ライフサイエンスコーパス: interrogate

1 s central to gene control but challenging to interrogate.

2 e (SSIAAD) in BALB/c mice were developed and interrogated.

3 lectron and liquid structure to be precisely interrogated.

4 Here we interrogate 0.9 million genetic variants in 939 CFM case

5 based genome-editing strategy and used it to interrogate 174 candidate regulatory sequences within th

6 nscript microarray analysis (770,317 probes, interrogating 28,853 transcripts) findings were consiste

7 roups (GONH2) on 15 immune cell populations, interrogating 30 markers at the single-cell level.

8 f 438 commercially available antibodies that interrogate 365 unique RBPs.

9 We interrogated 385 pancreatic cancer genomes to define hyp

10 a series of pharmacological interventions to interrogate 5-HT1B receptor binding and function and det

11 We interrogated 54 to 70 genes in 442 patients with CUP usi

12 To interrogate 6mA sites at single-base resolution, we repo

13 hat can simultaneously collect, transmit and interrogate a bio-fluid.

14 stallography, and computational chemistry-to interrogate a carbanionic/quinonoid intermediate analogu

15 We utilize this integrated assay to interrogate a dose-dependent response of model brain can

16 To interrogate a human lung cancer database for the presenc

17 , we present an unbiased systems-approach to interrogate a panel of 14 well-annotated HGS-OvCa patien

18 The authors interrogated a quantitative trait of CP (mean interproxi

19 otechnology in drug products by building and interrogating a technical profile of products containing

20 One ICD generator could not be interrogated after MRI and required immediate replacemen

21 hange of >/= 1.0 between patient groups were interrogated against known metabolic pathways.

22 user-friendly interface that allows users to interrogate all integrated data and interact by comparin

23 Moving forward, study designs that interrogate and model genetic variation [e.g., allelic p

24 nical traits that can be directly queried to interrogate and refine the regulatory framework defining

25 ICDs were interrogated and ambulatory ECGs monitored for NSVT epis

26 opportunities and challenges associated with interrogating and assimilating multiple, disparate high-

27 these materials, solution-based methods for interrogating and modifying perovskite thin films are ne

28 t RNA-sequencing analysis to comprehensively interrogate animal and vegetal pole RNAs in the fully gr

29 e opportunities and drawbacks of intensively interrogating antibodies isolated from HIV-infected indi

30 etramers have emerged as a powerful tool for interrogating antigen-specific CD4(+) T cells without re

31 We interrogated at massive scale the structural properties

32 The PDD risk haplotype has been interrogated at single nucleotide resolution and is uniq

33 We interrogated at single-cell resolution how these alterat

34 Devices were interrogated before and after MRI with the use of a stan

35 (532 nm), hold promise for manipulating and interrogating biological and material systems with the h

36 ave recently emerged as efficient probes for interrogating biomarkers in live cancer cells.

37 orts expand our understanding and ability to interrogate both sexual and sporozoite transmission stag

38 Here we use a transgenic mouse to interrogate both the characteristic firing properties of

39 d the differences in adsorption were further interrogated by atomic force microscopy.

40 n-selective multi-ionophore membranes can be interrogated by cyclic voltammetry to detect the ion act

41 esulting in nativelike complexes that can be interrogated by MS.

42 l neurons known to mediate neurotransmission interrogated by our behavioral tasks.

43 ed the mtDNA single-nucleotide polymorphisms interrogated by the Illumina HumanHap 550 chip to determ

44 Cellular and molecular mechanisms were interrogated by using mast cell- and FcgammaRIIb-deficie

45 solvents, and provides a simple platform for interrogating catalytic intermediates common to natural

46 Our ability to interrogate causes of imprinting instability has been hi

47 on enzyme-linked immunosorbent spot assay to interrogate CD8(+) and CD4(+) T cell responses in health

48 roposed model can be advantageously used for interrogating cell regulation events and developing phar

49 ein-based biosensors have been engineered to interrogate cellular signaling and manipulate function.

