ライフサイエンスコーパス: intersubunit

1 ciation with p55 was unperturbed, suggesting intersubunit affinities similar to WT.

2 lay a large role in establishing such strong intersubunit anchoring.

3 hexameric architecture that is stabilized by intersubunit and interdomain interactions of LRRNT and L

4 Here we investigate both intersubunit and intrasubunit interactions between TM he

5 stabilizes the neutral pH structure through intersubunit and intrasubunit interactions that presumab

6 ol slowed the rate of modification of L240C (intersubunit) and increased the rate of modification of

7 tive allosteric modulators by binding to the intersubunit anesthetic-binding sites in the GABAAR tran

8 romosomal instability, cancer, and decreased intersubunit association.

9 the extracellular domain that provides three intersubunit ATP binding sites.

10 genesis studies, has provided a model of the intersubunit ATP-binding sites and identified an extrace

11 define the location of three non-canonical, intersubunit ATP-binding sites, and suggest that ATP bin

12 imulations to demonstrate a coupling between intersubunit bending and the degree of flattening of eac

13 reB filaments exhibited nucleotide-dependent intersubunit bending, with hydrolyzed polymers favoring

14 ly, the FNIII-like domain forms a continuous intersubunit beta-sheet dimer, previously unobserved for

15 ermini of the mature protease are part of an intersubunit beta-sheet located distal from the active s

16 nd in all apicomplexan PBGS enzymes forms an intersubunit beta-sheet, stabilizing a pro-octamer dimer

17 pinwheel with elastic deformation modes and intersubunit binding interactions.

18 ed that S-mTFD-MPPB binds to the same GABAAR intersubunit binding site as R-mTFD-MPAB, but with negat

19 subunit interface site similar to its GABAAR intersubunit binding site.

20 ChR ion channel, but it does not bind to the intersubunit binding site.

21 otentiator, has identified a second class of intersubunit binding sites for general anesthetics in th

22 , disruptions of which alter the neighboring intersubunit binding sites in a similar fashion.

23 high selectivity to distinct but homologous intersubunit binding sites in the transmembrane domain o

24 tophans were within reach of both intra- and intersubunit binding sites.

25 on and provide a first demonstration that an intersubunit-binding site in the GABAAR transmembrane do

26 us but pharmacologically distinct classes of intersubunit-binding sites for general anesthetics in th

27 local shear force that accelerates filament intersubunit bond rupture.

28 ovirus-like human endogenous retrovirus--for intersubunit bonding and found that, as in the lentiviru

29 ed us to show that antibodies binding at the intersubunit boundary inhibit uncoating of the virion ou

30 tein uL2 to with rProtein bS6, forming a new intersubunit bridge 'B9'.

31 he S13 protein in the small subunit (forming intersubunit bridge B1a).

32 Dynamic remodelling of intersubunit bridge B2, a conserved RNA domain of the ba

33 iological role in establishing the ribosomal intersubunit bridge B2a and mediating translational fide

34 t, whereas G347U is located 77 A distant, at intersubunit bridge B8, close to where EF-Tu engages the

35 htly coupled to its ability to form a strong intersubunit bridge linking the primary and complementar

36 NS3920, the corresponding histidine forms an intersubunit bridge that reinforces the ligand-mediated

37 nd Lsg1 together embrace helix 69 of the B2a intersubunit bridge, inducing base flipping that we sugg

38 alyses of the cryo-EM maps reveal that eight intersubunit bridges (bridges B1a, B1b, B2a, B2b, B3, B7

39 lude rRNA segments in contact with the tRNA, intersubunit bridges and helices 28, 32 and 34 of the sm

40 Many intersubunit bridges are specific to the mitoribosome, w

41 S rRNA residues involved in the formation of intersubunit bridges B3, B5, B6, B7b and B8.

42 (i) the bulk transfer of energy through the intersubunit bridges from the large to the small subunit

43 In this study, the contribution of intersubunit bridges to the energy barrier of translocat

44 work propagating motion from the tRNA to the intersubunit bridges to the head swivel or along the sam

45 space is significantly different, with fewer intersubunit bridges, but more tunnels, and (iii) severa

46 osomal subunits remain associated through 17 intersubunit bridges, five of which are eukaryote specif

47 ere, we review the molecular nature of these intersubunit bridges, how they change conformation durin

48 n ribosomal components that comprise several intersubunit bridges, including bridge B2a, thereby stab

49 tions between the ribosomal subunits, termed intersubunit bridges, keep the ribosome intact and at th

50 d directly in the formation of six of the 15 intersubunit bridges.

