ライフサイエンスコーパス: intracellular

1 leading to accumulation of both secreted and intracellular Abeta40.

2 ell-shaped, relationship between the average intracellular abundance of eIF4G and rates of cell popul

3 iquitous features of the aging brain are the intracellular accumulation of aggregated proteins and in

4 e and contributing to enhanced synthesis and intracellular accumulation of cholesterol.

5 sal degeneration, which are characterized by intracellular accumulation of hyperphosphorylated tau.

6 or proteasomal degradation, thereby reducing intracellular accumulation of mutant collagen.

7 ant increases in both cholesterol uptake and intracellular accumulation of the aging biomarker lipofu

8 is approach by quantifying apoptosis-induced intracellular activity in individual cells following exp

9 otease resistance, cellular penetration, and intracellular activity that may be useful for the develo

10 at our nFTP technology could robustly detect intracellular AD-related protein changes caused by a wel

11 Upstream signaling of C5a-mediated intracellular alkalinization was dependent on C5aR1, int

12 time, demonstrates its capacity to dissolve intracellular amyloids.

13 tern recognition receptors, which survey the intracellular and extracellular environments for microbi

14 urpose of this study was to characterize the intracellular and extracellular metabolic profiles of fo

15 nine protein kinase 1 (Ripk1) increased both intracellular and extracellular PGRN protein levels by i

16 denine dinucleotide (NAD(+)) participates in intracellular and extracellular signaling events unrelat

17 gap surfaces, and on the difference between intracellular and interstitial pressures that is related

18 eported to have permeability effects on both intracellular and plasma membranes.

19 From the measurements, morphological, intracellular, and mechanical alterations of the RBCs we

20 hannel (CC) blocker - being able to diminish intracellular Angpt-2 protein in a time- and dose-depend

21 rate an unrecognized functional link between intracellular annexin A2 and tumor cell adhesion, migrat

22 We review critically the research related to intracellular antibodies, link this to the TRIM21 effect

23 with neutrophil activation, ROS production, intracellular antioxidation, and leukocyte migration plu

24 a consequence, oxygen consumption rates and intracellular ATP concentrations decreased and reactive

25 ical slices to AbetaOs transiently decreased intracellular ATP levels and AMPK activity, as evaluated

26 in Napa(hyh/hyh) CD4 T cells, which reduced intracellular ATP, [ATP]i.

27 detected by butyrophilin (BTN)3A1, using its intracellular B30.2 domain.

28 ious toxins and pathogens including viruses, intracellular bacteria and parasite.

29 chia is an archetype of maternally inherited intracellular bacteria that infect the germline of numer

30 adjuvants to improve disease outcomes during intracellular bacterial infections.

31 Intracellular bacterial pathogens have developed versati

32 In this review, we focus on how intracellular bacterial pathogens target innate immune s

33 r and more quantitative understanding of the intracellular behavior of drug-loaded nanoparticles, and

34 VI, which may facilitate the formation of an intracellular binding site that enhances G-protein coupl

35 stigated missense variants identified in the intracellular C-terminal domain of the GluN2B NMDAR subu

36 g C3 from plasma was a route of establishing intracellular C3 stores.

37 brane depolarization, prolonged elevation of intracellular Ca(2+) and diminution of releasable synapt

38 al to understanding the relationship between intracellular Ca(2+) and membrane excitability.

39 Intracellular Ca(2+) and Na(+) were simultaneously asses

40 high concentrations of EGTA, suggesting that intracellular Ca(2+) buffers play an important role in v

41 s exist in mature Mks because ABA induces an intracellular Ca(2+) increase ([Ca(2+)] i ) through PKA

42 ne whether altered NMDAR-mediated changes in intracellular Ca(2+) levels (NMDAR-DeltaCa(2+) ) occurre

43 lutionarily conserved molecular link between intracellular Ca(2+) levels and energy homeostasis.

44 ophageal cancer cells through Orai1-mediated intracellular Ca(2+) oscillations and reveal a possible

45 PAR-1 and PAR-2 are involved in FXa-mediated intracellular Ca(2+) release in HUVEC and FXa reactive I

46 ing mice while simultaneously monitoring the intracellular Ca(2+) responses of individual osteocytes

47 t that differs from wild type in both pH and intracellular Ca(2+) sensitivities.

