ライフサイエンスコーパス: intervertebral disc

1 content in biological tissues (i.e., porcine intervertebral disc).

2 cornea, and successive lamellar rings in an intervertebral disc.

3 adaptation to diurnal osmotic loading of the intervertebral disc.

4 TS activity in nucleus pulposus cells of the intervertebral disc.

5 yme regulating GAG synthesis in cells of the intervertebral disc.

6 ogically hyperosmotic environment within the intervertebral disc.

7 uctures, such as the articular cartilage and intervertebral disc.

8 directly by forming the nucleus pulposus of intervertebral discs.

9 re necessary for the resorption of herniated intervertebral discs.

10 us fibrosus in 48 (60%) of the 80 samples of intervertebral discs.

11 ome, which later comprises the vertebrae and intervertebral discs.

12 ignaling mechanisms control this response in intervertebral discs.

13 premature degeneration and calcification of intervertebral discs.

14 and water content in the nucleus pulposus of intervertebral discs.

15 g signaling is required for formation of the intervertebral discs.

16 cular mechanisms responsible for forming the intervertebral discs.

17 CCN3 was expressed in embryonic and adult intervertebral discs.

18 lcium phosphate-like whitlockite crystals in intervertebral discs.

19 perichondrium, and mesenchymal cells of the intervertebral discs.

20 f this study was that Chd synthesized in the intervertebral disc accumulates in the vertebral body.

21 y has correlated macroscopic and microscopic intervertebral disc alterations starting in the second d

22 hich only revealed a protrusion of the L5-S1 intervertebral disc and no apparent cause for the patien

23 low back pain is degenerative disease of the intervertebral disc and other structures of the lumbar s

24 e a novel mechanism of NGF regulation in the intervertebral disc and potentially other pathogenic con

25 ithin the developing annulus fibrosis of the intervertebral discs and increased apoptosis of chondroc

26 es were taken at lumbar vertebrae L1-L5 plus intervertebral discs and the thigh (midthigh, 10 cm dist

27 hat express substance P deep within diseased intervertebral discs and their association with pain sug

28 nt of anterior elements, relative sparing of intervertebral discs, and cold abscesses.

29 ading of the lower back with degeneration of intervertebral discs, and experiments on cadaver spines

30 Pathologic processes affecting the intervertebral disc are affected by genetic factors and

31 Nucleus pulposus (NP) cells of the intervertebral disc are essential for synthesizing extra

32 f a metameric series of vertebral bodies and intervertebral discs, as well as adjoining ribs and ster

33 Intervertebral disc calcification is a rare condition in

34 n our study, we present a case of idiopathic intervertebral disc calcification within the cervical se

35 tochord gives rise to the middle part of the intervertebral disc, called the nucleus pulposus.

36 we investigated LPP action in rabbit primary intervertebral disc cells cultured ex vivo in a three-di

37 CHST3 mRNA was significantly reduced in the intervertebral disc cells of human subjects carrying the

38 In intervertebral disc cells, hypoxia promotes expression o

39 Low-dose NVP-BGJ398 treatment reduced intervertebral disc defects of lumbar vertebrae, loss of

40 enitors also caused severe short stature and intervertebral disc defects.

41 Intervertebral disc degeneration (IDD) causes chronic ba

42 Intervertebral disc degeneration (IVDD) is linked to low

43 e therapeutic strategy for the prevention of intervertebral disc degeneration and its associated morb

44 ative connective tissue pathologies, such as intervertebral disc degeneration and osteoarthritis.

45 ation (Col9a1(-/-)), osteoarthritis (OA) and intervertebral disc degeneration develop prematurely.

46 was to assess the prevalence and timeline of intervertebral disc degeneration in mice homozygous for

47 The finding of premature onset of intervertebral disc degeneration in this mouse model may

48 Intervertebral disc degeneration is linked to loss of ex

49 Intervertebral disc degeneration is the leading cause of

50 Intervertebral disc degeneration was also detected, with

51 (12.5 mo old) showed increased incidence of intervertebral disc degeneration with a concomitant decr

52 represents a promising strategy for treating intervertebral disc degeneration.

53 ges consistent with anatomic signs of OA and intervertebral disc degeneration.

54 e to the changes occurring in the ECM during intervertebral disc degeneration.

55 defects in caudal vertebrae due to abnormal intervertebral disc development, although with higher pe

56 The nucleus pulposus (NP) of the intervertebral disc develops from the notochord.

57 thin a single breed (PBonferroni = 0.01) and intervertebral disc disease (IVDD) across breeds (PBonfe

58 is a promising avenue for treating advanced intervertebral disc disease.

59 pression of Sca1 in mesenchymal cells of the intervertebral discs during development of the spinal co

60 Interestingly, lubricin was prominent in the intervertebral disc, especially in the nucleus pulposus.

61 IX collagen is an important component of the intervertebral disc extracellular matrix.

62 d ADAMTS-4 messenger RNA expression in human intervertebral disc fibrochondrocytes.

