ライフサイエンスコーパス: intervene

1 ld suggest when and where to therapeutically intervene.

2 d to tissue hypoxia, but other factors could intervene.

3 Health and Human Services has been urged to intervene.

4 portant opportunities to recognize abuse and intervene.

5 national NBS program: screen only if you can intervene.

6 needed to help countries to more effectively intervene.

7 get gaps flanking Mu without replicating the intervening 37 kb of Mu, disassembling the stable transp

8 mylinomimetic, davalintide (AC2307), with an intervening 40 kD PEG moiety.

9 Over the intervening 40 years however a far more complicated pict

10 plice donor and thus causes retention of the intervening 7 bp of the intron and leads to premature tr

11 In the intervening 75 years, the transformation has grown to en

12 For hairpins with two or more intervening A-T, the transient absorption spectra of DPA

13 the DNA pi-stack is established by using an intervening AC mismatch to break this path.

14 eutralizing antibodies with the potential to intervene against multiple circulating HIV-1 strains.

15 rty punishment in which dominant individuals intervened against freeloaders, and partner choice.

16 bound alkynes to pi-allyls in the absence of intervening allenes.

17 interact with pathological brain signals to intervene and ameliorate their effects in disease states

18 me remain unclear, limiting opportunities to intervene and improve people's patience.

19 However, physicians rarely intervene and no trials have been done on the subject.

20 crystal structure of a small portion of the intervening and the complete keratin-like domain of SEP3

21 Quality control mechanisms intervene appropriately when defective translation event

22 arkers will help design clinical trials that intervene at appropriate times.

23 wever, combining molecules to simultaneously intervene at multiple regulatory nodes synergistically e

24 ported in the chloroplast, where they mostly intervene at posttranscriptional steps.

25 ne expression through numerous proteins that intervene at posttranscriptional steps.

26 veral hours post-PPCI, it may be too late to intervene at that time.

27 ion by HDACi is a novel and potent target to intervene at the center of neuroinflammation.

28 possible solution to this predicament is to intervene at the level of psychobiology, enhancing partn

29 Subsequently, we locally intervened at the level of GABAergic signaling by using

30 , unlike commonly used normalization methods intervening at the analysis stage, entails an experiment

31 degrees , 25 degrees , and 30 degrees , with intervening ATP binding, phosphate release, and catalyti

32 inolylcarbenes and 1-naphthylnitrene and the intervening aza-benzobicyclo[4.1.0]heptatrienes, aza-ben

33 n peptides and proteins are functions of the intervening backbone torsion angle varphi.

34 ssues allows the producer or veterinarian to intervene before the animals' production levels, or even

35 ale architecture wherein f-actin and drebrin intervene between microtubules and the plasma membrane.

36 uiry into sensorimotor computations that may intervene between MT and LIP.

37 eir timing and in their resistance to sounds intervening between the sample and match.

38 rol classes tested at the same times without intervening brain training.

39 amplicons while simultaneously deleting the intervening BRCA1 tumor suppressor locus.

40 as correlated with the proportion of habitat intervening, but was best explained by agricultural dist

41 eats of the histone H2A N-terminal sequence, intervened by the cathepsin D cleavage site.

42 animal experiments, we show here that SerRS intervenes by antagonizing c-Myc, the major transcriptio

43 ces voltage-dependent calcium channel (VDCC)-intervened calcium influx in airway epithelial cells, re

44 mers composed of two domains connected by an intervening calmodulin-binding region.

45 cal time for bone development and failure to intervene can lead to long-term problems.

46 g from direct arterial-venous shunts without intervening capillaries.

47 intervening items, half of which included an intervening category shift.

48 transplanted directly into the wound without intervening cell culture using PDGFRalpha, Osterix (OSX)

49 environmental factors have been linked, the intervening cellular and molecular mechanisms connecting

50 s involving the transport of CsOH through an intervening chloroform layer.

