ライフサイエンスコーパス: intoxicate

1 vercome the inhibition of caspases and still intoxicate.

2 tic brain-injured (TBI) patients are alcohol intoxicated.

3 grade memory task of alcohol impairment when intoxicated.

4 lls are not able to take up TpeL and are not intoxicated.

5 on produced by a moderate (0.75 g/kg) and an intoxicating (1.25 g/kg) EtOH dose was investigated in t

6 Finally, apoptosis was observed in CNF1-intoxicated 5637 cells.

7 .1% vs 7.1%) or conviction for driving while intoxicated (7.9% vs 1.2%).

8 onsistent with the hypothesis that ethanol's intoxicating actions in the brain include reducing synch

9 We also exposed Wistar rats to air or intoxicating alcohol levels in vapor chambers for 14-h/d

10 Intoxicated AM remained fully capable of B. anthracis sp

11 For this, thioacetamide (TAA)-intoxicated and bile-duct-ligated (BDL) rats were used a

12 Fibroblasts that were intoxicated and later stimulated to proliferate failed t

13 By contrast, cannabidiol, which is a non-intoxicating and potentially therapeutic component of ca

14 ry 24 h by gastric intubation, with repeated intoxicating and withdrawal episodes leading to a kindli

15 e drinking, physical fighting, driving while intoxicated, and alcohol-related health problems and wer

16 or driver age, sex, history of driving while intoxicated, and survival status, implementation of the

17 fects and clinical presentation if abused or intoxicated, and to know what anesthetic options would b

18 MPTP-intoxicated animals that received Cop-1 immune cells sho

19 f-function mutants resemble those of ethanol-intoxicated animals.

20 n intoxication allowed the rescue of 100% of intoxicated animals.

21 om agonist-treated mice administered to MPTP-intoxicated animals.

22 stry values from buffer-treated versus ricin-intoxicated animals.

23 ects on vulnerable neurons or mediated by GA-intoxicated astrocytes that fail to support neuron funct

24 unable to communicate clearly, and who were intoxicated at the time of screening.

25 However, intoxicated bees were as willing to engage in trophallax

26 ively bred (from the HS/Npt line) to achieve intoxicating blood alcohol levels (BALs) after binge-lik

27 0 adults who had blood alcohol measured were intoxicated (blood alcohol content >22 mmol/L [100 mg/dL

28 Intoxicated burned mice demonstrated a two-fold (p < 0.0

29 and sciatic nerves was reduced in galactose-intoxicated, but not streptozotocin-diabetic rats.

30 ouse diaphragm neuromuscular junctions fully intoxicated by BoNT serotype A.

31 In contrast, synapses fully intoxicated by BoNT serotypes D or E were refractory to

32 ndplate potentials in mouse diaphragms fully intoxicated by BoNT/A.

33 tantial redistribution in human airway cells intoxicated by ExoS, -T, and -Y.

34 in the evaluation of all patients who may be intoxicated by natural substances.

35 Dermonecrotic lesions of supernatant intoxicated CD36(-/-) mice are significantly larger, wit

36 ical membranes, resulting in an inability to intoxicate cells through either apoptotic or necrotic pa

37 To intoxicate cells, ACT binds to the cell surface, translo

38 oxin exploits DRMs for oligomer formation to intoxicate cells.

39 ating that BFT did not injure HT29/C1 cells, intoxicated cells exhibited regulatory volume decrease,

40 capacity of Stxs to alter gene expression in intoxicated cells have been limited to individual genes.

41 p1-induced mitochondrial fission within VacA-intoxicated cells inhibited the activation of the proapo

42 uction of lethal mitochondrial damage in TNF-intoxicated cells is discussed.

43 e the mammalian cell, ExoU rapidly lyses the intoxicated cells via its phospholipase A(2) (PLA(2)) ac

44 In Stx-intoxicated cells, the NLRP3 inflammasome triggered the

45 Within intoxicated cells, vacuolation precedes cytochrome c rel

46 ading to cell cycle arrest and distension of intoxicated cells.

