ライフサイエンスコーパス: interneuron

1 tive intestinal polypeptide (VIP)-expressing interneurons.

2 resulted in increased excitability of SST(+) interneurons.

3 dium spiny neurons as well as in cholinergic interneurons.

4 ut not with the loss of parvalbumin-positive interneurons.

5 tivity, arising from dysfunctional GABAergic interneurons.

6 esponses are mediated by a single pathway of interneurons.

7 involving loss of parvalbumin immunoreactive interneurons.

8 highly expressed, particularly in GABAergic interneurons.

9 requires pruning of excitatory inputs to PV interneurons.

10 5-HT2 receptor activation exciting GABAergic interneurons.

11 and cholecystokinin (CCK) expressing basket interneurons.

12 predicted lower PSD95+ puncta density on PV interneurons.

13 rgic currents in glomerular layer-projecting interneurons.

14 r configuration from CA3 pyramidal cells and interneurons.

15 neurons and the fast-spiking (FS) inhibitory interneurons.

16 yrus, but no change in density of calretinin interneurons.

17 ion and microcircuit assembly of neocortical interneurons.

18 ic, nicotinic excitation through cholinergic interneurons.

19 en excitatory pyramidal cells and inhibitory interneurons.

20 maturation of orientation selectivity in PV interneurons.

21 related transcription factor c-Jun in spinal interneurons.

22 pathways-as well as the striatal cholinergic interneurons.

23 , ganglion cell density, and organization of interneurons.

24 s PAX2, a transcription factor for GABAergic interneurons.

25 s were detected in mouse regular-spiking O/A interneurons.

26 ry bulb, where they differentiate into local interneurons.

27 fiber sprouting, astrogliosis, and GABAergic interneurons.

28 Slc6a15 protein was unaltered in ChAT interneurons.

29 blated from 50% of cortical and hippocampal interneurons.

30 nent was selectively reduced at SynII(-) CCK interneurons.

31 um (MS) as the major afferents to dentate PV interneurons.

32 put neurons as well as region-specific local interneurons.

33 branch-specific homophilic interactions with interneurons.

34 on selectivity emerges in visual cortical PV interneurons.

35 the extent of selective elimination of nNOS interneurons.

36 biting dorsal horn enkephalinergic/GABAergic interneurons.

37 al interneurons (ELs) are sensory processing interneurons.

38 naptogenesis in gamma-aminobutyric acidergic interneurons.

39 disturbances in the development of cortical interneurons.

40 ntation of multipolar, bipolar, and unipolar interneurons.

41 gence of broad orientation selectivity in PV interneurons.

42 ndent gamma rhythms depend critically on SOM interneurons.

43 of aromatase neurons as putative inhibitory interneurons.

44 ansmission was desynchronized at SynII(-) PV interneurons.

45 racellular perineuronal net enwrapping these interneurons.

46 occurring in two respective types of sensory interneurons.

47 eurons and used cluster analysis to classify interneurons according to their spiking and synaptic par

48 h decreased and delayed striatal fast-firing interneuron activity.

49 lc6a15, we examined Slc6a15 protein in these interneurons after CSDS.

50 monosynaptic glutamatergic excitation in NGF interneurons and a disynaptic, nicotinic excitation thro

51 o three LTMR classes, as well as spinal cord interneurons and corticospinal neurons.

52 of CCK-positive but not parvalbumin-positive interneurons and decreases the firing rate of pyramidal

53 nt increased excitatory synapse number on PV interneurons and displayed greater kinase activity than

54 ively expressed, respectively, in inhibitory interneurons and excitatory mitral projection neurons of

55 inobutyric acid (GABA) to identify GABAergic interneurons and non-GABAergic projection cells.

56 rise from imbalance between AnkG function in interneurons and principal cells and resultant excessive

57 electrical synapses between excitatory local interneurons and projection neurons.

