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1 d not impair translation directed by the HCV internal ribosome entry site.
2 ation without exhibiting typical features of internal ribosome entry site.
3 downstream expression ratios mediated by an internal ribosome entry site.
4 nes were separated by expressing Tax from an internal ribosome entry site.
5 was driven by an encephalomyocarditis virus internal ribosome entry site.
6 mRNA, indicating that the leader contains an internal ribosome entry site.
7 osis protein expression by translation at an internal ribosome entry site.
8 nucleotides 1 to 43) and a longer element of internal ribosome entry site.
9 s an important role in the hepatitis C virus internal ribosome entry site.
10 regulation is mediated, at least in part, by internal ribosome entry sites.
11 osome entry site was found to bind, with the internal ribosome entry site-40S subunit interaction bei
12 hree of the PPMOs, targeting domain 5 of the internal ribosome entry site (5D PPMO), and the two tran
14 prevented the ability of IL-6 to enhance Myc internal ribosome entry site activity, Myc protein expre
17 show that the JunD mRNA does not possess an internal ribosome entry site and is translated in a cap-
18 ng the PIG-A complementary DNA along with an internal ribosome entry site and the nerve growth factor
19 slation of antiapoptotic protein Bcl-2 at an internal ribosome entry site and this mechanism was iden
20 o human sequences, originally reported to be internal ribosome entry sites and later to instead be pr
21 shown to enhance the translation of several internal ribosome entry sites and upstream ORF-containin
22 rtTA2S-M2-IRES-EGFP vector (where IRES is an internal ribosome entry site) and permits relatively ine
23 on (NCR) of the viral genome functions as an internal ribosome entry site, and its unique 3' NCR is r
24 region showed some attributes of a type IVB internal ribosome entry site, and the polyprotein lacked
25 The regulation of expression from the URE2 internal ribosome entry site appears to be through the l
26 ssays did not validate the possibility of an internal ribosome entry site as a potential mechanism fo
27 etween NS2 and NS3, and second by placing an internal ribosome entry site between the two proteins (a
28 ration and characterization of a novel CXCR3 internal ribosome entry site bicistronic enhanced GFP re
29 ncanonical translation is not mediated by an internal ribosome entry site but requires the interactio
32 lasmids, and we were able to map a potential internal ribosome entry site-containing region to a 2474
34 gy, we discovered a specific defect in IRES (internal ribosome entry site)-dependent translation in D
36 ltiple proteins required for efficient viral internal ribosome entry site-dependent translation are l
37 ational environment to increase the ratio of internal ribosome entry site-dependent translation to ca
38 their replication was made dependent on the internal ribosome entry sites, derived from other positi
39 treatment, but an encephalomyocarditis virus internal ribosome entry site-driven element exhibited no
41 that express the p40 gene linked via a viral internal ribosome entry site element with fluorescent re
45 itiation on picornavirus genomes with type I internal ribosome entry site elements and also for RNA r
48 w c-myc was maintained, we studied myc IRES (internal ribosome entry site) function, which does not r
49 PDGF (platelet-derived growth factor)-IRES (internal ribosome entry site)-GFP (green fluorescent pro
50 a dual reporter, pQCXhSSTr2-IRES-GFP (IRES: internal ribosome entry site; GFP: green fluorescent pro
52 presence of upstream open reading frame and internal ribosome entry site in 5' UTR sequences of C. s
53 m the CDK11(p110) mRNA through the use of an internal ribosome entry site in a mitosis-specific manne
54 d due to enhanced translation mediated by an internal ribosome entry site in the 5'-UTR of the c-Myc
57 rast to cap-dependent and tobacco etch virus internal ribosome entry site interaction with eIF4F, pol
58 Rz3'X was found to substantially inhibit HCV internal ribosome entry site (IRES) activity and PSMA7 w
63 tion initiation despite a complex 5' UTR are internal ribosome entry site (IRES) and 5' proximal post
64 onal activity of the hepatitis C virus (HCV) internal ribosome entry site (IRES) and other HCV-like I
65 n D1 mRNA 5' untranslated region contains an internal ribosome entry site (IRES) and that both this I
66 process that requires uncapped RNA, the HCV internal ribosome entry site (IRES) and the 3' region of
67 viral (HCV) genome is translated through an internal ribosome entry site (IRES) as a single polyprot
68 slated region (5'NTR) which folds to form an internal ribosome entry site (IRES) as well as structure
70 taining an encephalomyocarditis virus (EMCV) internal ribosome entry site (IRES) at the same sites as
71 serting an encephalomyocarditis virus (EMCV) internal ribosome entry site (IRES) between these two pr
73 halomyocarditis virus mRNA is mediated by an internal ribosome entry site (IRES) comprising structura
74 dresses the properties of a newly identified internal ribosome entry site (IRES) contained within the
75 athway incorporates 4E-BP resistant cellular internal ribosome entry site (IRES) containing mRNAs, to
76 on on HIV genomic RNA relies on both cap and Internal Ribosome Entry Site (IRES) dependant mechanisms
79 erties of a conserved 75mer RNA motif of the internal ribosome entry site (IRES) element of encephalo
80 bosomal subunit to the mRNA cap structure or internal ribosome entry site (IRES) element, respectivel
81 r proteins identified to interact with viral internal ribosome entry site (IRES) elements and stimula
82 in-based screen to identify small, synthetic internal ribosome entry site (IRES) elements in vivo.
