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1 specific tissues, including lymph nodes, and interstitial fluid.
2 vective exchange of cerebrospinal fluid with interstitial fluid.
3 n are enveloped in their microenvironment by interstitial fluid.
4 the cells followed by Ca(2+) entry from the interstitial fluid.
5 y), resulting in the release of ATP into the interstitial fluid.
6 ation by altering Abeta clearance from brain interstitial fluid.
7 rgeting tumor cells based on the cues in the interstitial fluid.
8 high soluble Hsp27 levels in patients' tumor interstitial fluid.
9 tween models of different cell types via the interstitial fluid.
10 s present at significant levels in blood and interstitial fluid.
11 essures that is related to the volume of the interstitial fluid.
12 ed on the optical quantitation of glucose in interstitial fluid.
13 greater than that measured between lumen and interstitial fluid.
14 ral cells under conditions characteristic of interstitial fluid.
15 o determine the concentrations of insulin in interstitial fluid.
16 t was more similar to that of insulin in the interstitial fluid.
17 ng proteins; IGFBPs) that are present in the interstitial fluid.
18 ntly higher than that in normal subcutaneous interstitial fluid.
19 sis probe was placed in the tumor to collect interstitial fluid.
20 that are functionally incapable of draining interstitial fluid.
21 n the steady-state Abeta levels in the brain interstitial fluid.
22 iologically relevant analytes present in the interstitial fluid.
23 y readily gain access to and function within interstitial fluid.
24 thin extracellular matrix under perfusion of interstitial fluid.
25 es between the cerebrospinal fluid (CSF) and interstitial fluid.
26 llowed by excessive entry of Ca(2+) from the interstitial fluid.
27 As, messenger RNAs, or DNA between cells via interstitial fluids.
28 ase inhibitor found abundantly in plasma and interstitial fluids.
29 of APP were reduced, resulting in decreased interstitial fluid Abeta levels and attenuated amyloid d
30 tophan methylamide (GM 6001) increased brain interstitial fluid Abeta levels and elimination of half-
32 differences in the elimination half-life of interstitial fluid Abeta measured by in vivo microdialys
33 usterin(-/-) mice had elevated CSF and brain interstitial fluid Abeta, as well as significant differe
34 nic controls and the significant decrease of interstitial fluid Abeta, but not the effects on amyloid
37 ered a significant and transient increase in interstitial fluid amyloid-beta40 levels in old plaque-b
39 s in a buffer that mimics the composition of interstitial fluid and blood plasma, LJM-3064 rapidly sw
40 leared in part through the exchange of brain interstitial fluid and cerebrospinal fluid along a brain
41 o evidence that Ass was metabolized in brain interstitial fluid and degraded to smaller peptide fragm
42 el accounts for vascular, transvascular, and interstitial fluid and drug transport as well as the dia
43 are a promising technique to probe the brain interstitial fluid and estimate the extracellular concen
44 iquely adapted for the continuous removal of interstitial fluid and proteins and is an important entr
45 levels and shortened half-life in the brain interstitial fluid and reduced amyloid plaque load in th
46 s of CED in enhancing the convective flow of interstitial fluid and reducing the drug concentration d
48 the hypothesis that perivascular drainage of interstitial fluid and solutes out of brain tissue is dr
49 bservations in the human brain indicate that interstitial fluid and solutes, such as amyloid-beta (Ab
50 cid increases endothelin-1 addition to renal interstitial fluid and that inhibition of B- but not A-t
52 show that osmolarity differences between the interstitial fluid and the external environment trigger
53 on input and has three compartments (plasma, interstitial fluid and tissue fluid) with exchange betwe
54 ngiva is supplied with lymphatics that drain interstitial fluid and transport immune cells to the lym
55 c vessel function with decreased drainage of interstitial fluids and reduced dietary fat absorption.
56 vant samples including breath, urine, blood, interstitial fluid, and biopsy samples are summarized.
