ライフサイエンスコーパス: interneurone

1 CP-AMPARs to a specific subclass of cortical interneurone.

2 and other intermediate zone and ventral horn interneurones.

3 and are therefore attributed to dorsal horn interneurones.

4 diated primarily via lamina VIII commissural interneurones.

5 ough their disynaptic actions on commissural interneurones.

6 connections contribute to spike AHPs in many interneurones.

7 tic signal processing by distinct classes of interneurones.

8 y also be a reduced projection to inhibitory interneurones.

9 or Renshaw inhibition of Group Ia inhibitory interneurones.

10 y nonpyramidal cells, which are the cortical interneurones.

11 tive terminals contacting other ventral horn interneurones.

12 r muscle motor neurones, and (iii) ascending interneurones.

13 Acceptable fits were obtained for 24 CA3 interneurones.

14 information known to date about sympathetic interneurones.

15 f synaptic contacts made by single GABAergic interneurones.

16 sensitive muscle spindle Ia afferents and Ia interneurones.

17 mata and processes of pyramidal cells and in interneurones.

18 orded in postsynaptic pyramidal cells and in interneurones.

19 ctions involving two classes of postsynaptic interneurones.

20 tial after-hyperpolarization were greater in interneurones.

21 firing in hippocampal stratum oriens-alveus interneurones.

22 spontaneous EPSPs and IPSPs were recorded in interneurones.

23 ors were simulated on pyramidal cells and on interneurones.

24 gulating the inhibitory coupling between the interneurones.

25 structed of 1024 CA3 pyramidal cells and 256 interneurones.

26 ls to depolarization of divergent classes of interneurones.

27 presynaptic GABA(B) receptors on glycinergic interneurones.

28 sly, by synchronous firing in many myenteric interneurones.

29 pses onto pyramidal cells or the majority of interneurones.

30 o regulate presynaptic function in GABAergic interneurones.

31 f stratum oriens-lacunosum moleculare (O-LM) interneurones.

32 n the short term plasticity of synapses onto interneurones.

33 d from 3-4, on the other hand, mainly target interneurones.

34 litude in MSNs as well as in the majority of interneurones.

35 target pyramidal cells and to lesser degrees interneurones.

36 tions in the ventral neuropil (anterolateral interneurones 1-6, ALIN1-ALIN6) and those with arborisat

37 ent boutons appeared to belong to inhibitory interneurones: 3% were immunoreactive for GABA and glyci

38 Almost half the sample of interneurones (38 of 76) were characterized by an ipsila

39 The amplitude and width of interneurones' action potentials were smaller than those

40 at the loss of GABA-ergic inputs from spinal interneurones alone is insufficient to produce tonic fir

41 m projection length of CM motor neurones and interneurones along the bowel was 2.8 mm and 13 mm, resp

42 The conductance of the interneurone alpha-amino-3-hydroxy-5-methyl-4-isoxazole

43 We examined whether dorsal horn interneurones also contribute to these actions, as they

44 These interneurones also showed resonance at low frequencies (

45 The PF-LHA contains local GABAergic interneurones and also receives GABAergic inputs from sl

46 inhibition, upon electrical coupling between interneurones and between pyramidal neurones, and--at le

47 campal slices: pyramidal cells, fast-spiking interneurones and horizontal interneurones, and recorded

48 ion of glutamatergic input onto hilar-border interneurones and its regulation of feedback inhibition

49 f interacting neural populations with single interneurones and motoneurones described in the Hodgkin-

50 we performed dual recordings from GABAergic interneurones and MSNs.

51 clusters of Kv2.1-IR were observed in spinal interneurones and projection neurones, and some interneu

52 Rs dominate subthreshold calcium dynamics in interneurones and reveal the functional contribution of

53 tory postsynaptic potentials in fast-spiking interneurones and spikelet potentials in both pyramidal

54 Both interneurones and TC neurones fired action potentials re

55 Following a train of action potentials, interneurones and TC neurones generated a slow after-hyp

56 ed on the density of synapses made by single interneurones and the volume density of GABAergic synaps

57 can transfer to another, we compared layer 4 interneurones and their local connections across two age

58 tructions of labelled classical fast spiking interneurones and their postsynaptic pyramids (n = 5) de

59 one-quarter of the intracellularly recorded interneurones and virtually all were strongly excited by

60 g primary sensory neurones, motoneurones and interneurones, and in the anterior root ganglion.