58 ise in the epileptic brain, whereas axons of interneurons and pyramidal cells in CA1 appear to sprout

59 de insights into the development of cortical interneurons and that shed light on when their fate is d

60 rom CCK neurons disinhibits parvalbumin (PV) interneurons and, as a consequence, reduces the neuronal

61 k level including altered activity of spinal interneurons; and (iii) the increased power output neces

62 receptor 5 (mGluR5) on a small population of interneurons ( approximately 1%) expressing neuronal nit

63 Distinct subtypes of inhibitory interneuron are known to shape diverse rhythmic activiti

64 GABAergic interneurons are central to the correct formation of cir

65 w that dendrite-targeting somatostatin (SOM) interneurons are critical for a visually induced, contex

66 Excitatory synapses on PV interneurons are dependent on the AMPA receptor subunit

67 Surprisingly, dentate PV interneurons are depolarized by GABA signaling, which is

68 synaptic integration of GABAergic inhibitory interneurons are essential for functional neural circuit

69 GABAergic interneurons are essential for neural circuit function,

70 s of evidence suggest that parvalbumin (PV+) interneurons are essential in this process, but the mole

71 Interneurons are important for computation in the brain,

72 Moreover, CR+ interneurons are often treated in models as a single hom

73 Interneurons are potentially able to function on both a

74 he hypothesis that excitatory synapses on PV interneurons are pruned during adolescence.

75 We find that assemblies of excitatory spinal interneurons are recruited by sensory input into functio

76 The CR+/Scgn-/SP8-/Lhx7+ interneurons are relatively large-sized (typically 12-20

77 However, because CR+ interneurons are relatively scarce in rodent striatum, l

78 s to directly target major classes of spinal interneurons as well as motor neurons during spasms in a

79 be in GABAergic, parvalbumin, and calretinin interneurons, as well as hilar mossy cells, new adult-bo

80 nsory neuron HOA and its postsynaptic target interneuron AVG: BAM-2/neurexin-related in HOA binds to

81 on somatostatin-positive (SST(+)) GABAergic interneurons because of evidence that their function is

82 Post-CFC inhibition of PV+ interneurons blocks fear memory consolidation.

83 us MF GABAergic responses of stratum lucidum interneurons, but not of stratum radiatum interneurons,

84 anule cells, CA3c pyramidal cells, and local interneurons, but the influence of mossy cells on dentat

85 broad orientation selectivity emerges in PV interneurons by 2 weeks after vision onset, approximatel

86 xcitatory synapses on parvalbumin-containing interneurons by a retrograde trans-synaptic mechanism an

87 The impact of AIH on cervical spinal interneuron (C-IN) discharge and connectivity is unknown

88 ed on motoneurons; however, most midcervical interneurons (C-INs) also respond to hypoxia.

89 gues (2017) find that individual Grp+ spinal interneurons can respond to and distinguish between stim

90 model suggests that cortical feedback on OB interneurons can trigger both forms of plasticity.

91 rgely focusing on cholecystokinin-expressing interneurons (CCK-INTs), a prominent CB subtype-1 recept

92 re processed by distinct molecularly defined interneuron cell types.

93 Distinct cortical interneuron (CIN) subtypes have unique circuit functions

94 Many subtypes of cortical interneurons (CINs) are found in adult mouse cortices, b

95 our rhythm generators coupled by commissural interneurons (CINs), providing left-right interactions,

96 , which is known to exist on stratum lucidum interneurons, coexists in the same pathway with a presyn

97 Little is known about how local PV interneurons communicate with distal brain regions to re

98 Inhibitory interneurons comprise a diverse subpopulation of cells t

99 h laminar zones, Type II PV-IR synapses from interneurons comprised approximately 60% of all PV-IR sy

100 uble-patch recordings from inhibitory basket interneurons connected to pyramidal neurons and used clu

101 us (the putative location of motor neuron-to-interneuron connections).

102 As the production of interneurons continues until the end of pregnancy, we hy

103 m of valence determination in which the same interneurons contribute to both attractive and aversive

104 Thus, increased activity of excitatory DH interneurons coupled with the reduced excitability of in

105 ration of cortical parvalbumin-positive (PV) interneurons depends on the interaction of innate and ex

106 ts demonstrate a critical role for Arid1b in interneuron development and behavior and provide insight

107 in running speed, as the firing rates of PER interneurons did not show significant velocity modulatio

108 how the two major classes of olfactory bulb interneurons differentially contribute to differences in

109 These results provide a description of V2a interneurons differentiated from hPSCs that may be used

110 ons, we identified genes important for human interneuron differentiation.

