ライフサイエンスコーパス: intoxication

1 a model of binge drinking and acute ethanol intoxication).

2 rocytes during the recovery period after CPZ intoxication.

3 pithelial cell line and subsequent host cell intoxication.

4 he role of these enzymes of TcdB in cellular intoxication.

5 the development of hyperthermia during acute intoxication.

6 100% survival following lethal acetaminophen intoxication.

7 methylmercury chloride, and thimerosal after intoxication.

8 ging diseases, such as infection and alcohol intoxication.

9 anisms under oxidative stress caused by lead intoxication.

10 Animals that wield toxins face self-intoxication.

11 dent behaviors while conveying resistance to intoxication.

12 er tissue damage and regeneration after CCl4 intoxication.

13 erized by repeated episodes of heavy alcohol intoxication.

14 xidative stress in live organisms under lead intoxication.

15 I in the RCK1 domain was highly resistant to intoxication.

16 loss and behavioral deficits following MPTP intoxication.

17 increased psychotic-like experiences during intoxication.

18 n ethanol, and are more sensitive to alcohol intoxication.

19 term effects of chronic intermittent ethanol intoxication.

20 ifetime approximately 10 ms) compatible with intoxication.

21 ly inhaled at high concentrations to produce intoxication.

22 immunity proteins that protect against self-intoxication.

23 without apparent damage until 24 hours post intoxication.

24 with a marked increase in susceptibility to intoxication.

25 ivation may reflect subjective experience of intoxication.

26 l understood aspects of botulinum neurotoxin intoxication.

27 picting substantia nigra injury following CO intoxication.

28 nse may be relatively preserved from arsenic intoxication.

29 al therapeutic targets for infants with MeHg intoxication.

30 chelation therapy currently used to treat Mn intoxication.

31 ing were affected by both hunger and ethanol intoxication.

32 xposure by behavioral measures of anxiety or intoxication.

33 are consistent with known effects of mercury intoxication.

34 4, UGCG, and ELF4 as genes essential for CTx intoxication.

35 s CTA1 translocation into the cytosol and CT intoxication.

36 t not after injections producing only 3 h of intoxication.

37 ding the molecular mechanism of LCT cellular intoxication.

38 subsequent neurotoxicity in response to MPTP intoxication.

39 ts a challenge for medical treatment of BoNT intoxication.

40 ty influences the biological outcome of ExoU intoxication.

41 immune encephalomyelitis (EAE) and cuprizone intoxication.

42 as much as 17h, im 5.5h and tb 2h before the intoxication.

43 "zombielike" behavior reported in this mass intoxication.

44 rpose, greater anhedonia), and fewer days of intoxication.

45 f muscles due to botulinum neurotoxin (BoNT) intoxication.

46 l for treating the harmful effects of BoNT/A intoxication.

47 ulmonary failure after glyphosate-surfactant intoxication.

48 tensity of murine systemic organs after oral intoxication.

49 s used to treat severe glyphosate-surfactant intoxication.

50 iently high concentrations to pose a risk of intoxication.

51 f these were solely owing to the presence of intoxication.

52 micking the clinical situation of acute MDMA intoxication.

53 pects of Delta(9)-tetrahydrocannabinol (THC) intoxication.

54 ates akin to those reported for MDPV-induced intoxication.

55 ain tissue from a child that died of leucine intoxication.

56 compounds in the treatment of acute alcohol intoxication.

57 omise in patients with glyphosate-surfactant intoxication.

58 njury, unintentional injuries, and substance intoxication.

59 d toxin export to the cytosol and blocked PT intoxication.

60 glets infected with STEC from fatal systemic intoxication.

61 inherent burdens, including the risk of self-intoxication.

62 efflux pump and protects cells against iron intoxication.

63 (VNA-Stx) protected mice from Stx1 and Stx2 intoxication.

64 toxicity as well as other lipid soluble drug intoxications.

65 effective therapeutics to combat large-scale intoxications.

