ライフサイエンスコーパス: internucleosomal

1 e such array, the 208-12, by determining the internucleosomal- and end-distance distributions for arr

2 A delicate balance between tail-mediated internucleosomal attraction and repulsion among linker D

3 ears between 5 and 6 pN, corresponding to an internucleosomal attraction energy of approximately 2.0

4 of continuous deformation with little or no internucleosomal attraction.

5 ails is associated with a lengthening of the internucleosomal center-to-center distance, and that the

6 Since apoptosis is associated with internucleosomal chromatin fragmentation and creation of

7 totic cell death is typically accompanied by internucleosomal chromatin fragmentation.

8 results in cell death accompanied by strong internucleosomal cleavage of DNA, a typical feature of a

9 sis, as determined by nuclear fragmentation, internucleosomal cleavage of DNA, and processing of casp

10 The induction of apoptosis was confirmed by internucleosomal cleavage of DNA, assessed by agarose ge

11 optotic cell death is often characterized by internucleosomal cleavage of genomic DNA, which exhibits

12 sphatidylserine on the host cell surface and internucleosomal cleavage of host cell DNA.

13 ls from AraC-induced chromatin condensation, internucleosomal cleavage, and apoptotic death.

14 nt, as determined by nuclear morphology, DNA internucleosomal cleavage, and cleavage of poly(ADP-ribo

15 and activation of caspases-3 and -9 and DNA internucleosomal cleavage, without affecting the rate of

16 nd biochemical features, one of which is the internucleosomal degradation of genomic DNA.

17 by an increase in nuclease activity and the internucleosomal degradation of nuclear DNA, hallmarks o

18 thyl mark recognition is highly sensitive to internucleosomal distance, suggesting that the CD sticky

19 The internucleosomal-distance data provide clear evidence fo

20 roduce morphologically necrotic neurons with internucleosomal DNA cleavage (DNA laddering), a program

21 of FADD-DN additionally inhibited SM-induced internucleosomal DNA cleavage and caspase-6-mediated nuc

22 n human leukemic CEM cells, characterized by internucleosomal DNA cleavage and nuclear condensation.

23 icroscopy) and biochemical (demonstration of internucleosomal DNA cleavage by gel electrophoresis and

24 e of the major endonucleases responsible for internucleosomal DNA cleavage during apoptosis.

25 or (DFF40/CAD), is primarily responsible for internucleosomal DNA cleavage during the terminal stages

26 ble-strand breaks into SV40 DNA and produced internucleosomal DNA cleavage in isolated nuclei from un

27 ated to preparation artifacts, occurrence of internucleosomal DNA cleavage in necrotic as well as apo

28 permeabilized U937 cells to ceramide caused internucleosomal DNA cleavage that was blocked by an inh

29 Peroxynitrite-induced internucleosomal DNA cleavage was increased on BAPTA-AM

30 the > or = 1-mbp and 450-600-kbp fragments; internucleosomal DNA cleavage was never observed.

31 Internucleosomal DNA cleavage was observed also during n

32 Internucleosomal DNA cleavage was seen in these cultures

33 m PARP-deficient mice demonstrated increased internucleosomal DNA cleavage, caspase-3 processing and

34 apoptotic nucleases that are responsible for internucleosomal DNA cleavage, DNA fragmentation factor

35 The hallmarks of apoptosis, including internucleosomal DNA cleavage, plasma membrane and nucle

36 On the other hand, internucleosomal DNA cleavage, visualized as ladders, is

37 nkage, condensation of nuclear chromatin and internucleosomal DNA cleavage.

38 s confirmed by morphology and the absence of internucleosomal DNA cleavage.

39 hanges, assessment of DNA fragmentation, and internucleosomal DNA cleavage.

40 ing apoptosis and is in part responsible for internucleosomal DNA cleavage.

41 nt), as evidenced by morphologic changes and internucleosomal DNA cleavage.