84 ated GB virus B (GBV-B) genomes is driven by internal ribosome entry site (IRES) elements located wit
85 been demonstrated that selected picornaviral internal ribosome entry site (IRES) elements possess res
86 ranslation of a subgroup of mRNAs containing internal ribosome entry site (IRES) elements such as tho
87 n of translation can be mediated by specific internal ribosome entry site (IRES) elements that are lo
90 A replication, and a partial rescue of viral internal ribosome entry site (IRES) function from IFN su
91 vivo, we generated a knockin mouse where an internal ribosome entry site (IRES) green fluorescence p
92 ndent translation mediated by the poliovirus internal ribosome entry site (IRES) in a dose-dependent
94 C virus (HCV) genomic RNA initiates from an internal ribosome entry site (IRES) in its 5' untranslat
95 RNA genome of hepatitis C virus (HCV) has an internal ribosome entry site (IRES) in its first 370 bas
98 ein synthesis, suggesting the presence of an internal ribosome entry site (IRES) in the 5' UTR of VEG
99 g to a region between the cloverleaf and the internal ribosome entry site (IRES) in the 5'-nontransla
100 9 is located within a structurally conserved internal ribosome entry site (IRES) in the 5'-UTR of a n
101 lored cap-independent translation through an internal ribosome entry site (IRES) in the 5'-UTR of the
102 t the CMTX mutation abolished function of an internal ribosome entry site (IRES) in the 5'-UTR of the
105 anslation in a cap-independent manner via an internal ribosome entry site (IRES) in their 5' untransl
107 o alternative translation initiation routes, internal ribosome entry site (IRES) initiation and ribos
108 e under the translational control of the HCV internal ribosome entry site (IRES) into the livers of m
111 NA is translated in neural cell lines via an internal ribosome entry site (IRES) located in the 5'-un
112 to be regulated by an H ferritin-responsive internal ribosome entry site (IRES) located within the c
113 ivity of these two drugs at the level of HCV internal ribosome entry site (IRES) mediated translation
116 t on the foot-and-mouth disease virus (FMDV) internal ribosome entry site (IRES) occurs at two sites
117 of the pGL3-basic vector was replaced by the internal ribosome entry site (IRES) of encephalomyocardi
118 otein (PTB) to stimulate the activity of the internal ribosome entry site (IRES) of foot-and-mouth di
119 A promising target for treatment is the internal ribosome entry site (IRES) of HCV, a highly con
121 type 1 chimera, PV1(RIPO), with the cognate internal ribosome entry site (IRES) of human rhinovirus
122 lating protein translation directed from the internal ribosome entry site (IRES) of the encephalomyoc
123 on factor (eIF) 4F binds tightly to the mRNA internal ribosome entry site (IRES) of tobacco etch viru
124 t RNAs revealed the presence of an efficient internal ribosome entry site (IRES) overlapping ORF 72 c
125 e unknown structure of the hepatitis C virus internal ribosome entry site (IRES) pseudoknot domain.
