ライフサイエンスコーパス: internalization

1 cycling following constitutive and regulated internalization.

2 pe cell death via suppression of IL-12Rbeta1 internalization.

3 ween Tet38 and CD36 contributed to S. aureus internalization.

4 is Ca(2+)-dependent and accompanied by ORAI1 internalization.

5 Ocy454 cells prevented enhanced transferrin internalization.

6 e-mediated antigen release before subsequent internalization.

7 a desensitizing protocol induced significant internalization.

8 membrane perforation that lead to bacterial internalization.

9 EVs with age may be due in part to increased internalization.

10 egulation of GIT2 and VPS28 increased PrP(C) internalization.

11 carinic depolarizing current and M1 receptor internalization.

12 MEM16A at the cell surface by preventing its internalization.

13 chemical induction of LTD and AMPA receptor internalization.

14 kane molecules on cell membranes or cellular internalization.

15 binding affinity and PSMA-specific effective internalization.

16 coupling from heterotrimeric G proteins, and internalization.

17 is a major regulator of cell-surface protein internalization.

18 and activation of B cells by LPS enhanced EV internalization.

19 TNFR1 was found to inhibit TNF-induced TNFR1 internalization.

20 east in part, the consequence of M1 receptor internalization.

21 by the formation of vesicular structures and internalization.

22 ody and release their cytotoxic payload upon internalization.

23 h bind to glycans on host cell membranes for internalization.

24 resident naive receptors, resulting in their internalization.

25 itors and gain mechanistic insight into LGR5 internalization.

26 which triggers MAPK recruitment and receptor internalization.

27 receptor interactions or subsequent parasite internalization.

28 orm better than agonists despite the lack of internalization.

29 the action of beta-arrestin to mediate CB1R internalization.

30 effects on endothelium were dependent of its internalization.

31 anchoring BinA to receptor-bound BinB for co-internalization.

32 are largely sequestered from G proteins upon internalization.

33 smosterol and 7-dehydrocholesterol supported internalization.

34 s appear to be destined for degradation upon internalization.

35 o NMDAR stimulation and for consequent AMPAR internalization.

36 t PKC, were involved in agonist-induced KOPR internalization.

37 l cholesterol significantly reduced pathogen internalization.

38 kout (XLKO) pups showed enhanced transferrin internalization.

39 vation leads to F-actin--dependent bacterial internalization.

40 cificity, (2) expression level, (3) cellular internalization, (4) therapeutic function, and (5) poten

41 Thus, for rapid and maximal S1P1 receptor internalization a high potency in both G alphai signalin

42 nitors lacking Lgl1 had decreased N-cadherin internalization and abnormal cell junctions, generating

43 kine ligand 12 (CXCL12), results in receptor internalization and activation of several signal transdu

44 We compared the internalization and activity of GalNAc-conjugated ASOs a

45 s exited early endosomes (EEs) rapidly after internalization and became co-localized with LBPA by 2 h

46 p120-catenin overexpression blocks cadherin internalization and cleavage, coupling entry into the en

47 s entails three complementary mechanisms: 1) internalization and degradation of AbetaOs; 2) release o

48 on and its complexation with CD80/CD86 cause internalization and degradation of CD80/CD86.

49 Ageing increased internalization and degradation of VE-cadherin, resultin

50 ears to reflect Src-induced phosphorylation, internalization and degradation of VE-cadherin.

51 n endosomes/lysosomes and showed reduced LDL internalization and degradation relative to LDLR-WT.

52 tor phosphorylation that results in antibody internalization and degradation.

53 ly, the presence of APP attenuates alpha2AAR internalization and desensitization, which are arrestin-

54 Analytical microscopy demonstrated internalization and dissolution of AgNPs within microgli

55 n physically binds with EGFR to trigger EGFR internalization and downregulation of EGFR and its downs

56 dotropin releasing hormone receptor-mediated internalization and enhances radiosensitivity to both Er

57 To enhance the cancer cellular internalization and implement the controlled drug releas

58 io from accumulation of signal via selective internalization and improved specificity conferred by PR

59 1 (ELMO1) in macrophages mediates bacterial internalization and intestinal inflammation.