48 SK channels were activated by intracellular Ca(2+) sparks and mediated spontaneous tra

49 neurological function, which also depends on intracellular Ca(2+) transport, could be affected by the

50 -held view is that they are not regulated by intracellular Ca(2+).

51 p-Akt Thr-308 was significantly inhibited by intracellular Ca(2+)i chelation or CaM inhibition.

52 uorescence recovery after photobleach during intracellular [Ca] recording.

53 -R1 with CP-154526 caused an accumulation of intracellular calcium (Ca(2+)) over time and cell death.

54 Most importantly, experimental increase in intracellular calcium abolished Flunarizine's effect.

55 us positive feedback loop involving elevated intracellular calcium and enhanced mGluR1 function, a me

56 filament, but inhibits contractility at high intracellular calcium concentration by disrupting the ac

57 al of extracellular calcium, or chelation of intracellular calcium did not normalize the differences

58 Model results show that agonist-induced intracellular calcium dynamics can be modified by changi

59 The model reproduces intracellular calcium dynamics during control pacing and

60 ltered levels of SERCA, IP3R, and RyR on the intracellular calcium dynamics of VSMC and to understand

61 isation of these structures tightly controls intracellular calcium dynamics.

62 gy transfer (FRET), confocal microscopy, and intracellular calcium quantitation.

63 ed assay measuring inhibition of UTP-induced intracellular calcium release in 1321N1 astrocytoma cell

64 y in vitro, without influencing NMDA-induced intracellular calcium responses.

65 Intracellular calcium was higher after blue/green, and c

66 lular alkalinization was dependent on C5aR1, intracellular calcium, protein kinase C, and calmodulin,

67 eptor internalization, and ligand-stimulated intracellular cAMP accumulation.

68 s an essential albeit poorly defined role in intracellular capsid trafficking.

69 quantitatively with LC/MS analytics that the intracellular cargo release is controlled by the sequenc

70 In micro1 knockout cells, intracellular CCVs still form, but acidic cluster protei

71 Chloride intracellular channels (CLIC) are non-classical ion chan

72 ective in hepatocytes lacking collectrin, an intracellular chaperone protein that localizes within th

73 Obligate intracellular Chlamydia trachomatis replicate in a membr

74 ClC-4 is an intracellular Cl(-)/H(+) exchanger that is highly expres

75 ansport initiated by chloride binding at the intracellular cleft.

76 longs the stability of key components of the intracellular clock, the cryptochrome proteins, unexpect

77 lar processes through controlling acidity of intracellular compartments in eukaryotes.

78 Previous work described a new intracellular complex, the Wnt5a-receptor-actomyosin pol

79 ved oral bioavailability and achieves higher intracellular concentrations of active drug.

80 ous kinases, efficiently competing with high intracellular concentrations of ATP.

81 in the regulation of genes that control the intracellular concentrations of gemcitabine and several

82 inosa were killed by a process of condensing intracellular contents.

83 host secretory trafficking to support their intracellular cycle, but knowledge of these pathogenic p

84 ects of PGE2 on human ILC2 proliferation and intracellular cytokine and transcription factor expressi

85 Intracellular cytotoxic mediators (perforin/granzyme B),

86 Autophagy is a conserved intracellular degradation pathway and has emerged as a k

87 Autophagy is an evolutionarily conserved intracellular degradation/recycling system that is essen

88 We have employed this ProTide strategy for intracellular delivery of a nucleotide antagonist of eIF

89 Efficient intracellular delivery of biologically active macromolec

90 piperidine motif, and its antibody-mediated intracellular delivery results in 10-fold improvement of

91 obubbles, which enables controlled and local intracellular delivery to acoustic-transfection techniqu

92 The intracellular detection of PPi using PCG also carried ou

93 Intracellular distribution of the SiNPs was evaluated wi

94 mited by off-target activity and reliance on intracellular DNA delivery.

95 at can signal via a proteolytically released intracellular domain (ICD) in addition to classical rece

96 Conversely, receptors with the intracellular domain of IR display higher IRS-1 phosphor

97 response begins with sensing of pAg via the intracellular domain of the butyrophilin 3A1 (BTN3A1) mo

98 rgic receptor (alpha2AAR) that occurs at the intracellular domains of both proteins.