51 These intervening choice feedback signals predicted the subseq

52 cibly measure both size and stability of the intervening chromatin loops, and use it to demonstrate t

53 roximal promoter region through "looping" of intervening chromatin.

54 ep iterative homologation processes, without intervening column chromatography, to give contiguously

55 lternating rings of actin linked together by intervening complexes of spectrin.

56 ld involve the apolipoprotein E genotype and intervening conditions during trial.

57 meiotic chromosome separations occur without intervening cytokinesis, resulting in two spindles in on

58 e cell cycle by the nuclear double membrane, intervening cytoplasm, and the mitochondrial double memb

59 In the intervening decades, our understanding of the natural hi

60 nvolvement of two adjacent vertebrae and the intervening disc.

61 ogen bonds, and native contacts separated by intervening disordered regions (through the Wako-Saito-M

62 ns a visually guided delayed saccade with an intervening distractor, variability (measured by the Fan

63 e mutated Dmd exon23 resulted in excision of intervening DNA and restored the Dmd reading frame in my

64 nd OL through the formation of a loop by the intervening DNA segment.

65 xons in somatic hypermutation or deletion of intervening DNA sequences during class switch recombinat

66 r sites on the bacterial DNA and causing the intervening DNA to form a loop.

67 that requires structural deformation of the intervening DNA.

68 teract, forming an octamer and a loop of the intervening DNA.

69 The intervening dsRBD acts only as an RNA-sensing scaffold,

70 th care professionals are well positioned to intervene during the early teenage years by informing pa

71 th the ER lectin calnexin and preferentially intervenes during maturation of cysteine-containing, mem

72 rly recognition of patients at high risk, to intervene early and avoid development of chronic headach

73 n in global child protection sectors, and to intervene early for individual children experiencing dep

74 care pediatricians are in a good position to intervene early when indicated.

75 tress is achieved by chaperone activity that intervenes early in the protein misfolding process and i

76 Intervening early to boost resilience among those at ris

77 Intervening early with pharmacotherapy is recommended by

78 perimental and computational evidence for an intervening electron donor-acceptor complex, which is ne

79 thesized to be mechanically reinforced by an intervening electron-dense material (EDM).

80 The pattern of bristles and intervening epithelial cells (ECs) becomes established t

81 two epithelia and subsequent removal of that intervening epithelium.

82 for two aggradational phases separated by an intervening erosional phase.

83 nitric acid solution is passed, without any intervening evaporation step.

84 rn to the operating room and charging for an intervening exam when performing cataract surgery on bot

85 as Alu elements, are sufficient to allow the intervening exons to circularize in cells.

86 raction with objects of interest despite the intervening eye movements.

87 ight the importance of neural activity as an intervening factor between molecular and behavioral proc

88 le organism and there has been no history of intervening fluoroquinolone use.

89 ions arranged in an open or closed ring with intervening foci of punctate hypoautofluorescence.

90 In the intervening G2 phase, mitotic inducers accumulate, which

91 y the curvature of space around matter in an intervening galaxy.

92 geting gene-rich islands before spreading to intervening gene-poor domains.

93 alse-paternity event occurring in any of the intervening generations.

94 same chromosome can promote the deletion of intervening genomic segments with modest efficiencies.

95 cient in deleting the approximately 23 kb of intervening genomic sequences.

96 The dominance of a constantly intervening God in the Middle Ages lessened interest in

97 y the attendees, what we have learned in the intervening half century, and the relevance of their dis

98 ose deposited in bioturbated intervals under intervening higher oxygen.

99 ADS domain transcription factors through its intervening (I) and keratin-like (K) domains.

100 Screening adolescents for substance use and intervening immediately can reduce the burden of addicti

101 thermal ablation, offers the opportunity to intervene in a wide range of pulmonary and extrapulmonar

102 serve as a baseline for future directions to intervene in allergic disease development, progression,

103 ts, and provider systems to more effectively intervene in altering the course of asthma and to furthe

104 s are strongly age-associated, strategies to intervene in aspects of the stem cell aging process may

105 d delivery depth, or how plasma-derived RONS intervene in biological processes.