60 (18)F-FDG PET often exhibits nonspecific internalization and low specificity and sensitivity, esp

61 associate with claudin-7 and targeted it for internalization and lysosomal degradation in conjunction

62 e-incorporation by transglycosylation or via internalization and metabolic salvage of wall-derived su

63 The mechanisms of host vesicle internalization and processing within the PV remain unde

64 nic CAR signalling and establishes effective internalization and re-expression of the CAR following s

65 Internalization and recycling rates of the ACKR3 R142(3.

66 MC4R undergoes constitutive internalization and recycling to the plasma membrane wit

67 Tests of FM4-64 internalization and repression of ClaH corroborated the

68 h arrestins, whose binding promotes receptor internalization and signaling through G protein-independ

69 series of intracellular events dictating the internalization and subsequent MHC class I (MHC I) displ

70 tiple pathways participate in B. burgdorferi internalization and that different cell surface receptor

71 or binding to the sialic acid to allow virus internalization and the NA is a sialidase responsible fo

72 ed to signal and genetic modification of TCR internalization and trafficking altered the duration of

73 study highlights the impact of nanoparticle internalization and trafficking on the ability to use SE

74 nstriction nor its complete blockage prevent internalization and tube formation, although such manipu

75 ace-sarcolemmal caveolae underlies this, but internalization and/or micro-vesicle loss to the extrace

76 sequent improvement with respect to binding, internalization, and biodistribution through a rational

77 mation, including macropinocytosis, receptor internalization, and cell migration.

78 Btbd7 can enhance E-cadherin ubiquitination, internalization, and degradation in MDCK and peripheral

79 ding ligand binding, ligand-induced receptor internalization, and ligand-stimulated intracellular cAM

80 d blocked by inhibitors of clathrin-mediated internalization; and EGFR activity was insensitive to Cb

81 Host cell recognition and internalization are mediated by toxin B subunits sharing

82 Typically, intermediate levels of norm internalization are most frequent but there are also cas

83 echanism and physiological relevance of LGR5 internalization are unclear.

84 remain tethered to one another subsequent to internalization, arguing that they bud continuously from

85 ding and internalization as well as integrin internalization as a function of time were evaluated to

86 with SZ and HC, suggesting that striatal D2R internalization as measured by our imaging paradigm is n

87 Nanoparticle binding and internalization as well as integrin internalization as a

88 e cell membrane of PC-3 cells displaying low internalization, as expected for receptor antagonists.

89 by use of both a classical antibody feeding internalization assay in which cells were visualized usi

90 alized using confocal microscopy and a novel internalization assay that is based on real-time measure

91 cytosis (CME) is the major route of receptor internalization at the plasma membrane.

92 ro following IgG interaction with AQP4: AQP4 internalization, attenuated glutamate uptake, intramyeli

93 n tested the physiological relevance of LGR5 internalization blockade in vivo A LGR5-rainbow (LBOW) m

94 blocking EGF-mediated EGFR dimerization and internalization but also suppressed cell proliferation a

95 bind to cell membranes, thus promoting cell internalization by active pathways, attachment of cargo

96 icles with 'stealth' properties mostly avoid internalization by all cell types, but internalization c

97 However, upon internalization by bladder epithelial cells, UPEC defici

98 -ATPase inhibitors, which all inhibited LGR5 internalization by blocking clathrin-mediated endocytosi

99 equate decoupling of (18)F-FET perfusion and internalization by cells in the different regions of int

100 n, which involved K(+) efflux and M1 protein internalization by clathrin-mediated endocytosis.

101 ular sorting steps that occur after receptor internalization by endocytosis provide a critical level

102 d a kinase that is involved in C. neoformans internalization by host cells and in host resistance to

103 ENaC internalization by SPX-101 in primary human bronchial ep

104 In particular, the mechanisms of cellular internalization by various endocytosis pathways and subs

105 ECs), and RSV isolates suggest that antibody internalization can be considered a general feature of R

106 avoid internalization by all cell types, but internalization can be enhanced by functionalization wit

107 nical studies have shown agonist-induced D2R internalization can be imaged with positron emission tom

108 ells were overall more efficient at particle internalization compared with the four other populations

109 ed a lower level of agonist-independent KOPR internalization, compared with U50,488H.