50 and systems biology to make great strides in interrogating cellular metabolism but does not provide s

51 two naive pluripotency TFs, STAT3 and ESRRB, interrogate chromatin in a highly dynamic manner, in whi

52 entation on DNA, providing a useful tool for interrogating chromatin enzymes and allowing for the gen

53 vitro and mouse models that are designed to interrogate complex genetics and functionally test hypot

54 For the interrogated configurations containing HEU, the reconstr

55 ll-Mecak establish a biochemical platform to interrogate consequences of microtubule polyglutamylatio

56 de methylation quantification, the number of interrogated CpGs in RE remains limited.

57 By interrogating deep sequencing data generated from both p

58 ndings and discuss how they set the stage to interrogate developmental pathways during injury and dis

59 nusual enzymology involved, we enzymatically interrogated diverse thiolactomycin analogues and prepar

60 We interrogated DNA methylation at baseline and 3 hours in

61 stem/progenitor cell (HSPC) compartment and interrogated dominant clones for MDS-initiating cells.

62 tracking (SPT) has become a powerful tool to interrogate dynamics in a range of materials including l

63 MACC interrogates each genomic locus, measuring both nucleoso

64 This and FRET confirm that flexibility is interrogated early during the interaction between the tr

65 By interrogating Eng-dependent Wnt-mediated transcriptional

66 Thus, developing tools to interrogate FA-uptake by T cell subsets is important for

67 al regions across the human orthologous were interrogated for putative periodontitis-associated varia

68 idazolate frameworks, ZIF-67 and ZIF-8, were interrogated for their redox properties using Fourier tr

69 e describe the development of an approach to interrogate functional consequences of actin mutations i

70 Here we interrogate functional interaction between BRCA1 and COB

71 commonly used gain-of-function approach for interrogating gene functions and for manipulating biolog

72 the substrate(s) for the GLUT14 protein and interrogated genetic associations of SLC2A14 with IBD.Th

73 50K data is that many CpG sites the beadchip interrogates have very large measurement errors.

74 using mammalian surface display, capable of interrogating high quality and diverse scaffold librarie

75 promise of this approach for comprehensively interrogating how non-coding polymorphism shapes human b

76 Despite efforts to interrogate human genome variation through large-scale d

77 suggesting that mouse models can be used to interrogate human lung metabolome changes.

78 To investigate this model, we interrogate human platelets using approaches that includ

79 provide increasingly sophisticated tools to interrogate human-associated microbes, ultimately to imp

80 findings establish a functional platform for interrogating human p53 alleles and suggest that simple

81 genes require PRC2/H3K27me3 for silencing by interrogating imprinted mouse X-chromosome inactivation.

82 rate functional muscle tissue remodeling was interrogated in a porcine VML injury model using unbiase

83 amine human disease, and where plasma may be interrogated in lieu of BALF or lung tissue.

84 The system can be interrogated in numerous ways-from simple text and seque

85 sional and heterogeneous data is how best to interrogate increasingly specific subphenotypes while re

86 to our neural functions, yet difficulties in interrogating individual neurons has impeded understandi

87 ferent response materials can be arrayed and interrogated individually.

88 This methodology can be applied to interrogate intestinal epithelial dynamics and character

89 ithelial tissues, and computational tools to interrogate it and perform multi-scale analysis of morph

90 Watt spectra, which gave confidence that the interrogated items were undergoing induced fission.

91 emains a strong need for suitable tracers to interrogate ligand binding to this receptor.

92 as a simple and highly sensitive approach to interrogating lipid-protein interactions in a setting th

93 tion, we discuss the new challenges faced in interrogating lncRNA mechanisms and function in the immu

94 yping approach presented here can be used to interrogate local S. Typhi populations and help identify

95 quantification of these effects necessitates interrogating longitudinal data on macrofilariae with su

96 igomers on AD-related gene expression and to interrogate mechanisms involved in synaptic pruning.