106 Bet v 1, the major birch pollen allergen, to intervene in birch pollen allergy.

107 Modulation of protein function is used to intervene in cellular processes but is often done indire

108 gnaling, there are also new opportunities to intervene in Complement-mediated disease.

109 to the different ways in which awareness can intervene in decision making (as identified in our lens

110 ntial to developing new therapeutic tools to intervene in demyelinating diseases such as multiple scl

111 constitutes a safe and promising strategy to intervene in disease progression and preserve beta-cell

112 The ability to intervene in disease progression given a person's diseas

113 ed as an attractive means to therapeutically intervene in disease states.

114 ust pathogen and will enhance our ability to intervene in disease states.

115 V therapy within the CNS, and potentially to intervene in downstream mechanisms of neurotoxicity, rem

116 or devising endosymbiont-based strategies to intervene in insect immunity or nematode parasitism for

117 ew avenues to understand and therapeutically intervene in malignancies.

118 e findings could lead to novel approaches to intervene in neurodegenerative diseases in which myelin

119 conditions and is currently being tested to intervene in neuropsychiatric conditions.

120 ard of, and governments may need to actively intervene in nonsustainable lifestyles to achieve emissi

121 ghlight current efforts to pharmacologically intervene in Notch signaling and discuss promising ongoi

122 esity, suggesting that it may be possible to intervene in obesity by targeting the gut microbiota.

123 ecursors can provide clinicians with time to intervene in order to prevent or mitigate secondary brai

124 As Alzheimer disease (AD) research moves to intervene in presymptomatic phases of the disease, we mu

125 is essential to understand RAS action and to intervene in RAS-driven diseases.

126 and a third party chooses whether or not to intervene in the conflict.

127 We did not intervene in the control schools.

128 ve been identified by which immune cells can intervene in the metastatic cascade, leading to the deve

129 hould be a valid approach to therapeutically intervene in the pathogenesis of macrophage-driven infla

130 trategies have been developed to potentially intervene in these progressive neurodegenerative events

131 However, new strategies to detect and intervene in those patients at higher risk of ArLD are l

132 t the iron binding capability of lactoferrin intervened in DA cell rescue only when neurodegeneration

133 ogen sulfide is an essential catabolite that intervenes in the pathophysiology of several diseases fr

134 d the investigation of how energy metabolism intervenes in this process.

135 ersist scarcely explored as targets, despite intervening in a plethora of pathophysiological events i

136 Therefore, intervening in ER stress and modulating signaling compon

137 important to understanding and intelligently intervening in herpesvirus infections.

138 psid could prove to be a useful strategy for intervening in HIV-1 infection and transmission.

139 tems, we conducted randomized experiments by intervening in live social environments across the domai

140 but also opens up many new possibilities for intervening in networks.

141 ted interventions are therefore possible for intervening in the cellular pathway to senescence, but i

142 ied as high-potential therapeutic candidates intervening in the intracellular inflammation cascade of

143 rstanding its workings, to say nothing about intervening in them, is among the hardest problems in sc

144 Japan: New Zealand Intervening) in the International Court of Justice.

145 2%) of dentists/therapists stated they would intervene, increasing to 74% (95% CI, 56%-86%) with dent

146 ontrol based on an environmentally sensitive intervening intein sequence is described.

147 data included at least two outbreaks and the intervening inter-epidemic trough during which fadeout o

148 hion or in a stepwise fashion (i.e., with an intervening intermediate) depends on the substituents at

149 espite presentation of further images in the intervening interval.

150 irst computed tomographic scan or during the intervening intervals.

151 Then, the ferryl centre of compound II intervenes into the unprecedented S-oxygenation of homoc

152 rtion of dentists/therapists said they would intervene invasively (restoratively) on carious lesions

153 [CI], 15%-28%) of dentists/therapists would intervene invasively.

