ライフサイエンスコーパス: intestinal microbiota

1 and intestinal humoral responses and select intestinal microbiota.

2 this phenotype requires the presence of the intestinal microbiota.

3 cifically reduce the virome component of the intestinal microbiota.

4 n influencing the community structure of the intestinal microbiota.

5 mucosal surfaces and coats a fraction of the intestinal microbiota.

6 ic immune responses can be influenced by the intestinal microbiota.

7 g enterococci or between enterococci and the intestinal microbiota.

8 in has more impact than ciprofloxacin on the intestinal microbiota.

9 s to life in the cold are facilitated by the intestinal microbiota.

10 One possible modulator could be the intestinal microbiota.

11 acted from mouse fecal samples to assess the intestinal microbiota.

12 gnificantly affecting the structure of their intestinal microbiota.

13 odels, particularly in the presence of other intestinal microbiota.

14 tative (overgrowth) dysbiotic changes in the intestinal microbiota.

15 colonized with 2 different types of complex intestinal microbiota.

16 modeling and current efforts in modeling the intestinal microbiota.

17 without affecting the colitogenicity of the intestinal microbiota.

18 y based on modulating the composition of the intestinal microbiota.

19 ning and accompanying diversification of the intestinal microbiota.

20 diet markedly affects the composition of the intestinal microbiota.

21 Antibiotic therapy disrupts the human intestinal microbiota.

22 D88 pathways, and involves modulation of the intestinal microbiota.

23 rrelates strongly with the complexity of the intestinal microbiota.

24 be triggered through the intervention of the intestinal microbiota.

25 rlying role for aberrant immune responses to intestinal microbiota.

26 epithelium and thus promote tolerance to the intestinal microbiota.

27 stem has inappropriate interactions with the intestinal microbiota.

28 implicate an aberrant immune response to the intestinal microbiota.

29 e cell numbers depend on the presence of the intestinal microbiota.

30 elationship to other components of the human intestinal microbiota.

31 viously considered to be associated with the intestinal microbiota.

32 l alpha-diversity and differentially altered intestinal microbiota.

33 ction of endogenous ligands or modulation of intestinal microbiota.

34 ed by increased effector T cells reactive to intestinal microbiota.

35 dylcholine is dependent on metabolism by the intestinal microbiota.

36 ve treatments that significantly disrupt the intestinal microbiota.

37 ated intestinal fibrosis without influencing intestinal microbiota.

38 pplicability of new strategies targeting the intestinal microbiota.

39 tion of the diversity and composition of the intestinal microbiota.

40 ted responses of human CD4(+) T cells to the intestinal microbiota.

41 Here, we investigated the involvement of intestinal microbiota.

42 ave been shown to be vital components of the intestinal microbiota.

43 ted with host antigens, including autologous intestinal microbiota.

44 cooperative phenotypes within the mammalian intestinal microbiota.

45 ents in the establishment/maintenance of the intestinal microbiota.

46 tion of proteomics for functional studies of intestinal microbiota.

47 uman health benefits via their impact on the intestinal microbiota.

48 the gut, where their presence depends on the intestinal microbiota.

49 tibility to vancomycin-induced alteration of intestinal microbiota.

50 enefits of breastfeeding are conveyed by the intestinal microbiota.

51 We showed considerable shifts within the intestinal microbiota 14-24 d postweaning in mice that w

52 It is clear that intestinal microbiota actively modulate the immune syste

53 a2g1b by epithelial cells was dependent upon intestinal microbiota, adaptive immunity, and common-gam

54 he complex interactions between diet and the intestinal microbiota affect development of mucosal infl

55 Dysbiosis of the intestinal microbiota affecting the gut barrier could be

56 We investigated how the composition of the intestinal microbiota affects its endotoxicity and devel

57 recede arthritis, and that modulation of the intestinal microbiota after the onset of arthritis may o

58 NAFLD and the intestinal microbiota also differ between patients with

59 at additional environmental factors, such as intestinal microbiota alterations, are involved in its p

60 gs identify previously unknown links between intestinal microbiota alterations, circulating amino aci

61 al peptides, which leads to dysbiosis of the intestinal microbiota, alters the mucosal barrier, and p

62 fh cells demonstrated that they required the intestinal microbiota and a diverse repertoire of CD4(+)

63 e of the structure and function of the human intestinal microbiota and C. difficile pathogenesis has

64 determine the presence and levels of select intestinal microbiota and C. difficile toxin.

