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3 ssivity is mainly required for resistance to interstrand and intrastrand cross-linking agents, but no
4 A lesions, including nucleobase monoadducts, interstrand and intrastrand cross-links, and DNA-protein
7 , chemically stable, and photostable PAH LNA interstrand communication systems, including pyrene exci
8 dentification of alpha-helical stretches and interstrand connectivity in antiparallel beta-sheets, wh
9 MS and UV-sensitive protein81 in response to interstrand cross links and alkylated bases, whereas it
10 y integrity, recruiting FANCM to the site of interstrand cross links, preventing the cells from enter
14 The role of RAD51C in the FA pathway of DNA interstrand cross-link (ICL) repair and as a tumor suppr
15 Fanconi anemia (FA) pathway participates in interstrand cross-link (ICL) repair and the maintenance
16 rotein has nuclease activity and acts in DNA interstrand cross-link (ICL) repair within the Fanconi a
20 145), we investigated the role of WRN in the interstrand cross-link (ICL) response in cells derived f
23 strand cross-link or a cisplatin 5'-GC/5'-GC interstrand cross-link (ICL) were utilized in binding as
24 ciency nonmutagenic bypass of a psoralen DNA interstrand cross-link (ICL), whose structure resembles
26 the thermal stability of this carbinolamine interstrand cross-link and the stereochemical preference
27 at Pu-GATC-Py sequences, 1 can form a longer interstrand cross-link at Pu-GAATC-Py sequences, an intr
28 ed that, in addition to the previously known interstrand cross-link at Pu-GATC-Py sequences, 1 can fo
30 he dynamics were suppressed by an engineered interstrand cross-link in the dsDNA that prevented unwin
32 gest that the originally reported Pu-GATC-Py interstrand cross-link is more stable, consistent with t
33 t insights into the effects of an AP-derived interstrand cross-link on the efficiency and accuracy of
34 A-family polymerase with a putative role in interstrand cross-link repair and homologous recombinati
36 dditional, poorly characterized functions in interstrand cross-link repair, double-strand break repai
38 asic (Ap) site in duplex DNA can generate an interstrand cross-link via reaction with a guanine resid
42 intricate spatial arrangement and elaborate interstrand cross-linkages, they are difficult to prepar
45 ith this model, cells lacking RNF4 exhibited interstrand cross-linker hypersensitivity, and the gene
46 By assaying for sensitivity of cells to the interstrand cross-linker mitomycin C, we found that trea
48 cated in repairing DNA damage induced by DNA interstrand cross-linking (ICL) agents, topoisomerase I
51 in increased cellular sensitivity to the DNA interstrand cross-linking agent mitomycin C and the topo
55 this is the first example of photoswitchable interstrand cross-linking formation induced by a modifie
56 isomerase poisons, DNA synthesis inhibitors, interstrand cross-linking inducers, and base-damaging ag
63 ycosylases capable of unhooking highly toxic interstrand cross-links (ICLs) and bulky minor groove ad
64 uclei where it is important in repair of DNA interstrand cross-links (ICLs) and chromosome stability.
65 accompanied by enhanced repair of cisplatin interstrand cross-links (ICLs) and ICL-induced DNA doubl
75 ice displayed marked hypersensitivity to DNA interstrand cross-links (ICLs) but not whole-body irradi
76 ve both been implicated in the repair of DNA interstrand cross-links (ICLs) by cellular studies, and
79 MutSbeta heteroduplex, which interacts with interstrand cross-links (ICLs) induced by drugs such as
80 ation but are sensitive to agents that cause interstrand cross-links (ICLs) or replication stress.
81 sion in DNA reveals that it reversibly forms interstrand cross-links (ICLs) selectively with a dA opp
82 ) pathway is essential for the repair of DNA interstrand cross-links (ICLs), and a germline defect in
83 R) repair of double-strand breaks (DSBs) and interstrand cross-links (ICLs), but its mechanism of act
84 play an important role in the repair of DNA interstrand cross-links (ICLs), but the precise mechanis
85 ion of Fancd2 is essential for repairing DNA interstrand cross-links (ICLs), but the underlying mecha
86 d primarily to their ability to generate DNA interstrand cross-links (ICLs), which effectively block
97 sm of the stepwise formation of 5'-5' 1,4-GG interstrand cross-links (IXLs) by fully (15)N-labeled [{
98 th published work showing that KP1019 causes interstrand cross-links and bulky DNA adducts in mammali
99 ates with a decreased level of repair of DNA interstrand cross-links and chromosomal instability in F
100 was complete unhooking of cisplatin-induced interstrand cross-links and repair of IR-induced strand
101 or NLS mutations showed reduced unhooking of interstrand cross-links and repair of strand breaks.