154 A limiting step in our ability to intervene is the lack of objective, reliable predictors.

155 experiment revealed additional evidence for intervening item reinstatement during temporal order jud

156 oding, hippocampal pattern similarity across intervening items was associated with subsequent success

157 found evidence that the category content of intervening items was reactivated during recency judgmen

158 of items that had been presented with three intervening items, half of which included an intervening

159 ular approaches in neuroscience consider the intervening level of cellular and systems neurophysiolog

160 there is less understanding of pathology at intervening levels of organization.

161 y, and if two converging forks stall with no intervening licensed origin-a "double fork stall" (DFS)-

162 ate the influence of peptide orientation and intervening linker length on the peptides' interaction w

163 igomeric assembly domain, and portions of an intervening linker region.

164 -terminal protease domain connected by three intervening linkers.

165 ures reflected the local organization of the intervening lipids between the two interacting proteins.

166 ipants subsequently navigate, as well as for intervening locations along the route, consistent with t

167 ed with a further three short helices within intervening loops, DfsB belongs to a non-enzymatic class

168 cement learning and motivation, although the intervening mechanisms remain unclear.

169 s of tracers report on the properties of the intervening medium, characterizes viscosity at length-sc

170 ells alternate between G and S phase without intervening mitosis or cytokinesis, resulting in polyplo

171 determinant for plasticity in the brain, but intervening molecular signals are not well characterized

172 y function/damage markers and accounting for intervening mortality events.

173 We focused on the long intergenic/intervening ncRNAs (lincRNAs), hidden within the large a

174 quence harboring diverse cis elements and an intervening neighbor gene fushi tarazu (ftz).

175 ve or TRPV1-resistant, regardless of whether intervening neurons were excitatory or inhibitory.

176 Numerous long intervening noncoding RNAs (lincRNAs) are generated from

177 Long intervening noncoding RNAs (lincRNAs) are transcribed fr

178 xplain the observed nontrivial effect of the intervening nucleosome.

179 xpansion, and in 5, it was performed with an intervening observation period.

180 better cardiovascular health in children by intervening on multiple levels of influence on childhood

181 is the change in the outcome resulting from intervening on the risk factor.

182 osis and plasma membrane retrieval events by intervening only after SV fusion and endocytosis were co

183 mobility models like the gravity model, the intervening opportunities model, and the recently introd

184 drivers of population health so that we may intervene, paving the way for healthier populations.

185 adult testis; however, their role during the intervening period of testis development, in particular

186 h cognitive assessment as well as during the intervening period.

187 n" proteopathies, but also offers chances to intervene pharmacologically to promote bypassing of the

188 burst sources, and their propagation through intervening plasma, has limited their use as cosmologica

189 integrin domain of ChlD, particularly if the intervening polyproline linker region is retained.

190 tion requires a conformational change in the intervening polytopic sequence separating loops 1 and 7.

191 y transmembrane segments 5-6 (S5-S6) and the intervening pore loop, which is flanked by S1-S4 voltage

192 nd synaptogenesis but its potential roles in intervening processes have not been addressed.

193 The findings suggest that intervening product sites serve to increase the amount o

194 ng is a posttranslational modification where intervening proteins (inteins) cleave themselves from la

195 iously perceived the face stimuli due to the intervening questioning.

196 IV 3% sodium chloride as this is the time to intervene rather than waiting until more severe symptoms

197 nsitive sites HS1-2 within the Vkappa-Jkappa intervening region are essential for controlling locus c

198 ites HS1-2 within the mouse Igkappa gene V-J intervening region binds CCCTC-binding factor and specif

199 elices upon binding to TAZ1 and TAZ2 whereas intervening regions of the p53TAD remain flexible.

200 r epistatic gene interactions in the MAT-CEN intervening regions.