65 te that environmental factors, including the intestinal microbiota and changes in diet, can alter nor

66 e association between the composition of the intestinal microbiota and clinical features of irritable

67 e association between the composition of the intestinal microbiota and clinical features of irritable

68 pacts of metronidazole and vancomycin on the intestinal microbiota and colonization resistance are un

69 significant and long-lasting effects on the intestinal microbiota and consequently reduce colonizati

70 ection in that its expression suppressed the intestinal microbiota and enhanced the colonization of a

71 re fermentation end products produced by the intestinal microbiota and have anti-inflammatory and his

72 We review the relationships between the intestinal microbiota and host metabolism, including ene

73 e now emerged as a critical link between the intestinal microbiota and host metabolism.

74 a potential prebiotic fiber that influences intestinal microbiota and improves host metabolism.

75 icant expansion of Proteobacteria within the intestinal microbiota and increased proinflammatory LP c

76 Lyn plays a critical role in regulating the intestinal microbiota and inflammatory responses as well

77 spect to the composition and function of the intestinal microbiota and intestinal integrity.

78 The mutual relationship between the intestinal microbiota and its mammalian host is influenc

79 The mechanisms through which the intestinal microbiota and its metabolites affect host ho

80 iotics play important roles in the growth of intestinal microbiota and may impact on the intestinal h

81 our understanding of connections between the intestinal microbiota and metabolites at a whole-systems

82 information on the functional activities of intestinal microbiota and on host-microbe interactions a

83 of orally infected mice that alters the host intestinal microbiota and promotes intestinal colonizati

84 he presence of pyrrolobenzodiazepines in the intestinal microbiota and provide a mechanism for coliti

85 aled the ability of P. copri to dominate the intestinal microbiota and resulted in an increased sensi

86 , we discuss the novel and emerging field of intestinal microbiota and roles of gut permeability and

87 nd a prebiotic (OI) to selectively alter the intestinal microbiota and significantly reduce body weig

88 that IAP preserves the normal homeostasis of intestinal microbiota and that oral supplementation with

89 during early larval development requires the intestinal microbiota and that specific bacterial member

90 ew of the interactions occurring between the intestinal microbiota and the immune system, and we will

91 DUOX2 regulates interactions between the intestinal microbiota and the mucosa to maintain immune

92 The intestinal microbiota and tissue-resident myeloid cells

93 ropyl methylcellulose (HPMC) could alter the intestinal microbiota and whether such changes correlate

94 tion alters the composition of the bacterial intestinal microbiota and, conversely, that the presence

95 Antibiotic treatment can damage the intestinal microbiota and, paradoxically, increase susce

96 linkages between systemic/neuroinflammation, intestinal microbiota, and ammonia.

97 n humans, TMA is produced exclusively by the intestinal microbiota, and its metabolite, trimethylamin

98 erscore the importance of in vivo studies of intestinal microbiota, and the approach presented in thi

99 The effect of radiation on the intestinal microbiota, and the clinical implications of

100 ge, and the serum IgG response to a panel of intestinal microbiota antigens was assessed by using a n

101 d the highest level of IgG seroreactivity to intestinal microbiota antigens.

102 ta-glucuronidases expressed by the symbiotic intestinal microbiota appear to play important roles in

103 lationship between the host and its resident intestinal microbiota, appropriate mucosal T cell respon

104 ifferent bacterial communities, finding that intestinal microbiota are a major contributor to disease

105 une, and endothelial cells together with the intestinal microbiota are involved in IBD pathogenesis.