66 pothesis, we compared the effects of alcohol intoxication (0.75 g/kg alcohol vs placebo) on brain glu

67 lled cross-over design with moderate alcohol intoxication (~0.6 g/kg), 35 young healthy adults perfor

68 ts (46%; 22/48), showing alcohol use without intoxication (40%; 19/48), and providing clinical narrat

69 circulation during moderate-to-heavy alcohol intoxication (50-100 mM) modify Ca(2+)- and voltage-gate

70 bsolute risk was 2.6% (95% CI, 2.3, 2.9) for intoxication, 7.7% (95% CI, 6.4, 7.9) for harmful use, a

71 nsensus for investigation: depicting alcohol intoxication (73%; 35/48), violating patient confidentia

72 s, rapid deceleration mechanism, chest pain, intoxication, abnormal alertness/mental status, distract

73 0.001), CVD (AHR, 0.70; P = 0.001), alcohol intoxication (AHR, 0.52; P = 0.003), and violence-relate

74 atory tract of mice 6h after pulmonary ricin intoxication allowed the rescue of 100% of intoxicated a

75 HlyA intoxication also stimulated caspase activation, which o

76 lated, perfused livers with and without CCl4 intoxication and (2) a set of in vivo experiments.

77 ty to stop cocaine seeking, even during drug intoxication and after a long history of cocaine self-ad

78 The primary outcome measures were subjective intoxication and alcohol craving.

79 e-wide screen for resistance to T6S-mediated intoxication and by time-lapse fluorescence microscopy a

80 Here we demonstrate that after acute EtOH intoxication and CIE, upregulation of hippocampal alpha4

81 d public health costs associated with BoNT/A intoxication and could have potential biodefense implica

82 nducted on these drugs, and several cases of intoxication and deaths have been reported.

83 r mechanism of DHM for counteracting alcohol intoxication and dependence.

84 evelopment of novel therapeutics for alcohol intoxication and dependence.

85 ges accumulating in the liver following APAP intoxication and evaluated the role of galectin-3 (Gal-3

86 established zebrafish as a genetic model of intoxication and examined the Derlin and flotillin prote

87 ovascular leakage following combined alcohol intoxication and hemorrhagic shock, in a dose-related ma

88 nized mAbs provide insight into C. difficile intoxication and hold promise as potential nonantibiotic

89 These results revise current models for CT intoxication and implicate protein scaffolding of lipid

90 of small molecules for inhibiting oral BoNT intoxication and of delivery vehicles for oral administr

91 ions of the worm or human BK channel rescued intoxication and other BK channel-dependent behaviors in

92 exporter and aids GAS defenses against iron intoxication and oxidative stress.

93 ar potencies but different rates of cellular intoxication and pathology in a mouse model of botulism.

94 el of fluid redistribution during acute EtOH intoxication and recovery to account for rapid ventricul

95 toxicity in the absence of episodes of acute intoxication and that duration of therapy and cumulative

96 schizophrenia diagnoses independent of drug intoxication and the possibility of undetected schizophr

97 for the analysis of the kinetics of anthrax intoxication and ultimately drug discovery.

98 othalamic-pituitary-adrenal axis) by alcohol intoxication and withdrawal and consequent alterations i

99 ac, and respiratory disorders, and substance intoxication and withdrawal-is imperative.

100 Flies learned to associate cues with ethanol intoxication and, although transiently aversive, the exp

101 plex differences between the epithelial cell intoxication and, potentially, secretory outcomes induce

102 protease genes that may be related to Cry1Ab intoxication and/or resistance.

103 Cirrhotic (bile duct ligation/BDL; CCl4 intoxication) and non-cirrhotic (partial portal vein lig

104 medicines, counteracted acute alcohol (EtOH) intoxication, and also withdrawal signs in rats includin

105 wing prolonged exposure to cycles of alcohol intoxication, and is associated with persistent, wide-ra

106 o a variety of causes, including infections, intoxication, and ischemia.

107 greater alcohol-induced sedation, subjective intoxication, and lower alcohol craving on naltrexone, a

108 after partial hepatectomy and acetaminophen intoxication, and measured regenerative parameters and i

109 ity of illness, intubation status, recurrent intoxication, and several comorbidities.