97 d circulating tumor cell (CTC) biomarkers to interrogate mechanisms of sensitivity or resistance to t

98 benefit both researchers and clinicians for interrogating mechanisms of mutation-dependent drug resp

99 ic membranes, demonstrating the potential to interrogate mechanistic chemistry at the enzyme active s

100 tween oncogenic PIK3CA and OGDH function, we interrogated metabolic requirements and found an increas

101 e the application of single-cell genomics to interrogate microbial dark matter and to evaluate the pa

102 ions of the bacterial 16S ribosomal gene, to interrogate microbial profiles in term pregnancies, from

103 Several invasive modalities for interrogating microvascular function have been proposed.

104 clocks have the potential to simultaneously interrogate millions of atoms with a high spectroscopic

105 chnology as a feasible strategy for globally interrogating miRNA gene function and miRNA-based therap

106 Here we present a protocol for interrogating mitochondrial metabolites and measuring th

107 LC-MS) peptide mapping is routinely used for interrogating molecular and structural attributes such a

108 The D4 assay can interrogate multiple analytes from a drop of blood, is c

109 (89)Zr-transferrin is a useful tool to interrogate MYC via TfR-targeted PET imaging in TNBC.

110 luorescence detection (Nile Red staining) to interrogate Mycobacterium tuberculosis cell state.

111 lack of easily approachable methods that can interrogate nascent RNA structure at nucleotide resoluti

112 Studies interrogating neural synapses, or a specific neural circ

113 This novel approach to interrogate neuronal protein function has general applic

114 Here, we review recent discoveries and, by interrogating newly available plant genomes, we advance

115 equired for preclinical target validation to interrogate novel biological targets and pathways.

116 es are expanding our ability to agnostically interrogate nucleic acids within diverse sample types, b

117 he correct target sequence efficiently while interrogating numerous nontarget sequences associated wi

118 tic peptides, and lipoprotein particles, yet interrogate only a modest subset of pathways relevant to

119 Their conductance was interrogated optically, revealing quantised relative tra

120 iability, and one that uses targeted agents, interrogating pathophysiological features of disease.

121 d on thousands of variants have been used to interrogate pathways and systems instead of single varia

122 ion of molecular probes that can effectively interrogate pathways critical to disease.

123 trategy to evaluate the genomic structure of interrogated pathways, through permutation testing of ge

124 ce assays, and next generation sequencing to interrogate persister physiology and its heterogeneity.

125 n is a powerful technique routinely used for interrogating physicochemical properties of proteins.

126 noncanonical amino acid tagging (BONCAT) to interrogate protein synthesis in vegetative Arabidopsis

127 roof of principle, we apply this approach to interrogate proteins engaged by G-protein-coupled recept

128 enhanced two-dimensional NMR spectroscopy to interrogate reaction mechanisms as they occur.

129 Here, we systematically interrogated rearrangements in 560 breast cancers by usi

130 clinical aCGH only informs CNVs in the probe-interrogated regions.

131 ion with a novel means of irradiation of the interrogated sample, local analysis of semiconductor mat

132 operating at 60 GHz, which are placed across interrogated samples.

133 rcode chip (SCBC) was used to experimentally interrogate secreted proteins in hundreds of isolated gl

134 To interrogate signaling pathways activated in mantle cell

135 sis and a high-throughput inhibitor assay to interrogate signalling in liver buds, and show that vasc

136 everal tens of nanometers, we can excite and interrogate single NCs individually.

137 strate the utility of TERS as an approach to interrogate single-molecule properties, reactions, and d

138 Specifically, we interrogated site-specific binding by the transcription

139 solid tumour profiling use DNA sequencing to interrogate somatic point mutations because they are rel

140 ticularly functional imaging techniques that interrogate some specific aspect of underlying tumor bio

141 ativity-by-sequencing (Coop-seq) approach to interrogate Sox2/Pax6 dimerization on a DNA library wher

142 e the higher spatial resolution necessary to interrogate specific protein networks.

143 gions, previous studies have been limited to interrogating structure and function independently, and

144 Only 5 of the 100 interrogated sudden death genes hosted actionable pathog

145 sheet, due to the difficulty of locating and interrogating suitable archives that have the potential

146 The pipeline interrogates tandem mass spectra to find signatures of t

147 munity PCA - an immense national resource to interrogate, target, and intercept events that drive onc

148 ics provides a direct and effective means to interrogate targets while minimizing off-target effects.

