ライフサイエンスコーパス: internalize

1 clathrin by siRNA, activated PAR4 failed to internalize.

2 nabling the carrier to fold and subsequently internalize.

3 eceptors on phagocytic cells and are rapidly internalized.

4 e receptor is subsequently ubiquitinated and internalized.

5 expressed in dopamine neurons they too were internalized.

6 eptors are phosphorylated, desensitized, and internalized.

7 ls show 60.7% of the cell-bound activity was internalized.

8 ntitates the number of antigen-coupled beads internalized.

9 3% of the total receptor agonist uptake was internalized.

10 ls as CD25 is also rapidly downregulated and internalized.

11 They bind to cell membrane receptors and are internalized.

12 in peritoneal macrophages, despite not being internalized.

13 nsitization the tagged D2 receptors were not internalized.

14 least to cells and so was not significantly internalized.

15 ane segmentation for probes that are rapidly internalized.

16 less of maternal mental health and offspring internalizing.

17 x6-S32T mutant lungs, whereas degradation of internalized [(3)H]dipalmitoyl-PC was significantly decr

18 athrin-mediated endocytosis (CME) is used to internalize a diverse range of cargo proteins from the c

19 "Good" receptors internalize Abeta or promote its transcytosis out of the

20 em cells (CSCs), and these monomers were not internalized after drug binding.

21 h which surface-expressed RSV F proteins are internalized after interaction with RSV-specific antibod

22 ndritic cells (MoDC) and show only LAMP-2 is internalized after ligation by specific Abs, including H

23 We found that the high-internalizing agonist SNC80 preferentially recruits arre

24 In contrast, low-internalizing agonists (ARM390 and JNJ20788560) preferen

25 opioid receptor at the cell membrane and low-internalizing agonists promote this interaction.

26 KO revealed an acute tolerance to these low-internalizing agonists, an effect never observed in wild

27 ly accounts for the altered responses to low-internalizing agonists.

28 iates with the plasma membrane and partially internalizes, albeit to a limited extent, in response to

29 at human podocytes in vitro are committed to internalizing albumin through a receptor-mediated mechan

30 ce quencher trypan blue to selectively image internalized alpha-syn seeds in cultured primary neurons

31 was localized to early endosomes containing internalized alphavirus, and depletion of TSPAN9 inhibit

32 NK-92 cells do not internalize AML exosomes.

33 receptors, mediated by enhanced recycling of internalized AMPA receptors back to the postsynaptic mem

34 Thus, c-Met and beta1-integrin co-internalize and become progressively recruited on LC3B-p

35 Terrestrial plants can internalize and translocate nanoparticles (NPs).

36 Dimercaptosuccinic acid-coated SPIONs are internalized and accumulate in late endosomes/lysosomes,

37 still reach the cell surface and be normally internalized and degraded upon exposure to Hepc.

38 l surface GABAB receptors are constitutively internalized and either recycled to the plasma membrane

39 binding to host cellular receptors, becoming internalized and initiating hemifusion but failing to un

40 moted internalization, but is constitutively internalized and rapidly down-regulated.

41 Glut4 is internalized and recycled through a highly regulated sec

42 Signaling receptors are internalized and regulated by clathrin-mediated endocyto

43 to anti-ICAM, anti-ICAM-HRP was specifically internalized and transported across cells, which rendere

44 atypical chemokine receptor 2 (ACKR2) binds, internalizes and degrades most proinflammatory CC-chemok

45 f LGR5, a wild-type form that constitutively internalizes and two mutant forms whose internalization

46 ough which deprivation might confer risk for internalizing and externalizing psychopathology.

47 CRT, no observed; no CRT, 9%); and elevated internalizing and externalizing symptoms (global symptom

48 The LPP predicted both internalizing and externalizing symptoms after accountin

49 e to hurricane-related stress and children's internalizing and externalizing symptoms.