99 However, intracellular drivers of global reprogramming of the inf

100 We find that LAF-1 and other in vitro and intracellular droplets are characterized by an effective

101 Elucidation of the mechanism of intracellular dynamics of IAV assembly is necessary to u

102 ort velocities using FRAP data that captures intracellular dynamics through partial differential equa

103 t RRP exocytosis was poorly affected by 5 mm intracellular EGTA, suggesting that the Cav1.3 short iso

104 Here, we combine nanoscale intracellular electrodes with complementary metal-oxide-

105 rchestrated by a complex circuitry involving intracellular elements including cyclic AMP (cAMP).

106 Wolbachia pipientis is an intracellular endosymbiont infecting many arthropods and

107 sed form of the activation gate in which the intracellular ends of the four S6 segments are drawn tig

108 eceptor and the tetraspannin protein CD63 as intracellular entry factor for LUJV.

109 etoprofen showed that CYP450 is not the sole intracellular enzyme responsible for intracellular trans

110 Toxoplasma gondii is an obligate, intracellular eukaryotic apicomplexan protozoan parasite

111 Receptor signaling relays on intracellular events amplified by secondary and tertiary

112 cells ensure precision in the timing of key intracellular events despite such stochasticity is an in

113 mission electron microscopy to determine the intracellular fate of endocytosed exogenous mitochondria

114 e used this method to quantitatively map the intracellular fate of micelles of a recombinant polypept

115 We found that the loss of an intracellular fibroblast growth factor (FGF), FGF13, in

116 D spatial structure of calcium gradients and intracellular fluxes in both the cytoplasm and sarcoplas

117 cells drives the nuclear translocation of an intracellular fragment of ODZ1 through proteolytic cleav

118 t muscle is triggered by a transient rise in intracellular free calcium concentration linked to a cha

119 Despite this evidence of "silencing", intracellular free calcium imaging showed that the cells

120 the IL-1 family, has both extracellular and intracellular functions.

121 separated into distinct populations based on intracellular GATA3 expression and that GATA3(LO) cells

122 The interplay between the intracellular gate and the selectivity filter underlies

123 elease of the Na(+) ion from the Na2 site to intracellular gating, we applied a combination of the th

124 We also suggest that intracellular gene transfer may lead to extensive gene r

125 of extracellular virions but did not reduce intracellular genome levels or block intracellular virio

126 xposure resulted in immediate and reversible intracellular glucose depletion and lactate accumulation

127 Intracellular glucose transport activity of the p.Arg176

128 Brucella spp. are facultative intracellular Gram-negative bacteria that cause the zoon

129 nd death in cancer cells due to depletion of intracellular GSH and ensuing elevated ROS; yet this tre

130 onses implied labeling for CD63, CD203c, and intracellular histamine.

131 a four-subunit potassium pump that maintains intracellular homeostasis, cell shape and turgor under c

132 ical properties and functional role of these intracellular hydrogels are difficult to study, primaril

133 The amount of intracellular ice as well as ice crystal size played a r

134 This raises the prospect that intracellular immunization strategies that focus on cell

135 Using this PRIMMUS (PRoteomic analysis of Intracellular iMMUnolabelled cell Subsets) approach, we

136 Here, we show that by using specific intracellular immunolabelling protocols, FACS separation

137 Wolbachia pipientis, the most common intracellular infection on the planet, infects 40% of in

138 hich may be required for its function during intracellular infection.

139 -time detection and optical determination of intracellular ions.

140 f these changes is an accumulation of excess intracellular iron and an augmented dependence on iron f

141 n, the transport protein transferrin and the intracellular iron-storage protein ferritin, and for hem

142 expression levels suggests variant-dependent intracellular K(+) loss and cytotoxicity does not drive

143 cell-matrix adhesions that stably anchor the intracellular keratin network to the extracellular matri

144 hereas rapamycin-induced autophagy increased intracellular killing of Mtb.

