ライフサイエンスコーパス: intracellular domain

1 assessed by immunohistochemistry for Notch1 intracellular domain.

2 , translocation-associated (Notch1) receptor intracellular domain.

3 ophosphorylation of tyrosine residues at the intracellular domain.

4 es formed by distant portions of the cyclase intracellular domain.

5 ing with talin for binding to beta1-integrin intracellular domain.

6 with transgenic overexpression of the Notch intracellular domain.

7 ptor contains only one tyrosine motif in the intracellular domain.

8 long or short isoforms with respect to their intracellular domain.

9 action to the NH2-terminal region of the APP intracellular domain.

10 f Dachs, similar to overexpression of the Ft intracellular domain.

11 distinct from the amyloid precursor protein intracellular domain.

12 ubule dynamics through RUVBL proteins at its intracellular domain.

13 -mimetic of the beta4 sodium channel subunit intracellular domain.

14 crucial for mural cell recruitment, via its intracellular domain.

15 her processed into a small, rapidly degraded intracellular domain.

16 lex with the amyloid precursor protein (APP) intracellular domain.

17 diminished in cells overexpressing the CD44 intracellular domain.

18 logy 2 (SH2)-domain proteins to the receptor intracellular domain.

19 o products: the extracellular domain and the intracellular domain.

20 , 2 in the extracellular domain and 1 in the intracellular domain.

21 n or deletion tend to be enriched within the intracellular domain.

22 pts a preexisting conformation of the BTN3A1 intracellular domain.

23 amma-secretase to generate a cytosolic TNFR1 intracellular domain.

24 pment of inhibitors at the extracellular and intracellular domains.

25 ther processed by PS/gamma-secretase to KCNE intracellular domains.

26 P motif separates the transmembrane (TM) and intracellular domains.

27 iation of cytoplasmic proteins with integrin intracellular domains.

28 f10 and Notch1 interact via their respective intracellular domains.

29 cretase-dependent but RBPj-independent Notch intracellular domain activity operating in the first hai

30 Our results show that targeting the intracellular domain affects Dll4's ability to induce No

31 sis of APP leads to the formation of the APP intracellular domain (AICD) and amyloid beta that is cru

32 processes via two separate domains, the APP intracellular domain (AICD) and the soluble secreted APP

33 Evidence suggests that APP intracellular domain (AICD) could regulate synapse funct

34 ort that the amyloid precursor protein (APP) intracellular domain (AICD) downregulates Wiskott-Aldric

35 nitiated by the APP transcriptionally active intracellular domain (AICD) in response to 27-hydroxycho

36 Pbeta and also the amyloid precursor protein intracellular domain (AICD).

37 This activity requires the intracellular domain and apparently the dimerization of

38 ffects of Serrate ligand forms that lack the intracellular domain and are therefore incapable of endo

39 mTOR)-Akt, accumulation of HIF1alpha, Notch3 intracellular domain and beta-catenin, deficiency of pro

40 ven that TIGIT contains an ITIM motif in its intracellular domain and considering the potential impor

41 Furthermore, AIB1 interacted with Notch intracellular domain and Mastermind-like 1 and was recru

42 udy shows that residues 956-1154 of the HER2 intracellular domain and residue 83 of S100A14 are essen

43 es the direct binding of both the RBPJ/Notch intracellular domain and SOXF transcription factors.

44 ed an interaction between BBXXB motif of APP intracellular domain and the heterotrimeric G-protein su

45 f SHP-2 to phosphorylated forms of both LRP1 intracellular domain and the PDGFRbeta kinase domain.

46 Vamana also associates with the Dachsous intracellular domain and with a region of the Fat intrac

47 R1 and IFNAR2 promotes proximity between the intracellular domains and that differential signaling is

48 mide ketone inhibits formation of N-terminal intracellular domains and the corresponding secreted C-p

49 S4-S5 linker allow calmodulin to bind to the intracellular domains and to close the potassium pore, i

50 edicted allosteric pocket unique to the CD45 intracellular domain, and validated inhibitors by in vit

51 al fragment containing the transmembrane and intracellular domains, and this processing is dependent

52 recent years it became apparent that the APP intracellular domain (APP-ICD) might play a role in regu

53 led that amino acids 327-334 of the ephrinB1 intracellular domain are critical for the interaction wi

54 ic domain, indicating that the alphaIIbbeta3 intracellular domains are primed for activation while th

55 c property, suggesting a crucial role of the intracellular domain as a scaffold for recruitment of su

56 we report that the amyloid precursor protein intracellular domain associated-1 protein (AIDA-1), whic

57 Truncated FLS2 containing only the intracellular domain associates with full-length FLS2 an

58 he sensitivity of AXL to 17-AAG required its intracellular domain because an AXL intracellular domain

59 The intracellular domain binds, directly or indirectly, diff

60 cells decreased the production of the Notch intracellular domain but not the production of amyloid b

61 Our study provides clear evidence that APP intracellular domain can have a nontranscriptional role

62 Mutations in the intracellular domain can have profound effects on recept

63 he intracellular kinase domain and that this intracellular domain carries a functional nuclear locali

64 revealed a strong correlation between Notch1 intracellular domain, CD133, and p-p38 mitogen-activated

65 ne cleavage and the release of its cytosolic intracellular domain (CD74-ICD), which regulates cell su

66 expression and nuclear localization of Notch intracellular domain compared with ECs of AVFs in pair-f

67 attributed to haploinsufficiency but not to intracellular domain composition.