42 C demonstrated the typical ladder pattern of internucleosomal DNA cleavage.

43 donuclease that mediates caspase-3-dependent internucleosomal DNA degradation and related nuclear alt

44 rphological features of apoptosis as well as internucleosomal DNA degradation in a concentration- and

45 The Ca2+ionophore ionomycin also induced internucleosomal DNA degradation in transfected but not

46 ls showed evidence of nuclear morphology and internucleosomal DNA degradation indicative of apoptosis

47 -OH endonucleolytic activity even though the internucleosomal DNA degradation is impaired.

48 Although apoptosis causes internucleosomal DNA degradation that can be detected by

49 This is followed by cleavage of bcl-2 and internucleosomal DNA degradation.

50 y, poly(ADP)-ribose polymerase cleavage, and internucleosomal DNA degradation.

51 ptotic nuclear alterations in the absence of internucleosomal DNA degradation.

52 ndent endonucleases are equally important in internucleosomal DNA fragmentation (INDF), including the

53 ed significant specific cleavage of PARP and internucleosomal DNA fragmentation after 18 h of incubat

54 is revealed that KA (2.5 nmol) induced local internucleosomal DNA fragmentation after 6-48 h.

55 ected by analysis of DNA content and in situ internucleosomal DNA fragmentation and (ii) inhibition o

56 Internucleosomal DNA fragmentation and apoptotic bodies

57 d the anoikis of those cells, as assessed by internucleosomal DNA fragmentation and caspase-3 cleavag

58 tern in retinal DNA gel analysis, typical of internucleosomal DNA fragmentation and characteristic of

59 Disruption of the DFF45 gene blocks internucleosomal DNA fragmentation and confers resistanc

60 e 24-kD apoptotic protease (AP24) leading to internucleosomal DNA fragmentation and death.

61 ed that Ltx-treated cells showed evidence of internucleosomal DNA fragmentation and phosphatidylserin

62 Internucleosomal DNA fragmentation and presence of apopt

63 ibody (MoAb) induced apoptosis, evidenced by internucleosomal DNA fragmentation and propidium iodide

64 Plasminogen treatment also markedly reduced internucleosomal DNA fragmentation and reduced levels of

65 osteosarcoma cells blocked etoposide-induced internucleosomal DNA fragmentation and resulted in persi

66 Moreover, quinolinic acid-induced internucleosomal DNA fragmentation and striatal cell dea

67 Internucleosomal DNA fragmentation and terminal transfer

68 NMDA- and QA-induced internucleosomal DNA fragmentation and TUNEL-positive nu

69 roM) as single agents produced no detectable internucleosomal DNA fragmentation as revealed by gel el

70 A filter binding assay that measures internucleosomal DNA fragmentation associated with apopt

71 Several endonucleases are implicated in the internucleosomal DNA fragmentation associated with apopt

72 tion of HL60 cells from apoptosis-associated internucleosomal DNA fragmentation by specific protease

73 nic mice showed increased TUNEL staining and internucleosomal DNA fragmentation compared with wild-ty

74 e of poly(ADP-ribose) polymerase (PARP), and internucleosomal DNA fragmentation during the later stag

75 atures such as caspase-3 mRNA expression and internucleosomal DNA fragmentation in 1-cm long spinal c

76 atase inhibitor, led a dramatic reduction in internucleosomal DNA fragmentation in both cell lines.

77 rom contralateral or control tissue, induced internucleosomal DNA fragmentation in isolated nuclei wi

78 g apoptosis and has the capacity to activate internucleosomal DNA fragmentation in isolated nuclei.

79 hibitor, DFF45, were not sufficient to cause internucleosomal DNA fragmentation in osteosarcoma cells

80 ed the role of CAD/DFF40 in the induction of internucleosomal DNA fragmentation in the hippocampus in

81 poptotic protease (AP24), which then induces internucleosomal DNA fragmentation in the nucleus.