50 scales; however, it was associated with more internalizing and somatizing behaviors in boys, but not

51 ions in contributing to adaptive immunity by internalizing and transporting antigen and influencing a

52 confirmed a subset of particles to be fully internalized, and high-contrast ptychographic images sho

53 ACKR3 contributes to chemotaxis by binding, internalizing, and degrading the chemokines CXCL11 and C

54 -2 cells were evaluated for their ability to internalize anti-CA19.9 antibodies using a fluorometric

55 xPC3 and Capan-2 cells were shown to rapidly internalize anti-CA19.9 monoclonal antibodies, including

56 tes large amounts of CA19.9 and more rapidly internalizes anti-CA19.9 antibodies--showed that this ap

57 ritical steps in this process, the export of internalized antigen to the cytosol, has been suggested

58 n cross-presentation, ERAD, and transport of internalized antigens into the cytosol.

59 crophages are uniquely programmed to process internalized apoptotic cell-derived fatty acids, cholest

60 this with other assays tracking the fate of internalized APP in hippocampal neurons, we found that A

61 n situ on the surface of the target cell and internalized as nanoclusters.

62 Cystatin E/M was internalized as well but at a modest rate.

63 ratures (15 degrees C), while less than 0.2% internalized at 37 degrees C.

64 nels that have reached the cell membrane are internalized at a comparable rate, mutant channels are d

65 alian macrophages that are unable to degrade internalized bacteria also exhibit compromised NF-kappaB

66 ansporter ClC-b/CLCN7 delayed degradation of internalized bacteria.

67 halate (MBzP) was positively associated with internalizing behavior and relationship problems scores

68 halate (MnBP) was positively associated with internalizing behavior, relationship problem, and emotio

69 uman mammary epithelial cells upregulate and internalize beta4-integrin along with its matrix substra

70 C3A cells internalized both coated and uncoated polyester NPs to a

71 Lp(a) was maximally internalized by 2 hours and was detected by an antiapo(a

72 Furthermore, sd-rxRNAs are internalized by a specific class of early endosomes and

73 Endocytosis analysis revealed that MOFs are internalized by active transport and that inhibiting the

74 We found that anti-ICAM was specifically internalized by all tested ICAM-1-expressing cells, incl

75 Alveolar macrophage-derived MVs were fully internalized by alveolar epithelial cells in a time-, do

76 tumor cells with low-nanomolar affinity, is internalized by an integrin-mediated process, releases i

77 EVs from older individuals were more readily internalized by B cells and increased MHC-II expression

78 nthetic vesicles, or polymersomes, which are internalized by binding to scavenger receptors and subse

79 al fibroblasts secreted exosomes, which were internalized by bronchial epithelial cells.

80 two major inorganic forms of Se, are readily internalized by C. reinhardtii, but selenite is accumula

81 ed in temperature-sensitive particles can be internalized by cancer and endothelial cells resulting i

82 , we found that FA-CS-UA-NPs could be easily internalized by cancer cells through a folate receptor-m

83 , we observe that the microresonators remain internalized by cells during cell division, which enable

84 VSG molecules released from trypanosomes are internalized by cells of the cardia-the tissue responsib

85 ated the Hex nanocarrier that is efficiently internalized by cells without cytotoxicity.

86 S. aureus is internalized by Cftr-deficient macrophages in the lung,

87 he mouse nasopharynx and to adhere to and be internalized by cultured human epithelial cells and rest

88 anoprobe, which we call NanoSOSG, is readily internalized by E. coli cells and does not interact with

89 tered by autophagy or extracellular material internalized by endocytosis and phagocytosis.

90 to ischemic hindlimbs, were most efficiently internalized by endothelial cells relative to smooth mus

91 cal factor in the pathogenesis of sepsis, is internalized by endothelial cells, leading to intracellu

92 Moreover, they were internalized by endothelial cells, thus supporting their

93 ve therapeutic agent active against bacteria internalized by host cells.

94 DC-EV were readily internalized by human bone marrow-derived MSC, without i

95 ded exosomes are preferentially captured and internalized by human plasmacytoid DCs (pDCs) that expre

96 The radiolabeled analogue was bound and internalized by LNCaP cells, with both functions blocked

97 levels of cytokine production despite being internalized by macrophages more than Burkholderia cenoc

98 found that the CuDox complex was efficiently internalized by mammary carcinoma cells after release fr

99 C36 C. acnes strains were significantly less internalized by osteoblasts and osteoclasts than CC18 an

100 hment to cell surface receptors, reovirus is internalized by receptor-mediated endocytosis.

101 xosomes and shed microvesicles (MVs), can be internalized by recipient cells to modulate function.