110 the one hand, this antigen-antibody complex internalization could result in an antiviral effect, sin

111 Following internalization, DAT robustly targeted to retromer-posit

112 Because other ADC may use the same internalization-degradation pathway to deliver active pa

113 tructure dependence of Y. pseudotuberculosis internalization differed from that of endocytosis, as mo

114 ourse revealed that genetic blockade of LGR5 internalization diminished cell fitness.

115 Further studies documented that receptor internalization, down-regulation, direct recycling, or S

116 thelial (VE)-cadherin undergoes constitutive internalization driven by a unique endocytic motif that

117 +/- 0.18 vs. 1.38 +/- 0.54 nM) and receptor internalization (EC50: 41.9 +/- 29.8 vs. 455 +/- 299 nM)

118 of FGFR2 in cells correlated with efficient internalization, efficacy, and cytotoxic effects in vitr

119 Because of its improved internalization efficiency and superior in vivo stabilit

120 that cooperation becomes "instinctive." Norm internalization evolves much more easily and has much la

121 g agent-based simulations, we show that norm internalization evolves under a wide range of conditions

122 Internalization experiments with different cell lines, w

123 Phagocytic cargo, upon internalization, follows a defined trafficking route to

124 show that Shu1 undergoes rapid hemin-induced internalization from the cell surface to the vacuolar me

125 This suggests that upon agonist-independent internalization, GPRC6A is recycled via the Rab11-positi

126 s affected by multiple parameters, including internalization, hydrophobicity, and chemical modificati

127 iolabeling, in assays including cell uptake, internalization, hydrophobicity, and in vivo imaging usi

128 stimulates the ferroportin (FPN) transporter internalization, impairing the iron absorption; clinical

129 e bending as a mechanism for initiating CTxB internalization in cells that could be independent of cl

130 5-methyl-4-isoxazolepropionic acid) receptor internalization in hippocampal neurons.

131 mGlu3-LTD is mediated by postsynaptic AMPAR internalization in PFC pyramidal cells, and we observed

132 ease in binding may reflect prolonged mGluR5 internalization in response to the glutamate surge.

133 nge to test the hypothesis that impaired D2R internalization in SZ leads to blunted late-phase displa

134 xpressing cells, subsequently affecting CDH2 internalization in the anterior compartment of the futur

135 Here, we show that upon internalization in thyroid cells, endogenous TSH recepto

136 ai signaling determines the rate of receptor internalization in vitro.

137 ) blocks potentiation, suggesting that EAAT3 internalization increases extracellular glutamate concen

138 LO internalization induced reprogramming of human normal pr

139 Blocking receptor internalization, inhibiting PKA II/interfering with its

140 roduct library was screened to discover LGR5 internalization inhibitors and gain mechanistic insight

141 We postulated a model that incorporates internalization into a neurovascular-coupling relationsh

142 to heterologous guest molecules led to their internalization into AaLS assemblies both in vivo and in

143 The siRNA internalization into non-tumorigenic kidney cells was ne

144 se imaging bioconjugates underwent selective internalization into ovarian cancer cells via PRLR-media

145 by activating NF-kappaB signaling following internalization into PEL cells.

146 ocytogenes, and adenovirus) to promote their internalization into target cells.

147 Receptor internalization is associated with a late cAMP/protein k

148 We also show here that the mGluR1 internalization is dependent on a specific E3 ubiquitin

149 Because a key step in Y. pseudotuberculosis internalization is interaction of the bacterial adhesins

150 Given that TNFR1 internalization is known to be essential for apoptosis i

151 First, we show that receptor internalization is required for agonist-induced phosphor

152 e now report that PAR4 and P2Y12 heterodimer internalization is required for beta-arrestin recruitmen

153 Moreover, activated PAR4-P2Y12 internalization is required for sustained Akt activation

154 PSMA affinities (IC50) and internalization kinetics of (99m)Tc-MAS3-y-nal-k(Sub-KuE

155 ditionally, the two receptors show differing internalization kinetics, and we identify the membrane p

156 l media and facilitates their rapid cellular internalization, making them effective TLR-9 immunomodul

157 This internalization mechanism has been exploited with the de

158 air CXCL12-mediated cell migration and CXCR4 internalization more efficiently than the clinically app

159 oDCs and CD23 aggregation, as well as IgE-IC internalization, occurred in both cell types.