82 resis revealed that both NMDA and QA induced internucleosomal DNA fragmentation in the striatum 12 to

83 Internucleosomal DNA fragmentation induced by 1S,3R-ACPD

84 xpressing cells were relatively resistant to internucleosomal DNA fragmentation induced by AP24 isola

85 Interestingly, 1S,3R-ACPD attenuated internucleosomal DNA fragmentation induced by NMDA, but

86 lls, nerve growth factor (NGF) inhibited the internucleosomal DNA fragmentation induced by serum depl

87 death in S. pombe was accompanied neither by internucleosomal DNA fragmentation nor by activation of

88 1S,3R-ACPD induced internucleosomal DNA fragmentation of striatal cells in

89 press endogenous DNAS1L3) was accompanied by internucleosomal DNA fragmentation only after transfecti

90 Internucleosomal DNA fragmentation started at 6 h and pe

91 NMDA- and QA-induced internucleosomal DNA fragmentation was attenuated by the

92 Internucleosomal DNA fragmentation was detected by gel e

93 Internucleosomal DNA fragmentation was investigated in t

94 several hallmarks of apoptosis are apparent, internucleosomal DNA fragmentation was not detected.

95 ation of the 68-kD neurofilament protein and internucleosomal DNA fragmentation were also increased.

96 re to UVB, enhanced annexin V-positivity and internucleosomal DNA fragmentation were observed in p27

97 ei isolated from these cells did not exhibit internucleosomal DNA fragmentation when incubated in the

98 Internucleosomal DNA fragmentation, a hallmark of apopto

99 ncluding caspase-9 and caspase-3 activation, internucleosomal DNA fragmentation, and cytochrome c rel

100 nimal effect on cell growth, elicited little internucleosomal DNA fragmentation, and induced no cell

101 e (PARP) and DNA fragmentation factor (DFF), internucleosomal DNA fragmentation, and morphologic feat

102 xpressed, it inhibits the nuclease activity, internucleosomal DNA fragmentation, and nuclear fragment

103 ytic processing of CPP32 to its active form, internucleosomal DNA fragmentation, and nuclear morpholo

104 Internucleosomal DNA fragmentation, another hallmark of

105 Nuclear changes, including internucleosomal DNA fragmentation, are characteristic f

106 Nuclear changes, including internucleosomal DNA fragmentation, are classical manife

107 ed for the onset of caspase-3 activation and internucleosomal DNA fragmentation, as well as the gener

108 ge and blebbing, chromatin condensation, and internucleosomal DNA fragmentation, consistent with apop

109 rons, including nuclear fragmentation and/or internucleosomal DNA fragmentation, doses as high as 32

110 ges, phosphatidylserine externalization, and internucleosomal DNA fragmentation, in p53(null) Saos-2

111 is in pancreatic cancer cells as measured by internucleosomal DNA fragmentation, phosphatidylserine e

112 of the predominant features of apoptosis are internucleosomal DNA fragmentation, plasma membrane bleb

113 Hallmarks of apoptosis, such as internucleosomal DNA fragmentation, pyknotic and uniform

114 Consistent with the detection of internucleosomal DNA fragmentation, the effects measured

115 by viability staining and the appearance of internucleosomal DNA fragmentation, was accelerated in d

116 antially reduced the intensity of QA-induced internucleosomal DNA fragmentation.

117 ar morphology without displaying concomitant internucleosomal DNA fragmentation.

118 HeLa nuclei, NUC70 was capable of generating internucleosomal DNA fragmentation.

119 iability, in situ DNA nick-end labeling, and internucleosomal DNA fragmentation.

120 ating cells and massive apoptosis by in situ internucleosomal DNA fragmentation.

121 ochrome c release, caspase-3 activation, and internucleosomal DNA fragmentation.

122 c, activation of caspase-3 and induction of internucleosomal DNA fragmentation.

123 These markers included membrane blebbing and internucleosomal DNA fragmentation.

124 of cholinergic neurons and the induction of internucleosomal DNA fragmentation.

125 biochemical evidence of apoptosis by showing internucleosomal DNA fragmentation.

126 h, caused G1 arrest, and induced significant internucleosomal DNA fragmentation.