102 he cysteine protease inhibitor cystatin C is internalized by some cancer cells, which affects cellula

103 Exosomes are not internalized by T cells, but signals they carry and deli

104 -)) and hydroxyl radical, are preferentially internalized by T lymphocytes over other splenic immune

105 ross tested NPs (5.4 to 300 ngAg mL(-1)), Ag internalized by the algal cells at EC50 was similar (0.8

106 roscopy analysis suggests that the CNTs were internalized by the cell after fermentation bridging the

107 The novel findings that Lp(a) is internalized by the plasminogen receptor, plasminogen re

108 It is internalized by these fungi, but uses spatially distinct

109 ics and releases pDox nanoparticles that are internalized by tumor cells.

110 We also report that macrophage-internalized C. glabrata cells express CgFtr1 on the cel

111 that many types of human cells specifically internalized C3(H2O), the hydrolytic product of C3, and

112 lysosomes responsible for the degradation of internalized cargo.

113 n, activate inositol phosphate signaling, or internalize CB2 receptors.

114 Golgi complex for cell invasion, but not for internalized cell degradation.

115 The internalized cell was shown to be degraded due to the ly

116 t some GPCRs activate G proteins from within internalized cellular compartments, resulting in sustain

117 Trans-internalized Celsr1 carries with it additional core PCP

118 lation via differences in the degradation of internalized channels.

119 monstrated that these DC subsets efficiently internalize CLEC12A, whereupon it quickly translocates t

120 trate that autologous patient CD4(+) T cells internalize CLL-EVs containing miR-363 that targets the

121 he reductive one-carbon (C1) metabolism, and internalizes CO2 via two biochemical reactions: the reve

122 These internalized coat proteins are the most asymmetrically a

123 In the second pattern, seen in the internalizing conditions of major depression and anxiety

124 for antidepressant medications in pediatric internalizing conditions.

125 ith prolonged beta-agonist exposure, TAS2R14 internalized, consistent with slow recycling of naked TA

126 , social withdrawal, and attention problems (internalizing; CRT, 31%; no CRT, 16%); elevated headstro

127 All cells internalized cystatin C added to culture media, leading

128 classic recycling endosomes, suggesting that internalized DAT targets to either degradation or an und

129 a clump in dead cells, and macrophages which internalized dead infected cells were very likely to die

130 ation, the process by which pathogen Ags are internalized, degraded, and presented by MHC class I, is

131 formation of cancer spheroids, and then were internalized/degraded through a process resembling the w

132 In contrast, the low-internalizing delta agonists (ARM390, JNJ20788560) prefe

133 A high-internalizing delta opioid receptor agonist (SNC80) pref

134 gaster gastrula is delayed until mesoderm is internalized, despite the early expression of Snail in t

135 Complementary assessment of internalizing disorders and brain imaging in children su

136 During an ongoing infection, macrophages can internalize dozens of bacteria.

137 The viral entry receptor Nectin-1 is also internalized during HSV-1 infection in a Cbl-dependent m

138 used to distinguish between cell-surface and internalized EGFR on the basis of the addition of red or

139 We show that cargo internalized either via clathrin-mediated endocytosis (C

140 protein turnover and impaired degradation of internalized epidermal growth factor, whereas endosomal

141 These subsets varied in their ability to internalize Escherichia coli, Staphylococcus aureus, and

142 arying confounds (e.g., other substance use, internalizing/externalizing problems) were recorded annu

143 -1 ortholog, SIDT2, is required to transport internalized extracellular dsRNA from endocytic compartm

144 ts of the plasma membrane that protrudes and internalizes extracellular material by cup-shaped struct

145 for processing images acquired with rapidly internalized fluorescent probes.

146 Our data indicate that a large fraction of internalized fluorescent tRNA (>70%) appears to diffuse

147 that, in response to TGF-beta, cell surface-internalized FN is not degraded by the lysosome but inst

148 radiotracer uptake (both membrane-bound and internalized fractions) and the produced DNA double-stra

149 nd glycolytically in the cilia using glucose internalized from the mucus.

150 mVEGFR1 is highly stable and constitutively internalizes from the plasma membrane.

151 preciated sustained G protein signaling from internalized GPCRs.

152 stin in HEK293 cells, and nearly half of the internalized GPR15 receptors were recycled to the plasma

153 Internalized GPRC6A was mainly co-localized with the ear

154 stigated by assessing the co-localization of internalized GPRC6A with selected Rab protein markers.