61 was significantly larger than in hippocampal interneurones, and not significantly different from NMDA

62 s, fast-spiking interneurones and horizontal interneurones, and recorded their response to sinusoidal

63 cal stimulation of the optic tract evoked in interneurones apparently pure EPSPs, pure IPSPs or a mix

64 An additional class, burst firing, spiny interneurones appear to activate GABAA receptors on more

65 In addition, a small subset of interneurones (approximately 15%) had paired-pulse depre

66 The properties of the interneurones are compared with those of others in the l

67 nto CA1 pyramidal cells and stratum radiatum interneurones are due to a higher initial release probab

68 In particular, stratum oriens 'horizontal' interneurones are easily recognizable in living hippocam

69 GABAergic interneurones are essential in cortical processing, yet

70 Interneurones are important regulators of neuronal netwo

71 to the re-examination of the extent to which interneurones are involved in CA3 network excitability.

72 sses of recently identified TH(+) and NPY(+) interneurones are key mediators of striatal nicotinic re

73 GABAergic interneurones are necessary for the emergence of hippoca

74 alpha7-containing nAChRs in rat hippocampal interneurones are significantly less permeable to Ca2+ t

75 In both visual and somatosensory cortex, LTS interneurones are somatostatin-positive, concentrated in

76 nhibition in pyramidal cells, and that these interneurones are synchronized by recurrent excitation.

77 erformed in a model with pyramidal cells and interneurones, arranged in a chain of five cell groups.

78 t spiking (n = 3, including one burst-firing interneurone), as unclassified, or slow interneurones (n

79 se lag between firing of pyramidal cells and interneurones, as observed in the rat hippocampus in viv

80 onto pyramidal cells versus the majority of interneurones at steady state during 2-10 Hz trains.

81 stimulation of mAChRs on adjacent GABAergic interneurones attenuates synaptic glycine release throug

82 One presumptive regular spiking interneurone axon made four somatic and five dendritic c

83 s were also clearly distinguishable from the interneurone based on the presence of their prominent ou

84 tum oriens and stratum pyramidale inhibitory interneurones, before and following the induction of pha

85 both modes, the entire dendritic tree of LTS interneurones behaved as a 'global' single spiking unit.

86 Finally, interneurones belonging to different classes may fire pr

87 rect nAChR-mediated activity was observed in interneurones but not MSNs.

88 d a slow after-hyperpolarizing potential: in interneurones but not TC neurones this potential was fol

89 urse correlated with the type of presynaptic interneurone, but not with IPSP latency, amplitude, reve

90 -current relationships were nearly linear in interneurones, but highly non-linear in TC neurones.

91 naptic excitation of lamina VIII commissural interneurones by group II afferents much less effectivel

92 were classified as horizontal oriens-alveus interneurones by the pronounced 'sag' in response to hyp

93 e model because of delayed excitation of the interneurones by the synchronized burst.

94 abdominal ganglion, the non-giant projection interneurones can be divided into those with main centra

95 reviously found that lower layer neocortical interneurones can reach action potential threshold in re

96 the context of what is known of the sensory interneurones carrying information from slow- and rapid-

97 Choline acetyltransferase-expressing interneurones (ChAT)(+) of the striatum influence the ac

98 In conclusion, at least three distinct interneurone classes receive local excitatory pyramidal

99 lglycine (DHPG) robustly depolarizes several interneurone classes that form GABAergic synapses onto S

100 At these pyramid-interneurone connections, facilitation of the 2nd EPSP (

101 d by each afferent in alpha-motoneurones and interneurones contacted by terminals of both endings, an

102 acid (GABA) were also investigated, as were interneurones containing reduced nicotinamide adenine di

103 servations we conclude that that dorsal horn interneurones contribute to the late actions of group II

104 ptic excitation, indicating that dorsal horn interneurones contribute to this disynaptic excitation.