145 cular analysis revealed that Ent can chelate intracellular labile iron that is required for neutrophi

146 The effects on intracellular legumain activity were nevertheless pronou

147 mice, gamma interferon (IFN-gamma) controls intracellular Leishmania donovani infection and the effi

148 ffective pro-drug strategies to increase the intracellular levels of itaconate, which will enable mor

149 e IPO5 knockdown significantly decreased the intracellular levels of overexpressed FLIL33, reversed b

150 ified Rab27 as an important regulator of the intracellular LFA-1 translocation.

151 nary tract infections, undergoes a transient intracellular lifestyle during which bacteria clonally e

152 The accumulation of neutral lipids in intracellular lipid droplets has been associated with th

153 iglyceride lipase (ATGL), the key enzyme for intracellular lipolysis.

154 androgen-regulated tumor suppressor and its intracellular localization can be modulated by ultraviol

155 This discovery highlights the role that intracellular localization plays in specialized metaboli

156 gs define a novel and functionally important intracellular location of CD24; they explain why surCD24

157 me b562-RIL (BRIL) fusion (A2AR-BRIL) in the intracellular loop 3 (ICL3) was crystallized in detergen

158 Our results reveal the intracellular mechanisms that mediate DAT endocytic recy

159 Many intracellular membraneless organelles form via phase sep

160 to the molecular composition and function of intracellular membranes.

161 Ca(2+) is a ubiquitous intracellular messenger that controls diverse cellular f

162 Intracellular metabolic profiling revealed that PknG is

163 re we show that tight regulation of buffered intracellular metal concentrations is a prerequisite for

164 trophoresis for label-free quantification of intracellular mitochondrial modifications that alter cyt

165 Here, we study the intracellular mobility and spatial distribution of LacI

166 Shigella mediates intracellular motility and spreading via actin comet tai

167 ations that were insufficient to act against intracellular Mtb, providing proof of principle for the

168 -M. tuberculosis cytokines and inhibition of intracellular mycobacteria.

169 n Containing 5 (ABHD5) is a key regulator of intracellular neutral lipids that has been recently iden

170 athogenic Escherichia coli (UPEC) from their intracellular niche.

171 ablish pathogen-containing vacuoles (PVs) as intracellular niches for microbial growth.

172 Spleen tyrosine kinase (Syk) is an intracellular nonreceptor tyrosine kinase, which has bee

173 ement across epithelia, and acidification of intracellular organelles.

174 metabolite flux across membranes of cells or intracellular organelles.

175 obes, is mainly confined to the detection of intracellular oxidative stress in vitro.

176 xpress the viral E6/E7 oncogenes, that their intracellular p53 levels are reconstituted on E6/E7 repr

177 ation/memory genes during infection with the intracellular parasite Trypanosoma cruzi, as evidenced b

178 Obligate intracellular parasites must efficiently invade host cel

179 idating host mechanisms that regulate fungal intracellular parasitism.

180 candidiasis disease might also have viral or intracellular pathogen infections.

181 Macrophage intracellular pathogen killing is defective in cystic fi

182 After erythrocyte invasion, the intracellular pathogen must increase host cell uptake of

183 monocytogenes is a facultative intracellular pathogen that escapes from phagosomes, gro

184 Chlamydia trachomatis is an obligate intracellular pathogen that resides in a membrane-bound

185 Many intracellular pathogens exploit host secretory trafficki

186 Intracellular pathogens manipulate host organelles to su

187 To establish these replicative niches, intracellular pathogens secrete various virulence protei

188 Many intracellular pathogens subvert host membrane traffickin

189 Brucella species are infectious intracellular pathogens that replicate in professional a

190 Salmonella enterica are invasive intracellular pathogens that replicate within a membrane

191 The development of vaccines against complex intracellular pathogens, such as Plasmodium spp., where

192 nomous immunity that restrict replication of intracellular pathogens.

193 enotype that participates in defense against intracellular pathogens.

194 through the epithelial cell monolayer by an intracellular pathway to the submucosa.

195 line to clearly define the FcRn involvement, intracellular pathway, and kinetics of albumin trafficki

196 strocytes; mediates HCO3(-) efflux) enhances intracellular pH (pHi ) recovery (decrease) from alkali

197 +/HCO3- co-transporter NBCn1 which regulates intracellular pH (pHi).