68 )(-/-) with the overexpression of the Notch1-intracellular domain, confirming the role of Notch signa

69 Binding of extracellular signals stabilizes intracellular-domain conformations that selectively acti

70 istically direct transmembrane receptors-the intracellular domain contains a transcriptional regulato

71 mplement receptor CD46, and specifically its intracellular domain CYT-1, was required for induction o

72 ired its intracellular domain because an AXL intracellular domain-deleted mutant was insensitive to t

73 e pluripotent stem cell line increased NOTCH intracellular domain-dependent (NICD-dependent) activati

74 tch1 intracellular domain expression, Notch1 intracellular domain-dependent CD133-mediated mitogen-ac

75 Transgenic mice expressing the Notch-4 intracellular domain (designated Int3) in the mammary gl

76 ing site of the transiently transfected CD44 intracellular domain diminished the inhibitory effects o

77 discrete membrane subdomains, and the Gpr125 intracellular domain directly interacted with Dvl in pul

78 endowed the substituted thyrotropin receptor intracellular domain elements with spatial constraints a

79 espite their highly diverged sequences, each intracellular domain elicits repulsion via a common path

80 ng of PGRP domain-encoding exons to a common intracellular domain-encoding exon generates three recep

81 Intracellular domains engage in extensive interactions t

82 rimeric complexes with their ligands and the intracellular domains engage in higher-order oligomeriza

83 We identified the GB(1a) intracellular domain essential for the presynaptic homeo

84 Andrographolide inhibits Notch1 intracellular domain expression, Notch1 intracellular do

85 An endogenous intracellular domain fragment of p75(NTR) (p75(ICD)) con

86 cific 29-amino acid peptide derived from the intracellular domain fragment of p75(NTR) interacts with

87 They lack ECD but may retain intracellular domain functionality, potentially associat

88 containing the inducible costimulator (ICOS) intracellular domain generates tumor-specific IL-17-prod

89 ong the entire length of Ecadherin, with the intracellular domains having a surprisingly strong favor

90 nts and at two -sites to release human EPCAM intracellular domain HEPICD, which is efficiently degrad

91 at can signal via a proteolytically released intracellular domain (ICD) in addition to classical rece

92 phenocopy deleting a specific portion of the intracellular domain (ICD) of Ft that regulates both gro

93 vious studies have shown that the N-terminal intracellular domain (ICD) of teneurins can be cleaved a

94 s study, we investigated the function of the intracellular domain (ICD) of the Notch ligand Delta-lik

95 leavable isoforms of ErbB4 release a soluble intracellular domain (ICD) that can translocate to the n

96 IgG to HER2 intracellular domain (ICD), HER2-ECD, p53, IGFBP2, CEA,

97 The intracellular domain (ICD), however, has been orphaned i

98 ndidate Dco phosphorylation sites in the Fat intracellular domain (ICD), the mutation of which impair

99 goes cleavage at the membrane and the Notch4-intracellular domain (ICD), translocates to the nucleus

100 , we show that Fra is cleaved to release its intracellular domain (ICD), which shuttles between the c

101 -mediated p75NTR cleavage and release of its intracellular domain (ICD).

102 that this is achieved by cleavage-regulatory intracellular-domain (ICD)-modifications of the precurso

103 -secretase cleavage of NOTCH3 to release its intracellular domain (ICD3), and sequenced the negative

104 However, the intracellular domains (ICDs) of ADAM10 and -17 can be re

105 ation by using chimeric ligands with swapped intracellular domains (ICDs), demonstrated that the Jagg

106 ransfer ubiquitin to lysines of the ligands' intracellular domains (ICDs), which sends them into an E

107 one, or in tandem with the CD28 or the 4-1BB intracellular domains, ICOS signaling increased IL-17A,

108 show that constitutive expression of Notch1 intracellular domain impairs secretory function of mouse

109 g by promoting the degradation of the Notch1 intracellular domain in cardiomyocytes.

110 on in clinical CRPC, tumors driven by Notch1 intracellular domain in combination with multiple pathwa

111 n strongly promotes dimerization of the TLR4 intracellular domain in MAPPIT.

112 in clear contrast to the requirement of its intracellular domain in mediating axon guidance.

113 of serine residue S1163 of the alphaE chain intracellular domain in polarization of CD103 and recrui

114 ALCAM shedding, defined as detection of the intracellular domain in the absence of the corresponding

115 RP8, revealing an unprecedented role for its intracellular domain in the regulation of synaptically g

116 that detects both the extracellular and the intracellular domains in formalin-fixed tissue.

117 Notch1 intracellular domain induced genes associated with stemn

118 ylate cyclase mediates membrane-tethered APP intracellular domain-induced neurite outgrowth.

119 ne-inducible genetic system (inducible Notch intracellular domain [iNICD]).