105 d the synaptically induced doublet firing in interneurones, contribute to the stability and tight syn

106 largest cell to cell variation, and a single interneurone could evoke both small and slow as well as

107 Interneurones could be subdivided according to their ele

108 tion using cytoplasm from single hippocampal interneurones demonstrated the expression of BB2 recepto

109 tion using cytoplasm from single cholinergic interneurones demonstrated the expression of the ATP-sen

110 e to suprathreshold voltage excursions, with interneurones demonstrating a greater degree of spike-fr

111 5/5 burst firing, sparsely spiny neocortical interneurones did not.

112 Interneurones differed in their firing properties.

113 ntermittently at theta frequency, trilaminar interneurones discharged on every gamma cycle and showed

114 lation spikes, as did the first spike of the interneurone doublet.

115 represent the substrate for phasic drive to interneurones during persistent gamma oscillations in th

116 Finally, quantal events on to interneurones elicited spike transmission, owing in part

117 he probability of obtaining a pyramidal cell-interneurone EPSP was also higher for the bistratified c

118 Thus, zinc-mediated modulation of dentate interneurone excitability and GABA release regulates inf

119 The morphologically identified interneurone exhibited no outward rectification, only mo

120 thers, such as some fast spiking neocortical interneurones, exhibited this phenomenon.

121 f MSNs and distinct populations of GABAergic interneurones expressing neuropeptide Y (NPY)(+), parval

122 The numbers of hilar interneurones expressing somatostatin mRNA and neuropept

123 Interneurones fired a single action potential or a burst

124 d precision, and extended the bandwidth that interneurone firing phase-locked.

125 d 5-HT7 receptors did not affect cholinergic interneurone firing, while the 5-HT2 receptor agonist al

126 It is proposed that MCs are crucial interneurones for feedback inhibition in and between neo

127 eurogliaform subtypes of NPY(+) (NPY(+) NGF) interneurones form synaptic connections with MSNs, altho

128 Interneurones formed 5240 +/- 1600 (range, 2830-9690) sy

129 constructions of low threshold spiking (LTS) interneurones from mouse neocortex.

130 larger relative impact per quantum on to CA3 interneurones generate strong feedforward inhibition at

131 This subclass of interneurones generated large, fast postsynaptic current

132 depression, produced by activating GABAergic interneurones, greatly prolonged GABAB receptor-mediated

133 This interneurone had a regular accommodating firing pattern,

134 Excitatory synapses onto the majority of interneurones had less paired-pulse facilitation than sy

135 Interneurones had resting membrane potentials (-52 mV) r

136 ses onto pyramidal cells, synapses onto most interneurones had very little facilitation in response t

137 One interneurone has an ascending axon in the ipsilateral co

138 One interneurone has an ipsilaterally ascending axon and an

139 We propose that interneurones have a perisomatic and a distal dendritic

140 Throughout the mammalian spinal cord, interneurones have been shown to exhibit distinct firing

141 Two interneurones have contralaterally ascending axons and m

142 Five interneurones have unilateral ventral dendritic fields.

143 alamocortical (TC) neurones and those of one interneurone in the cat ventrobasal (VB) thalamus were e

144 group II mGluRs modulate excitatory drive to interneurones in a developmentally regulated manner and

145 In this study of ventral horn interneurones in a thick slice preparation of the lumbar

146 aptic response indicate a differentiation of interneurones in activity-dependent responses.

147 and cholecystokinin-immunoreactive (CCK-IR) interneurones in CA1, dual intracellular recordings usin

148 The current view of the role of GABAergic interneurones in cortical-network function has shifted f

149 Given the central role of CA3 interneurones in mossy fibre synaptic transmission, thes

150 re a potential role of hippocampal GABAergic interneurones in providing spatial and temporal conditio

151 ings were made from rat striatal cholinergic interneurones in slices of brain tissue in vitro.

152 re made from visually identified hippocampal interneurones in slices of rat brain tissue in vitro.

153 nvestigate this issue in rat hippocampal CA1 interneurones in slices under conditions where synaptic

154 ChRs in rat hippocampal CA1 stratum radiatum interneurones in slices, we describe a novel transient u

155 the hypothesis of a selective loss of these interneurones in temporal lobe epilepsy seems unlikely.