51 Zn(II) binds to a pair of intersubunit C-terminal alpha5-sensing sites, some 15 A

52 ably, the TnrA sensor domains insert into GS intersubunit catalytic pores, destabilizing the TnrA dim

53 odels, we investigate cholesterol binding to intersubunit cavities of the GABAAR transmembrane domain

54 tive of binding stability; the extracellular intersubunit cavity expanded and intersubunit electrosta

55 Propofol-induced motions in the intersubunit cavity were distinct from motions associate

56 C shows R-ketamine bound to an extracellular intersubunit cavity.

57 of CeFIGL-1-AAA has adapted to establish an intersubunit charge interaction, which contributes to it

58 polyanions, which probably can help minimize intersubunit charge repulsion caused mainly by arginine-

59 hes, whereas the G4941I mutation resulted in intersubunit clashes among the mutated isoleucines.

60 mechanism of activation, and the role of the intersubunit cleavage.

61 of the KCNE1 TMD forms an interface with an intersubunit cleft in the channel that is associated wit

62 ried ligand-binding pocket at interdomain or intersubunit clefts, facilitating proper solvent shieldi

63 sp104 hexamers adapt different mechanisms of intersubunit collaboration to disaggregate stress-induce

64 aggregates but employ distinct mechanisms of intersubunit collaboration.

65 hus, the dynamic response of mTORC1 requires intersubunit communication by the Rag GTPases, providing

66 Importantly, Hsp104 variants with impaired intersubunit communication dissolve disordered aggregate

67 onvenient format for assessing mechanisms of intersubunit communication from a variety of NMR measure

68 tinct roles of intrasubunit interactions and intersubunit communication in allostery.

69 This intersubunit communication pushes the Rag GTPases into e

70 ved residues for roles in ATP hydrolysis and intersubunit communication.

71 critical for its functionality in alpha/beta intersubunit communication.

72 quired multiple nucleotide binding sites and intersubunit communication.

73 drolysis, to study allosteric regulation and intersubunit communication.

74 ing of individual subunits as well as of the intersubunit communications.

75 Bacillus subtilis enzyme undergoes dramatic intersubunit conformational alterations during formation

76 ergy transfer assays that reveal a ribosomal intersubunit conformational cycle in real time during in

77 ions demonstrated that IM-CKV063 binds to an intersubunit conformational epitope on domain A, a funct

78 to induce signaling in T cells via intra- or intersubunit conformational rearrangements within the ex

79 ally aromatic compounds devoid of long-range intersubunit conjugation.

80 de a wealth of data on the stoichiometry and intersubunit connectivity of endogenous protein assembli

81 knowledge of their subunit stoichiometry and intersubunit connectivity.

82 from crosslinking experiments identifying an intersubunit contact most consistent with that number; s

83 he Fab binds across the outer surface of the intersubunit contact, which contains two Ca2+ sites.

84 turn influences the formation of stabilizing intersubunit contacts and thus the reaction's degree of

85 op, which was hypothesized to make important intersubunit contacts between coat proteins in adjacent

86 t only provides further understanding of the intersubunit contacts in allosteric coupling in the HCN

87 (HCN) channel as a model system to study the intersubunit contacts in cAMP-dependent gating.

88 t from steric hindrance of the W domain with intersubunit contacts in the actin filament.

89 te receptors, NMDA receptors have additional intersubunit contacts in the ligand binding domain that

90 Intersubunit contacts in the polymerization nucleus, tho

91 talytic-right subunits, which make extensive intersubunit contacts in the tetramer.

92 ing and limited proteolysis, the alpha-gamma intersubunit contacts previously observed within the int

93 Extensive intersubunit contacts stabilize a bent filament-like arr

94 We identified intra- and intersubunit contacts that formed with the LA loops; the

95 erminal extension makes transient intra- and intersubunit contacts with the substrate binding site an

96 the AMPA receptor structure, this face forms intersubunit contacts with the transmembrane helices of

97 d by ATP hydrolysis lead to an alteration of intersubunit contacts within and across the rings, ultim

98 In non-NMDA receptors, the strength of intersubunit contacts within ligand-binding domains is i

99 es on the regulation of PhK activity through intersubunit contacts, because both retained the regulat

100 structure, which are not involved in native intersubunit contacts, likely provide a scaffold for the

101 Freed of intersubunit contacts, the apical domain of each subunit

102 d upon desensitization and replaced by newer intersubunit contacts.