57 ire mouse CNS--brain and spinal cord tissue, interstitial fluid, and CSF--while having no effect on b
58 These two ions are key components of the interstitial fluid, and their concentrations change in a
59 e demonstrate that Abeta levels in the brain interstitial fluid are dynamically and directly influenc
60 emonstrate a positive relation between renal interstitial fluid ATP concentrations and both autoregul
62 hatic system is responsible for transporting interstitial fluid back to the bloodstream, but unlike t
64 ss of the lymph pump system impacts not only interstitial fluid balance but other aspects of overall
65 striction or ANG II infusion increased renal interstitial fluid BK, and cyclic guanosine 3', 5'-monop
66 AT2-null mice had low basal levels of renal interstitial fluid bradykinin (BK), and cyclic guanosine
68 microfluidic system enhanced the exchange of interstitial fluids by 567-fold, which increased the rat
69 im through viscous fluids, such as blood and interstitial fluid, by undulating their bodies as travel
70 changes that report on acidification of the interstitial fluid caused by an accelerated glycolysis.
71 ure of the physiological environment (blood, interstitial fluid, cell cytoplasm, etc.), and the durat
72 curves with a model composed of a capillary-interstitial fluid-cell exchange region and nonexchangin
75 il has been developed, and it shows that (1) interstitial fluid channels form before lymphatic endoth
76 suggest that the skin contains a hypertonic interstitial fluid compartment in which MPS cells exert
79 gned to serve this need by collecting dermal interstitial fluid containing biomarkers without the dan
80 t such that the glucose concentration of the interstitial fluid could be measured by spectroscopicall
85 glycocalyx and that the oncotic pressure of interstitial fluid does not directly determine fluid bal
87 esis that Abeta is deposited in periarterial interstitial fluid drainage pathways of the brain and co
88 esis that Abeta is deposited in periarterial interstitial fluid drainage pathways of the brain in Alz
90 could potentially be used to monitor how the interstitial fluid dynamics affect cancer microenvironme
94 mphatic regeneration by uniquely correlating interstitial fluid flow and lymphatic endothelial cell m
95 mor growth is characterized by both abnormal interstitial fluid flow and the associated interstitial
96 ferential sprouting toward paths of draining interstitial fluid flow as might occur to connect capill
99 ding is critical for skeletal integrity, and interstitial fluid flow is an important stimulus for ost
100 medium, the physical property that dictates interstitial fluid flow is the hydraulic permeability.
101 e explants showed that intermediate level of interstitial fluid flow selectively decreased cytokine-i
102 ocity, we used a simple model of peritumoral interstitial fluid flow to calculate the fluid flow velo
108 creted by maternal intestinal cells into the interstitial fluid for transport of heme to extraintesti
111 from arteries and veins that serves to drain interstitial fluid from surrounding tissues and plays a
112 pothesized to represent impaired drainage of interstitial fluid from the brain and may reflect underl
113 is firm evidence in animals for drainage of interstitial fluid from the brain to cervical lymph node
114 individual microneedle shafts melted away by interstitial fluid from the epidermis and upper dermis,
117 m is the preferred route for the drainage of interstitial fluid from tissues and also serves as a con
119 to determine the gradient between plasma and interstitial-fluid glucose concentrations, and open-flow
120 ockdown produced profound suppression of VMH interstitial fluid glutamine concentrations in the basal
121 t with insulin sensitization, adipose tissue interstitial fluid glycerol concentrations fell under hy
122 nsulinemia failed to suppress adipose tissue interstitial fluid glycerol release (180 +/- 50 micromol
125 tic vasculature is essential for maintaining interstitial fluid homeostasis, and dysfunctional lympha
127 blood flow and VEGF expression in myocardial interstitial fluid in a canine model of repetitive myoca
128 minimally invasive glucose monitoring in the interstitial fluid in the dermal region, in contrast to
129 Whereas the relatively minor role of free interstitial fluid in the fluid mechanics and perfusion
130 ) often corresponds with the accumulation of interstitial fluid in the retina [i.e., the development
132 trated ascending vasa recta (AVRs) drain the interstitial fluid in this location, but this function h
134 (Western analyses of VEGF(164) in myocardial interstitial fluid) in controls peaked at day 3 of the r
135 mg), cortisol concentrations within adipose interstitial fluid increased (4.3 +/- 1.1 vs. 14.2 +/- 2
139 acinar cells, to drive transcellular flux of interstitial fluid into the labyrinth of the salivary du