160 We conclude that MV internalization occurs via a pathway more consistent wit

161 hen this shedding is blocked, excessive ICOS internalization occurs.

162 ent were similar in both models, binding and internalization of (125)I- asialoorosomucoid was signifi

163 is appropriate to quantify the perfusion and internalization of (18)F-FET by cells in various tissues

164 Internalization of (67)Ga-, (111)In-, and (177)Lu-NeoBOM

165 Although the internalization of Ag was comparable to that of moDCs, A

166 Multiple pathways for internalization of aggregates have been proposed, includ

167 We show, using a pH-sensitive probe, that internalization of alpha-synuclein amyloid fibrils in ne

168 Concomitantly, agonist-induced internalization of alpha2AAR is significantly enhanced i

169 bility of the ATPase Thorase to regulate the internalization of AMPA receptors (AMPARs) in order to s

170 ition, TREM2 deficiency reduces myeloid cell internalization of amyloid throughout pathology, but dec

171 turation are driven by B cell extraction and internalization of antigen from immune synapses.

172 Here we study the mechanism of internalization of asymmetric, chemically stabilized, ch

173 Although it is known that AM induces internalization of CLR*RAMP2, little is known about the

174 and c-Jun N-terminal kinases, as well as the internalization of cNK-2 into the cells.

175 The distribution and lack of agonist-induced internalization of D2 receptors on dopamine neurons indi

176 The cell internalization of designed oligoarginine peptides equip

177 During progressive internalization of EGFP-E. coli, fluorescence lifetimes

178 ignal that affects surface expression and/or internalization of Env from the plasma membrane can modu

179 of ERBB2 signaling suppression and endosomal internalization of ERBB2, Therefore, reexpression of PTP

180 eases, seeding is a process initiated by the internalization of exogenous protein aggregates.

181 cin induced heterologous desensitization and internalization of FPR1.

182 The presence of PTX2 is essential to prevent internalization of FX by SR-AI, and the presence of FX i

183 ddition to their role in desensitization and internalization of G protein-coupled receptors (GPCRs),

184 We confirm the internalization of gold nanoprobes by transmission elect

185 ocrine mechanism to elevate STAT1 and induce internalization of gp130, a common component of many het

186 classical' signalling to G proteins, trigger internalization of GPCRs via interaction with the clathr

187 We show here that ligand-mediated internalization of group I mGluRs is ubiquitination-depe

188 emical composition assist in the binding and internalization of highly polar anionic single stranded

189 DCs to T-cells by increasing the binding and internalization of HIV-1 in DCs.

190 observed to participate in DC-SIGN mediated internalization of HIV-1 in DCs.

191 e target of hFCMR, and show that binding and internalization of IgM by hFCMR is glycan-independent.

192 ane, and that p40 neutralization induced the internalization of IL-12Rbeta1 via caveolin and caused c

193 2 integrin expression and affinity, impaired internalization of integrin attachments, and resulted in

194 e the ability of host cell miRNA to regulate internalization of KSHV, EBV, and HSV-2 in hematopoietic

195 lignan justicidin B blocked the constitutive internalization of LGR5.

196 both prevented the cell surface binding and internalization of Lipoplex, diminished the siRNA concen

197 trate that Nedd4-1 is required for efficient internalization of major growth factor receptors involve

198 age-dependent Ca(2+) channel (VDCC)-mediated internalization of Mn(2+), the clinical utility of this

199 Internalization of Mtb aggregates caused macrophage deat

200 g. length and surface charge, can affect the internalization of MWNT-antigen by DCs, hence the induce

201 ow that LLGL1 directly binds to and promotes internalization of N-cadherin, and N-cadherin/LLGL1 inte

202 ured in cultured cells predict the extent of internalization of nanoparticles in cell populations.