103 utamate-gated channels for largely conserved intersubunit contacts.

104 MR titration data reveal that there is minor intersubunit cooperativity in formation of a ternary com

105 ike EcoSSB, the mtSSB does not show negative intersubunit cooperativity.

106 Here we report the direct observation of the intersubunit coordination and step size of such a ring A

107 study the mechanisms of force generation and intersubunit coordination in the ClpXP protease from E.

108 that may functionally facilitate intra- and intersubunit coordination, including the 5.8S rRNA.

109 uld activate the Hsp104 hexamer by promoting intersubunit coordination, suggesting that Hsp70 is an a

110 e interaction, mechanochemical coupling, and intersubunit coordination.

111 al step-size of 1 nm and a certain degree of intersubunit coordination.

112 We find that long-range intersubunit correlation of amino-acid pairs is weaker i

113 tructures: on the T(6) surface but within an intersubunit crevice in R-containing hexamers.

114 Our results suggest that intersubunit crevices found in the TM domain of the ATP-

115 We have performed intersubunit cross-linking using glutaraldehyde of the O

116 By inducing RyR intersubunit cross-linking, ROS can increase SR Ca(2+) l

117 dine receptor (RyR) subunits, referred to as intersubunit cross-linking.

118 Intersubunit cross-talk between this domain and the DnaA

119 Remarkably, several intersubunit crosslinks abrogated membrane fusion, but b

120 ing is instead inhibited by oxidation of the intersubunit cysteine pair to a mixture of disulfide and

121 ter thermautotrophicus (mtMCM) hexamer shows intersubunit distances suitable for bonding contacts, in

122 We found intersubunit distances to average 16 A between neighbori

123 binding zinc, but no changes are observed in intersubunit distances.

124 aliana revealed the presence of a regulatory intersubunit disulfide bond (Cys(86)-Cys(119)).

125 tivity is biochemically regulated through an intersubunit disulfide bond between Cys86 and Cys119 in

126 r this enzyme and reveals the presence of an intersubunit disulfide bond between Cys86 and Cys119.

127 odimers being trapped by the formation of an intersubunit disulfide bond between cysteine residues st

128 antibodies and nearest neighbor analyses via intersubunit disulfide bond formation.

129 s 166 and 254 thus appear to be required for intersubunit disulfide bond formation.

130 es bound the enzyme in close proximity to an intersubunit disulfide bond interactions that covalently

131 n the lentiviruses, the Env subunits lack an intersubunit disulfide bond.

132 gly, Y424C-G428C monomers were associated by intersubunit disulfide bonds and were insensitive to MTS

133 utant HIV-1 particles capable of spontaneous intersubunit disulfide bonds at the interhexamer interfa

134 We now demonstrate that intersubunit disulfide bonds exist between monomeric sub

135 the spatial constraints introduced by these intersubunit disulfide bonds in the outer vestibule of t

136 47, P48, and G49 to cysteine, allowing novel intersubunit disulfide bonds to form with the free C153

137 Intersubunit disulfide bonds were detected in purified p

138 was discovered to be a homotetramer with an intersubunit disulfide bridge.

139 partial proteolysis and to reduction of its intersubunit disulfide bridges by glutathione.

140 Intersubunit disulfide bridges, Cys-206-Cys-206 and Cys-

141 the subunit interface of sfALR, close to the intersubunit disulfide bridges.

142 of excitatory amino acid transporter 1 form intersubunit disulfide cross-links within the trimer.

143 This suggests that the intersubunit disulfide induces a conformational change t

144 atoms (from R194 itself and from C95 of the intersubunit disulfide of the other protomer) and with t

145 ess and the possibility that both intra- and intersubunit dynamic binding (i.e., loss and restoration

146 protein synthesis, but direct observation of intersubunit dynamics has been obscured by the repetitiv

147 hrough the single heme moiety rather than an intersubunit electron pathway through a potential domain

148 ate residue, which is believed to facilitate intersubunit electron transfer between the Rieske center

149 This long-range, intersubunit electron transfer occurs by a multistep "ho

150 zed that an arginine-119 residue was forming intersubunit electrostatic bonds with D97.