105 le PBD binding sites where neither intra- or interstrand cross-links are feasible because of the unav
108 SG2285 is highly efficient at producing DNA interstrand cross-links in cells, but they form more slo
109 midine nucleotides, the aryl iodides produce interstrand cross-links in duplex regions of DNA when ex
112 e that REV1 and Polzeta facilitate repair of interstrand cross-links independently of PCNA monoubiqui
114 cient repair of DNA double strand breaks and interstrand cross-links requires the homologous recombin
115 ing because the highly deleterious nature of interstrand cross-links suggests that even small amounts
116 M), which is required for the repair of DNA interstrand cross-links to ensure replication progressio
117 halide nucleotide analogues that produce DNA interstrand cross-links under anaerobic conditions upon
121 p, 5-(2'-deoxyuridinyl)methyl radical, forms interstrand cross-links with the opposing 2'-deoxyadenos
122 alkylation damage), mitomycin C (generating interstrand cross-links), or potassium bromate (generati
123 itive specifically to UV irradiation and DNA interstrand cross-links, similar to cells lacking ERCC1.
124 by inducing DNA monoadducts and ultimately, interstrand cross-links, which block DNA replication.
137 pression, abrogation of BRIP1 foci after DNA interstrand crosslink (ICL) damage and hypersensitivity
138 other key cellular processes, including DNA interstrand crosslink (ICL) repair and DNA double-strand
139 s roles in nucleotide excision repair (NER), interstrand crosslink (ICL) repair, homologous recombina
145 es profound cellular hypersensitivity to DNA interstrand crosslink lesions in vivo, highlighting the
146 emonstrated that neither mismatch repair nor interstrand crosslink repair affects the production of t
147 ing replication and its participation in DNA interstrand crosslink repair and/or heteroduplex rejecti
148 CM participates in recombination-independent interstrand crosslink repair by facilitating recruitment
149 esults suggest that FAN1 has a minor role in interstrand crosslink repair compared with true FA genes
151 roper RAD51 function is important during DNA interstrand crosslink repair outside of homologous recom
152 the deficiency in replication-dependent DNA interstrand crosslink repair pathway commonly referred t
153 ce that BRCA1 plays an important role in DNA interstrand crosslink repair that is distinct from its e
154 genetic complementation groups implicated in interstrand crosslink repair, FANCJ encodes a DNA helica
155 ty-DNA double-strand break (DSB) repair, DNA interstrand crosslink repair, repair of stalled replicat
156 monoubiquitinated FANCD2 and is required for interstrand crosslink repair, suggesting that mutation o
157 lication-dependent and transcription-coupled interstrand crosslink repair, while SNM1B/Apollo is requ
161 ified NEIL1 protein bound stably to psoralen interstrand crosslink-containing synthetic oligonucleoti
164 conferred resistance to mitomycin C (MMC, an interstrand crosslinker) and camptothecin (CPT, a type 1
167 (FA) patients are extremely sensitive to DNA interstrand crosslinking (ICL) agents, but the molecular
168 nts cause defective cellular response to DNA interstrand crosslinking agent and telomere maintenance,
169 n, knockdown of NONO sensitizes cells to the interstrand crosslinking agent, cisplatin, whereas knock
171 acted doses of 14 alkylating and similar DNA interstrand crosslinking drugs from medical records.
176 ay plays a central role in the repair of DNA interstrand crosslinks (ICLs) and regulates cellular res
177 CA pathway is critical for the repair of DNA interstrand crosslinks (ICLs) and the maintenance of chr
186 esolving double-strand DNA breaks (DSBs) and interstrand crosslinks (ICLs) by homologous recombinatio
187 ins thought to function in the repair of DNA interstrand crosslinks (ICLs) comprise what is known as
190 not essential for cells to survive toxic DNA interstrand crosslinks (ICLs), although MMR proteins bin
191 otein network is necessary for repair of DNA interstrand crosslinks (ICLs), but its control mechanism
192 Several important anti-tumor agents form DNA interstrand crosslinks (ICLs), but their clinical effici
194 le-deficient cells are hypersensitive to DNA interstrand crosslinks (ICLs), indicating that BRCA1 has
196 r hypersensitivity to agents that induce DNA interstrand crosslinks (ICLs), such as mitomycin C (MMC)
197 agents used in cancer chemotherapy cause DNA interstrand crosslinks (ICLs), which covalently link bot
199 itin are required for localizing SLX4 to DNA interstrand crosslinks (ICLs), yet how SLX4 is targeted
206 were exposed to chemicals that generate DNA interstrand crosslinks (repaired by FA proteins), but no
207 fective in promoting replication traverse of interstrand crosslinks and is also inefficient in promot
209 NEIL1 recognizes specifically and distinctly interstrand crosslinks in DNA, and can obstruct the effi
210 the cellular level, hypersensitivity to DNA interstrand crosslinks is the defining feature in Fancon
211 itutional genomic disorders, suggesting that interstrand crosslinks may play a pathogenic role in suc
212 to aid replication machines to traverse DNA interstrand crosslinks prior to post-replication repair.