156 ACh (100 microM) were detected on inhibitory interneurones in the Ca1 field of the hippocampus proper

157 The role of interneurones in the control of sympathetic activity has

158 ACh excited interneurones in the hippocampus and dentate gyrus in cu

159 at rest and possibly mediated by inhibitory interneurones in the motor cortex.

160 ate populations of excitatory and inhibitory interneurones in the motor cortex.

161 activated inward currents were recorded from interneurones in the presence of blockers of synaptic tr

162 presence of functional nAChRs on inhibitory interneurones in the rat hippocampus.

163 ermeability of the nAChRs in rat hippocampal interneurones in the slice, which contain diverse subtyp

164 Horizontal interneurones in the stratum oriens showed firing prefer

165 latory properties of CA1 stratum oriens (SO) interneurones in vitro.

166 etwork model of cortical pyramidal cells and interneurones including short-term plasticity of inhibit

167 erneurones and projection neurones, and some interneurones, including Renshaw cells, lacked demonstra

168 Fast spiking interneurones inhibited one in four or five of their clo

169 Interneurone-to-interneurone inhibitory postsynaptic potentials (IPSPs),

170 As different interneurones innervate distinct domains of the pyramida

171 and/or descending tracts and motoneurones or interneurones interposed in the spinal pathways.

172 vast electrophysiological knowledge on these interneurones into a more focused picture, which is rele

173 In cerebellar interneurones, intracellular application of 20 microM mi

174 for the functional identification of spinal interneurones involved in the mammalian locomotor patter

175 Regular spiking interneurone IPSPs had intermediate half-widths (27.3 +/

176 ral activity patterns in distinct classes of interneurone is essential to understanding the cellular

177 g of the intrinsic oscillatory properties of interneurones is a novel mechanism that may be crucial f

178 hat they may function as last-order premotor interneurones is discussed.

179 e the monosynaptic activation of dorsal horn interneurones is more weakly and more briefly depressed

180 Understanding the organisation of spinal interneurones is no easy task.

181 The conventional approach to interneurones is to focus on the mean values of various

182 and mAChRs appear to co-localize to the same interneurones, it is not clear whether there is crosstal

183 e percentage decrease in the number of hilar interneurones labelled with either GAD67 or parvalbumin

184 h depolarization of both pyramidal cells and interneurones, largely produced by activation of metabot

185 her these effects reflect a direct effect on interneurones localized to SG or indirectly via sensory

186 ell RT-PCR were obtained from 180 Martinotti interneurones located in layers II to VI of the somatose

187 It is suggested that three broad classes of interneurones may activate GABAA receptors on relatively

188 raction of Bi and Tri implying that Group Ia interneurones may be under segmental and suprasegmental

189 Thus, the authors conclude that some of the interneurones mediating inhibition of the electrical syn

190 All three types of interneurone (n = 6; 2 for each type of cell) elicited s

191 interneurones (n = 8), or as regular spiking interneurones (n = 3), i.e. interneurones whose electrop

192 n CA1 pyramidal cells (n = 46) by identified interneurones (n = 43) located in str. oriens were recor

193 elicited in basket (n = 7) and bistratified interneurones (n = 7) by action potentials activated in

194 ring interneurone), as unclassified, or slow interneurones (n = 8), or as regular spiking interneuron

195 r recordings from pyramidal cells in CA1 and interneurones near the stratum oriens-alveus border reve

196 The interneurone network output is then imposed upon pyramid

197 These data suggest that, while interneurone networks alone can generate locally synchro

198 This model had suggested previously that interneurone networks alone could generate synchronous g

199 glutamatergic (Glu) from premotor excitatory interneurones, nicotinic cholinergic (nACh) from more ro

200 wledge of the presence of these receptors in interneurones, no clear physiological function (other th

201 in and somatostatin, two markers of striatal interneurones, nor for calbindin D-28k, a marker of a su

202 that loss of somatostatin and neuropeptide Y interneurones occurs in proportion to overall hilar cell

203 en behaviour-contingent network oscillation, interneurones of a given type exhibit similar firing pat

204 s, of both principal neurones and inhibitory interneurones of the cortex and hippocampus.

