ライフサイエンスコーパス: interstitial collagenase

1 he occurrence in colorectal cancer of MMP-1 (interstitial collagenase).

2 rillar collagen by a previously unidentified interstitial collagenase.

3 ity toward a collagen substrate as the human interstitial collagenase.

4 tic of the cleavage of fibrillar collagen by interstitial collagenase.

5 for TFPI-2 but intensely for gelatinases and interstitial collagenases.

6 ls, and it is mediated, at least in part, by interstitial collagenase 1 (matrix metalloproteinase 1 (

7 gen-degrading matrix metalloproteinase (MMP) interstitial collagenase-3 (MMP-13) and the previously s

8 Initiation of collagen breakdown requires interstitial collagenases, a matrix metalloproteinase (M

9 llar cell suspension, while gelatinase A and interstitial collagenase activities were not detected by

10 Although the autolytic processing and interstitial collagenase activity of MT1-MMP were not im

11 es from Mmp14-/- mice had significantly less interstitial collagenase activity than those from Mmp14+

12 s demonstrate that this Xenopus enzyme is an interstitial collagenase and has an essentially identica

13 orrelated positively with mRNA expression of interstitial collagenase and inversely with that of alph

14 fects on the affinity of N-TIMP-1 for MMP-1 (interstitial collagenase) and MMP-2 (gelatinase A).

15 OSM induced/enhanced transcription of MMP-1 (interstitial collagenase) and MMP-3 (stromelysin 1) in a

16 ssayed for levels of active and total MMP-1 (interstitial collagenase) and MMP-9 (gelatinase B).

17 osed in vitro to matrix metalloproteinase-1 (interstitial collagenase), and examined for biochemical

18 cluding stromelysin-3, gelatinase A, MT-MMP, interstitial collagenase, and stromelysin-1 were localiz

19 rs, including matrix metalloproteinase-1, an interstitial collagenase, and Tie-2, a receptor for angi

20 tric oxide synthase, inflammatory cytokines, interstitial collagenases, and tissue factor expression.

21 nt of bone cells with an inhibitory anti-rat interstitial collagenase antiserum reduced bone resorpti

22 These results indicate that interstitial collagenase can function as a "coupling fac

23 Interstitial collagenase, collagenase 3, and gelatinases

24 stern immunoblots, procollagenase and active interstitial collagenase could be readily detected in na

25 actor-alpha (TNF-alpha) alone did not induce interstitial collagenase expression in rat lung fibrobla

26 ase inducer), which stimulates production of interstitial collagenase, gelatinase A, and stromelysin-

27 es, whereas gelatinase B, stromelysin-1, and interstitial collagenase gene expression was not signifi

28 ungs was found to induce rat lung fibroblast interstitial collagenase gene expression.

29 ivated by particulates in vitro also induced interstitial collagenase gene expression.

30 s to two distinct sequences within the human interstitial collagenase gene.

31 on of matrix metalloproteinase (MMP)-1 as an interstitial collagenase, great importance has been ascr

32 hen the stomelysins in catalytic efficiency; interstitial collagenases had little capacity to generat

33 Here we show that interstitial collagenase has an essential role in initia

34 Matrix metalloproteinase-1 (MMP-1), or interstitial collagenase, has been hypothesized to contr

35 The activation of the gene for interstitial collagenase in myometrial smooth muscle cel

36 Dissociation of Ca2+ from human interstitial collagenase induced either by chelation wit

37 Immunostaining revealed that interstitial collagenase is produced at high levels by s

38 B and D, E-cadherin, gelatinase B, gelsolin, interstitial collagenase, laminin B2t, plasminogen activ

39 ix metalloproteinase-1 (MMP-1) is one of the interstitial collagenases likely to be involved in tumor

40 ide-in signals delivered by exogenous MMP-1 (interstitial collagenase) markedly increase the number o