149 We used it to interrogate the 2-Mb POU5F1 locus in human embryonic ste

150 show that Sox8-EGFP BAC mice can be used to interrogate the altered dSPN development in Isl1 conditi

151 the native tumor heterogeneity, in order to interrogate the antitumor effects of EGFR-targeted drugs

152 Here we interrogate the appropriateness of a range of previously

153 Here, we interrogate the biochemical activity and nucleic acid su

154 This unique model can be used to further interrogate the biology of EMT in prostate cancer.

155 metry presents an exceptional opportunity to interrogate the biology of highly heterogeneous cell pop

156 We have used this microarray to interrogate the C-terminal tails of a small group of can

157 One way to interrogate the complex carcinogenic process and interac

158 In this study, we interrogate the complexity in cAMP/PKA-MAPK/ERK1&2 cross

159 gene encoding the 16S rRNA were performed to interrogate the composition and function of the neonatal

160 Here we interrogate the consequences of chronic necroptosis on i

161 ility to rapidly isolate and mechanistically interrogate the CSC-enriched, partially mesenchymal carc

162 isualization interface for allowing users to interrogate the currently available transcriptome-wide R

163 ific heterogeneity in luminal progenitors to interrogate the differentiation repertoire of candidate

164 recovery after photo-bleaching) modified to interrogate the diffusion path-lengths of membrane assoc

165 of a paradigm shift as it is now possible to interrogate the entire sequence of the human genome (cod

166 Using voltage-sensitive dye imaging to interrogate the evoked response of the CA1 microcircuit,

167 erved residues in the MeaB switch I motif to interrogate the function of this loop.

168 To interrogate the functional requirement for PKM2 during d

169 iting has provided numerous opportunities to interrogate the functional significance of any given gen

170 These results begin to interrogate the functions of NoV proteins during virus r

171 To interrogate the genetic activity of human p53 variants,

172 used whole exome capture sequencing (WXS) to interrogate the genomic landscape of matched trios repre

173 glycosylated and nonglycosylated species, we interrogate the hormone biosynthesis.

174 This observation led us to interrogate the human genome for dCn runs.

175 High-throughput methods now allow us to interrogate the human immune system for multiple markers

176 erimental and clinical studies to fruitfully interrogate the immune system.

177 evaluate individual responses to vaccines to interrogate the immunocompetence of their patients.

178 To systematically interrogate the impact of cell morphology on bacterial p

179 us, experimental methods that can be used to interrogate the key factors required for this critical s

180 However, methods to store and interrogate the large datasets produced by these experim

181 Here, we interrogate the local structure of the M(III) surface si

182 e used biochemical and structural methods to interrogate the LRH-1-PGC1alpha complex.

183 ld towards more fine-grained approaches that interrogate the many sources of heterogeneity within psy

184 d X-ray diffraction were further employed to interrogate the material in situ at high pressure.

185 To further interrogate the mechanism by which Akt modulates PRB tra

186 These contrasting differences led us to interrogate the mechanism by which Mdm2 SNP309 regulates

187 Here, we interrogate the mechanism by which the white-opaque swit

188 To interrogate the mechanistic relationship between the mol

189 computational (CoGEF) analyses allowed us to interrogate the mechanochemical activation of these addu

190 To interrogate the metabolic alterations associated with su

191 Here we interrogate the molecular consequences of CRISPR/Cas9-me

192 c platforms have transformed our capacity to interrogate the molecular landscapes of human cancers, i

193 Our findings emphasize the need to interrogate the mutations in coding regions beyond their

194 By targeting PLE to neurons, VF-EX2 can interrogate the neuromodulatory effects of serotonin in

195 amples analysed so far, to our knowledge, we interrogate the noncoding transcriptome, alternative spl

196 somal engineering to rapidly and effectively interrogate the oncogenic potential of genomic rearrange

197 n the limitations of conventional methods to interrogate the order and mechanism by which editing pro

198 virus-based rapid gene replacement method to interrogate the physiopathology of BRaf and approximatel

199 Here, the authors interrogate the proteome of pancreatic cancer endotheliu

200 kout cell lines to examine cell function and interrogate the proteome.