111 um interneurons, but not of stratum radiatum interneurons, displayed a Hebbian form of LTP that was m

112 We show that Even-skipped lateral interneurons (ELs) are sensory processing interneurons.

113 addition, following extinction learning, PV interneurons enable a competing interaction between a 6-

114 vasoactive intestinal peptide (VIP)-positive interneurons enhanced behavioral performance and neurona

115 vating somatostatin- or parvalbumin-positive interneurons, even transiently during the delay, impaire

116 Molecular layer interneurons exhibit bidirectional firing rate changes d

117 n excitatory and four inhibitory subtypes of interneurons exhibiting unique morphological, physiologi

118 Chemosensory valence-encoding interneurons exist across phyla, and valence is typicall

119 PV interneurons express only isoforms containing exon 1b, w

120 -expressing choline acetyltransferase (ChAT) interneurons express Slc6a15, we examined Slc6a15 protei

121 analyses, including rare subpallial-derived interneurons expressing dopamine biosynthesis genes enri

122 Pyramidal cells and interneurons expressing parvalbumin (PV), somatostatin (

123 Here we find that a single class of interneuron, fast-spiking interneurons (FSIs), modulates

124 tum lucidum and stratum radiatum, but not in interneurons from stratum lacunosum-moleculare.

125 naptic responses evoked by MF stimulation in interneurons from stratum lucidum and stratum radiatum,

126 Fast-spiking interneurons (FSIs) are sparsely distributed throughout

127 Before song learning, fast-spiking interneurons (FSIs) densely innervated glutamatergic pro

128 a single class of interneuron, fast-spiking interneurons (FSIs), modulates all of these habit-predic

129 raise the possibility that modulation of PV+ interneuron function may alter the development or expres

130 s associated with a reduction in hippocampal interneuron function.

131 nses to experience by dynamically gating PV+ interneuron function.

132 We further demonstrate that these interneurons gate sensory inputs and control pain throug

133 c milieu or estrogen treatment might reverse interneuron generation.

134 In the tonic-firing inhibitory lamina II interneurons, glutamatergic drive was reduced while glyc

135 argeting both pyramidal cells and inhibitory interneurons has recently been shown to elicit propagati

136 KEY POINTS: Spinal parvalbumin-expressing interneurons have been identified as a critical source o

137 weeks after vision onset, we found that tPV interneurons have not developed broad orientation select

138 , SOMIs with axon in the hilus, termed hilar interneurons (HILs), provide perisomatic inhibition onto

139 Hilar-perforant-path-associated interneurons (HIPP cells) have been considered to be syn

140 e for a unique, tonically active, excitatory interneuron in the songbird basal ganglia that makes str

141 s are tightly controlled by local inhibitory interneurons in a spatially and temporally defined manne

142 ropeptide Y, parvalbumin, and GAD65-positive interneurons in central networks collectively support th

143 synapse formation between sparsely labelled interneurons in clusters and the same nearby excitatory

144 Our data support a key role for VIP interneurons in cortical circuit development and suggest

145 expressed on parvalbumin-positive GABAergic interneurons in corticolimbic brain regions and contribu

146 nt of a sparse population of nNOS-expressing interneurons in cue-induced cocaine seeking, revealing a

147 ty of parvalbumin- and somatostatin-positive interneurons in dentate gyrus, but no change in density

148 the properties and synaptic connectivity of interneurons in Fmr1 KO mice during a critical period of

149 cantly correlated with the loss of GABAergic interneurons in or adjacent to the granule cell layer, b

150 Excitatory V2a interneurons in particular are an integral component of

151 lly target GABAergic axo-axonic and some CCK interneurons in restricted septo-temporal CA3 segments.

152 ayer V-VI pyramidal neurons and fast-spiking interneurons in slices from male and female mice and in

153 Many interneurons in stratum lucidum and stratum radiatum rec

154 te the selective involvement of fast spiking interneurons in structured temporal sequences during spo

155 having a preponderance of multipolar ChAT-ir interneurons in the caudate nucleus and putamen, whereas

156 most ErbB4 studies have focused on GABAergic interneurons in the hippocampus and neocortex, particula

157 l transplantation of precursors of GABAergic interneurons in the IL-31Tg mice.