151 This intersubunit electrostatic interaction among GlyR subuni

152 tracellular intersubunit cavity expanded and intersubunit electrostatic interactions involved in chan

153 We conclude that intra- and intersubunit electrostatic networks at the extracellular

154 mation that exposes the surfaces engaging in intersubunit FliGC/FliGM contacts.

155 Intersubunit fluorescence resonance energy transfer meas

156 Although the typical S100 protein intersubunit four-helix bundle is conserved upon S-nitro

157 Specifically, we ask to what extent intersubunit geometry affects oligomerization state.

158 indirect, or allosteric mutations affecting intersubunit geometry via indirect mechanisms are as imp

159 ct changes outside the interface that affect intersubunit geometry.

160 that the synthesis of the primer proceeds by intersubunit glucosylation of dimeric glycogenin, even t

161 The MSAE produced by heterodimer intersubunit glucosylation was 60% of that produced by t

162 and critical role for this centrally located intersubunit helix (H69) in accurate and efficient subst

163 n sites for sensory adaptation that lie near intersubunit helix interfaces of the Tsr homodimer.

164 thereby properly position a backbone NH for intersubunit hydrogen bonding to the key Asp.

165 rs at the dimer interface and enhancement of intersubunit hydrogen bonds in the presence of bt10, whi

166 ntrasubunit in P22 and HK620 tailspikes, but intersubunit in Sf6, demonstrating how phages can adapt

167 l for ATPase activity, Lys335 is involved in intersubunit interaction and activation of ATPase activi

168 tional changes that lead to disruption of an intersubunit interaction between a "hot-spot" loop in th

169 Disruption of any single intersubunit interaction results in a >2.6 kcal mol(-1)

170 nterface and designed mutants to perturb the intersubunit interaction.

171 brium toward particle formation by promoting intersubunit interactions and stabilizing assembly inter

172 eucine zipper region of UL6 is important for intersubunit interactions and stable ring formation.

173 cture of the open state that has stabilizing intersubunit interactions and that is compatible with av

174 the role of residues involved in intra- and intersubunit interactions and their link with the channe

175 We identified numerous intersubunit interactions and up to six Rab-binding site

176 mechanism of the complex RbsABC2, we probed intersubunit interactions by varying the presence of the

177 s and modeling to probe these class-specific intersubunit interactions for their role in glutamate bi

178 as crystallized as a pentamer, revealing the intersubunit interactions in a wild type neuronal nAChR

179 C-linker is the site of virtually all of the intersubunit interactions in the C-terminal region.

180 Glu(42), an amino acid that participates in intersubunit interactions in the CRP pentamer and is bur

181 Intersubunit interactions involving 11 hydrogen bonds an

182 In the unliganded Env, intersubunit interactions maintain the gp41 ectodomain h

183 t phosphorylation-induced destabilization of intersubunit interactions mediated by the N-terminal dom

184 In efforts to identify the intersubunit interactions of K33, we performed alanine-s

185 We have identified one of the key intersubunit interactions that controls pH-induced monom

186 important sites of dynamic intrasubunit and intersubunit interactions that regulate assembly of the

187 g short range and long range interdomain and intersubunit interactions that uniquely regulate the act

188 ary for pump activation or the modulation of intersubunit interactions to diminish RyR1 channel activ

189 s did not, suggesting the inhibitors enhance intersubunit interactions to overcome channel biogenesis

190 uggest that the tethering arm contributes to intersubunit interactions within the EGF receptor dimer.

191 These two regions appear to undergo intersubunit interactions within the multimeric channel

192 Through a series of intersubunit interactions, the spike protein (VP4) adopt

193 interactions and 2) trans-allostery requires intersubunit interactions.

194 identified two regions involved in critical intersubunit interactions.