110 rders; neoplasms; alcohol-intoxication; drug intoxication; and violence-related injury (note: the lat

111 elf-harm (aOR range, 3.9-4.2), and substance intoxication (aOR range, 3.0-4.0).

112 germination or downstream events in anthrax intoxication are also under investigation.

113 ociated with impaired cognition during acute intoxication as well as in the unintoxicated state in lo

114 up examinations in 4 patients with manganese intoxication associated with intravenous administration

115 assay, and two of those protected cells from intoxication at concentrations of 1-10 muM.

116 and animal studies demonstrate that alcohol intoxication at the time of injury worsens postburn outc

117 disturbances, extra-axial injuries, alcohol intoxication at time of injury, and presence of an axis

118 s derived from the Greek methuo (to drink to intoxication) because the hallmark of this form of cell

119 When combined with EtOH intoxication, burn injury significantly decreased IL-17

120 tolerance after injections producing 6 h of intoxication, but not after injections producing only 3

121 ate that an frvA mutant is sensitive to iron intoxication, but not to other metals.

122 The brain adapts to chronic ethanol intoxication by altering synaptic and ion-channel functi

123 CDT-host interactions, were not required for intoxication by any of the CDTs tested.

124 differential contribution of gangliosides to intoxication by CTx.

125 hannel, SLO-1, convey dramatic resistance to intoxication by ethanol.

126 producer Streptomyces azureus prevents self-intoxication by expressing the thiostrepton-resistance m

127 istributed over 12 human genes important for intoxication by four different CDTs.

128 we demonstrate that ciA-C2 prevents BoNT/A1 intoxication by inhibiting its binding to neuronal recep

129 compound identified in the screen, inhibits intoxication by lethal toxin and blocks the entry of mul

130 eviously implicated in CDT binding, affected intoxication by only a subset of CDTs tested.

131 Intoxication by organophosphate (OP) nerve agents and pe

132 cell surface sialic acid sensitized cells to intoxication by three of the four CDTs tested.

133 rapeutically for the treatment of acute iron intoxication, carries three hydroxamate groups and shows

134 activity by inhibiting the first step of the intoxication cascade.

135 Alcohol (EtOH) intoxication causes changes in the rodent brain gamma-am

136 We demonstrate that after cuprizone intoxication, CCR2-dependent infiltration of mouse bone

137 cal record is laden with evidence of mercury intoxication consistent with effects recognized today.

138 Self-reported ratings of intoxication correlated with striatal activation, sugges

139 ); respiratory disorders; neoplasms; alcohol-intoxication; drug intoxication; and violence-related in

140 ants reported significantly lower subjective intoxication effects ('feel high': F=14.2, p=0.001; 'fee

141 ntR null mutant is still sensitive to Mn(II) intoxication even if both of the import systems are abse

142 Our results show that alcohol intoxication exacerbated hemorrhagic shock and resuscita

143 rogression, while TNF-alpha production after intoxication exacerbates disease.

144 Intoxication exacerbates postburn hepatic damage through

145 Consistent with the known intercellular self-intoxication exhibited by the T6S pathway, we observe th

146 ormation about the biochemical mechanisms of intoxication exists, research has been hampered by limit

147 Intoxication experiments showed that TeNT efficiently cl

148 receiving nabiximols did not report greater intoxication (F1,6 = 0.22; P = .97).

149 ith severe myocardial hypertrophy or cocaine intoxication facilitating a cardiac death without verifi

150 ed after 8 and 16 weeks carbon tetrachloride intoxication, following bile duct ligation, and in tissu

151 -was effective in preventing all symptoms of intoxication from Stx1 and Stx2 when coadministered with

152 educed the sensitivity of the cells to ricin intoxication further confirming a role for this enzyme i

153 e 316 patients kept in a cervical collar for intoxication had no missed CSIs but were kept immobilize

154 dmission (12.3%); a combination of different intoxications had the lowest (6.3%).

155 tial hospital contact with alcohol problems (intoxication, harmful use, or dependence) during 1998-20

156 el of binge drinking as acute ethanol (EtOH) intoxication has become an alarming health problem.