155 tonomous pathway in which a growth factor is internalized, has its localization regulated by phosphor

156 sion of LdRab5b:WT enhanced the transport of internalized Hb to the lysosomes in comparison with cont

157 Neither internalized HCMV virions nor THY-1 in virus-infected ce

158 Once internalized, heme is cleaved by both oxidative and nono

159 Irradiation of cells that have internalized HGNs releases surface attached siRNAs and l

160 ing a cellular miRNA to target IkappaBalpha, internalized HIV-1 Vpr inhibits KSHV lytic replication.

161 Certain norms are internalized (i.e., acting according to a norm becomes a

162 o and examined for their ability to bind and internalize IAV, and synthesize viral proteins and RNA.

163 mediated phagocytosis and endocytosis, which internalize immunoglobulin G (IgG)-opsonized particles a

164 Here we report an internalizing immunotoxin targeting the hematopoietic-ce

165 Surprisingly, whereas Fz6 and Vangl2 both internalize in trans, Vangl2 proteins intrinsic to the d

166 and attachment (G) protein were found to be internalized in both infected and transfected cells afte

167 nderstanding of mechanisms by which ASOs are internalized in cells and their intracellular traffickin

168 We optically trap micrometer-sized beads internalized in cells plated on crossbow-shaped adhesive

169 miRNA-loaded PLGA-NP were internalized in HCC cells and anti-apoptotic proteins we

170 When AS is internalized in its monomeric form, however, it nucleate

171 ere we demonstrate that MaBiDZ sensor can be internalized in live MCF-7 breast cancer cells and activ

172 ltering the total cellular pool of AT2Rs and internalized/inactivated major RPT Na(+) transporters Na

173 ranslocation to RPT apical plasma membranes, internalizes/inactivates Na(+)-H(+)-exchanger-3 and Na(+

174 dicated that the CuDox complex was initially internalized intact but breaks down over time within cel

175 The ability of the formulated lipoplexes to internalize into melanoma cells, knockdown the expressio

176 nverts to a crystal hydrate, water molecules internalize into the crystal structure resulting in diff

177 Soluble protein and external aggregates are internalized into AC16 cells via macropinocytosis.

178 entifies chemical scaffolds that are rapidly internalized into blood-feeding parasites.

179 Whereas SMV1 is efficiently internalized into both types of human cells, SSV2 differ

180 gainst bacteria incorporated in a biofilm or internalized into cells without harming human osteoblast

181 the cell membrane as compared to that being internalized into cells.

182 OCS2 binding is delayed until EphA2 has been internalized into endosomes.

183 rapidly endocytosed, targeted to endosomes, internalized into intraluminal vesicles (ILVs), and excr

184 Bacteria internalized into osteoblasts were reduced by the AMP.

185 EVs are then specifically internalized into platelets in a Mac1-dependent fashion,

186 cultures, BoNT/C1 ad light chain is rapidly internalized into presynaptic compartments, but does not

187 Cyto-012 is specifically internalized into rat cortical and hippocampal neurons,

188 These muropeptides are internalized into the cytoplasm and bind to the transcri

189 athyroid hormone (PTH) stimulation, the PTHR internalizes into early endosomes and subsequently traff

190 the LINGO1 protein acts as a gateway protein internalizing into the tumor cells when engaged by antib

191 srupt endothelial adherens junctions through internalized iron oxide nanoparticles, activating the pa

192 echanism by which extracellular vesicles are internalized is incompletely characterized, it is genera

193 s efficiently; however, when P. stomatis was internalized, it was promptly eradicated.

194 Botulinum neurotoxin (BoNT) binds to and internalizes its light chain into presynaptic compartmen

195 i) monocytes, a cell type that inefficiently internalized L. monocytogenes With bone marrow-derived i

196 increased release in the medium of the bound/internalized LDL, as compared with LDLR-WT.

197 ells (MSCs) express scavenger receptors that internalize lipids, including oxidized low-density lipop

198 bserved that cultured lung fibroblasts could internalize live NTHi.

199 epatoma cells, the apo(a) component from the internalized Lp(a) was resecreted back into the cellular

200 crophage subtype was different from collagen-internalizing M2-like macrophages.