106 Intestinal microbiota are involved in the pathogenesis o

107 ested the hypothesis that alterations in the intestinal microbiota are linked with the progression of

108 ed on geographic and cultural differences in intestinal microbiota are necessary to define applicabil

109 responses directed against antigens from the intestinal microbiota are observed in certain diseases,

110 Metabolites produced by the intestinal microbiota are potentially important physiolo

111 The role of the intestinal microbiota as a regulator of autoimmune diabe

112 summary a 3-day juice-based diet altered the intestinal microbiota associated with weight loss, incre

113 In conclusion, the diversity of the intestinal microbiota at engraftment is an independent p

114 t on the expansion of a common member of the intestinal microbiota Bacteroides vulgatus, which also m

115 Acquisition of the intestinal microbiota begins at birth, and a stable micr

116 t genetics as well as the composition of the intestinal microbiota, but the effects of stressor expos

117 Diet has major effects on the intestinal microbiota, but the exact mechanisms that alt

118 Depletion of intestinal microbiota by administration of broad-spectru

119 data also demonstrate that disruption of the intestinal microbiota by antibiotic treatment prevents p

120 flore), in 20 of the 64 NICUs, analyzed the intestinal microbiota by culture and 16S ribosomal RNA g

121 Modulation of intestinal microbiota by oral antibiotics or germ-free c

122 in which the host may maintain tolerance to intestinal microbiota by rendering lamina propria macrop

123 pAOS modified the intestinal microbiota by stimulating the growth of speci

124 kely secondary to innate immune responses to intestinal microbiota by the premature infant's intestin

125 The intestinal microbiota can both positively and negatively

126 For instance, the intestinal microbiota can prevent invading microbes from

127 Experimental evidence indicates that intestinal microbiota can transfer an obese phenotype fr

128 undance and metabolic characteristics of the intestinal microbiota change substantially in those who

129 bjects with moderate genetic susceptibility, intestinal microbiota changes may be a factor that incre

130 to a challenge with C. rodentium alters the intestinal microbiota community structure, including a r

131 which recognizes flagellin, have an altered intestinal microbiota composition compared with wild-typ

132 se phenotypes are not clear; modification of intestinal microbiota composition has been reported to r

133 Perturbations in intestinal microbiota composition have been associated w

134 Further, the changes in intestinal microbiota composition related to the improve

135 sed the relation between feeding strategies, intestinal microbiota composition, and the development o

136 Host immunity shapes intestinal microbiota composition, influencing health an

137 e gastrointestinal tract is regulated by the intestinal microbiota composition, particularly the pres

138 on was associated with significantly altered intestinal microbiota composition, which was linked to a

139 sociated hepcidin induction is influenced by intestinal microbiota composition.

140 abundant Gram-negative bacteria of the human intestinal microbiota comprising more than half of the b

141 In mice, the intestinal microbiota contributed to the regulation in e

142 ize that generation of this biopterin by the intestinal microbiota contributes to its tissue increase

143 ge-dependent and societal differences in the intestinal microbiota could result from differences in d

144 ironmental factors with a profound impact on intestinal microbiota, data on antibiotic use as a risk

145 Antibiotic treatment altered intestinal microbiota, decreased tissue inflammation, im

146 We investigated the relationship among intestinal microbiota-dependent metabolism of dietary ph

147 We hypothesized that inactivation of intestinal microbiota-derived LPS by AOAH influences the

148 nt metronidazole, are associated with marked intestinal microbiota destruction and greater risk of co

149 Anomalous intestinal microbiota development is supposedly associat

150 In mice with an intact intestinal microbiota, dietary supplementation with TMAO

151 Specific members of the intestinal microbiota dramatically affect inflammatory b

152 The intestinal microbiota drives host immune homeostasis by

153 Elimination of the intestinal microbiota during established arthritis speci

154 host mild but significant differences in the intestinal microbiotas during a critical early window of

155 what we have learned about the mechanisms of intestinal microbiota dysfunction.