205 Interneurones of the first type possess four to six seco

206 to the possibility of preselecting GABAergic interneurones of the hippocampus on the basis of some pe

207 ions representing two distinct brain states, interneurones of the same class show different firing pa

208 Interneurones of the second type send three to four seco

209 e of GABAA receptors or of AMPA receptors on interneurones, or by augmenting AMPA-mediated EPSCs.

210 Five types of visualised presynaptic interneurone, oriens-lacunosum moleculare (O-LMC), baske

211 mma activity, two distinct classes of oriens interneurones, oriens lacunosum-moleculare (O-LM) and tr

212 doublet firing to be synaptically induced in interneurones, oscillation phase lags were < 2.25 ms acr

213 from synaptically coupled pyramidal cell-to-interneurone pairs (n = 5) of the cat visual cortex in v

214 opagation in three types of V1 supragranular interneurones: parvalbumin-positive fast spikers (FS), c

215 als in three types of mouse V1 supragranular interneurones: parvalbumin-positive fast spikers (FS), c

216 The axons of the projection interneurones pass through a lateral or dorsal tract to

217 Two other classes of fast spiking interneurones, perisomatic targeting basket and bistrati

218 ing membrane potential of CA1 stratum oriens interneurones persistently increased following experimen

219 spiny projection neurones (SPNs) and various interneurone populations demonstrated that the group I m

220 ellular levels of calcium ([Ca(2+)]i) in all interneurone populations tested.

221 ocortical local circuit GABAergic inhibitory interneurones possess glutamate receptors with inwardly

222 One interneurone possesses bilateral ventral branches.

223 ecorded basket cells, suggested that coupled interneurones, possibly through electrotonic junctions,

224 Some interneurones project only in the eighth abdominal neuro

225 showing that perisomatic-targeting GABAergic interneurones provide prominent rhythmic inhibition in p

226 Gamma-aminobutyric acid (GABA) interneurones provide the major inhibitory synaptic inpu

227 synapses, it was calculated that an average interneurone provides 0.66 +/- 0.20% of the GABAergic sy

228 reduced inhibitory synaptic transmission at interneurone-Purkinje cell (IN-PC) synapses, causing cle

229 y and, also, inhibitory neurotransmission at interneurone-Purkinje cell (IN-PC) synapses.

230 Recent anatomical evidence that inhibitory interneurones receive approximately 10 times more synaps

231 Interneurones receiving excitatory input from group II m

232 phologically defined subtypes of hippocampal interneurones remains unclear.

233 modulation on the oscillatory properties of interneurones remains virtually unexplored.

234 In most cases, increased heterogeneity in interneurones resulted in stronger inhibition of princip

235 eleasable vesicle pool size at synapses onto interneurones, resulting in a higher initial release pro

236 These interneurones showed resonance at beta-gamma frequencies

237 icompartmental models of principal cells and interneurones showed that changes in the variance in the

238 rophysiological and anatomical properties of interneurones significantly alter the input-output funct

239 c excitatory pathway via C3-C4 propriospinal interneurones similar to that in the cat.

240 ever, it remains to be resolved how distinct interneurone subtypes contribute to gamma-frequency osci

241 ippocampal rhythms are mediated by different interneurone subtypes.

242 Depressing inputs onto some interneurones, such as CA1 basket-like and bistratified

243 cally distinct subpopulations of hippocampal interneurones, suggesting that there may be organizing p

244 he weighted quantal amplitude was similar at interneurone synapses and pyramidal cell synapses, altho

245 Mossy fibre transmission at CA3 interneurone synapses can be explained by a lower number

246 physiological properties of mossy fibre-CA3 interneurone synapses have been previously described, an

247 At six of seven interneurone synapses in which a high concentration of C

248 riability in quantal amplitude was larger at interneurone synapses.

249 fect the membrane properties of six of seven interneurones tested.

250 spontaneous firing rate of 37/45 cholinergic interneurones tested.