47 to quantify the cytosolic pool of PTS1 from intoxicated cells.

48 xoS trafficking to the perinuclear region of intoxicated cells.

49 Cholera toxin (CT) intoxicates cells by trafficking from the cell surface t

50 BoNT intoxicates cells in a highly programmed fashion initiat

51 esults suggest that the process by which ETA intoxicates cells requires a low vacuolar pH for another

52 Helicobacter pylori vacuolating toxin (VacA) intoxicates cells.

53 that is devoid of the CROP domain but still intoxicates cells.

54 ileukin diftitox fusion toxin-targeting and -intoxicating cells expressing high-affinity IL-2R.

55 We sought to determine whether a mildly intoxicating concentration of ethanol could alter morphi

56 Many studies have demonstrated that intoxicating concentrations of ethanol (10-100 mM) can s

57 unction of all GIRK channels was enhanced by intoxicating concentrations of ethanol, but other, relat

58 iposomes and demonstrate that cholesterol or intoxicating concentrations of ethanol, i.e., >20 mM, ea

59 ion renders these receptors sensitive to low intoxicating concentrations of ethanol.

60 At intoxicating concentrations, ethanol activation of DAerg

61 These two toxins intoxicate cultured cells by similar mechanisms, and Tcd

62 cannot be further stimulated by ARF6 fail to intoxicate cultured cells.

63 , which inhibits the accumulation of cAMP in intoxicated cultured cells, significantly decreases the

64 1-556) plus anthrax toxin protective antigen intoxicated cultured mammalian cells and caused actin re

65 re significantly reduced or abolished in Stx-intoxicated D-THP-1 cells in which the expression of NLR

66 ntoxication over 5-fold, lowered the minimal intoxicating dose by over 100-fold, and allowed complete

67 tive responses before and after receiving an intoxicating dose of alcohol (.8 g/kg) or a placebo beve

68 er a single or repeated administration of an intoxicating dose of alcohol (3 g/kg).

69 ic injections of the vehicle or a moderately intoxicating dose of alcohol (3.0 gm/kg) daily for 3 d.

70 mice following repeated administration of an intoxicating dose of alcohol.

71 /kg) was reduced 87% by pretreatment with an intoxicating dose of ethanol (3.5 g/kg).

72 vioral changes in rats treated with a single intoxicating dose of ethanol (EtOH).

73 Following administration of an intoxicating dose of ethanol, Adh1 -/- mice, and to a le

74 e GlyR with the sedative effects produced by intoxicating doses of ethanol.

75 alcohol dehydrogenase with ethanol, given in intoxicating doses, and adjunctive hemodialysis.

76 h physiologically relevant (i.e., moderately intoxicating) doses of ethanol inhibits clearance of 5-H

77 involvement in risky driving, riding with an intoxicated driver and being taken advantage of sexually

78 e validity of this test in the conviction of intoxicated drivers.

79 astrocytes in the hippocampus of 26 lethally intoxicated drug addicts and 35 matched controls are des

80 0,+)AT-rBAT transfectants became selectively intoxicated during exposure to Cys-S-Hg-S-Cys.

81 oluntary ethanol consumption and some of the intoxicating effects caused by administration of ethanol

82 A(A)-R) has been implicated in mediating the intoxicating effects of ethanol and the motor ataxic eff

83 tion of BK channels is responsible for acute intoxicating effects of ethanol in C. elegans.

84 The acute intoxicating effects of ethanol in the central nervous s

85 In contrast, sensitivity to the acute intoxicating effects of ethanol is reduced.

86 system lead to increased sensitivity to the intoxicating effects of ethanol.

87 ncreased or reduced sensitivity to the acute intoxicating effects of ethanol.

88 actions of ethanol translate to its observed intoxicating effects remains poorly understood.

89 LF has mononuclear phagocyte-specific intoxicating effects that are not well understood.

90 by children, adolescents, and adults for its intoxicating effects.