201 We interrogate the psychological and neural basis of this p

202 catalytic materials, systematic studies that interrogate the relationship between their catalytic per

203 pora crassa as a model filamentous fungus to interrogate the requirements for trafficking of cellulas

204 low cytometric method that will be useful to interrogate the role of the respiratory epithelium in mu

205 used SF3b1 mutations associated with MDS to interrogate the role of the yeast ortholog, Hsh155, in B

206 To interrogate the role of this cross-talk in metastasis, w

207 structures of a fungal LOV protein ENVOY to interrogate the role of Thr(101) in recruiting water to

208 in vitro and H1 mutant transgenes in vivo to interrogate the roles of these domains in multiple bioch

209 hod with saturation mutagenesis libraries to interrogate the sequence specificities of PCSK9 cleavage

210 To better interrogate the significance of the hydrogen bond provid

211 ifferent structural classes were employed to interrogate the structure-activity of the BiOctR and DmO

212 developed a genome-wide functional screen to interrogate the transcription factors and cofactors in t

213 esent study we conducted RNA-seq analysis to interrogate the transcriptome of M1 macrophages derived

214 l migration across epithelia is desirable to interrogate the underlying mechanisms of neutrophilic br

215 We also interrogate the vascular phenotype of RCC xenografts exh

216 muOCT-PTM could also be generally applied to interrogate the viscosity of biological media such as bl

217 al susceptibility loci for breast cancer, we interrogated the 2q35 gene desert for chromatin architec

218 We interrogated the activity of the PSMA-PI3K axis through

219 A nuclear export is essential, we previously interrogated the budding yeast proteome to identify cand

220 in PanIN 3 lesions and pancreatic tumors, we interrogated the comparative ability of adult pancreatic

221 Here, we interrogated the contribution of common polygenic variat

222 eported in the chicken embryo as a whole, we interrogated the existence or absence of genomic imprint

223 Guided by this finding, we have further interrogated the expression and function of one of these

224 Here we have interrogated the genetic cause of albinism in a well phe

225 We have now interrogated the integrity and function of both categori

226 that increases blood ACE activity 7-fold and interrogated the mechanism by which this mutation signif

227 Few studies have interrogated the molecular mechanisms of beta-cell dysfu

228 We further interrogated the morphological effect of the 3D track on

229 We interrogated the pattern of expression of esophagus-spec

230 atterns at our institution, and specifically interrogated the relationship between platelet usage and

231 We recorded antimicrobial drug exposures and interrogated the resistome at points in production when

232 ell, Martincorena et al. and Campbell et al. interrogated the selection dynamics during tumor evoluti

233 We interrogated the Smc3p subunit of cohesin by random inse

234 e characterized the activities of Spt4/5 and interrogated the structural features of Spt5 required fo

235 Here we interrogated the transcriptional effects of BETi and ide

236 In addition, we interrogated the transcriptional regulation of primary m

237 We interrogated the whole-transcriptome in human umbilical

238 is not specific for the microvasculature but interrogates the entire coronary circulation.

239 ging methods for identifying, isolating, and interrogating the cells that may provide technical advan

240 e the utility of this zebrafish resource for interrogating the complex behavior of immune cells at ce

241 Although instrumental to interrogating the complex composition of the HSC niche a

242 re illuminate the value of this strategy for interrogating the conformational mechanism of the more c

243 d receptors makes it particularly useful for interrogating the differential contributions of each ind

244 Interrogating the genomes of over 4000 brain cancers we

245 demonstrate the performance of our method by interrogating the IGF-1/AKT signaling pathway, showing t

246 Our work provides a general strategy for interrogating the interactome of RNA modifications and r

247 ed random circuit perturbation (RACIPE), for interrogating the robust dynamical behavior of a gene re

248 We highlight the utility of this system by interrogating the role of TFAP2 transcription factors in

249 holography has been proposed as a means for interrogating the spatial and temporal information of el

250 s for grabbing one cell and short pulses for interrogating the target cell.