156 Multiple factors help shape the infant intestinal microbiota early in life.

157 l cancer cell colonization or proliferation, intestinal microbiota effects, or tumoricidal activity b

158 gA(-/-) and wild-type mice disappeared after intestinal microbiota equalization.

159 ronment, which suggests major changes in the intestinal microbiota following movement to saltwater.

160 ouse mammary tumor virus (MMTV) requires the intestinal microbiota for persistence.

161 Our approach unlocks the human intestinal microbiota for phenotypic analysis and reveal

162 standing how the mammalian immune system and intestinal microbiota functionally interact have yielded

163 Wild-type mice depleted of intestinal microbiota had ENS defects and GDNF deficienc

164 Our intestinal microbiota harbors a diverse microbial commun

165 Here we compared the intestinal microbiota harboured in the distal digesta of

166 Our intestinal microbiota harbours a diverse bacterial commu

167 As such, the intestinal microbiota has been advanced as an important

168 BACKGROUND & AIMS: Dysbiosis of the intestinal microbiota has been associated with developme

169 The intestinal microbiota has been identified as an environm

170 The study of the intestinal microbiota has begun to shift from cataloging

171 ions in the composition and functions of the intestinal microbiota have been implicated in multiple d

172 The intestinal microbiota have been shown to affect precirrh

173 rganisms as well as members of the commensal intestinal microbiota have been shown to be able to brea

174 urinary 3-indoxyl sulfate is a biomarker of intestinal microbiota health and predicts reduced intest

175 Diet influences host metabolism and intestinal microbiota; however, detailed understanding o

176 to lead to durable alterations to the murine intestinal microbiota, ileal gene expression, specific i

177 Despite evidence that the intestinal microbiota (IM) is involved in the pathogenes

178 h host and environmental antigens, including intestinal microbiota (IM).

179 cular, experimental manipulations that alter intestinal microbiota impact exploratory and communicati

180 We characterised the intestinal microbiota in 6-11 month-old infants in India

181 jective was to identify early differences in intestinal microbiota in a cohort of breastfeeding infan

182 ted with alterations in the structure of the intestinal microbiota in both dosing models.

183 ids in fecal samples, and composition of the intestinal microbiota in children with overweight or obe

184 licated in changes in the composition of the intestinal microbiota in Crohn's disease, but its role o

185 to investigate the role of TLR pathways and intestinal microbiota in disease progression.

186 The role of the mammalian intestinal microbiota in health and disease of the host

187 otential pathophysiological contributions of intestinal microbiota in HF.

188 ablished through characterization of altered intestinal microbiota in IBS patients and reported impro

189 state of knowledge regarding the role of the intestinal microbiota in immunologic development, highli

190 tive cancer, supporting a potential role for intestinal microbiota in mediating the association betwe

191 amentous bacteria (sfb), but the role of the intestinal microbiota in pulmonary host defense is not w

192 These data support a role for the intestinal microbiota in regulation of granulocytosis, n

193 supporting the important role for early-life intestinal microbiota in the development of childhood as

194 have produced evidence for a causal role of intestinal microbiota in the etiology of obesity and ins

195 The potential role of intestinal microbiota in the etiology of various human d

196 inical observations that have implicated the intestinal microbiota in various diseases.