198 KEY POINTS: Intracellular pH regulation is vital to neurons as nerve

199 We show that proton binding at the intracellular pH sensor perturbs the potassium affinity

200 Single cell analysis further identifies an intracellular pH threshold 6.5.

201 ondrial membrane potential (MMP) and lowered intracellular pH, while red/NIR had the opposite effect.

202 new oxazolidinone with improved in vitro and intracellular potency against Mycobacterium tuberculosis

203 ential of presynaptic thalamic cells and the intracellular potential of postsynaptic cortical cells i

204 cells facilitate this process by generating intracellular pressure, which the contractile actomyosin

205 y more folded within cells, as determined by intracellular probing.

206 However, the specific intracellular processes governing this transmission rema

207 h have been widely used to optically control intracellular processes.

208 response determining the efficiency of AAVs intracellular processing in hepatocytes and thus the out

209 nce-based metabolic analysis demonstrate the intracellular production of BCAAs by BCAT1.

210 two species triggered calcium signaling and intracellular protein translocation events, respectively

211 ) plays a critical role in removing unwanted intracellular proteins and is involved in protein qualit

212 rowth and survival autonomously by recycling intracellular proteins and/or organelles.

213 In living cells intracellular proteolysis is crucial for protein homeost

214 Intracellular reactive species content was assayed using

215 The inflammasome contains intracellular receptors that recognize various pathogen-

216 cal electrophysiological imager for parallel intracellular recording at the network level.

217 Here, using intracellular recording, we monitored inputs and plastic

218 proximately 15-30 nm) to establish the first intracellular recordings from targeted spine heads under

219 We used intracellular recordings in rat (both sexes) neocortical

220 urther provides opportunities for evaluating intracellular redox states in biochemical investigations

221 gating of thermal TRP channels involving an intracellular region assembled around the TRP domain.

222 Using mass spectrometry, we found that the intracellular region of neuropilin and tolloid-like prot

223 formational changes in the transmembrane and intracellular regions of ACKR3 that elucidate fundamenta

224 (CBS) domains (IPR000664) and represents an intracellular regulatory module of the transporter.

225 at the Ub pathway is critical for ehrlichial intracellular replication and survival.

226 ption validate the essentiality of GAPDH1 in intracellular replication but we confirmed that glycolys

227 CME inhibitors or antioxidants, attesting to intracellular replication of S. pneumoniae as a key firs

228 multiple processes that are critical to the intracellular replicative cycle of T. gondii including s

229 KCNQ1 is largely in an intracellular reservoir under basal conditions but can t

230 compete with cellular processes for limited intracellular resources.

231 ptors able to modify contractility and other intracellular responses signal through a variety of othe

232 Mechanistically, PLXNB2 mediates intracellular RNA processing that contribute to cell gro

233 expression but was inversely correlated with intracellular SAP levels.

234 Nevertheless, TRs also rapidly activate intracellular second-messenger signaling pathways indepe

235 many species rely on a simple molecule, the intracellular secondary messenger c-di-GMP (Bis-(3'-5')-

236 xtracellular ligand-binding regions but have intracellular sequences with opposing signaling function

237 to detachment of myocytes and alteration of intracellular signal transduction.

238 myr-Akt mouse model for GBM are enriched for intracellular signaling cascade proteins (GO: 0007242) a

239 However, the intracellular signaling cascades that mediate the osteob

240 Our results identify a novel intracellular signaling module that synergistically regu

241 ween an epigenetic regulator, WHSC1, and key intracellular signaling molecules, AKT, RICTOR, and Rac1

242 ermore, we found that the fumarase-dependent intracellular signaling of the B. subtilis DDR is achiev

243 However, the intracellular signaling pathway triggering Src activatio

244 ow and fast neurotransmitter systems through intracellular signaling pathways-and may unify a number

245 SR, which was associated with alterations in intracellular signaling pathways.

246 nding events trigger receptor activation and intracellular signaling remains unclear.

247 This reduction required intracellular signaling via second messengers-cytosolic

248 ted that efficient HIV entry also depends on intracellular signaling, but this remains controversial.

249 king FMRP show aberrant mRNA translation and intracellular signalling.

250 anoikis resistance pathway, focusing on the intracellular signals associated with integrins that mod

251 s require MTs to transport to and from their intracellular sites of replication.