142 tivated by NMDA receptors and regulate brain interstitial fluid (ISF) Abeta levels in opposite direct
145 vity regulates the regional concentration of interstitial fluid (ISF) Abeta, which drives local Abeta
146 f this study, catecholamines from myocardial interstitial fluid (ISF) and aortic and coronary sinus p
147 cellular tau from various sources, including interstitial fluid (ISF) and CSF from an AD transgenic m
148 ogical insulin clamp significantly increased interstitial fluid (ISF) and plasma Abeta compared with
150 ent did not suppress Ang II levels in the LV interstitial fluid (ISF) despite marked inhibition of AC
152 ar pathway for cerebrospinal fluid (CSF) and interstitial fluid (ISF) exchange that facilitates effic
154 The physiological lag between blood and interstitial fluid (ISF) glucose is a major challenge fo
156 D uses an osmotic gradient to withdraw brain interstitial fluid (ISF) in a controlled manner via an i
159 aracterized soluble Abeta oligomers in brain interstitial fluid (ISF) of awake, freely moving APP/PS1
160 erebral microdialysis to obtain serial brain interstitial fluid (ISF) samples in 18 patients who were
161 t a novel method of quickly acquiring dermal interstitial fluid (ISF) samples using a Lorentz-force a
162 (NE) and epinephrine (Epi) into the cardiac interstitial fluid (ISF) space in experimentally induced
163 d that angiotensin II (Ang II) levels in the interstitial fluid (ISF) space of the heart are higher t
166 om the adjacent subarachnoid space and brain interstitial fluid (ISF) via the glymphatic system.
167 duced by neurons and released into the brain interstitial fluid (ISF), a process regulated by synapti
168 le Abeta levels and Abeta half-life in brain interstitial fluid (ISF), as measured by in vivo microdi
169 Abeta is released by neurons into the brain interstitial fluid (ISF), in which it can convert into t
170 ther tau is normally released into the brain interstitial fluid (ISF), its concentration in ISF in re
171 NN304 appearance in lymph, representing interstitial fluid (ISF), was slow compared with insulin
172 o, we used microdialysis to sample the brain interstitial fluid (ISF), which contains the most solubl
180 ishes proliferative properties of myocardial interstitial fluid (MIF) by enhancing expression of matr
181 asurements were made in myocardial tissue or interstitial fluid (MIF) from dogs undergoing repetitive
182 by altering the chemical composition of the interstitial fluid near the surface of the aggregate.
183 nged the half-life of soluble Abeta in brain interstitial fluid of awake animals, 3) raised the conce
184 e (Ado) have been documented recently in the interstitial fluid of carcinomas growing in animals, we
186 etabolism of sAbeta by astrocytes and in the interstitial fluid of mice that received apoE infusions
188 ical hyperinsulinemia on the response of the interstitial fluid of skeletal muscle to intravenously i
189 from postmortem cortical extracts and brain interstitial fluid of tau-transgenic mice, as well as hu
190 hypoxanthine, xanthine, and uric acid in the interstitial fluid of the canine myocardium was develope
191 showed that T0 decreased Abeta levels in the interstitial fluid of the hippocampus, supporting the co
194 oncentrations found in the cerebrospinal and interstitial fluids of the human brain, and the mechanis
196 Abeta oligomers were sequestered from brain interstitial fluid onto brain membranes much more rapidl
198 ghts a surprising and unrecognized role that interstitial fluid plays in setting the discharge rate,
199 lect the ability of ponezumab to mobilize an interstitial fluid pool of amyloid-beta40 in brain.
201 has been hypothesized that tumors with high interstitial fluid pressure (IFP) and/or hypoxia respond
203 draining lymphatic vasculature and decrease interstitial fluid pressure (IFP) by reducing vascular p
204 total tissue pressure (TTP) increasing above interstitial fluid pressure (IFP) directly with collagen
205 s can decrease tumor vessel permeability and interstitial fluid pressure (IFP) in a process of vessel
207 low of interstitial fluid and the associated interstitial fluid pressure (IFP) in solid tumors and su
212 observations, we hypothesized that the tumor interstitial fluid pressure (IFP) should increase follow
214 t drug delivery is complicated by high tumor interstitial fluid pressure (IFP), irregular vascular di
217 71 with the stromal PDGFr-beta reduced tumor interstitial fluid pressure (P(IF)) by >50% and in so do
221 ion, vascular volume, microvascular density, interstitial fluid pressure and the number of viable, ci
222 of both freely mobile fluid and gel fluid to interstitial fluid pressure by performing simultaneous,
224 mph nodes by controlling edema formation and interstitial fluid pressure in the presence of LPS.