201 LRP1 binds and internalizes many plasma components, playing multiple cr

202 ystals, to soluble protoxin heterodimers, to internalized mature toxin, and finally to toxic oligomer

203 Human stabilin-1(+) monocytes efficiently internalized MDA-LDL and this suppressed their ability t

204 clathrin, a cellular process by which cells internalize membrane receptors and their extracellular l

205 dosomes, after the antibody-virus complex is internalized, might be important to block virus spread i

206 d expansion, and the ability to disintegrate internalized MNP in both proliferating and contact-inhib

207 Internalized MOG colocalized with autophagosomes, which

208 ue based on the subdiffractional tracking of internalized molecules (sdTIM).

209 nt efferocytosis, phagocytes must be able to internalize multiple ACs.

210 Inflamed BECs internalized myelin, which was routed to endo-lysosomal

211 The internalized nanomagnets align themselves to the plane o

212 Internalized NET strongly colocalized with the "long loo

213 eroxide is released by activated NOX2 on the internalized neutrophil membrane.

214 ncreasingly important role if the ability to internalize norms emerges.

215 Humans' capacity to internalize norms likely evolved in our ancestors to sim

216 Evolving the ability to internalize norms was likely a crucial step on the path

217 the evolutionary origins of the capacity to internalize norms.

218 d mean fiber cross-sectional area, increased internalized nuclei, and increased fibrosis, compared to

219 Distinctive histopathology showed abundant internalized nuclei, myofibrillar disorganization, desmi

220 To internalize nutrients and cell surface receptors via cla

221 hared characteristics with exosomes and were internalized or remained attached to the recipient cDCs.

222 with >/= 30 Gy CRT conferred greater risk of internalizing (OR, 1.7; 95% CI, 1.0 to 2.8) and global s

223 rapidly degraded; unlike PAM-1, very little internalized PAM-1/OSX was detected in multivesicular bo

224 Internalized PAM-1/OSX was rapidly degraded; unlike PAM-

225 We revealed that a phagocyte is able to internalize particles via a chemoattractant-mediated eng

226 yses revealed that the size distributions of internalized particles differed between the NPs and BPs

227 Macrophages internalize pathogens through phagocytosis, entrapping t

228 xperiences of social evaluation, adolescents internalized peer rejection, experiencing a feedback-ind

229 Consistently, annexin A2 and a cell-internalizing, penetratin-fused version of the selected

230 In vitro, internalized peptide suppressed STAT activation and targ

231 h endothelial and microglial cells bound and internalized PGPFs before trafficking them to lysosomes.

232 rks and potential inhibitors, we screened an internalizing phage (iPhage) display library in tumor ce

233 that macrophages were the primary cells that internalized PLN in the tumor microenvironment and that

234 BAT rapidly replenishes these stores by internalizing primarily lipoprotein triglyceride-derived

235 Remarkably, internalized proteins aligned with the applied voltage b

236 te lysosomal processing as the major fate of internalized proteopathic seeds, and suggest lysosomal i

237 essary for clearance of endosomes containing internalized PRRs, failure of which resulted in enhanced

238 previously thought to bind DNA, do bind and internalize PS ASOs.

239 on-introversion and grouped neuroticism with internalizing psychopathology (e.g., depression or anxie

240 ing anxious phenotypes to the development of internalizing psychopathology and set the stage for deve

241 Internalized quantities of gold nanoparticles in D. magn

242 xistence, functionality, and architecture of internalized receptor complexes composed of a single GPC

243 for the insulin receptor (IR) that redirects internalized receptor molecules from endosomes to the pl

244 Yet, little is known about the fate of internalized receptors, and whether the sorting events d

245 induced by crosslinking of cell surface non-internalizing receptors.

246 ole in producing a cognitive map of space-an internalized representation of the animal's environment.

