ライフサイエンスコーパス: intervertebral

1 , DAPS maintained their structure, prevented intervertebral bony fusion, and matched native disc mech

2 t the protein is required for maintenance of intervertebral, carpal and sternal joints, and the joint

3 From nucleus pulposus of the intervertebral disc (in which the bulk collagen monomer

4 r understanding of functional changes in the intervertebral disc (IVD) and interaction with endplate

5 mplicated in the regulation of articular and intervertebral disc (IVD) cartilage homeostasis.

6 l loads are important for homeostasis of the intervertebral disc (IVD) cell matrix, with physiologic

7 dies have demonstrated biologic responses of intervertebral disc (IVD) cells to loading, although the

8 Intervertebral disc (IVD) degeneration and associated sp

9 of significant socio-economic importance and intervertebral disc (IVD) degeneration has been implicat

10 The aetiology of intervertebral disc (IVD) degeneration remains poorly un

11 ted the role of HTRA1 in the pathogenesis of intervertebral disc (IVD) degeneration.

12 ain is extremely high and is often linked to intervertebral disc (IVD) degeneration.

13 The nucleus pulposus (NP) of the intervertebral disc (IVD) demonstrates substantial chang

14 Intervertebral disc (IVD) disorder and age-related degen

15 embedded within the nucleus pulposus of the intervertebral disc (IVD) during maturation.

16 The main pathogenesis of intervertebral disc (IVD) herniation involves disruption

17 Recurrence of intervertebral disc (IVD) herniation is the most importa

18 anabolic and anti-catabolic growth factor on intervertebral disc (IVD) matrix and cell homeostasis.

19 Narrowed intervertebral disc (IVD) space is a characteristic of I

20 -derived shear stiffness measurements of the intervertebral disc (IVD) taken throughout the day and t

21 flammatory cytokine expression in pathologic intervertebral disc (IVD) tissues.

22 al bodies were only mildly affected, but the intervertebral disc (IVD) was reduced or missing.

23 commonly implicated in this condition is the intervertebral disc (IVD), which frequently herniates, r

24 f this study was that Chd synthesized in the intervertebral disc accumulates in the vertebral body.

25 y has correlated macroscopic and microscopic intervertebral disc alterations starting in the second d

26 hich only revealed a protrusion of the L5-S1 intervertebral disc and no apparent cause for the patien

27 low back pain is degenerative disease of the intervertebral disc and other structures of the lumbar s

28 e a novel mechanism of NGF regulation in the intervertebral disc and potentially other pathogenic con

29 Pathologic processes affecting the intervertebral disc are affected by genetic factors and

30 Nucleus pulposus (NP) cells of the intervertebral disc are essential for synthesizing extra

31 Intervertebral disc calcification is a rare condition in

32 n our study, we present a case of idiopathic intervertebral disc calcification within the cervical se

33 we investigated LPP action in rabbit primary intervertebral disc cells cultured ex vivo in a three-di

34 CHST3 mRNA was significantly reduced in the intervertebral disc cells of human subjects carrying the

35 In intervertebral disc cells, hypoxia promotes expression o

36 Low-dose NVP-BGJ398 treatment reduced intervertebral disc defects of lumbar vertebrae, loss of

37 enitors also caused severe short stature and intervertebral disc defects.

38 Intervertebral disc degeneration (IDD) causes chronic ba

39 Intervertebral disc degeneration (IVDD) is linked to low

40 e therapeutic strategy for the prevention of intervertebral disc degeneration and its associated morb

41 ative connective tissue pathologies, such as intervertebral disc degeneration and osteoarthritis.

42 ation (Col9a1(-/-)), osteoarthritis (OA) and intervertebral disc degeneration develop prematurely.

43 was to assess the prevalence and timeline of intervertebral disc degeneration in mice homozygous for

44 The finding of premature onset of intervertebral disc degeneration in this mouse model may

45 Intervertebral disc degeneration is linked to loss of ex

46 Intervertebral disc degeneration is the leading cause of

47 Intervertebral disc degeneration was also detected, with

48 (12.5 mo old) showed increased incidence of intervertebral disc degeneration with a concomitant decr

49 represents a promising strategy for treating intervertebral disc degeneration.

50 ges consistent with anatomic signs of OA and intervertebral disc degeneration.

51 e to the changes occurring in the ECM during intervertebral disc degeneration.

52 defects in caudal vertebrae due to abnormal intervertebral disc development, although with higher pe

53 The nucleus pulposus (NP) of the intervertebral disc develops from the notochord.

54 thin a single breed (PBonferroni = 0.01) and intervertebral disc disease (IVDD) across breeds (PBonfe

55 is a promising avenue for treating advanced intervertebral disc disease.

56 IX collagen is an important component of the intervertebral disc extracellular matrix.

57 d ADAMTS-4 messenger RNA expression in human intervertebral disc fibrochondrocytes.