157 le toxin A and B (TcdA and TcdB) to cellular intoxication has been studied extensively, but their imp

158 Existing strategies to negate BoNT/A intoxication have looked to antibodies, peptides, or org

159 Pharmacological attempts to ablate BoNT/A intoxication have sought to either nullify cellular toxi

160 he New Orleans Criteria findings (>60 years, intoxication, headache, vomiting, amnesia, seizure, or t

161 both mammalian and insect models of ethanol intoxication, high doses of ethanol induce motor impairm

162 Bonnet syndrome, Parkinson's disease, fever, intoxications, hypnagogic and hypnopompic states.

163 ranal pore, thus preventing the last step of intoxication, i.e. the translocation of LF/EF into the c

164 We directly investigated how alcohol intoxication impacts hemorrhagic shock and resuscitation

165 d demonstrates protection and rescue of BoNT intoxication in a human neuron model.

166 )-infected rhesus macaques and acute ethanol intoxication in a murine model were used.

167 bility to recognize modest levels of alcohol intoxication in a range of life situations.

168 educed signaling through D2 receptors during intoxication in active cocaine abusers regardless of cue

169 315C4 completely protected guinea pigs from intoxication in an in vivo lethality model, yielding an

170 and acetaldehyde levels after acute ethanol intoxication in both wild-type and ALDH2-deficient, ALDH

171 ced by cyanobacteria and are responsible for intoxication in humans and animals.

172 ncentrations just above the legal limits for intoxication in humans can inhibit alpha7 nAChRs in LDTg

173 nd assesses the potential role for Cu and Zn intoxication in innate immune function and their direct

174 manganese (hepatic encephalopathy, manganese intoxication in intravenous drug abusers).

175 determined by stereological tests after MPTP intoxication in mice pretreated with either VIPR1 or VIP

176 nravels its protective effect against severe intoxication in response to binge drinking.

177 ted to express CR3 and examined the steps in intoxication in the presence and absence of the integrin

178 ay be limited by variable protection against intoxication in vivo.

179 otassium permanganate, became a new cause of intoxications in Poland.

180 ing (peaking at ~8 min) during acute cocaine intoxication, in chronically treated mice D1R predominan

181 he TEM8 extracellular domain blocked anthrax intoxication, inhibited tumor-induced angiogenesis, disp

182 nsmission in MS/DB neurons are vulnerable to intoxication injury.

183 For treatments that can reverse intoxication, interest has focused on developing inhibit

184 n the granulopoietic response, acute alcohol intoxication (intraperitoneal injection of 5 g alcohol/k

185 nate immunity proteins, indicating that self-intoxication is a general property of antibacterial T6SS

186 Alcohol (EtOH) intoxication is a risk factor for increased morbidity an

187 , reciprocity or retribution are impossible, intoxication is absent and when the "other" to be harmed

188 novel therapeutic strategies aimed at severe intoxication is apparent.

189 e and motor disabilities that result from OP intoxication is hampered by a limited understanding of t

190 Although ricin intoxication is not transmittable from person to person,

191 ructural analyses also demonstrate that self-intoxication is prevented by the immunity protein throug

192 Zinc intoxication is prevented in S. pneumoniae by expression

193 on for the ethanol-paired cue, implying that intoxication is rewarding.

194 or factor contributing to the persistence of intoxication is the long half-life of the catalytic ligh

195 Excessive drinking to intoxication is the major behavioral characteristic of t

196 Binding, an obligate event for cell intoxication, is believed to occur through the heavy-cha

197 ratory failure due to altered mental status (intoxication, ischemic brain injury), indirect lung inju

198 Therefore, acute alcohol intoxication leads to decreased MRSA clearance in part b

199 beta-catenin-deficient hepatocytes, ethanol intoxication led to significant redox imbalance in the h

200 In mammalian and insect models of ethanol intoxication, low doses of ethanol stimulate locomotor a

201 These observations suggest that the dampened intoxication may contribute to the increased rates of al

202 Analyzing speech during intoxication may present a more direct, objective measur

203 Here, the intoxication mechanisms of CDTs from Escherichia coli (E

204 variants were investigated in mice in an SEB intoxication model, as well as in sepsis and deep-tissue