127 tment of U-937 cells is associated with: (i) internucleosomal DNA fragmentation; (ii) cleavage of pol

128 t was associated with caspase 3 cleavage and internucleosomal DNA fragmentation; this cytotoxicity al

129 gamma-H2AX forms before the appearance of internucleosomal DNA fragments and the externalization o

130 tical results were obtained on incubation of internucleosomal DNA fragments from apoptotic cells with

131 uld be modulated by changes in the length of internucleosomal DNA spacers.

132 tidyl transferase (TdT)-mediated labeling of internucleosomal DNA strand breaks in a flow cytometric

133 nal sequences, which could be nucleosomal or internucleosomal even in their inaccessible configuratio

134 teractions occur via an intra- as well as an internucleosomal fashion, supporting an additional intra

135 emature onset and accelerated progression of internucleosomal fragmentation in these mutants.

136 ARP into Mr 89,000 and 28,000 fragments, and internucleosomal fragmentation of DNA (all of which are

137 Internucleosomal fragmentation of DNA (DNA ladders) was

138 Here, we report that accompanying the internucleosomal fragmentation of DNA, the newly formed

139 e were time- and dose-related appearances of internucleosomal fragmentation of retinal DNA and a time

140 y development, wheat endosperm DNA underwent internucleosomal fragmentation that was detectable from

141 Internucleosomal fragmentation typical of apoptosis was

142 striatal tissue indicated that 3-NP induced internucleosomal fragmentation typical of apoptosis.

143 s 50-kilobase pair DNA fragmentation but not internucleosomal fragmentation.

144 chondrial breakdown, caspase activation, and internucleosomal fragmentation.

145 to 50-300-kb fragments and subsequently into internucleosomal fragments.

146 s of H2A and H2B, but not of H3 and H4, make internucleosomal histone-DNA interactions within the din

147 scribed herein suggest that transient binary internucleosomal interactions can mediate distant commun

148 the hypothesis that the tails participate in internucleosomal interactions during salt-dependent chro

149 interactions within a nucleosome may affect internucleosomal interactions in higher order chromatin

150 Taken together, our data suggest that internucleosomal interactions involving the histone tail

151 omatin structures likely involves long-range internucleosomal interactions mediated by the core histo

152 -3 arises from the attenuation of long-range internucleosomal interactions more than from the destabi

153 ils are most important in terms of mediating internucleosomal interactions, especially in highly comp

154 In addition to mediating internucleosomal interactions, the H3 histone tails cruc

155 n suggested to reflect histone tail-mediated internucleosomal interactions; these observations are co

156 of the 10n +/- 5 nt periodicity found in the internucleosomal ladder of DNase I digests of chromatin

157 sis by the demonstration of a characteristic internucleosomal ladder of genomic DNA by agarose gel el

158 large fragments at high concentrations, but internucleosomal laddering was not observed.

159 phological changes, in situ TdT labeling and internucleosomal laddering.

160 Increasing the length of internucleosomal linker DNA from 25 to 60 bp results in

161 bility group protein B1 (HMGB1) binds to the internucleosomal linker DNA in chromatin and abuts the n

162 for GGR in both nucleosomal core regions and internucleosomal linker DNA, but play no role in TCR.

163 which stimulates the removal of lesions from internucleosomal linker regions but not from the nucleos

164 cur near nucleosome midpoints rather than in internucleosomal linker regions.

165 nd that Paf1C facilitates GGR, especially in internucleosomal linker regions.

166 ove that the enzyme attacks chromatin in the internucleosomal linker, generating oligonucleosomal DNA

167 Both enzymes preferentially cleave internucleosomal (linker) DNA, although they do so by ma

168 , and progressive fragmentation of DNA in an internucleosomal or ladder pattern.

169 ent and the chromosomal DNA is degraded into internucleosomal repeats.

170 , its mutation causes a disruption of normal internucleosomal spacing of chromatin and reduced nuclea

171 atin remodeling, ACF is able to modulate the internucleosomal spacing of chromatin by an ATP-dependen

172 matin structure no effect is observed on the internucleosomal spacing of chromatin or the pattern of

173 s of apoptosis in several cell systems, when internucleosomal strand breaks became evident.