126 4 nucleotide domain of the Hepatitis C virus internal ribosome entry site (IRES) RNA adopts an indepe
134 was fused in frame with p51, followed by an internal ribosome entry site (IRES) sequence and the p66
135 ation of a bicistronic system, involving the internal ribosome entry site (IRES) sequence from the 5'
136 tes based on the insertion of a picornavirus internal ribosome entry site (IRES) sequence into the ge
138 nslation of the HCV RNA is facilitated by an internal ribosome entry site (IRES) that can autonomousl
139 -UTR sequence of mouse PTEN does not have an internal ribosome entry site (IRES) that can mediate cap
140 , RNA upstream of the coding region forms an internal ribosome entry site (IRES) that directly binds
141 hypothesized that this 5'-UTR may contain an internal ribosome entry site (IRES) that facilitates BCL
142 -1 Arg/Lys transporter is translated from an internal ribosome entry site (IRES) that is regulated by
144 ein H2, and CUG-binding protein 1-responsive internal ribosome entry site (IRES) that regulates SHMT1
145 droxymethyltransferase 1 (SHMT1) contains an internal ribosome entry site (IRES) that regulates SHMT1
146 lex secondary structure, and functions as an internal ribosome entry site (IRES) to initiate translat
147 They use a structured RNA element termed an internal ribosome entry site (IRES) to recruit the 40S r
149 translation of MPD6 was mediated by a novel internal ribosome entry site (IRES) upstream of the MPD6
152 orescent protein (GFP) transgene fused to an internal ribosome entry site (IRES) was inserted after t
155 e yeast Saccharomyces cerevisiae contains an internal ribosome entry site (IRES) whose activity is su
157 e that this isoform results from usage of an internal ribosome entry site (IRES) within exon 5 that i
158 We demonstrate the presence of a functional internal ribosome entry site (IRES) within the 5' leader
160 inine/lysine transporter (cat-1) mRNA via an internal ribosome entry site (IRES) within the mRNA lead
161 gion alone is insufficient to function as an internal ribosome entry site (IRES) without including a
162 ss in detail the recent discovery of the p53 internal ribosome entry site (IRES), its role in p53 tra
163 A recent study indicated that full-length internal ribosome entry site (IRES), present in the 5'-u
164 non-canonical means of initiation, including internal ribosome entry site (IRES), ribosome shunting,
165 and domain II of the hepatitis C virus (HCV) internal ribosome entry site (IRES), we measured the rat
166 planted sequence comprised domain III of the internal ribosome entry site (IRES), which directly bind
167 us 5' nontranslated region (NTR) contains an internal ribosome entry site (IRES), which facilitates t
168 sites as well as the cricket paralysis virus internal ribosome entry site (IRES), which interacts wit
169 5'-untranslated region, is initiated from an internal ribosome entry site (IRES), which is modulated
170 ein through a cap-independent, or rather, an internal ribosome entry site (IRES)-dependent mechanism.
172 A1 regulates a salvage pathway facilitating internal ribosome entry site (IRES)-dependent mRNA trans
173 chanistically, we demonstrate that decreased internal ribosome entry site (IRES)-dependent Myc mRNA t
174 w that during OIS, a switch between cap- and internal ribosome entry site (IRES)-dependent translatio
175 otein with CCND1 messengerRNA and that CCND1 internal ribosome entry site (IRES)-dependent translatio
176 d that Pdcd4 inhibited cap-dependent but not internal ribosome entry site (IRES)-dependent translatio
177 icistronic cellular reporter system with HCV internal ribosome entry site (IRES)-dependent translatio
178 uced the expression of Runx1 protein from an internal ribosome entry site (IRES)-dependent, cap-indep
179 nhibits the translation of cap-dependent and internal ribosome entry site (IRES)-driven mRNAs, includ
180 e that LSm1 contributes to activation of HCV internal ribosome entry site (IRES)-driven translation b
181 by higher levels of eIF4G1 were found to use internal ribosome entry site (IRES)-mediated alternate t
183 of the cyclin D1 and c-myc mRNAs occurs via internal ribosome entry site (IRES)-mediated initiation
184 several studies suggest that it may modulate internal ribosome entry site (IRES)-mediated initiation
185 by regulating translation possibly using an internal ribosome entry site (IRES)-mediated mechanism.