158 a genetically defined population of balance interneurons in the larval zebrafish relates to the comp

159 However, chemogenetic activation of nNOS interneurons in the NAcore reinstated sucrose seeking.

160 maturation of the intrinsic properties of FS interneurons in the sensory cortex, and a deficit in the

161 We sequenced the transcriptome of brainstem interneurons in the specialized respiratory rhythmogenic

162 ng activity of both pyramidal and inhibitory interneurons in the subiculum.

163 is at odds with the known anatomy of layer 4 interneurons in visual cortex and differs from recent fi

164 l nets (PNNs) around fast-spiking inhibitory interneurons, in a rat model of TBI as well as in brains

165 ey can also corelease these amino acids onto interneurons, in a target-dependent manner.

166 e cells (GCs) and inhibitory molecular layer interneurons-in processing of whisking signals.

167 porating excitatory pyramidal and inhibitory interneurons indicated that tACS effects likely depend o

168 oaches to show that dorsolateral striatal PV interneurons influence the initial expression of reward-

169 nule cell inputs and bidirectional tuning of interneuron inputs are required to generate the kinemati

170 Inhibitory interneurons (INs) comprise a small, heterogeneous fract

171 Here, we show that inhibitory interneurons (INs) expressing the RORbeta orphan nuclear

172 boutons synapsing onto parvalbumin-positive interneurons (INs) than in low Pr boutons synapsing onto

173 Hz) evoked a short-latency excitation of BA interneurons (INs) that was depressed at higher frequenc

174 ultiple BMPs are required to specify sensory interneurons (INs).

175 into a densely connected hub sensory neuron/interneuron, integrating a large number of male-specific

176 Appropriate integration of GABAergic interneurons into nascent cortical circuits is critical

177 show tangential migration of young GABAergic interneurons into the developing hippocampus is slowed i

178 on of group I mGluRs at the same time as the interneuron is hyperpolarized, or by postsynaptic trains

179 e evidence that the function of fast-spiking interneurons is disrupted due to a deficiency in neurotr

180 lts demonstrate that a population of newborn interneurons is endowed with specific cdhr proteins nece

181 The function of cortical GABAergic interneurons is largely determined by their integration

182 ing that the effect of ErbB4 signaling in PV interneurons is mediated by alternative splicing.

183 Here we identified a subset of spinal interneurons, labeled by gastrin-releasing peptide (Grp)

184 t of maternal CB intake on mouse hippocampal interneurons largely focusing on cholecystokinin-express

185 er, the lack of a robust source of human V2a interneurons limits the ability to molecularly profile t

186 coupling during suppression, suggesting that interneurons local to the hippocampus implement control

187 In the brain, many types of interneurons make functionally diverse inhibitory synaps

188 ority of these cells also express inhibitory interneuron markers.

189 e onset of visual experience determines when interneurons mature in the visual cortex.

190 he hypothesis that degeneration of GABAergic interneurons may be the cause of supraspinal GABAergic d

191 patterns of these interactions suggest that interneurons mediating lateral inhibition in the central

192 ed by live imaging enabled analysis of human interneuron migration and integration.

193 Here, we show that preterm birth disrupts interneuron neurogenesis in the medial ganglionic eminen

194 h a presynaptic form of GABAergic LTP, while interneurons of stratum radiatum, despite receiving this

195 We found that, in cartwheel inhibitory interneurons of the dorsal cochlear nucleus, the likelih

196 eceptors in cholecystokinin (CCK) inhibitory interneurons of the mammalian dentate gyrus (DG) initiat

197 These data show a requirement for PV+ interneurons of the NAc in behavioral responses to AMPH,

198 Silencing PV+ interneurons of the NAc selectively inhibited the expres

199 nt for parvalbumin (PV) expressing GABAergic interneurons of the nucleus accumbens (NAc) in the behav

200 se afferents and the ascending propriospinal interneurons of the reflex.

201 med by parvalbumin- or somatostatin-positive interneurons on pyramidal layer 5 neurons in the medial

202 tum interneurons, whereas in stratum lucidum interneurons only GABAergic responses were potentiated.