197 Jucara pulp can modulate the intestinal microbiota in vitro, promoting changes in the

198 Transfer of intestinal microbiota, including members of the Clostrid

199 Antibiotic administration disrupts the intestinal microbiota, increasing susceptibility to path

200 ed to spontaneous colitis in the presence of intestinal microbiota, indicating that microbial factors

201 It was our hypothesis that changes in the intestinal microbiota induced by a juice-based diet play

202 The intestinal microbiota influence neurodevelopment, modula

203 The composition of the intestinal microbiota influences the development of infl

204 hogens and changes in the composition of the intestinal microbiota initiate this process, which leads

205 The endotoxicity of LPS produced by the intestinal microbiota is a determinant of whether mice d

206 The intestinal microbiota is a microbial ecosystem of crucia

207 The intestinal microbiota is an ecosystem susceptible to ext

208 The intestinal microbiota is an important determinant of the

209 The intestinal microbiota is composed by 500-1000 distinct s

210 The intestinal microbiota is considered to play an important

211 tiple antibiotics, tend to colonize when the intestinal microbiota is dysbiotic, and elicit a severe

212 Intestinal microbiota is emerging as one of the key envi

213 The indigenous intestinal microbiota is frequently considered an additi

214 Moreover, it is now well admitted that the intestinal microbiota is involved in shaping and maturat

215 The infant intestinal microbiota is often colonized by two subspeci

216 the normal human adaptive immune response to intestinal microbiota is poorly defined.

217 ed to bacteria, the role of fungi within the intestinal microbiota is poorly understood.

218 eating organized ecological units within the intestinal microbiota, knowledge of which can be applied

219 s aureus and Staphylococcus epidermidis) and intestinal microbiota (Lactobacillus reuteri, Enterococc

220 odulatory activity or through effects on the intestinal microbiota leading to reduced microbial trans

221 ouse colons is accompanied by a reprogrammed intestinal microbiota, leading to a transmissible reduce

222 we present a pipeline for the assessment of intestinal microbiota localization within immunofluoresc

223 , chronic infections and disturbances in the intestinal microbiota; low-grade mucosal inflammation, i

224 Increasing our understanding of how the intestinal microbiota manage C difficile could lead to b

225 These results indicate that the intestinal microbiota may be an important factor in the

226 These observations suggest that altered intestinal microbiota may be associated with disease sus

227 Perturbations in the intestinal microbiota may disrupt mechanisms involved in

228 An emerging body of work suggests that the intestinal microbiota may help to explain some of these

229 Alterations in the intestinal microbiota may play a role in microbial trans

230 A recent study suggested that early-life intestinal microbiota may play an important role in the

231 ce, but not in LFD mice, indicating that the intestinal microbiota may play differing roles during th

232 Intestinal microbiota may thus contribute to the well-es

233 Intestinal microbiota metabolism of choline and phosphat

234 In contrast, the two intestinal microbiota metabolites with deprotonated mole

235 The intestinal microbiota might contribute to enteropathy as

236 nship between inflammasome signaling and the intestinal microbiota might provide insight into the com

237 Here, we have shown that the intestinal microbiota modulates inflammatory responses c

238 sulitis, an effect that was dependent on the intestinal microbiota; moreover, they developed autoimmu

239 ociations, along with interactions among the intestinal microbiota, mucus layer, bile acids, and muco

240 hing a critical mechanistic link between the intestinal microbiota, namely segmented filamentous bact

241 hough both Toll and IMD effectors controlled intestinal microbiota, neither affected Trypanosoma cruz

242 Methods The intestinal microbiota of 541 patients admitted for allo-

243 east 50-60% of the bacterial genera from the intestinal microbiota of a healthy individual produce re

244 Examples include differences in the intestinal microbiota of breastfed vs formula-fed infant

245 We demonstrate here that metabolism by intestinal microbiota of dietary L-carnitine, a trimethy

246 Here we show that the intestinal microbiota of diseased Pstpip2(cmo) mice was

247 The intestinal microbiota of finishing pigs, fed with 16%, 1

248 In an analysis of intestinal microbiota of mice and human beings, we obser

249 Our aim in this study was to identify the intestinal microbiota of patients at risk for NEC.

250 The intestinal microbiota of patients with constipated-predo

251 Interestingly, Bacteroidetes dominated the intestinal microbiota of streptomycin-treated animals, w

252 The effect of alterations in intestinal microbiota on microbial metabolites and on di

253 e systemic impact of both these Treg and the intestinal microbiota on the human immune homeostasis.