195 ations that reduce dimerization or alter the intersubunit interface affect both the second conformati

196 emonstrated that point mutations in the EpsE intersubunit interface also reduce ATPase activity witho

197 e non-adhesive CfaB subunit localized to the intersubunit interface and significantly reduced fimbria

198 effects whether it contributed either to an intersubunit interface containing a canonical ACh bindin

199 this is due to minor differences between the intersubunit interface formed by the NTDs and the abilit

200 Therefore, mutations at the gamma/beta intersubunit interface have specific long-distance effec

201 M3 residues beta2M286 and beta2F289 face the intersubunit interface in close proximity to alpha1-M1 a

202 Earlier we hypothesized that the intersubunit interface in CYP3A4 oligomers is similar to

203 e inhibitors act through a unique pH-sensing intersubunit interface in GPC, but atomic-level structur

204 le open conformation in which changes at the intersubunit interface in the CTD also alter the electro

205 the mutations reside at or near the GP1-GP2 intersubunit interface in the membrane-proximal base of

206 uces the binding of a neurotransmitter at an intersubunit interface into the opening of a central ion

207 The JMJD5-PKM2 interaction resides at the intersubunit interface region of PKM2, which hinders PKM

208 transmembrane segments of the VSDs form the intersubunit interface that mediates coupling between bi

209 dentified, allowing modeling of the complete intersubunit interface.

210 g a third Glu-binding site at an alpha/alpha intersubunit interface.

211 lphaW493R rewires structural dynamics of the intersubunit interfaces alpha1beta and alpha2gamma.

212 mbrane-associated domains (M3 and M4) at the intersubunit interfaces form putative sites of alcohol a

213 tivated CaMKII acts as a wedge by docking at intersubunit interfaces in the hub.

214 exert similar long-distance effects on other intersubunit interfaces involved in GABA and benzodiazep

215 Intersubunit interfaces play a critical role in alloster

216 GluClalphaR, we introduced mutations at the intersubunit interfaces where Glu (the neurotransmitter)

217 es at the distant beta/alpha and alpha/gamma intersubunit interfaces, respectively.

218 ogues) that are located at and stabilize the intersubunit interfaces, together with a single tightly

219 o equivalent Glu-binding sites at beta/alpha intersubunit interfaces, where the GluClbeta and GluClal

220 are near, but not in, the active site or at intersubunit interfaces.

221 formation of heterologous (i.e., asymmetric) intersubunit interfaces.

222 ting of five amino acids at the M3-M4 domain intersubunit interfaces.

223 c subunits, harboring 10 active sites at the intersubunit interfaces.

224 ncluding a more thorough characterization of intersubunit interfaces.

225 s, quantifiable manner for the heterogeneous intersubunit, intraring, noncovalent cross-links provide

226 Antibodies that bind at the intersubunit junction neutralize as monovalent Fabs, whi

227 P2-binding sites in the regions close to the intersubunit junctions, suggesting that NSP2 binding cou

228 e top of the pore-lining M2 helices, and the intersubunit link of R210 on the M1-linker to E168 on th

229 Following cleavage, the intersubunit linker (and associated conformational chang

230 Here, we demonstrate that cleavage of the intersubunit linker of c-FLIP(L) by procaspase-8 potenti

231 evaluation of the role of the prodomain and intersubunit linker on caspase-6 structure and function

232 s L1, L3, and L4 and in the 130s region, the intersubunit linker region, the 26-32 region as well as

233 Short intersubunit linker regions provide the molecular basis

234 structures of caspase-6 with and without the intersubunit linker.

235 UGDHs where structural divergence within the intersubunit loop structure likely contributes to the Ca

236 in the C-terminal domain and another in the intersubunit MHR interface.

237 Two types of intersubunit modules formed by the large ATPase domain o

238 ffect of tetramerization is modulated by the intersubunit motions in the tetramer such that a complex

239 bonds between adjacent subunits to restrict intersubunit movements inhibited channel function.

240 inhibits InsP3R activity by restricting the intersubunit movements that initiate gating.

241 no structural information describing how the intersubunit organization facilitates MAC assembly.

242 ncode both surface recognition and favorable intersubunit packing interactions.

243 us residues in the homodimer is required for intersubunit packing.

244 n histidine kinase autophosphorylates via an intersubunit phosphorylation reaction in which each prot

245 he 20S alpha-subunits and indicates that the intersubunit pocket in the 20S undergoes an induced-fit

246 nition by P-TEFb and reveal an unanticipated intersubunit pocket on the AFF4 SEC that potentially rep

247 and revealed specific binding to the 2-fold intersubunit pocket.

248 By reconfiguring intersubunit protein-protein contacts, we directed the a

249 We conclude that both intrasubunit and intersubunit reaction mechanisms are necessary for the d

250 o glucosylate exclusively by intrasubunit or intersubunit reaction mechanisms.