201 30 seconds of renal ischemia with 30 seconds intervening reperfusion.

202 This analysis revealed the intervening residues involved in the dynamic coupling of

203 ere is great need to understand decisions to intervene restoratively and to find implementation inter

204 5% CI, 40%-56%) of dentists/therapists would intervene restoratively.

205 The extent that dentists' thresholds for intervening restoratively have changed with this evidenc

206 thalpy-entropy trade-offs merely reflect the intervening role of temperature in activation free energ

207 rounds of chromosome segregation without an intervening S phase.

208 Despite the intervening saccade, the second saccade curved away from

209 connection, and therefore the absence of an intervening seaway, between the Panama arc and South Ame

210 The intervening secular (year-to-year) variation in field in

211 tress communication between loci through the intervening segment.

212 entify restenosis and new disease beyond the intervened segments, both of which may jeopardize patenc

213 nearby insertions generate nucleosome-sized intervening segments.

214 Older age, male sex, multiple intervening self-poisoning episodes, higher socioeconomi

215 n arise from chronic pressure erosion of the intervening septal myocardium, leading to left-to-right

216 nucleotide polymorphisms (SNPs) rs74421874 [intervening sequence (IVS) 3+nt460-G>A], rs3825172 (IVS3

217 logy is required between the donors, and the intervening sequence from the invading molecule is inser

218 erved tryptophan (W) and arginine (R) and an intervening sequence with a high content of tyrosines (Y

219 ur CCCTC-binding factor (CTCF) sites and the intervening sequence, approximately 75% of the ICR.

220 Split eukaryotic genes contain intervening sequences or introns disrupting protein-codi

221 The presence of intervening sequences, termed introns, is a defining cha

222 Stwintrons are complex intervening sequences, where an 'internal' intron interr

223 AluSx and AluY resulting in the deletion of intervening sequences.

224 00% self-homology, separated by 3-9 bases of intervening sequences.

225 f distant loci results in the removal of the intervening sequences.

226 This update incorporates changes over the intervening seven database releases.

227 h the imposed perturbations or to explicitly intervene so as to minimize the influence of the perturb

228 crystallographic alignment, expulsion of the intervening solvent and particle coalescence are enabled

229 nsisting of multiple palindromic repeats and intervening spacers through the function of Cas6e endori

230 n with DIY kits is the simplification of the intervening steps going from basic design to fabrication

231 environmental exposure may be confounded by intervening stochastic and environmental variation.

232 ic coldspot was also found in the form of an intervening strip stretching from the posterior OFC thro

233 tant from the globin heme pocket and, via an intervening structural domain, positions the C-terminal

234 deflection of their light by the gravity of intervening structures-and estimating the corresponding

235 d their responses based on the strain of the intervening substrate.

236 discharged prior to 28-days post decision to intervene surgically.

237 While the presence of an intervening tBu group is found to be optimal for maximum

238 xygenase (15-LOX) is a promising strategy to intervene the arachidonic acid (AA) metabolite network a

239 as yet no clear consensus about how best to intervene therapeutically in CJD, prion infections can b

240 appreciation of features indicating when to intervene therapeutically.

241 e vaccination has emerged as one approach to intervene through the rapid sequestering of the circulat

242 ing communities), using systems science, and intervening through combinations of individual, family,

243 However, in the intervening time since these reviews, a number of new mo

244 se may help to determine the optimal time to intervene to achieve best outcomes.

245 r basket protein Nup60 and analyzed how they intervene to control the plasticity of the NPC.

246 ned, and may prove useful in treatments that intervene to manipulate the body image.

247 e a window of opportunity to therapeutically intervene to preserve graft function before graft failur

248 These new insights offer opportunities to intervene to support more adaptive development than befo

249 urrently, there are only limited therapeutic intervenes to offer patients diagnosed with pulmonary fi

250 f further DNA synthesis unless recombination intervenes to restart replication.