252 Thus, intracellular sorting steps that occur after receptor in

253 s work is exposing the previously restricted intracellular space to the potential of therapeutic anti

254 eripheral blood mononuclear cells (PBMCs) by intracellular staining and dual-secretion assay.

255 to make decisions based on information about intracellular state and the environment.

256 -entry process activated by the depletion of intracellular stores and has an important role in many c

257 ion leads to robust Ca(2+) mobilization from intracellular stores via activation of phospholipase C a

258 ary for the release of free fatty acids from intracellular stores within neutrophil precursor cells.

259 oxidized phospholipids (OxPls) formed under intracellular stress seem to directly induce apoptotic a

260 ique features, including an unusual rotating intracellular structure of unknown function.

261 Dynamic protein-rich intracellular structures that contain phase-separated in

262 integration of high-resolution images of 3-D intracellular structures with models of calcium cycling,

263 echanism that favors lipid biosynthesis when intracellular sugar levels are elevated and KIN10 is inh

264 ific antioxidant MitoQuinone (MitoQ) reduced intracellular superoxide and inhibited cyst epithelial c

265 ne helices and effector docking sites at the intracellular surface of the beta1AR, but the extracellu

266 of NO by N(G)-monomethyl-L-arginine enhanced intracellular survival of Mtb.

267 thesize purines has been associated with the intracellular survival of multiple bacterial pathogens.

268 d host protein stability in order to promote intracellular survival.

269 er, our results identify Nur77 as a critical intracellular target for celastrol and unravel a mechani

270 e use of this simple motif to provide active intracellular targeting provides a promising strategy fo

271 the cell surface is phosphorylated, whereas intracellular TMPRSS13 is predominantly non-phosphorylat

272 xpression of Tnfalpha and Il1beta, increased intracellular TNFalpha immunoreactivity, and reduced exp

273 The retention of intracellular Toll-like receptors (TLRs) in the endoplas

274 bsence of CobB in a DeltacobB mutant reduces intracellular TopA catalytic activity and increases nega

275 chable CNPs can be synthesized for efficient intracellular tracking.

276 nidulans are useful for studying long-range intracellular traffic.

277 lysomal marker LAMP1; this signified altered intracellular trafficking and decreased degradation of H

278 -2 regulates ENaC activity by modulating its intracellular trafficking and surface expression.

279 n of CpG-A and CpG-B may be related to their intracellular trafficking in B cells.

280 nclude that Ambra1 is a core component of an intracellular trafficking network linked to tight spatia

281 hog (Shh) receptor, Patched, and involved in intracellular trafficking of cholesterol.

282 Intracellular trafficking studies of HIV-1 in cocaine tr

283 Siglec-8 intracellular trafficking was followed by confocal micro

284 Rapid uptake of TrOCs and intracellular transformation through diverse enzymatic s

285 Fine characterization of intracellular transformation using ketoprofen showed tha

286 he sole intracellular enzyme responsible for intracellular transformation.

287 These findings reveal the importance of intracellular transport in steady-state lymph formation

288 roteins, not only play a central role in the intracellular transport of virus particles but also regu

289 argoes are resolved accurately to render the intracellular transport process in live cells.Distinguis

290 ict AMPAR dendritic mobility, leading to the intracellular trapping of receptors and impairing their

291 glucose uptake in association with decreased intracellular triglyceride content.

292 eron-gamma (IFN-gamma)-mediated depletion of intracellular tryptophan, and some Ct strains utilize ex

293 As a likely UVB photoproduct of intracellular tryptophan, FICZ represents a de facto end

294 bladder epithelial cells (BECs) that expels intracellular uropathogenic Escherichia coli (UPEC) from

295 cteria mineralize both arsenic and barium on intracellular vesicles.

296 These complexes limit intracellular vesicular trafficking and trap AMPARs insi

297 reduce intracellular genome levels or block intracellular virion production.

298 Importantly, altering the intracellular zinc concentration by treatment with the z

299 miR-183 cluster reduced zinc transporter and intracellular zinc levels in benign prostate cells, PCa

300 To assess the consequences of the intracellular Zn(2+) accumulation, we used OGD exposures