41 The interstitial collagenase matrix metalloprotein-ase-1 (MM

42 ERK signaling drives the production of the interstitial collagenase matrix metalloproteinase-1 (MMP

43 pable of up-regulating the expression of the interstitial collagenase (matrix metalloproteinase-1 or

44 Macrophage accumulation and interstitial collagenase (matrix metalloproteinase-1, MM

45 etween collagen synthesis and degradation by interstitial collagenase (matrix metalloproteinase-1, MM

46 egulates the transcription and production of interstitial collagenase (matrix metalloproteinase-13; M

47 nal responses, including upregulation of the interstitial collagenase/matrix metalloproteinase 1 (MMP

48 PHSRN-induced invasion requires interstitial collagenase MMP-1 activity and is suppresse

49 lation of three secreted MMPs, including the interstitial collagenase MMP-1 and the two gelatinases,

50 TFPI-2 diminished the ability of the interstitial collagenases MMP-1 and MMP-13 to degrade tr

51 d with macrophages, probably mediated by the interstitial collagenases MMP-1 and MMP-13.

52 tion of PGE2 resulting in the suppression of interstitial collagenase (MMP-1) and gelatinase B (MMP-9

53 xpression of gelatinase B (MMP-9), increased interstitial collagenase (MMP-1) and stromelysin (MMP-3)

54 MMPRIN not only stimulates the production of interstitial collagenase (MMP-1) but also forms a comple

55 Transgenic mice expressing human interstitial collagenase (MMP-1) in the epidermis were u

56 We report here that interstitial collagenase (MMP-1) RNA, protein, and activ

57 Interstitial collagenase (MMP-1), a metalloproteinase pr

58 nhibition (MMPi), particularly inhibition of interstitial collagenase (MMP-1), may not be clinically

59 Relative LV myocardial abundance of interstitial collagenase (MMP-1), stromelysin (MMP-3), 7

60 Interstitial collagenase (MMP-1), stromelysin (MMP-3), a

61 ression of the matrix-degrading enzymes, ie, interstitial collagenase (MMP-1), stromelysin (MMP-3), g

62 nase (MMP-9) and TIMP-1 but failed to induce interstitial collagenase (MMP-1).

63 atinases (MMP-2, 65 kDa, and MMP-9, 92 kDa), interstitial collagenase (MMP-1, 52 kDa) and stromelysin

64 d RNA expression of TNF, alpha1(I) collagen, interstitial collagenase (MMP-13), and its inhibitor (TI

65 alized increase in the expression of the rat interstitial collagenase (MMP-13; collagenase-3) gene fr

66 We show here that rodent interstitial collagenases (MMP-13), but not human fibrob

67 The function of the major interstitial collagenase, MMP-13, in the initial phase o

68 her skeletal effects of PTH because abundant interstitial collagenase mRNA was detected in the calvar

69 ession of matrix metalloproteinase-1 (MMP-1, interstitial collagenase), one of the proteolytic enzyme

70 d by pretreatment of dentine slices with rat interstitial collagenase or by precoating the dentine sl

71 immunohistochemical analyses confirmed that interstitial collagenase protein appears in association

72 r extent also with gelatinases, but not with interstitial collagenase, resulted in the degradation of

73 Recombinant interstitial collagenase (rMMP-1) forms insoluble inclus

74 mbinant CD40L (rCD40L) induced expression of interstitial collagenase, stromelysin, and TF protein an

75 IN stimulates human fibroblast production of interstitial collagenase, stromelysin-1, and gelatinase

76 trix metalloproteinase-8 (MMP-8) is a potent interstitial collagenase thought to be expressed mainly

77 he expression of gelatinase A, gelatinase B, interstitial collagenase, tissue inhibitor of metallopro

78 clusion, distinct from the known function of interstitial collagenase to reduce liver fibrosis by deg

79 Such a collagen matrix environment regulates interstitial collagenase (type I metalloproteinase [MMP-

80 In IL-1alpha cultures, active interstitial collagenase was always detected, and active

81 levels of matrix metalloproteinase-1 (MMP-1; interstitial collagenase) were reduced and type I procol