203 the endocytic machinery necessary for normal internalization of native cargo in yeast.

204 This interaction causes internalization of NKG2D from the NK cell surface and tr

205 Moreover, our data suggest that internalization of Notch via endocytosis plays a role in

206 al death and AxD in a manner that depends on internalization of NR.

207 17) show that the LPS receptor CD14 promotes internalization of oxidized phospholipids, a hallmark of

208 required for Cbl-mediated ubiquitination and internalization of PDGFRalpha for feedback inhibition of

209 n mechanisms, such as time-averaging and the internalization of pheromone molecules, have been propos

210 Antibody-mediated internalization of platelets by macrophages correlated w

211 Internalization of proteins from the plasma membrane (PM

212 ng cargo entry through CME, Syp1 can promote internalization of Ptr2 through a recently identified cl

213 e presence of FX is needed to interfere with internalization of PTX2.

214 ested, regardless of their epitopes, induced internalization of RSV F.

215 y to the scavenger receptor CD36 reduced the internalization of S. aureus RN6390 by A549 cells, but t

216 ule and a facilitator of the recognition and internalization of sialic acid decorated apoptotic bodie

217 lls is dependent on heparan sulfate, whereas internalization of smaller non-amyloid oligomers is not.

218 ed that the Tet38 efflux pump is involved in internalization of Staphylococcus aureus by A549 lung ep

219 Our results show internalization of STBEVs into primary HCAEC, and transf

220 sses surface signaling responses by inducing internalization of surface components.

221 n of surface signaling responses by inducing internalization of surface receptors.

222 X-101 binds selectively to ENaC and promotes internalization of the alpha-, beta-, and gamma-subunits

223 termed "GPCR-APEX," we track activation and internalization of the angiotensin II type 1 receptor an

224 ffect agonist-driven, beta-arrestin-mediated internalization of the CB1R.

225 by T-DM1 showed that the early steps in the internalization of the drug were unaltered.

226 e bone marrow-derived mast cells via driving internalization of the IgE/FcepsilonRI complex.

227 lls provided membrane expansion required for internalization of the invading cell.

228 illin, its association with VE-cadherin, and internalization of the latter.

229 learance of bacteria by macrophages involves internalization of the microorganisms into phagosomes, w

230 t trigger of FZD4 ubiquitination and induces internalization of the NDP receptor complex into the end

231 Thus, internalization of the PAR4-P2Y12 heterodimer is necessa

232 t activation of PAR4 but not of P2Y12 drives internalization of the PAR4-P2Y12 heterodimer.

233 n transfected cells, XLalphas also inhibited internalization of the parathyroid hormone and type 2 va

234 P dimers allows one to follow the process of internalization of the particles by the mammalian cells

235 Until recently, it was thought that internalization of the radiolabeled agonist was mandator

236 which is comparable to the time required for internalization of the ventral furrow during gastrulatio

237 sterol substitution had a similar effect on internalization of these bacterial deletion strains as o

238 del for in vivo clearance, antibody-mediated internalization of these platelets by macrophages was in

239 A interaction, and (3) a metal-promoted cell internalization of this basic peptide.

240 palladium reagent induces an efficient cell internalization of this peptide.

241 Internalization of transferrin and these G protein-coupl

242 ession of XLalphas in HEK293 cells inhibited internalization of transferrin, a process that depends o

243 ein expression, along with receptor-mediated internalization of transferrin, was also significantly d

244 Requirement of FcgammaR engagement for internalization of two astrocytic membrane proteins crit

245 t agents could be designed to interfere with internalization of Yersinia without disturbing endocytos

246 edding of ICOSL on B cells and moderate ICOS internalization on T cells.

