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1 r endocytic adaptor, also binds to Eps15 and intersectin.
2  Eps-homology (EH) domain proteins Eps15 and intersectin.
3 ) via interactions with the scaffold protein intersectin.
4 enerated strong binding to the EH domains of Intersectin.
5 e C terminus of RAB/Rip to the EH domains of Intersectin.
6 entified the multidomain scaffolding protein intersectin 1 (ITSN1) as an important regulator of this
7 e report that loss of the signaling scaffold intersectin 1 (ITSN1) in mice leads to defective neurona
8                                              Intersectin 1 (ITSN1) is a scaffold protein that regulat
9          The multidomain scaffolding protein intersectin 1 (ITSN1) is an important regulator of this
10   These phenotypes were rescued by wild-type intersectin 1 but not by a locked mutant of intersectin
11       Mutations in unc-11 (AP180) or itsn-1 (Intersectin 1), which reduce clathrin-dependent endocyto
12  a multi-modular protein, Cin1 (cryptococcal intersectin 1), whose domain structure is similar to tha
13 th the Src homology 3 domain-bearing protein Intersectin 1, an intracellular protein involved in syna
14 ts of SCAMP1 bind to two EH domain proteins, intersectin 1, which is involved in endocytic budding at
15  intersectin 1 but not by a locked mutant of intersectin 1.
16 regulated by an intramolecular switch within intersectin 1.
17 ocytic machinery proteins Eps15, Eps15R, and intersectin 1.
18 Eps15 homology domains of Eps15, Eps15R, and intersectin 1.
19                                  Deletion of intersectin 1/2 in mice alters the presynaptic nanoscale
20       We have identified the long isoform of intersectin-1 (ITSN-1), a guanine nucleotide exchange fa
21                                              Intersectin-1 (Itsn1) is a scaffold protein that plays a
22  does so through different adaptor proteins, Intersectin-1 and Cdc42, that trigger N-WASP-mediated br
23                                Specifically, intersectin-1 forms dynamic molecular condensates with e
24             In the absence of endophilin A1, intersectin-1 is mislocalized, and this replacement pool
25  release from infected cells, as the lack of intersectin-1 recruitment leads to a loss of Cdc42 activ
26                                 Mutations in intersectin-1 that disrupt endophilin A1 binding result
27                            In the absence of intersectin-1, fewer vesicles cluster within 20 nm of th
28 microenvironment, as well as cell-autonomous intersectin-1-dependent phosphoinositide 3-kinase-mediat
29 th the Epsin15 homology domains of Eps15 and intersectin-1.
30 ous nuclear ribonucleoprotein H', Br140, and intersectin-1.
31 he active zone where release sites reside by intersectin-1.
32 ssion of exchange activity suggests that the intersectin 1L exchange activity is regulated by endocyt
33                                              Intersectin 1L is a scaffolding protein involved in endo
34 by an intramolecular interaction between the intersectin 1L SH3 domain region and the adjacent DH dom
35                      We demonstrate that the intersectin 1L SH3 domains, which bind endocytic protein
36 controlling the actin nucleation activity of intersectin 1L.
37              Herein, we investigated whether intersectin-1s (ITSN) deficiency and prolonged lung expr
38 es used a murine model of plexiform PAH, the intersectin-1s (ITSN) heterozygous knockout (KO(ITSN+/-)
39               We now show that a decrease in intersectin-1s (ITSN-1s) expression due to granzyme B (G
40 specific transcript (Xist), as induced by an intersectin-1s protein fragment with proliferative poten
41                Here we addressed the role of intersectin-2L (ITSN-2L), a guanine nucleotide exchange
42                                              Intersectin, a multiple Eps15 homology and Src homology
43  160 kDa (dap160), the Drosophila homolog of intersectin, a putative adaptor for proteins involved in
44 ts with the SH3A (Src homology 3A) domain of intersectin, an endocytic-exocytic adaptor protein.
45  GEF activity afforded by DH/PH fragments of intersectin and Dbs are also not altered by phosphoinosi
46                      While the PH domains of intersectin and Dbs promiscuously bind several multiphos
47                    We used dominant-negative intersectin and dynamin constructs to show that SGK1-med
48 t EHSH1 is very similar to Xenopus and human intersectins and to human SH3P17.
49 ytic machinery, including dynamin and Dap160/intersectin, and negatively regulates retrograde BMP gro
50 ophila endocytic proteins Nwk/FCHSD2, Dap160/intersectin, and WASp relieve Nwk autoinhibition and pro
51                              Our data reveal intersectin as an autoinhibited scaffold that serves as
52 y the endocytic multidomain scaffold protein intersectin as an important regulator of SV replenishmen
53 ed protein 160 (Dap160; related to mammalian intersectin) as an aPKC-interacting protein in Drosophil
54 ) immunogold labeling studies indicated that intersectin associated preferentially with the caveolar
55                        We named this protein Intersectin, because it potentially brings together EH a
56 /Rip) and two novel proteins, which we named Intersectin-binding proteins (Ibps) 1 and 2.