203 ive number of dopaminergic and GABAergic AOB interneurons or locally introducing DA or GABA receptor

204 Removing Cntn5 from either ooDSGCs or interneurons partially phenocopies Satb1 mutants, demons

205 Moreover, it remains unclear whether MC-interneuron plasticity is unique to specific behaviors,

206 ms underlying the influence of experience on interneuron plasticity remain poorly understood.

207 protein Brevican is a critical regulator of interneuron plasticity.

208 populations of striatal neuropeptide Y (NPY) interneurons, plateau low threshold spike (PLTS) and NPY

209 GABAergic interneurons play critical roles in seizures, but it rem

210 entified in the rat with lumbar galaninergic interneurons playing a pivotal role (Science 2002;297:15

211 so identified a topographically distinct CR+ interneuron population with a rostral bias similar to th

212 eminence, as most studies have examined this interneuron population.

213 determined by whether appetitive or aversive interneuron populations are activated.

214 activity, as well as regulated distinct CA1 interneuron populations in multiple tasks and behavioral

215 odor-evoked activity in GABAergic inhibitory interneuron populations in the OB.

216 ng reflexive behavior.SIGNIFICANCE STATEMENT Interneuron populations use specific anatomical projecti

217 statin-expressing and parvalbumin-expressing interneurons positively correlated with locomotion.

218 th the reduced excitability of inhibitory DH interneurons post-SCI could provide a neurophysiological

219 , the entry of Cdhr23- and Cdhr15-expressing interneuron precursors into the embryonic cortex was als

220 "early adhesion code" targets populations of interneuron precursors to restricted neocortical regions

221 w is that striatal parvalbumin (PV)-positive interneurons primarily function to downregulate medium s

222 othesized that premature birth would disrupt interneuron production and that restoration of the hypox

223 rior ventral V-SVZ and regulate deep granule interneuron production depending on feeding behavior.

224 erses this perturbation in the population of interneuron progenitors in the MGE.

225 GABA-ergic interneurons provide diverse inhibitions that are essent

226 PNNs), which surround parvalbumin-expressing interneurons (PV-cells).

227 from perisomatically projecting parvalbumin interneurons (PV-IPSCs), but decreased depression of IPS

228 d selective chemogenetic stimulation of nNOS interneurons recapitulated MMP activation and t-SP induc

229 How GABAergic interneurons regulate the segregation and communication

230 euronal VGF, expressed in part in inhibitory interneurons, regulates depression-like behavior.

231 However, selective markers for MOB interneurons remain largely unknown, limiting mechanisti

232 l the functional organization of neocortical interneurons remain largely unknown.

233 We suggest that these interneurons represent the main targets for supraspinal

234 signals converge on two axonal domains of an interneuron RIA, where the sensory-evoked signal suppres

235 ing a reduced number of striatal cholinergic interneurons (SCIN), are involved in their pathophysiolo

236 We also found a reduction in the number of interneuron-selective calretinin-ir cells in the dentate

237 sticity from a single pathway onto different interneuron sets.

238 The GAD(+) interneurons showed relatively low expression of GABAA r

239 rocessing in the olfactory system, GABAergic interneuron signaling shapes principal neuron activity t

240 insic excitability changes in Arc-expressing interneurons.SIGNIFICANCE STATEMENT The accessory olfact

241 cally inhibited parvalbumin-positive (PV(+)) interneurons, since their activity is important for regu

242 d with parvalbumin- or somatostatin-positive interneuron stimulation.

243 -RZ interneuron subtypes, while each LTMR-RZ interneuron subtype samples inputs from at least one to

244 rse of GABA release, and that this effect is interneuron subtype specific.

245 that this SynII function is dependent on the interneuron subtype.SIGNIFICANCE STATEMENT Deletion of t

246 Understanding how each of the many interneuron subtypes affects brain network activity is c

247 s responsible for the lifelong generation of interneuron subtypes and oligodendrocytes.

248 tic approach, we report here that LFS of two interneuron subtypes and, even more so, of principal cel

249 alysis of the release time course at the two interneuron subtypes demonstrated that the asynchronous

250 it remains unknown whether these vary across interneuron subtypes or evolve during a seizure.