58 We obtained 34 control samples of intervertebral disc from previously healthy individuals

59 Nerve ingrowth deeper into diseased intervertebral disc has been reported, but how common th

60 painful neuroinflammation that can accompany intervertebral disc herniation, is associated with local

61 likely to have low back pain or symptoms of intervertebral disc herniation, with secondary problems

62 We examined nerve growth into the intervertebral disc in the pathogenesis of chronic low b

63 an important role for nerve growth into the intervertebral disc in the pathogenesis of chronic low b

64 e outer third of the annulus fibrosus of the intervertebral disc is innervated.

65 to hypoxia in nucleus pulposus cells of the intervertebral disc is regulated by the hypoxia-inducibl

66 hondrocytes in knee joint and in NP cells in intervertebral disc led to the decrease in CTGF expressi

67 obtained from healthy and pathological human intervertebral disc matrices.

68 study to assess the therapeutic benefits of intervertebral disc matrix repair and regeneration by ev

69 ned peptide therapy with LfcinB and BMP7 for intervertebral disc matrix repair and to understand cell

70 patients: dyspnoea, headache, hypertension, intervertebral disc protrusion, and malignant lung neopl

71 ting potential for future studies related to intervertebral disc replacement therapy.

72 Thirty-six formalin-fixed embedded intervertebral disc samples of varying grades of degener

73 CT images at the level of the L4-5 intervertebral disc space were extracted from the medica

74 expression of Notch signaling components in intervertebral disc tissue from mature rats and from hum

75 the PKC pathways, specifically PKCdelta, in intervertebral disc tissue homeostasis.

76 anases other than ADAMTS-8 was identified in intervertebral disc tissue, as was mRNA for TIMP-3.

77 ell type than BM-MSCs for use in engineering intervertebral disc tissue.

78 aggrecanase activities were also detected in intervertebral disc tissue.

79 r of metalloproteinases 3 (TIMP-3), in human intervertebral disc tissue.

80 biosynthesis towards maintenance of healthy intervertebral disc tissues.

81 grecan-rich hydrated tissue that permits the intervertebral disc to resist compressive loads.

82 a CV2-dependent flow of Chd protein from the intervertebral disc to the vertebral body.

83 content in biological tissues (i.e., porcine intervertebral disc).

84 tochord gives rise to the middle part of the intervertebral disc, called the nucleus pulposus.

85 Interestingly, lubricin was prominent in the intervertebral disc, especially in the nucleus pulposus.

86 Nucleus pulposus, the central zone of the intervertebral disc, is gel-like and has a similar colla

87 proteins in articular cartilages, meniscus, intervertebral disc, rib, and tracheal cartilages on sam

88 n nucleus pulposus (NP) cells of the healthy intervertebral disc, the mechanisms that control express

89 uctures, such as the articular cartilage and intervertebral disc.

90 cornea, and successive lamellar rings in an intervertebral disc.

91 adaptation to diurnal osmotic loading of the intervertebral disc.

92 TS activity in nucleus pulposus cells of the intervertebral disc.

93 ogically hyperosmotic environment within the intervertebral disc.

94 yme regulating GAG synthesis in cells of the intervertebral disc.

95 Intervertebral discs (IVD) are essential components of t

96 ures of nucleus pulposus (NP) cells from the intervertebral discs (IVD) of bovine tails were transfec

97 reporter genes and injected in isolated goat intervertebral discs (IVD).

98 al bodies were only moderately affected, the intervertebral discs (IVDs) were either missing or incom

99 ithin the developing annulus fibrosis of the intervertebral discs and increased apoptosis of chondroc

100 es were taken at lumbar vertebrae L1-L5 plus intervertebral discs and the thigh (midthigh, 10 cm dist

101 hat express substance P deep within diseased intervertebral discs and their association with pain sug

102 pression of Sca1 in mesenchymal cells of the intervertebral discs during development of the spinal co

103 We collected 46 samples of intervertebral discs from 38 patients during spinal fusi

104 Nerve growth into degenerate intervertebral discs has been linked with the developmen

105 Immunohistochemical staining of intervertebral discs of Ccn2 null embryos shows a decrea

106 Aggrecan extracted from human lumbar intervertebral discs was incorporated into tissue cultur

107 a murine organ culture model in which intact intervertebral discs were cocultured with peritoneal mac

108 of the spine and hips, and deterioration of intervertebral discs with characteristic radiographic ch

109 nt of anterior elements, relative sparing of intervertebral discs, and cold abscesses.

110 ading of the lower back with degeneration of intervertebral discs, and experiments on cadaver spines

111 f a metameric series of vertebral bodies and intervertebral discs, as well as adjoining ribs and ster

112 Indeed, entire intervertebral discs, normally composed by nucleus pulpo

113 sforming growth factor can be transferred to intervertebral discs, resulting in increased proteogylca

114 lcium phosphate-like whitlockite crystals in intervertebral discs.