57 rotein, the GTPase Cdc42, and its activator, Intersectin, biochemically and by solving the crystal st
58 r example, SH3 domains from c-Src, Grb2, and intersectin bound only to the C-terminal half of dynamin
59 pha Gpa1, protein kinase Pkc1, and endocytic intersectin Cin1.
60 otide exchange activities of these synthetic Intersectin constructs can be controlled in a rapid and
61                                      Second, intersectin cooperated with epidermal growth factor to p
62                                 And finally, intersectin cooperated with progesterone to accelerate m
63 mains of three distinct Dbl family proteins, intersectin, Dbs, and Tiam1, selectively bind lipid vesi
64                                We found that intersectin directly associates with synapsin I through
65 al data reveals that the Dbl exchange factor intersectin engages a strictly conserved GTPase residue
66 adaptor complex composed of FCHO, Eps15, and intersectin, ESCRT-0 accumulation at the cell surface is
67                                       Third, intersectin expression was sufficient to induce oncogeni
68               A cell-free system depleted of intersectin failed to support caveolae fission from the
69 elationship between stereotypic behavior and intersectin function has not been established.
70                                      Indeed, intersectin functions in the intermediate stages of clat
71 t, we provide several lines of evidence that intersectin has the capacity to activate mitogenic signa
72 election experiments with the SH3 domains of Intersectin identified two endocytic proteins, dynamin a
73 Our findings unravel a physiological role of intersectin in cortico-striatal neurotransmission to cou
74 er, the results indicate the crucial role of intersectin in the mechanism of caveolae fission in endo
75 phological analysis of ECs overexpressing wt-intersectin indicated a wide range of morphological chan
76                          We also showed that intersectin interaction with dynamin was important in re
77                              We propose that Intersectin is a component of the endocytic machinery.
78                                              Intersectin is a member of a growing family of adaptor p
79                                       Dap160/Intersectin is a multidomain adaptor protein that coloca
80 n glycerol gradients, and cross-linking that intersectin is present in ECs in a membrane-associated p
81                The endocytic protein, Dap160/intersectin, is a major binding partner of Eps15, and ep
82 ed protein Dap160, homolog of the vertebrate Intersectins, is thought likely to act as a molecular sc
83 vered that the endocytic scaffolding protein intersectin (ITSN) cooperated with epidermal growth fact
84                               Members of the intersectin (ITSN) family of scaffold proteins consist o
85 e endocytic and signal transduction scaffold intersectin (ITSN) increased aggregate formation by muta
86                                              Intersectin (ITSN) is a molecular scaffold involved in r
87                                              Intersectin (ITSN) is a multidomain scaffolding protein
88                                              Intersectin (ITSN) is a multimodular endocytic scaffold
89 ave highlighted a role for EH and SH3 domain Intersectin (Itsn) proteins in synaptic vesicle recyclin
90   Based on the interaction between Cdc42 and intersectin (ITSN), a specific Cdc42 guanine nucleotide
91 ion on a recently described adaptor protein, intersectin (ITSN), which provides a link to both the en
92 ne nucleotide exchange factors Elmo/Dock and intersectin (ITSN).
93                                              Intersectins (ITSNs) are multidomain adaptor proteins im
94 logical analyses showed that the striatum of intersectin KO mice is decreased in size.
95                                  Full-length intersectin-L exhibited little ability to stimulate nucl
96 specific guanine nucleotide exchange factor, intersectin-L, in fibroblasts.
97            Together, these data suggest that intersectin links endocytosis with regulation of pathway
98                  Our data suggest that EHSH1/intersectin may be a novel adaptor protein that couples
99 uropsychiatric symptoms of patients carrying intersectin mutations that correlates with the observati
100 ound reduced Trio or Tiam1 but not Vav, Lbc, Intersectin, or a constitutively active Rac1 mutant-stim
101                                       First, intersectin overexpression activated the Elk-1 transcrip
102                                    Replacing Intersectin's regulatory domains with the BH3 peptide/Bc
103 lated by orthoIntersectin, but not wild-type Intersectin, showing that the designed interaction can t
104 nd recruited the scaffold proteins eps15 and intersectin, which in turn engaged the adaptor complex A
105 gy to the guanine nucleotide exchange factor Intersectin, which is a selective activator of the GTPas
106 rther, the structural determinants unique to intersectin, which permit selective recognition and conc
107 ver, Cdc42(Y32F) is exclusively activated by intersectin, while virtually unresponsive to other Cdc42
108 antially increases the affinity of Cdc42 for intersectin, yet severely cripples interaction with Dbs,
109 e embryo cDNA library with the EH domains of Intersectin yielded clones for the Rev-associated bindin

 
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