254 The intestinal microbiota performs essential functions for h

255 Our observations suggest that intestinal microbiota perturbations precede arthritis, a

256 ause accumulating evidence has revealed that intestinal microbiota play an important role in human he

257 The intestinal microbiota plays a critical role in the devel

258 The intestinal microbiota plays a pivotal role in human heal

259 The intestinal microbiota plays an important role in modulat

260 The human intestinal microbiota plays vital functions in nutrient

261 s have described how helminths may alter the intestinal microbiota, potentially representing a mechan

262 o assess the adaptive immune response to the intestinal microbiota present in 143 healthy adults and

263 Mice colonized with intestinal microbiota presented significantly higher PP

264 ates the composition and localization of the intestinal microbiota, preventing diseases associated wi

265 BS and healthy individuals, we identified an intestinal microbiota profile that is associated with th

266 verse microbial populations constituting the intestinal microbiota promote immune development and dif

267 The intestinal microbiota provides colonization resistance a

268 During health, the intestinal microbiota provides many benefits to the host

269 odeficient or chemotherapy-treated mice, the intestinal microbiota provides nonredundant defense agai

270 ngs provide mechanistic insight into how the intestinal microbiota regulates body composition and est

271 racteristic shifts in the composition of the intestinal microbiota, reinforcing the view that IBD res

272 Further, 16S rRNA sequence analysis of the intestinal microbiota revealed marked changes in the com

273 Inhibition of FPRL1, but not suppression of intestinal microbiota, reversed these protective effects

274 acterial pathogenicity in the context of the intestinal microbiota should unveil new approaches for d

275 of 16S rRNA transcripts from the indigenous intestinal microbiota showed that WD resulted in signifi

276 By using this intestinal microbiota signature, we found IBS symptom se

277 In this study, the intestinal microbiota signatures associated with the sev

278 Intestinal microbiota, systemic and neuroinflammation (i

279 esting a stronger resilience capacity of the intestinal microbiota than cutaneous microbiota.

280 which lack all NKT cells, harbor an altered intestinal microbiota that is associated with exacerbate

281 icobacter hepaticus is a member of the mouse intestinal microbiota that is tolerated by the host.

282 The equilibrium linking the intestinal microbiota, the intestinal epithelium, and th

283 demonstrate that reintroduction of a diverse intestinal microbiota to densely VRE-colonized mice elim

284 potential therapeutic power of manipulating intestinal microbiota to ensure host metabolic health an

285 in vitro studies of the contribution of the intestinal microbiota to infectious disease are discusse

286 Since mothers transmit intestinal microbiota to their offspring during labor, w

287 Thaiss et al. report that the intestinal microbiota undergoes diurnal oscillation, whi

288 lationships among diet, GI motility, and the intestinal microbiota using mice that are germ-free (GF)

289 The butyrate-producing capacity of the intestinal microbiota was also quantified.

290 d atherosclerosis, but this did not occur if intestinal microbiota was concurrently suppressed.

291 rus replication was reduced in vivo when the intestinal microbiota was depleted by means of oral anti

292 The intestinal microbiota, which is composed of bacteria, vi

293 The intestinal microbiota, which is composed of diverse popu

294 system also acts indirectly by "farming" the intestinal microbiota, which then influences brain devel

295 However, alteration of the intestinal microbiota with antibiotics or probiotics has

296 to characterize taxa-specific coating of the intestinal microbiota with immunoglobulin A (IgA-SEQ) an

297 Correlation of distortions of the intestinal microbiota with LOS is a necessary first step

298 AIMS: It might be possible to manipulate the intestinal microbiota with prebiotics or other agents to

299 acteria are impacted, leading to an impaired intestinal microbiota with reduced diversity.

300 l tract is the first point of contact of the intestinal microbiota with the host.