205 ory host response in both the sepsis and the intoxication models, which justifies further development

206 hages accumulate in the liver following APAP intoxication; moreover, Gal-3 plays a role in promoting

207 During intoxication, MRI revealed expansion of ventricles, but

208 did not interfere with the initial steps of intoxication, namely its ability to bind to the anthrax

209 2, 2016, a synthetic cannabinoid caused mass intoxication of 33 persons in one New York City neighbor

210 consistent with our results indicating that intoxication of Acanthamoeba by these exotoxins does not

211 , there is no laboratory evidence to support intoxication of airline crew members by CBDP.

212 B and subsequent molecular events leading to intoxication of cells.

213 s, we designed a screening platform based on intoxication of Drosophila larvae with paclitaxel (taxol

214 exotoxin delivery into predator cells allows intoxication of predators that lack a cell surface recep

215 The intoxication of the cell is a consequence of a reductive

216 nt, including the effects of acute marijuana intoxication on driving abilities, unintentional ingesti

217 rotein member of the PDI family, in the cell intoxication operated by type 2 RIPs ricin and abrin.

218 nesis induced by either carbon tetrachloride intoxication or bile duct ligation and promote fibrosis

219 tion (BDL), CCl4 intoxication, thioacetamide intoxication or continuous AngII infusion.

220 npatient or outpatient treatment for alcohol intoxication or misuse (HR = 1.98, 95% CI 1.76-2.21, p <

221 fluence relapse, nor did it affect marijuana intoxication or most symptoms of withdrawal relative to

222 , there is no approved therapeutic for their intoxication or one that has even advanced to clinical t

223 g ethanol metabolism, sensitivity to ethanol intoxication, or continuous-access drinking.

224 proteins not previously implicated in the PE intoxication pathway were identified, including GPR107,

225 the microvascular leakage following alcohol intoxication plus hemorrhagic shock and resuscitation.

226 ubstrate for resting brain metabolism during intoxication (presumably shifting to acetate or other ke

227 Platelet intoxication prevents endothelial barrier repair and fac

228 ERdj3 as a host protein involved with the CT intoxication process and provide new molecular details r

229 oNTs exploit this design at each step of the intoxication process, thereby achieving an exquisite tox

230 which play distinct roles in the multi-step intoxication process, transforming from harmless, robust

231 f the steps taking place during the PA-based intoxication process, we found that cAb29 did not interf

232 still critical gaps in information about the intoxication process.

233 eukaryotic cells is an essential step in the intoxication process.

234 l inhibitors targeting common steps of their intoxication process.

235 s to propagate between domains to facilitate intoxication processes.

236 Acute ethanol intoxication promotes fasting hypoglycemia through an in

237 t not CD36(-/-) macrophages near the site of intoxication reduces dermonecrosis, IL-1beta production

238 r-impairing effects of ethanol contribute to intoxication-related injury and death.

239 n </= 5 y of age with severe paediatric lead intoxication reported to date to our knowledge.

240 ssive consumption may acutely cause caffeine intoxication, resulting in tachycardia, vomiting, cardia

241 TcdA intoxication results in an apoptotic cell death that is

242 cond, we show that two previously described "intoxication reversers" raise Tc and counter ethanol's e

243 We discovered that both intoxication routes caused similar increases in serum cr

244 elopment of drug-seeking habits in the binge/intoxication stage involve changes in dopamine and opioi

245 cholera toxin A1 (CTA1) peptide, a critical intoxication step.

246 Alcohol intoxication strongly attenuates early visual responses

247 otal intoxicated population and for specific intoxication subgroups based on the Acute Physiology and

248 Alcohol intoxication suppressed ERK activation in granulopoietic

249 ronic alcohol consumption plus acute alcohol intoxication suppressed the increase in blood granulocyt

250 Acute ethanol intoxication suppresses the host immune responses agains

251 issue damage, resulting in infection-induced intoxication that can become fatal in the absence of ant

252 s could be precipitated by pesticide-induced intoxication that disrupts navigation.