115 perichondrium, and mesenchymal cells of the intervertebral discs.

116 directly by forming the nucleus pulposus of intervertebral discs.

117 re necessary for the resorption of herniated intervertebral discs.

118 us fibrosus in 48 (60%) of the 80 samples of intervertebral discs.

119 ome, which later comprises the vertebrae and intervertebral discs.

120 ignaling mechanisms control this response in intervertebral discs.

121 premature degeneration and calcification of intervertebral discs.

122 and water content in the nucleus pulposus of intervertebral discs.

123 g signaling is required for formation of the intervertebral discs.

124 cular mechanisms responsible for forming the intervertebral discs.

125 CCN3 was expressed in embryonic and adult intervertebral discs.

126 spine alters the osmotic environment in the intervertebral disk (IVD) as interstitial water is expre

127 gulatory role of PN-1 in the pathogenesis of intervertebral disk (IVD) degeneration.

128 Degeneration of the intervertebral disk (IVD) is a major pathological proces

129 yD88 pathway has yet to be elucidated in the intervertebral disk (IVD).

130 The lumbosacral intervertebral disk angle (LSIVDA), defined as the angle

131 ant role in the development of back pain and intervertebral disk degeneration in adults.

132 other widespread pathology related to GAG is intervertebral disk degeneration.

133 e for HTRA1 in the pathogenesis of joint and intervertebral disk degeneration.

134 The images obtained in the excised intervertebral disk demonstrated a signal intensity vari

135 had ligamentous injuries, three patients had intervertebral disk edema, and one patient had a cord co

136 rs; 42% women) with imaging-confirmed lumbar intervertebral disk herniation and persistent signs and

137 cal candidates with imaging-confirmed lumbar intervertebral disk herniation who were treated at 13 sp

138 ctures, vertebral body and facet contusions, intervertebral disk herniations, ligamentum nuchae strai

139 Magnetic resonance (MR) images of a lumbar intervertebral disk in a healthy volunteer were obtained

140 cord contusion, a ligamentous injury, and an intervertebral disk injury.

141 A well-formed, complete S1-2 intervertebral disk is associated with LSTVs, but altera

142 ee-dimensional reconstruction of lamellae of intervertebral disk is presented.

143 rids by systemic immunization with cartilage/intervertebral disk proteoglycan (PG).

144 s, of which 24 resulted from misplacement of intervertebral disk space markers.

145 A complete S1-2 intervertebral disk was associated with LSTVs (P = .004)

146 Thin-section spin-echo images of an excised intervertebral disk were obtained with a horizontal fiel

147 ium (from the occiput to the second cervical intervertebral disk) may be radiographically obscure due

148 The results suggest that MR imaging of the intervertebral disk, using sodium imaging and T2 mapping

149 n the literature this year include herniated intervertebral disk-associated radiculopathy, facet join

150 fate of cells of the nucleus pulposus in the intervertebral disk.

151 ation of facet joints, sacroiliac joints, or intervertebral disks (combination trial, 202 participant

152 The magic angle effect in intervertebral disks will be observed with vertical magn

153 onal procedures involving bone, soft tissue, intervertebral disks, and joints are safe and sufficient

154 ation of facet joints, sacroiliac joints, or intervertebral disks, radiofrequency denervation combine

155 tomy and the relationship of nerve roots and intervertebral disks.

156 for 5-7 d by L-shaped rods inserted into the intervertebral foramina.

157 Similar intervertebral joint defects and fusions occurred in Col

158 res, scoliosis, and altered cartilage in the intervertebral joints of the spinal column.

159 The MRI slice at the intervertebral level between the lumbar (L) 2 and 3 vert

160 nal adipose tissue compartments at the L2-L3 intervertebral level by MRI is an acceptably reliable an

161 fidus muscles in a region of interest at the intervertebral level of L4 through L5.

162 onance imaging (MRI) slices taken at various intervertebral levels from the 12th thoracic to 1st sacr

163 Furthermore, compared with other intervertebral levels, the L2-L3 level had a higher amou

164 e height of disk space was measured at 3,568 intervertebral levels.

165 ponsive to hypoxia, we speculate that in the intervertebral niche, notch proteins participate in the

166 ypoxia on degenerating resident cells in the intervertebral niche.

167 The same is true for the intervertebral ramules of the recurrent facial ramus, wh

168 al development, Smad1 phosphorylation in the intervertebral region was decreased in the Cv2 mutant, e

169 vels of Chd/BMP complexes diffusing from the intervertebral region.

170 sensitivity included decreased height of the intervertebral space (n = 23, 52.3% sensitivity) and dis

171 bra in 85% of subjects and crossed the L2-L3 intervertebral space or the L2 vertebra for 15% of subje

172 Its cells became removed first from intervertebral spaces and then from vertebral bodies, an