186 ic RNA and, at least in part, by stimulating internal ribosome entry site (IRES)-mediated translation
188 -cytoplasmic SR protein, SRp20, functions in internal ribosome entry site (IRES)-mediated translation
189 psh-53, psh-274, and psh-375) suppressed HCV internal ribosome entry site (IRES)-mediated translation
190 at the expression of p27kip1 is regulated by internal ribosome entry site (IRES)-mediated translation
191 rine leukemia virus (MLV) vectors containing internal ribosome entry site (IRES)-transgene cassettes
211 domain 3 of the foot-and-mouth disease virus internal ribosome entry site (IRES); this junction conta
212 use of molecular tags on viral mRNA such as internal ribosome entry sites (IRES) and genome-linked v
213 imize the coding potential of viral genomes, internal ribosome entry sites (IRES) can be used to bypa
214 ly encode one target protein, but the use of internal ribosome entry sites (IRES) can confer the abil
216 tion, mitotic raptor promotes translation by internal ribosome entry sites (IRES) on mRNA during mito
217 ciated with protein expression of mRNAs with internal ribosome entry sites (IRES) that are sensitive
218 F mRNA 5'-untranslated region (5'-UTR) bears internal ribosome entry sites (IRES), which confer susta
224 t (6- to 22-nt) sequences that functioned as internal ribosome entry sites (IRESes) and enhanced tran
225 ndependent translation, which is mediated by internal ribosome entry sites (IRESes) located in the 5'
227 urring nucleotide sequences that function as internal ribosome entry sites (IRESes) within the 5' lea
231 The use of bicistronic vectors carrying internal ribosome entry sites (IRESs) allows the coexpre
232 ein syntheses mediated by cellular and viral internal ribosome entry sites (IRESs) are believed to ha
236 widespread class of RNA viruses that utilize internal ribosome entry sites (IRESs) for translation in
241 se selective translation of mRNAs containing internal ribosome entry sites (IRESs) that include key p
242 V) messenger RNAs contain related (HCV-like) internal ribosome entry sites (IRESs) that promote 5'-en
243 ve to L13a-mediated silencing when driven by internal ribosome entry sites (IRESs) that require initi
246 se structured RNA elements, resembling viral internal ribosome entry sites (IRESs), are found in subs
247 pression were essential for the discovery of internal ribosome entry sites (IRESs), it is becoming in
248 ber of cellular mRNAs are thought to possess internal ribosome entry sites (IRESs), sequences that pe
249 UTR of luciferase reporter mRNAs containing internal ribosome entry sites (IRESs), so that potential
250 ed by recruitment of ribosomes to structured internal ribosome entry sites (IRESs), which are located
251 swine fever virus or cricket paralysis virus internal ribosome entry sites (IRESs), which do not use
257 that the cricket paralysis virus intergenic internal ribosome entry site is able to support Sec inco
258 n in HCV in detail, mRNAs containing the HCV internal ribosome entry site linked to a luciferase codi
259 Thus, GPR41 expression is mediated via an internal ribosome entry site located in the intergenic r
262 hat eIF2A functions as a suppressor of Ure2p internal ribosome entry site-mediated translation in yea
263 c accumulation of hnRNP A1, which attenuates internal ribosome entry site-mediated translation of ant
267 iator ATG and that it can be initiated by an internal ribosome entry site, neither of which has been
268 G, the hepatitis C virus E2 epitope, and the internal ribosome entry site of cricket paralysis virus.
270 thetic hairpin RNAs (sshRNAs), targeting the internal ribosome entry site of hepatitis C virus (HCV)
271 (sshRNAs) (SG220 and SG273) that target the internal ribosome entry site of the hepatitis C virus (H
272 of translation initiation as directed by the internal ribosome entry sites of certain picornaviruses.
273 whether driven by homologous or heterologous internal ribosome entry sites or from a capped message.
274 and ribosome recruitment found in the viral internal ribosome entry site (PKB223) and the V4 domain
275 enteroviral infection, along with the viral internal ribosome entry site, plays a role in mediating
276 eam of the UTRs demonstrated the presence of internal ribosome entry sites, providing an additional,
277 NA-derived template substrate (complementary internal ribosome entry site), R1479-TP showed similar p
279 Dicistroviridae intergenic region (IGR) internal ribosome entry site(s) (IRES) RNAs drive a cap-
280 to the poliovirus type 1 (Mahoney) (PV-1(M)) internal ribosome entry site/segment (IRES)-the question
282 Interestingly, however, the presence of the internal ribosome entry site significantly decreases Sec
283 ue hepatovirus features, including predicted internal ribosome entry site structure, a truncated VP4
284 n for either m(7)G cap or tobacco etch virus internal ribosome entry site, suggesting that the 3' BTE
286 ways; they are uncapped, and they contain an internal ribosome entry site that allows the ribosome to
287 that the 5'-untranslated region contains an internal ribosome entry site that is constitutively acti
289 egy, we rationally designed two thermosensor internal ribosome entry site (thermo-IRES) elements, who
291 cIAP1 (cellular inhibitor of apoptosis), an internal ribosome entry site translation-dependent prote
292 rtially overlaps with the site where the HCV internal ribosome entry site was found to bind, with the
293 genomes in which a heterologous picornaviral internal ribosome entry site was inserted at the 2A/2B j
294 which a Cre recombinase gene preceded by an internal ribosome entry site was inserted into the 3' un
295 protein synthesis of LAMB1 by activating its internal ribosome entry site, which in turn led to incre
296 han translation dependent on the HCV or CSFV internal ribosome entry sites, which do not require eIF4
297 mple of a 5-nt bulge, from hepatitis C virus internal ribosome entry site, with a different sequence
298 strated that the differential utilization of internal ribosome entry sites within the mRNAs of these
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