251 stars and sea urchins are model systems for interrogating the types of deep evolutionary changes tha

252 c 'CAG' factors (Cdx2, Arid3a and Gata3), we interrogate their chromosomal target occupancies, modula

253 e same environment, to visualize and further interrogate their results.

254 e residues Phe(79), His(85), and Arg(245) to interrogate their roles in substrate binding and catalyt

255 pecificity of such stapled peptides based on interrogating their capacity to disrupt p53/HDM2 and p53

256 gy investigations that produced them, and to interrogate them via API interfaces.

257 y of the square-wave potential pulse used to interrogate them, with the optimal square-wave frequency

258 pplied metabolic profiling to systematically interrogate these disorders at rest, when muscle symptom

259 time-resolved fluorescence spectroscopy, we interrogate these emitters at the single-molecule level

260 he sophistication and power of techniques to interrogate these processes has developed at an unpreced

261 Here we experimentally interrogate these two hypotheses by measuring arm kinema

262 Here, we interrogated these compartments in hepatocellular carcin

263 mpered by the lack of suitable techniques to interrogate this complex under native conditions.

264 We interrogate this series of molecules with pulsed electro

265 ow Transplant Research (CIBMTR) Database was interrogated to analyze the impact of CMV reactivation o

266 are predictive of poor prognosis and can be interrogated to determine biomarkers predictive of recur

267 A hollow tungsten sphere was interrogated to evaluate the response to a possible hoax

268 authoritative academic research database was interrogated to identify all current state statutes pert

269 ctral data-activity relationship) and can be interrogated to identify molecular features responsible

270 ucleases and variant-aware library design to interrogate trait-associated regulatory DNA at high reso

271 nt to biological processes implicated in the interrogated traits, such as the interleukin-27 pathway

272 of RNA from normal and PE human placentae to interrogate transcriptome-wide gene expression and alter

273 RNA-sequencing was used to interrogate transcriptomic changes between 8- and 14-wee

274 imaging, which can be used to noninvasively interrogate tumor metabolism.

275 gulation as a versatile tool to reproducibly interrogate tumor phenotypes in vivo.

276 h ultradeep barcode sequencing (Tuba-seq) to interrogate tumor-suppressor function in mouse models of

277 tegrated genomic and proteomic strategy that interrogates tumour antigen peptides presented by major

278 ach named topological data analysis (TDA) to interrogate two perturbed networks.

279 Here we develop DNA-based nanosensors to interrogate two previously proposed mechanisms, enzymati

280 the generation of targeted genetic models to interrogate uniplex function in vivo.

281 a found in association with the colonies was interrogated using a series of molecular-based methodolo

282 validated by direct ex vivo enumeration, and interrogated using a variety of in silico methods.

283 lectrocatalytic current when the sensors are interrogated using cyclic voltammetry at a slow scan rat

284 leukemia drug) are magnetically actuated and interrogated using laser-induced fluorescence.

285 chitecture of amyloids formed in vivo can be interrogated using luminescent conjugated oligothiophene

286 ression among individual cells are typically interrogated using single whole cell approaches.

287 luorescence intensities and allow PPIs to be interrogated using standard epifluorescence microscopy.

288 The robustness of candidate models was then interrogated using the bootstrapping procedure.

289 Here we interrogated, using three separate but complementary exp

290 sequence kernel association test was used to interrogate variant burden among 54 lysosomal storage di

291 ity of UCOEs has remained poorly defined, we interrogated various CBX3 subfragments in the context of

292 an high-resolution data were retrospectively interrogated versus a list of more than 100 compounds an

293 and apply integrated methodologic steps for interrogating WGS data to characterize the genetic archi

294 We leveraged alpha-syn as a model to interrogate whether FKBP12 plays a role in regulating ca

295 To interrogate whether insulin exerts endocrine effects in

296 mple is captured using a "magnetic plug" and interrogated with a laser allowing simple and fast optic

297 f PSMA that can be exploited for therapy and interrogated with imaging.

298 More than 20,000 genes were interrogated with individual siRNAs and those that promi

299 chemically exposed TMD films intermittently interrogated with Raman and photoluminescence spectrosco

300 This array was interrogated with sera from infected mice, rhesus monkey