253 During alcohol intoxication, the human brain increases metabolism of ac

254 e the etiological agent responsible for BoNT intoxication, the LC protease.

255 In oral intoxication, the process by which the toxin transits ac

256 as induced by bile duct ligation (BDL), CCl4 intoxication, thioacetamide intoxication or continuous A

257 unity proteins depends on intercellular self-intoxication through an active type VI secretion system,

258 ge of concentrations in the brain, eliciting intoxication through to sedation.

259 anged from as few as 5 studies for bacterial intoxications through to 494 studies for diarrheal patho

260 ns, was optimized by toxin concentration and intoxication time, and the specificity of caspase activi

261 balance between D1R and D2R signaling during intoxication to a predominance of D1R (stimulatory) over

262 rged in which the host utilizes Cu and/or Zn intoxication to reduce the intracellular survival of pat

263 l-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication to render them parkinsonian and then local

264 lated behaviors in flies, ranging from acute intoxication to self-administration and reward, have bee

265 o vaccine or therapeutic treatment for ricin intoxication, ultrasensitive analytical assays capable o

266 To avoid self-intoxication, V. cholerae expresses an anti-toxin encode

267 APAP intoxication was also associated with an accumulation of

268 In this study, alcohol or drug intoxication was common and resulted in significant dela

269 We found that in mammalian cells, CT intoxication was dependent on the flotillins for traffic

270 Intoxication was determined by serum alcohol levels and

271 Intoxication was identified in 632 of 1429 of patients t

272 proximity to target cells by centrifugation, intoxication was increased 4-fold.

273 dynamics of this attenuation during cocaine intoxication was longer lasting for D2R than for D1R.

274 s in TcdB that are essential for target cell intoxication, we identified a region at the junction of

275 lances D1R over D2R signaling during cocaine intoxication, we used microprobe optical imaging to comp

276 BoNT/D entry and intoxication were enhanced by membrane depolarization vi

277 ted TcdB autoprocessing and delayed cellular intoxication, whereas E3 intrabody completely blocked th

278 tR null mutant is highly sensitive to Mn(II) intoxication, which is attributed in part to the constit

279 (i.e., acetate) for resting activity during intoxication, which might persist through early sobriety

280 rotein release is a pre-requisite of colicin intoxication, which occurs on a timescale of minutes.

281 y method and estimated deaths from drug self-intoxication whose manner was an "accident" or was undet

282 by flaccid paralysis, which can be caused by intoxication with any of the seven known serotypes of bo

283 terized by a cycle composed of drug seeking, intoxication with drug taking and withdrawal associated

284 We show that intoxication with GAP domain results in: (i) JNK1/2 acti

285 f environmental exposure of honeybees to and intoxication with neonicotinoid insecticides, namely, th

286 In vivo intoxication with PTX elicits a variety of immunologic a

287 as CD36 also limits dermonecrosis caused by intoxication with sterile bacterial supernatant or purif

288 n extended mean time to death, compared with intoxication with Stx2a only.

289 .9 mug, but no morbidity occurred after oral intoxication with up to 157 mug of Stx1a.

290 Intoxications with alcohol or antidepressants have a sig

291 The adjusted observed mortality showed that intoxications with street drugs and "other toxins" have

292 ke repressor (Fur) cooperate to prevent iron intoxication, with iron sequestration by the MrgA mini-f

293 motor function is most affected during acute intoxication, with some evidence for persistence in chro

294 the effects of cigarette smoking, marijuana intoxication, withdrawal, and relapse were assessed in d

295 tient laboratory studies assessing marijuana intoxication, withdrawal, and relapse were combined to a

296 in three stages of a recurrent cycle: binge/intoxication, withdrawal/negative affect, and preoccupat

297 pendence induced by 1 month of alcohol vapor intoxication/withdrawal cycles, and prefrontal myelin wa

298 ed parkinsonism, compared with those with CO intoxication without parkinsonism or normal volunteers (

299 h poisoning (CFP) is the most common seafood intoxication worldwide, its burden has been difficult to

300 task immediately following learning (before intoxication) yet performance was better when tested the