247 MSV-nAb-PTX remained viable and were able to internalize, retain, and release significantly higher qu

248 blood circulation; and (iii) surface-encoded internalizing RGD (iRGD) to enhance tumor targeting and

249 composed of the following key components: i) internalizing RGD (iRGD) to enhance tumor targeting and

250 rd, monocyte-derived cells, depleted by CLs, internalized S. pneumoniae in vivo, whereas CD11c(low) d

251 All subsets were more efficient at internalizing S. aureus and B. anthracis compared with E

252 ta-arrestin recruitment is required to fully internalize S1P1 receptors, the potency in inducing G al

253 alizing scale (effect size, 0.34; P < .001), internalizing scale (effect size, 0.35; P < .001), and t

254 N-terminal of iRGD, which was linked to the internalizing sequence (CendR motif), and a quencher to

255 Internalized SFV particles colocalized with TSPAN9 in ve

256 CD19-expressing tumor cells rapidly internalize SGN-CD19B, and the released PBD drug induces

257 Silencing of TSSC1 impairs transport of internalized Shiga toxin B subunit to the TGN, as well a

258 Internalized Siglec-8 localized to the lysosomal compart

259 rk reveals how some bacteria may avoid being internalized simply because of their shape, and suggests

260 We show that internalized SiNPs accumulate in lysosomes resulting in

261 nt component of the inflammatory milieu, PKA internalizes Slack channels from the DRG membrane, reduc

262 Both Cys(2)-ADAPT6 and Cys(59)-ADAPT6 were internalized slowly by HER2-expressing cancer cells.

263 dendritic cells, unaffected by CL injection, internalized soluble OVA.

264 -presenting cell surfaces affect how B cells internalize surface-tethered antigens.

265 DCs rapidly and efficiently internalized SVLPs, which was dominated by slow endocyti

266 nalizing symptoms (e.g., aggression) but not internalizing symptoms (e.g., depression), and more help

267 Higher ratings for externalizing and internalizing symptoms at baseline predicted smaller inc

268 ances presented by a circulating antigen and internalized targeting vector.

269 we studied the role of ELMO1 in the fate of internalized targets.

270 y to respond to TCR-mediated stimulation and internalize TCRs mediates detection of ligand density or

271 Finally, internalized TCRs continued to signal and genetic modifi

272 ectively delayed proliferation in cells with internalized TCRs.

273 ed cells revealed a marked colocalization of internalized TfR1 with late endosomes/lysosomes, whereas

274 icroglia-like cell lines have other means to internalize the fibrils.

275 C26 recruited beta-arrestin-2, and internalized the Green Fluorescent Protein (GFP)-taggedb

276 and selective; over 99.6% of cells in vitro internalized the peptide carrier at low temperatures (15

277 suggesting that the cognate BCR efficiently internalizes the Id in an IC with nucleosomes.

278 e cells suppress oHSV-1 growth in gliomas by internalizing the virus through phagocytosis.

279 Once GA is internalized, the interaction between GA and UV-A induce

280 crease the availability of NMDA receptors by internalizing them.

281 ma membrane, as a result of the inability to internalize TLR4, Siglec-E-deficient dendritic cells wer

282 Our results demonstrated that HCV-exo internalized to HSC and increased the expression of prof

283 Further, C4BP was internalized together with IAPP into INS-1 cells.

284 Whereas the CME of constitutively internalized transferrin receptors is mainly dependent o

285 subunit to the TGN, as well as recycling of internalized transferrin to the plasma membrane.

286 We show that internalized TrkA receptors promote insulin granule exoc

287 We internalized tRNA labeled with organic fluorophores into

288 rmation that Ig-like transcript 7 is rapidly internalized upon receptor-mediated endocytosis of TLR7/

289 Our results showed that, once internalized, VAMP2-pHluorin/Atto647N-tagged nanobodies

290 Finally, the disruption of internalized vesicle membranes was enhanced by the phosp

291 PS-ASOs are known to be internalized via a number of endocytotic pathways and ar

292 This protein complex is internalized via clathrin-mediated endocytosis and degra

293 uristatin and saporin toxins are efficiently internalized via hCD22 resulting in killing of B-cell ly

294 The internalized viral envelope fuses with the macropinocyti

295 Internalized virus remained capable of expressing report

296 ing a cellular miRNA to target IkappaBalpha, internalized Vpr inhibits KSHV lytic replication.

297 parated by problem type (maladaptive groups; internalizing vs. externalizing problems) and behavioral

298 we report that GLP-1R agonists activate and internalize within NTS astrocytes, while behavioral data

299 ncircled area of membrane can be severed and internalized within the lumen as a fragment upon lipid b

300 added to cells, this fluorescent peptide is internalized within vesicular structures, including glyc