215 to oxidative DNA damage and psoralen-induced interstrand crosslinks was differentially affected by th
216 hor complex that recognizes damage caused by interstrand crosslinks, a multisubunit ubiquitin ligase
217 re rapidly recruited to forks stalled by DNA interstrand crosslinks, and both are required for cellul
219 as well as trioxsalen (psoralen)-induced DNA interstrand crosslinks, but not to angelicin monoadducts
220 ke MUS81-EME1, is required for repair of DNA interstrand crosslinks, but this role appears to be inde
221 otoxic agents that generate alkylated bases, interstrand crosslinks, DNA-protein crosslinks, and doub
222 this groove for efficient digestion past DNA interstrand crosslinks, facilitating the key DNA repair
223 resolution of non-B DNA structures including interstrand crosslinks, G quadruplexes and DNA triplexes
224 alter the accumulation of NEIL1 at sites of interstrand crosslinks, suggesting distinct recognition
225 repair (BER) proteins in the response to DNA interstrand crosslinks, which block replication and tran
226 Their main role is in the repair of DNA interstrand crosslinks, which, by covalently binding the
235 e also observe the emergence of delocalized, interstrand CT excitations, whose excitation energies ma
236 of the CT band (representing both intra- and interstrand CT states) appears at energies comparable to
238 the Xaa and Yaa positions, we conclude that interstrand dipole-dipole interactions are the primary d
239 In contrast, dsRNA is not able to reduce its interstrand distance and can only elongate by unwinding.
242 tal results that show, surprisingly, that an interstrand disulfide bond can stabilize parallel beta-s
244 p) to Cys-374 (C-terminal) but increases the interstrand disulfide cross-linking of Cys-265 (hydropho
245 R)-gamma-hydroxytrimethylene N(2)-dG:N(2)-dG interstrand DNA cross-link in 5'-d(G(1)C(2)T(3)A(4)G(5)C
249 cs, coordinate replication-coupled repair of interstrand DNA cross-links, and mitigate conflicts betw
250 ferative effects by creating intrastrand and interstrand DNA cross-links, which block DNA replication
253 recruitment of the Fanconi anemia complex to interstrand DNA crosslink sites and for interaction with
256 ternative paired-end sequencing method using interstrand DNA photo cross-linking to covalently link t
261 mon type of endogenous DNA damage, can forge interstrand DNA-DNA cross-links via reaction with the ex
262 eotide repeat does not form stable intra- or interstranded DNA structures, being a DNA unwinding elem
264 by applying it to probe the dynamic role of interstrand H-bond formation in the folding kinetics of
266 he folding rate, suggesting that most native interstrand H-bonds in beta-hairpins are formed only aft
267 rands 4 and 5 in the beta-barrel, which lack interstrand hydrogen bonding, and we speculate that it c
269 itiated by hydrophobic collapse, followed by interstrand hydrogen-bond formation and turn formation.
270 and causing the formation of intrastrand and interstrand (ICL) crosslinks, but the precise downstream
271 uding analysis of functional consequences of interstrand interactions and mutations located at substa
276 n methods and are primarily localised in the interstrand loops that encompass the C-terminal hemisphe
283 n transfer induced by UV excitation triggers interstrand proton transfer in the alternating miniduple
285 This suggests that perturbations of the interstrand region can destabilize spectrin tetramers an
287 nfinement entropy is already included in the interstrand repulsion free energy derived from osmotic s
288 in the CT theories this role is fulfilled by interstrand repulsion, and there is no explicit entropy
290 resonance distance measurements capture the interstrand separation within monomer units during the t
291 opy reconstruction analysis to determine the interstrand spacing of double-stranded DNA encapsidated
293 lting replisome is liable to intrastrand and interstrand switches leading to replication errors.
294 2-thiothymine and 2,6-diaminopurine, and +1 interstrand zipper arrangements of intercalator-function
296 -sequence dsDNA through modification with +1 interstrand zippers of intercalator-functionalized nucle
297 f double-stranded probes featuring different interstrand zippers of pyrene-functionalized monomers ba
298 obes are activated for DNA recognition by +1 interstrand zippers of pyrene-functionalized nucleotides
299 nts using Invader duplexes with different +1 interstrand zippers of the four canonical 2'-O-(pyren-1-
300 ition of dsDNA through modification with "+1 interstrand zippers" of 2'-N-(pyren-1-yl)methyl-2'-amino
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