251 gly, pediatric health care organizations are intervening to address family social adversity.

252 readiness to transfer on a regular basis and intervening to address individual needs.

253 liosis' in Pisa syndrome should not preclude intervening to improve posture as most patients had litt

254 By intervening to increase spinal cord perfusion pressure,

255 cision, and impact of factors other than the intervening torsion angle on (3)J will be minimal, makin

256 group of participants tested twice, without intervening training, exhibited neither threshold improv

257 re repeated within 2 d of each other with no intervening treatment.

258 formation of RNA secondary structure in the intervening unbound regions.

259 tween an exposure and an outcome which, when intervened upon, will block (some or all of) the causal

260 entered) effected through knowledge about an intervening variable (e.g., gaze position); and the inco

261 ular, we speculate that body image may be an intervening variable mediating the relationship between

262 ables is a simplification neglecting various intervening variables.

263 around the light-emitting diffuser, with no intervening viable parenchymal cells.

264 t baseline MA yet developed MA by 18 months, intervening visits were assessed to determine the first

265 al alignment and systematically decreases as intervening water density increases.

266 ree energy wells distinguished by numbers of intervening water layers, which reach a minimum when ali

267 ng glycoside hydrolase mechanism wherein the intervening water molecule enables a Grotthuss proton sh

268 force spectroscopy, highlighting the role of intervening water molecules.

269 60(o) periodicity, revealing the key role of intervening water structuring as a basis to generate the

270 RD is stacked a top the TMD, separated by an intervening wedge-like linker domain.

271 nic intermittent ethanol (CIE) exposure with intervening weeks of test drinking sessions, whereas the

272 whereas basal respiration is accompanied by intervening whisks that occur between breaths.

273 in size and topographical complexity (e.g., intervening white matter tracts) in larger brains may se

274 Schools offer an excellent opportunity to intervene with adolescents presenting emotional problems

275 l edema (nausea, vomiting, and headache) and intervene with IV 3% sodium chloride as this is the time

276 hese findings suggest a need to identify and intervene with military-connected adolescents and reflec

277 ruses, phytoplasma, or symbiotic bacteria to intervene with phytohormone-regulated defenses.

278 reduce incarceration itself and effectively intervene with prisoners to screen, diagnose, and treat

279 is, but also identifying in whom and when to intervene with the 2 treatment modalities available: EBT

280 Subjects were instructed either to not intervene with the imposed perturbations or to explicitl

281 metic neuron, with the capacity to precisely intervene with the underlying malfunctioning signalling

282 ellular context to target G-quadruplexes and intervene with their function.

283 which patients best benefit from and when to intervene with TPIAT, current limitations of the surgica

284 llular inhibitor and point to new methods to intervene with viral cyclins.

285 slices and cultured pericytes were used, and intervened with endothelial nitric oxide synthase (eNOS)

286 n carcinogens (e.g., tobacco or asbestos) to intervening with anticarcinogenic strategies (behavioral

287 n carcinogens (e.g., tobacco or asbestos) to intervening with anticarcinogenic strategies (behavioral

288 Our results demonstrate that intervening with endogenous ADAM sheddase modulatory mec

289 ram cells as potential therapeutic nodes for intervening with maladaptive behavioural states.

290 inhibiting reactive oxygen species (ROS) or intervening with ROS-dependent JNK activation that leads

291 MicroRNAs also intervene, with emerging evidence for the role of other

292 Disease progression during the intervening years between resection and relapse is poorl

293 However, research over the intervening years has revealed that both splice site sel

294 The legacy of the intervening years is that definitions of lone AF in the

295 In the intervening years it became clear that both viruses were

296 ered by adult stem cells 4 years ago.(1) The intervening years since that first review has witnessed

297 In the intervening years, a recommendation is proposed that a d

298 During the intervening years, resuscitation science has advanced co

299 fragmentations, have been reviewed over the intervening years.

300 m of intensive clinical treatment during the intervening years.