91 rhea by colonizing the human small bowel and intoxicating epithelial cells.

92 rats are exposed to intermittent episodes of intoxicating ethanol and withdrawal, leading to a kindli

93 M2 (MthK) or TM6 (slo1), with sensitivity to intoxicating ethanol levels.

94 ilization and impedes the ability of PAO1 to intoxicate eukaryotic cells effectively in a type III-de

95 ilizes a type III secretion system (T3SS) to intoxicate eukaryotic host cells.

96 cyclase (AC) toxin from Bordetella pertussis intoxicates eukaryotic cells by increasing intracellular

97 Here, we show that even a single intoxicating exposure to ethanol causes non-cell-autonom

98 ere were 65 abnormal CT scans (10.3%) in the intoxicated group.

99 Pet-intoxicated HEp-2 and HT29 cells stained with fluorescei

100 lobacter jejuni differ in their abilities to intoxicate host cells with defined defects in host facto

101 ra toxin (CT) holotoxin must be activated to intoxicate host cells.

102 Gram-negative pathogens communicate with and intoxicate host cells.

103 ilizes a type III secretion system (T3SS) to intoxicate host cells.

104 plasma membrane to the perinuclear region of intoxicated host cells.

105 Cholera toxin (CT) enters and intoxicates host cells after binding cell surface recept

106 rchers suggest that, since the toxin rapidly intoxicates HT-29 cells, it may be internalized.

107 iated with diarrhea rapidly and irreversibly intoxicates human intestinal epithelial cells (HT29/C1)

108 Alcohol-intoxicated humans have high levels of fatty acid ethyl

109 ntamicin or gamma irradiation were unable to intoxicate, illustrating that toxin delivery requires vi

110 ifetime ounces of alcohol consumed and times intoxicated in lifetime estimated at visits 1 week or mo

111 ol concentration-levels that would be mildly intoxicating in humans.

112 2 are activated in vivo in the colon of Stx2-intoxicated infant rabbits, a model in which Stx2 induce

113 e receptor, entering the cell, and, finally, intoxicating it.

114 Pre-exposure to moderate, high, or intoxicating levels of alcohol had no effect on cocaine

115 ch animals are exposed to and withdrawn from intoxicating levels of ethanol on a daily basis-produces

116 uction pathway in the behavioral response to intoxicating levels of ethanol.

117 ght percent of trespassers were killed while intoxicated (median alcohol level, 56 mmol/L [260 mg/dL]

118 ary bacterial burden was observed in alcohol-intoxicated mice at 16 and 24 h and was associated with

119 Orally intoxicated mice could be rescued by MAb 11E10 6 h but n

120 etected Stx2a in kidney sections from orally intoxicated mice in the same region as the epithelial ce

121 stration 4 h after MRSA infection in alcohol-intoxicated mice rescued USA300 clearance in vivo.

122 Furthermore, kidney sections from Stx2a-intoxicated mice revealed multifocal, acute tubular necr

123 l-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated mice where it inhibits parkin through tyrosi

124 istopathology, and full protection of orally intoxicated mice with monoclonal antibody (MAb) 11E10 di

125 s and protected dopaminergic neurons in MPTP-intoxicated mice, but at levels less than simvastatin.

126 to non-transplanted, X-irradiated cuprizone-intoxicated mice.

127 itters, and improved motor functions in MPTP-intoxicated mice.

128 nigra pars compacta of PD patients and MPTP-intoxicated mice.

129 istent and progressive disease in acute MPTP-intoxicated mice.

130 inuous impairment of motor functions in MPTP-intoxicated mice.

131 e nigrostriatal dopaminergic pathway in MPTP-intoxicated mice.

132 l-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated mice.

133 is downregulated in PD patients and in MPTP-intoxicated mice.

134 itters, and improved motor functions in MPTP-intoxicated mice.

135 t against nigrostriatal degeneration in MPTP-intoxicated mice.

136 l-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated mice.