63 We obtained 34 control samples of intervertebral disc from previously healthy individuals

64 We collected 46 samples of intervertebral discs from 38 patients during spinal fusi

65 Nerve ingrowth deeper into diseased intervertebral disc has been reported, but how common th

66 Nerve growth into degenerate intervertebral discs has been linked with the developmen

67 painful neuroinflammation that can accompany intervertebral disc herniation, is associated with local

68 likely to have low back pain or symptoms of intervertebral disc herniation, with secondary problems

69 We examined nerve growth into the intervertebral disc in the pathogenesis of chronic low b

70 an important role for nerve growth into the intervertebral disc in the pathogenesis of chronic low b

71 From nucleus pulposus of the intervertebral disc (in which the bulk collagen monomer

72 e outer third of the annulus fibrosus of the intervertebral disc is innervated.

73 to hypoxia in nucleus pulposus cells of the intervertebral disc is regulated by the hypoxia-inducibl

74 Nucleus pulposus, the central zone of the intervertebral disc, is gel-like and has a similar colla

75 r understanding of functional changes in the intervertebral disc (IVD) and interaction with endplate

76 mplicated in the regulation of articular and intervertebral disc (IVD) cartilage homeostasis.

77 l loads are important for homeostasis of the intervertebral disc (IVD) cell matrix, with physiologic

78 dies have demonstrated biologic responses of intervertebral disc (IVD) cells to loading, although the

79 Intervertebral disc (IVD) degeneration and associated sp

80 of significant socio-economic importance and intervertebral disc (IVD) degeneration has been implicat

81 The aetiology of intervertebral disc (IVD) degeneration remains poorly un

82 ted the role of HTRA1 in the pathogenesis of intervertebral disc (IVD) degeneration.

83 ain is extremely high and is often linked to intervertebral disc (IVD) degeneration.

84 The nucleus pulposus (NP) of the intervertebral disc (IVD) demonstrates substantial chang

85 Intervertebral disc (IVD) disorder and age-related degen

86 embedded within the nucleus pulposus of the intervertebral disc (IVD) during maturation.

87 The main pathogenesis of intervertebral disc (IVD) herniation involves disruption

88 Recurrence of intervertebral disc (IVD) herniation is the most importa

89 anabolic and anti-catabolic growth factor on intervertebral disc (IVD) matrix and cell homeostasis.

90 Narrowed intervertebral disc (IVD) space is a characteristic of I

91 -derived shear stiffness measurements of the intervertebral disc (IVD) taken throughout the day and t

92 flammatory cytokine expression in pathologic intervertebral disc (IVD) tissues.

93 al bodies were only mildly affected, but the intervertebral disc (IVD) was reduced or missing.

94 commonly implicated in this condition is the intervertebral disc (IVD), which frequently herniates, r

95 Intervertebral discs (IVD) are essential components of t

96 ures of nucleus pulposus (NP) cells from the intervertebral discs (IVD) of bovine tails were transfec

97 reporter genes and injected in isolated goat intervertebral discs (IVD).

98 al bodies were only moderately affected, the intervertebral discs (IVDs) were either missing or incom

99 hondrocytes in knee joint and in NP cells in intervertebral disc led to the decrease in CTGF expressi

100 obtained from healthy and pathological human intervertebral disc matrices.

101 study to assess the therapeutic benefits of intervertebral disc matrix repair and regeneration by ev

102 ned peptide therapy with LfcinB and BMP7 for intervertebral disc matrix repair and to understand cell

103 Indeed, entire intervertebral discs, normally composed by nucleus pulpo

104 Immunohistochemical staining of intervertebral discs of Ccn2 null embryos shows a decrea

105 patients: dyspnoea, headache, hypertension, intervertebral disc protrusion, and malignant lung neopl

106 ting potential for future studies related to intervertebral disc replacement therapy.

107 sforming growth factor can be transferred to intervertebral discs, resulting in increased proteogylca

108 proteins in articular cartilages, meniscus, intervertebral disc, rib, and tracheal cartilages on sam

109 Thirty-six formalin-fixed embedded intervertebral disc samples of varying grades of degener

110 CT images at the level of the L4-5 intervertebral disc space were extracted from the medica

111 n nucleus pulposus (NP) cells of the healthy intervertebral disc, the mechanisms that control express

112 expression of Notch signaling components in intervertebral disc tissue from mature rats and from hum

113 the PKC pathways, specifically PKCdelta, in intervertebral disc tissue homeostasis.

114 anases other than ADAMTS-8 was identified in intervertebral disc tissue, as was mRNA for TIMP-3.

115 ell type than BM-MSCs for use in engineering intervertebral disc tissue.

116 aggrecanase activities were also detected in intervertebral disc tissue.

117 r of metalloproteinases 3 (TIMP-3), in human intervertebral disc tissue.

118 biosynthesis towards maintenance of healthy intervertebral disc tissues.

119 grecan-rich hydrated tissue that permits the intervertebral disc to resist compressive loads.

120 a CV2-dependent flow of Chd protein from the intervertebral disc to the vertebral body.

121 Aggrecan extracted from human lumbar intervertebral discs was incorporated into tissue cultur

122 a murine organ culture model in which intact intervertebral discs were cocultured with peritoneal mac

123 of the spine and hips, and deterioration of intervertebral discs with characteristic radiographic ch