251 We report that GABAergic interneurones that are depolarized by muscarinic recepto

252 Interneurones that elicited IPSPs were classified as cla

253 neocortical networks of mutually inhibitory interneurones that generate collective 40 Hz rhythms whe

254 ity of some of the groups of spinal premotor interneurones that have been studied, focusing particula

255 utaneous and corticospinal axons converge on interneurones that inhibit the machinery of presynaptic

256 To identify the GABAergic interneurones that mediate the response, we performed du

257 by NMDA than for alpha7-containing nAChRs in interneurones; the activation of the non-alpha7 nAChRs d

258 l cell activity, and by which mechanisms the interneurones themselves are synchronized.

259 nes originate from intrinsic spinal premotor interneurones, these are key targets for interventions t

260 can spill over to presynaptic mGluRs on GABA interneurones to suppress GABA release at the second-ord

261 of the relative contribution of dorsal horn interneurones to these PSPs, since the monosynaptic acti

262 Interneurone-to-interneurone inhibitory postsynaptic pot

263 m being evoked disynaptically by commissural interneurones, trisynaptic components of these PSPs were

264 These results suggest roles for specific interneurone types in structuring the activity of pyrami

265 its orally and anally projecting cholinergic interneurones underlying the peristaltic reflex in the d

266 Many studies of cortical interneurones use immature rodent tissue, while many rec

267 eceptor (mAChR) activation on stratum oriens interneurones using whole-cell patch clamp recordings fr

268 xcitatory synapses onto CA1 stratum radiatum interneurones versus pyramidal cells in acute hippocampa

269 ease probability is greater at synapses onto interneurones versus pyramidal cells.

270 a powerful excitatory control on cholinergic interneurones via 5-HT2 receptors, by suppressing the AH

271 ity in rat hippocampal stratum oriens-alveus interneurones was studied using whole-cell and perforate

272 l cell firing, by inducing spike doublets in interneurones, was necessary for the occurrence of highl

273 the circuit roles of lower layer neocortical interneurones, we combined two-photon calcium imaging wi

274 The directly evoked action potentials of interneurones were characterized by an initial slow pre-

275 Postsynaptic interneurones were classified as horizontal oriens-alveu

276 The linear membrane responses of CA3 interneurones were determined with the use of whole-cell

277 ive per cent of the extracellularly recorded interneurones were discharged by group II afferents of t

278 Cortical interneurones were identified immunocytochemically by th

279 afterhyperpolarisations (spike AHPs) of CA1 interneurones were investigated in 25 basket, three bist

280 The interneurones were located mainly in the lateral parts o

281 The latter interneurones were reciprocally connected with pyramidal

282 y-four IPSPs activated by single presynaptic interneurones were studied in simultaneously recorded py

283 y co-localized on individual rat hippocampal interneurones where the activation of these particular m

284 rs (mAChRs) are expressed on rat hippocampal interneurones where they can regulate excitability, syna

285 cal properties of eight non-giant projection interneurones which originate from the locust terminal a

286 regular spiking interneurones (n = 3), i.e. interneurones whose electrophysiological characteristics

287 st strongly depressing EPSPs, while bitufted interneurones with broader spikes and adapting and burst

288 In contrast, fast-spiking interneurones with cell bodies in the pyramidal cell lay

289 The primary neurites of interneurones with contralateral axons transverse the ga

290 ne (5-HT, serotonin) in striatal cholinergic interneurones with gramicidin-perforated whole-cell patc

291 rsal and lateral to the main region in which interneurones with input from group I muscle afferents a

292 Multipolar interneurones with narrow spikes generated the fastest I

293 ells, indicating no preferential survival of interneurones with respect to the non-GABAergic hilar ce

294 fibre (MF)-evoked excitatory drive to these interneurones with significantly greater depression in j

295 Interneurones with spike AHPs affected by the GABA(A) re

296 he degeneration of NADPH-diaphorase positive interneurones within 24 h.

297 ted via NK1 receptors expressed on GABAergic interneurones within the nucleus of the solitary tract (

298 It is concluded that cholinergic interneurones within the rat striatum exhibit a KATP cha

299 are highly expressed in neonatal hippocampal interneurones, yet the role and mechanisms by which they

300 When recording from dentate fast-spiking interneurones, zinc chelation facilitated T-type Ca(2+)