251 umin and calbindin are molecular markers for interneuron subtypes, and are co-expressed with aromatas

252 Sst interneuron subtypes, residing in different cortical lay

253 when modulation coincidently drove all three interneuron subtypes, ruling out either inhibition or di

254 form synapses on between four and 11 LTMR-RZ interneuron subtypes, while each LTMR-RZ interneuron sub

255 somatic inhibition mediated by PV-containing interneurons, suggesting that their sustained silencing

256 ates, in which the relative abundance of CR+ interneurons suggests that they play a critical role in

257 dministration or pharmacogenetic parvalbumin-interneuron suppression.

258 g mid-embryogenesis to produce astroglia and interneurons, switch their fate and generate granule neu

259 nses through modulation of sensory neuron to interneuron synapses.

260 We focus on cortical interneurons that are derived from the medial ganglionic

261 ke frequencies in both principal neurons and interneurons that are irregular in time and much lower t

262 nd cortex with fast-spiking parvalbumin (PV) interneurons that control network excitability and rhyth

263 e expressed not only by ooDSGCs, but also by interneurons that form a scaffold on which ooDSGC ON den

264 Amacrine cells are a heterogeneous group of interneurons that form microcircuits with bipolar, amacr

265 at spinal locations that contain last-order interneurons that innervate hand motoneurons.

266 MCs also synapse with GABAergic interneurons that mediate feed-forward inhibition onto G

267 command neuron for escape and the inhibitory interneurons that regulate swimming provide a cellular m

268 zed mice, we found that two major classes of interneurons, the parvalbumin and the somatostatin posit

269 ral axis, phasing the firing of specific CA3 interneurons, thereby contributing to the selection of p

270 of spillover transmission to molecular layer interneurons, these results reveal that climbing fibers

271 The excitatory interneuron thus serves as one biophysical mechanism for

272 r neurons to generate spasms, and inhibitory interneurons to curtail them.

273 ress functional differences within GABAergic interneurons to highlight the importance of diverse, fle

274 as of parvalbumin- or somatostatin-positive interneurons to study the effects of such repetitive act

275 By comparing the transcriptomes of immature interneurons to those of more mature neurons, we identif

276 Thus, we posit that stem cell-derived interneuron transplants may be an effective therapeutic

277 hese data suggest that the stem cell-derived interneuron transplants may represent a novel therapeuti

278 e inhibitory control of state transition was interneuron-type specific.

279 Comparison with motor and interneuron types in the vertebrate neural tube indicate

280 in the two morphofunctionally characterized interneuron types of adult cortical layer I, suggesting

281 focus has been the iGluR profile of cortical interneuron types.

282 les may evolve during seizures, PV+ and SOM+ interneurons ultimately help maintain ongoing seizures.

283 clamp recordings from spinal motoneurons and interneurons, we describe a long-duration ( approximatel

284 mimicked mGluR5 signaling through Gq in nNOS interneurons, we recapitulated cue-induced reinstatement

285 Putative interneurons were discriminated from principal cells bas

286 Furthermore, immobility-activated interneurons were distributed across cell layers, with s

287 Contacts on interneurons were most common in the Pv (39%), intermedi

288 n or nitric oxide-expressing and cholinergic interneurons were normal in Hdc KO mice.

289 Circuitoids of purified excitatory interneurons were sufficient to generate oscillatory bur

290 glutamatergic responses of stratum radiatum interneurons, whereas in stratum lucidum interneurons on

291 extual fear conditioning (CFC), fast-spiking interneurons (which typically express parvalbumin (PV))

292 pecies are composed of bilaterally symmetric interneurons, which are individually identified and reci

293 ons, Kv3.1b staining in parvalbumin-positive interneurons, which show strong Kv3.1b immunoreactivity.

294 to the adapting-firing excitatory lamina II interneurons while GABAergic and glycinergic inhibition

295 manner, to activation of a specific pair of interneurons with a critical role in learning.

296 s included viral transfection of hippocampal interneurons with channelrhodopsin for the optogenetic m

297 onal stem cell can produce a large number of interneurons with similar functional capacity that are d

298 f a novel population of deep short-axon cell interneurons with superficial axonal projections to the

299 f pyramidal cells, spiny stellate cells, and interneurons within the extrastriate cortex.

300 d DDmg are reciprocally connected to pallial interneurons within the misnamed rostral entopeduncular