137 of neuronal cell bodies and termini in MPTP-intoxicated mice.

138 unced effects in VIPR2 agonist-treated, MPTP-intoxicated mice.

139 nd that ricin rapidly reaches the kidneys of intoxicated mice.

140 itters, and improved motor functions in MPTP-intoxicated mice.

141 and GGTI also protected nigrostriata in MPTP-intoxicated mice.

142 itters, and improved motor functions in MPTP-intoxicated mice.

143 n the substantia nigra pars compacta of MPTP-intoxicated mice.

144 We used the progressively MPTP-intoxicated monkey model that expresses recovery from mo

145 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated monkey model to further elucidate the nature

146 l-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-intoxicated monkeys (when motor symptoms are less appare

147 rior olive neurons obtained from chronically intoxicated monkeys revealed a significant up-regulation

148 xins exhibited an extremely low capacity for intoxicating mouse Y1 adrenal cells and for inducing pro

149 only used antimalarial agent, endows anthrax-intoxicated murine peritoneal macrophages with a 50% and

150 vents by increasing risk-taking behaviors in intoxicated or impaired persons.

151 SH and GSSG in rat urine and plasma samples, intoxicated or not by lead.

152 chemical and histological parameters in mice intoxicated orally versus intraperitoneally with Stx2a.

153 We also propose that mice intoxicated orally with ricin likely die from distributi

154 ne clearance based on a normal CT scan among intoxicated patients with no gross motor deficits appear

155 en; mean age, 40.3 years), 13 age-matched CO-intoxicated patients without parkinsonism, and 13 age-ma

156 the cervical spine should not be cleared in intoxicated patients, resulting in prolonged immobilizat

157 on reduces GCS, thus limiting its utility in intoxicated patients.

158 mal CT scans are sufficient to clear CSIs in intoxicated patients.

159 e" outbreak because of the appearance of the intoxicated persons.

160 ompare the unadjusted mortality of the total intoxicated population and for specific intoxication sub

161 tive 5-HT(2A) receptor agonists may lack the intoxicating properties of hallucinogens such as LSD.

162 ared to both control (P<0.001) and galactose-intoxicated rats (P<0.05).

163 e-mediated function in LED-treated, methanol-intoxicated rats.

164 onses were profoundly attenuated in methanol-intoxicated rats.

165 ith unchanged metallothionein-I in manganese-intoxicated rats.

166 n bile duct-ligated and carbon tetrachloride intoxicated rats.

167 3-beta-glucanase mRNA was up-regulated in Al-intoxicated roots, with highest expression after 12 h.

168 nors differ dramatically in their ability to intoxicate SN56 cells, probably because of the different

169 ists that rescue neurotransmission in BoNT/A-intoxicated synapses provides compelling evidence for po

170 cyclase toxin (ACT) of Bordetella pertussis intoxicates target cells by generating supraphysiologic

171 removed by trypsin, were fully competent for intoxicating target cells, demonstrating that surface-bo

172 thanol in C. elegans that directly equate to intoxicating through to supralethal blood alcohol concen

173 ocations of the individual subunits in cells intoxicated, under various conditions, with hybrid heter

174 ith toxins) and endogeneous (serum from mice intoxicated via oral, intranasal, and intravenous routes

175 mates of lifetime ounces of alcohol or times intoxicated were observed.

176 In addition, many trauma patients are also intoxicated, which generally worsens outcomes.

177 estrain violent subjects, who are frequently intoxicated with cocaine and other drugs of abuse.

178 odulate enterotoxin expression because cells intoxicated with heat-labile toxin overproduce and relea

179 Rats were intoxicated with methanol, and retinal function was asse

180 We observed similar results in aged monkeys intoxicated with MPTP: they developed severe DOPA-respon

181 WldS and wild-type mice were intoxicated with the cancer chemotherapeutic agent pacli

182 K28 is a viral A/B protein toxin that intoxicates yeast and fungal cells by endocytosis and re