue to the external quencher and the internal motion of the tryptophan residue increase upon

87 igid body motions are removed, the remaining internal motions of all three tRNAs are essentially the

88 enches both rapid and intermediate timescale internal motions of apo-CzrA while stabilizing the nativ

89 The internal motions of backbone NH groups were determined u

90 The internal motions of DNA appear to be governed by strong

91 we investigated the ionic hydrogen bonds and internal motions of lysine side-chain NH3(+) groups invo

92 Controlling the internal motions of molecules by outside stimuli is a de

93 te its importance, the precise nature of the internal motions of protein macromolecules remains a mys

94 It is likely that changes in the internal motions of proteins have a major role in regula

95 The internal motions of proteins may serve as a "gate" in so

96 Since the internal motions of proteins play an essential role in t

97 distorted, and their spectra indicate slowed internal motions of the alkyl groups within the space.

98 The internal motions of the backbone nitrogen atoms of the k

99 n hydrogen/deuterium exchange protection and internal motions of the backbone of the D/D when free an

100 ths (500 and 600 MHz) were used to probe the internal motions of the individual residues.

101 sion detected with ELDOR reveals microsecond internal motions of the protein.

102 n of HIF-alpha, disrupts the coordination of internal motions of the pVHL.HIF-1alpha complex.

103 suppression of the amplitudes of localized, internal motions of the sugar-phosphate backbone of the

104 th the aim of assessing the character of the internal motions of this native-like protein of de novo

105 Chemical shift changes and internal motions on microsecond-to-millisecond time scal

106 Our results show that internal motions on pico- to nanosecond time scales in t

107 demonstrated no conformational exchange and internal motions on the nanosecond time scale.

108 r parameters (S(2)), which report on protein internal motions on the picosecond to nanosecond and slo

109 roteins are not rigid molecules, but exhibit internal motions on timescales ranging from femto- to mi

110 lues and T1/T2 ratios suggesting significant internal motion or chemical exchange at these sites.

111 ld be fitted without invoking terms for fast internal motion or chemical exchange, and out of the rem

112 e (helices 1 and 4), only one has measurable internal motion (Q71), and the order parameters of the r

113 of residues undergoing slower (micros to ms) internal motions, reflected in unusually large transvers

114 at the protein undergoes multiple time scale internal motions related to the secondary structure.

115 ies types of domain motion that dominate the internal motion's contribution to the NSE signal, with t

116 helices which undergo virtually unrestricted internal motions (S2 approximately 0.2) in the ARG bound

117 (S2), effective correlation times for their internal motions (tau e), and terms to account for motio

118 ers (S2), the effective correlation time for internal motions (tau e), and the 15N exchange broadenin

119 ter (S2), the effective correlation time for internal motions (tau(e)), 15N exchange broadening contr

120 2)), the effective correlation time for fast internal motions (tau(e)), and the global rotational cor

121 ant trends in the NMR data, but suggest more internal motions than inferred from the NMR analysis.

122 mmediately prior to alpha 5) exhibits faster internal motions than that bearing His-39 (at the C-term

123 th polyamines, the monoimines formed execute internal motions that have been characterized by extensi

124 n of K1(Pg) with ligand mainly reduced those internal motions that occurred on a 100 ps to 5 ns time-

125 ions were found to correlate with changes in internal motions that were previously recognized as a so

126 ild type and P101L have extensive nanosecond internal motions throughout the helices.

127 imate the contribution of individual residue internal motion to overall protein dynamics and alloster

128 The relevance of internal motions to molecular recognition and to the ear

129 Lysozyme internal motions were modeled by assuming a protein of t

130 ive to the slow, subnanosecond time scale of internal motion, whereas J(0) and J(omega(N)) are domina

131 which, in the a fold, couples redox state to internal motions which may enhance catalysis and specifi

132 require separability of overall tumbling and internal motions, which makes it applicable to a wide ra

133 ts of the ligand glutamate exhibited minimal internal motion, while those contacting the gamma-consti

134 In particular, internal motion with a 5- to 10-ns correlation time has

135 e presence of a strong Py-tract but exhibits internal motion with weak Py-tracts.

136 ly because of the interaction of wind-driven internal motions with the lake's bathymetry, and the Ear

137 r abilities to capture overall the important internal motions, with comparisons having been made agai