225 th Starling's hypothesis relating the higher interstitial fluid pressure in the tumor with flux acros
227 vessels through normalization decreases the interstitial fluid pressure in tumours, thus allowing sm
230 polymerase eta-deficient mice and found that interstitial fluid pressure was already elevated in the
233 y 2.5-fold (immunohistochemistry), and tumor interstitial fluid pressure was suppressed by approximat
235 re in tumors is consistent with the elevated interstitial fluid pressure, and it contributes to the s
236 ted that PDGFR-beta inhibition reduces tumor interstitial fluid pressure, and thus increases the upta
237 ve been studied including cut-off pore size, interstitial fluid pressure, and tumor tissue microstruc
238 wn to exhibit high vascular permeability and interstitial fluid pressure, but the transport pathways
239 o transport in these fibroids is likely high interstitial fluid pressure, correlating with high colla
240 ascular permeability without effecting tumor interstitial fluid pressure, leading to increased delive
241 DC101 (a VEGF-receptor-2 antibody) decreases interstitial fluid pressure, not by restoring lymphatic
242 d; increased diffusional distances, elevated interstitial fluid pressure, regions of dense extracellu
243 Compression of lymphatic vessels elevates interstitial fluid pressure, whereas compression of bloo
245 nvironment-characterized by hypoxia and high interstitial fluid pressure--fuels tumor progression and
248 plastic reaction generates inordinately high interstitial fluid pressures (IFPs), exceeding those pre
249 suggested that condylar cartilage relies on interstitial fluid pressurization to a greater extent th
251 s an increase in chymase activity in cardiac interstitial fluid, providing an alternate pathway for A
252 tercurrent exchange and efficient removal of interstitial fluid resorbed from the loop of Henle and c
254 sis technique, we monitored changes in renal interstitial fluid (RIF) cGMP in response to intravenous
255 ensin II (AngII) concentrations in the renal interstitial fluid (RIF) of anesthetized rats were in th
256 sis technique, we monitored changes in renal interstitial fluid (RIF) prostaglandin E2 (PGE2) and cyc
257 system to the blood vasculature that returns interstitial fluid, salts, small molecules, resorbed fat
259 sharp gradient of S1P between blood and the interstitial fluids seems to be essential to ensure the
260 Pgp inhibitor, Abeta levels within the brain interstitial fluid significantly increased within hours
263 uch as amyloid-beta peptide (Abeta) from the interstitial-fluid space of the brain to the bloodstream
265 pond to potential interferences found in the interstitial fluid, such as fructose, vitamin C and lact
266 deep substance of the brain, mixes with the interstitial fluid surrounding neurons and glia, and pla
268 rocess in which serotonin accumulates in the interstitial fluid surrounding the mammary secretory epi
269 on had higher endothelin-1 addition to renal interstitial fluid than those given distilled H2O (480+/
271 ould result in an accumulation of ATP in the interstitial fluid that would be related with a rise in
273 barrier and dissolve upon contact with skin interstitial fluid thus releasing the nanoparticles into
277 ept that neurons continuously acquire C from interstitial fluid to permit plasma membrane turnover an
279 surface and transferred against the flow of interstitial fluid to the luminal surface of endothelial
280 or immune surveillance and the regulation of interstitial fluid transport in the endocrine pancreas a
281 ness, to quantify and understand the role of interstitial fluid transport, lymphatic-convective drain
283 monitoring of glucose concentrations in the interstitial fluid using near IR as the interrogating me
284 but little is known about how tumor IFP and interstitial fluid velocity (IFV) are affected by change
285 permeability was calculated by measuring the interstitial fluid velocity through the clots at a const
286 and a fast pulse, that is, traveling at the interstitial fluid velocity, or only a retarded shock.
289 the insulin analog NN304 in skeletal muscle interstitial fluid was constant whether in the absence o
291 ods, cerebral microdialysis samples of brain interstitial fluid were collected, and adenosine and pur
292 time course and concentration of insulin in interstitial fluid were similar in the patients with dia
294 e hyperaemia of substances released into the interstitial fluid, with emphasis on whether they are en
295 to known interfering species present in the interstitial fluid, with resolution and sensitivity (1.5
296 ference-free ethanol detection in artificial interstitial fluid without compromising its sensitivity,
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