251 with deformation of these domains as well as intersubunit rearrangements during AMPA receptor desensi

252 These results suggest that (i) the ribosomal intersubunit reorganizations upon RRF binding and subseq

253 ion, leaving the ribosome in a non-canonical intersubunit rotated state with an exposed codon in the

254 Intersubunit rotation and movement of the L1 stalk, a mo

255 Here, we use single-molecule FRET to monitor intersubunit rotation and the inward/outward movement of

256 del in which L1 stalk movement is coupled to intersubunit rotation and/or IF2 binding.

257 s long axis and orthogonal to the well-known intersubunit rotation distinguishes the posttranslocatio

258 A model is presented describing how cyclic intersubunit rotation ensures the unidirectionality of t

259 ribosomal subunit and slows down spontaneous intersubunit rotation in pretranslocation ribosomes.

260 steric interactions involved in coordinating intersubunit rotation originating from rpL10 in the core

261 Our results provide direct evidence that the intersubunit rotation that underlies ribosomal transloca

262 iotic to predictably perturb the dynamics of intersubunit rotation, a structural rearrangement of the

263 elbow, stalk movement is directly linked to intersubunit rotation, rotation of the 30S head domain a

264 nd B4, B7a and B8 are predicted to constrain intersubunit rotation, these data provide evidence that

265 n) state involves both 30S head movement and intersubunit rotation.

266 cs bound, that reveal intermediate states of intersubunit rotation.

267 that the L1 stalk can move independently of intersubunit rotation.

268 ectively, impacts translation by controlling intersubunit rotation.

269 olecular ratchets, involving both intra- and intersubunit rotational movements, to drive the synchron

270 Intersubunit rotational states differ in these structure

271 translocation, characterized by intermediate intersubunit rotations, L1 stalk positions, and tRNA con

272 We identified a new putative intersubunit salt bridge (R128-E132-Kir1.1b) in the P-lo

273 In R297C, this was due to disruption of intersubunit salt bridge Glu(288)-Arg(297).

274 ociation between the binding and breakage of intersubunit salt bridges in the EC domain.

275 Intersubunit salt bridging between Arg(4) and Glu(53) du

276 Several potentially important intersubunit salt-links form in both the nAChR and GABAR

277 We identify the intersubunit side of the large subunit as the binding si

278 followed by the polypeptide exit tunnel, the intersubunit side, and finally the central protuberance.

279 it via a conserved but structurally distinct intersubunit-signaling pathway common to diverse AAA+ ma

280 A second intersubunit site partially overlaps with the GABA site

281 demonstrated to act through a transmembrane intersubunit site situated in the upper three helical tu

282 subunit sites for most halothane binding and intersubunit sites for thiopental binding.

283 m as well as propofol bind to the homologous intersubunit sites in the GABAAR transmembrane domain th

284 el homology model suggests propofol binds to intersubunit sites in the TMD in the resting state.

285 size that binding at any of these homologous intersubunit sites is sufficient for anesthetic action a

286 yl) determines selectivity for intra- versus intersubunit sites, in contrast to GABAARs, where this d

287 l, a general anesthetic that binds to GABAAR intersubunit sites, inhibited [(3)H]S-mTFD-MPPB photolab

288 de that ML277 activates IKs by binding to an intersubunit space and allosterically influencing pore c

289 hape and position of this IRES domain in the intersubunit space compared to those of tRNA, supporting

290 erably more porous, (ii) the topology of the intersubunit space is significantly different, with fewe

291 reveal that, like pY, PSRP1 binds within the intersubunit space of the 70S ribosome, at a site overla

292 MRP complex shows that FMRP binds within the intersubunit space of the ribosome such that it would pr

293 The spin label mobility, intersubunit spin-spin proximity, and the solvent-access

294 s of the IF2.tRNA sub-complex forming on the intersubunit surface of the 30S IC may play a significan

295 ilament bending and torsional rigidities and intersubunit torsional flexibility measured experimental

296 The linker length between P1 and P3 dictates intersubunit (trans) versus intrasubunit (cis) autophosp

297 suggests that all bind to a broadly similar intersubunit transmembrane site.

298 ternal GXY repeats of gp12 to build a stable intersubunit triple helix in a prokaryotic setting.

299 Despite this intersubunit uncoupling, both I domains remain individua

300 in the GLIC TMD that frame intrasubunit and intersubunit water-accessible cavities were individually