247 t were unaffected by either accelerating DAT internalization or binding a high-affinity cocaine analo

248 No Ag internalization or sorption on the cell wall was detecte

249 which may trigger uptake into non-productive internalization pathways in target cells, did not change

250 ular structure, micellar stability, and cell internalization pathways, pinpointing the high sensitivi

251 Inhibition of LO internalization prevented activation of MYC and impaired

252 Here, we analyzed an internalization process of antigen-antibody complexes af

253 oA-ROCK-myosin II signaling axis in this MeV internalization process, highlighting a novel role for t

254 vely internalizes and two mutant forms whose internalization properties have been compromised by gene

255 ding affinity of the ligand for PSMA and its internalization properties were evaluated in vitro with

256 in signaling through its unique constitutive internalization property that clears negative regulators

257 er SFA, and lower LDL binding and hepatocyte internalization, provide mechanisms for the greater LDL-

258 Internalization rate is only 1 factor that affects in vi

259 ial addition of each antibody visualized the internalization rate of PrP(C) (Z' factor >0.5).

260 2 mAbs were screened and evaluated for EphA2 internalization rate, binding affinity, epitope binding,

261 affinities for EphA2 but exhibited different internalization rates following the order of 1C1 > 3B10

262 reporting membrane expression and real-time internalization rates of PrP(C) The assay is suitable fo

263 /- 1.7 nM for PSMA and an exceptionally high internalization ratio (67% +/- 13%) in vitro.

264 on ENaC surface number, changes in rates of internalization, recycling, and membrane delivery were i

265 Similarly, receptor-mediated internalization reduced from 33.76% +/- 1.22% applied do

266 ation for examining whether blockade of PAR4 internalization reduces integrin and platelet activation

267 ral concepts of receptor signaling, receptor internalization, regulation of distinct signaling pathwa

268 Here, we demonstrate that AQP4 internalization requires AQP4-bound IgG to engage an ast

269 nduced gene expression and activate receptor internalization, respectively.

270 their neighbors remain intact during mitotic internalization, resulting in an uptake of Celsr1 protei

271 athrin-mediated endocytosis (CME) is a major internalization route for PM proteins.

272 Internalization seems to involve scaffolding proteins, s

273 observed, as CXCL11 induced faster receptor internalization, slower recycling, and longer intracellu

274 Internalization studies using B16F1 melanoma cells show

275 The internalization studies were conducted using B16F1 cells

276 ocytic cup formation and thereby reduced RBC internalization, suggesting a potential role of the Rab

277 ent Vangl2 stabilizes Celsr1 and impedes its internalization, suggesting that dissociation of Vangl2

278 y of the PMMA-NPs to promote the survivin-MB internalization, suggesting that this complex might repr

279 tent with a mechanism of desensitization and internalization that depends upon drug efficacy and affi

280 ct with cell membranes, following a complete internalization that leads to cellular apoptosis.

281 g intracellular trafficking.IMPORTANCE After internalization, the nonenveloped human papillomavirus v

282 with rapid membrane association followed by internalization through a selective, saturable subset of

283 later steps of MC4R and transferrin receptor internalization to endosomes as well as traffic of agoni

284 dissociates HER2 from HSP90, and causes the internalization, ubiquitination, and degradation of HER2

285 s cycle by triggering surface beta1-integrin internalization via anti-beta1-integrin antibodies or th

286 st that Tet38 plays a role both in bacterial internalization via interaction with CD36 and in bacteri

287 TCR internalization was associated, regardless of the ligand

288 Conversely, Lp(a) internalization was enhanced 2-fold in HAP1 and 1.6-fold

289 Internalization was enhanced by extracellular proteins b

290 en the different MAbs, indicating that RSV F internalization was epitope independent.

291 n with Rab9 was only partially decreased and internalization was observed in response to phorbol este

292 We found that cellular albumin internalization was proportional to FcRn expression and

293 Lp(a) internalization was reduced 0.35-fold in HAP1 and 0.33-f

294 Remarkably, activated PAR4 internalization was required for recruitment of beta-arr

295 ore specifically for RSV F, the mechanism of internalization was shown to be clathrin dependent.

296 Cell internalization was studied by flow cytometry and confoc

297 mannose 6-phosphate receptor) blocked PrP(C) internalization, whereas down-regulation of GIT2 and VPS

298 GPRC6A predominantly undergoes constitutive internalization, whereas the agonist-induced effects wer

299 dependence of wildtype Y. pseudotuberculosis internalization with that of Deltainv, DeltayadA, and De

300 dermal cells, is sufficient to trigger their internalization without affecting their fate.