120 accumulate in SMC mitochondria, and the Fat1 intracellular domain interacts with multiple mitochondri

121 We also determined that the ROBO intracellular domain interacts with the Myo9b RhoGAP dom

122 asmic domain of CD44, we determined that the intracellular domain interfered with anchoring of the fu

123 The data suggest that release of the CD44 intracellular domain into the cytoplasm of cells such as

124 n of TH17 cells with a CAR encoding the ICOS intracellular domain is a promising approach to augment

125 by transcription, suggesting that the Notch intracellular domain is acting through a novel mechanism

126 Mouse neogenin lacking the intracellular domain is also capable of mediating BMP si

127 ation is unclear as studies suggest that its intracellular domain is dispensable for some AdV infecti

128 roteins, suggesting that generation of Notch intracellular domain is dispensable for this function.

129 tochemistry, we also demonstrated that Notch intracellular domain is not modulated by the compounds.

130 to aberrant Notch trafficking and the Notch intracellular domain is stalled in sorting endosomes.

131 k analysis reveals that communication in the intracellular domains is greatly weakened during activat

132 nsmembrane core domain of TRPV1, but not the intracellular domains, is responsible for sensing these

133 , upon ligand stimulation, is coupled to its intracellular domain kinase activation.

134 binds to growth factors, is coupled with the intracellular domain kinase activation.

135 d transmembrane (TMD) domains, as well as an intracellular domain known as the common region (CR).

136 (Notch intracellular domain) to total Notch intracellular domain levels using immunocytochemistry, w

137 amma-secretase-dependent release of the LRP1 intracellular domain (LRP1-ICD).

138 Coupling between the extracellular and intracellular domains may involve a switch between alter

139 How the intracellular domain modification communicates with the

140 We propose that substrate intracellular domain modification induces a relative rot

141 ive by specific intracellular signal-induced intracellular domain modifications of the substrates, wh

142 ngth (defined here as the ultimate number of intracellular domain molecules reaching the nucleus, int

143 Also, most pore mutations--in contrast to intracellular domain mutations--were found to have sever

144 tors were expressed normally, nuclear Notch1 intracellular domain (N1ICD) expression was severely red

145 e by conditionally overexpressing the Notch1 intracellular domain (N1ICD) in the reproductive tract d

146 gnaling through overexpression of the Notch1 intracellular domain (N1ICD) rescued the TWEAK-mediated

147 e examined in detail mice in which the Notch intracellular domains (N1ICD and N2ICD) were swapped.

148 , leading to the increased expression of the intracellular domain (N3IC), finally enhancing Notch3-de

149 4th and 5th transmembrane domains and to an intracellular domain near the carboxyl terminus of HR2.

150 f autophagy required ligand-dependent, Notch intracellular domain (NIC) activity, which controlled mi

151 tase dependent and releases the active Notch intracellular domain (NIC).

152 trate that ERG directly interacts with Notch intracellular domain (NICD) and beta-catenin and is requ

153 trengthens the association between the Notch intracellular domain (NICD) and CBF1, resulting in incre

154 ply conserved and includes the cleaved Notch intracellular domain (NICD) and Mastermind.

155 f the bivalent interaction between the Notch intracellular domain (NICD) and the transcription factor

156 y by nuclear translocation of cleaved Notch1 intracellular domain (NICD) and upregulation of target m

157 PT, to inhibit cleavage and release of Notch Intracellular Domain (NICD) blocked cardiac architectura

158 ng because inducible expression of the Notch Intracellular Domain (NICD) can reverse the effect.

159 ce with conditional activation of the NOTCH1 intracellular domain (NICD) in germ cells.

160 pression of the constitutively active Notch1 intracellular domain (NICD) in Nkx2.1-cre-expressing cel

161 During TMCH, relative levels of the Notch intracellular domain (NICD) increased significantly, alo

162 that overexpression of either her12 or Notch intracellular domain (NICD) increases the number of immo

163 A knockdown, resulted in a decrease in Notch intracellular domain (NICD) protein degradation.

164 ata showed that over-expression of the Notch Intracellular Domain (NICD) significantly induced the ex

165 of its neighboring cell, releasing the Notch Intracellular Domain (NICD) that activates many downstre

166 nse pathway through recruitment of the Notch intracellular domain (NICD) transcriptosome to a conserv

167 nd in vitro assays, we show that the Nephrin intracellular domain (NICD), a disordered protein, drive

168 Tak1 deletion also down-regulated Notch intracellular domain (NICD), but increased the levels of

169 e half-life of the positive regulator, Notch intracellular domain (NICD), can lead to elevated NICD l

170 ssion of the Notch signaling effector, Notch intracellular domain (NICD), rescued the expansion of MC

171 In contrast, overexpression of Notch1 intracellular domain (NICD), to constitutively activate

172 avage and nuclear translocation of the Notch intracellular domain (NICD), which associates with Epste

173 ancer by directly interacting with the Notch intracellular domain (NICD).

174 mediated processing and release of the Notch intracellular domain (NICD).

175 ion and enhancing nuclear transport of Notch intracellular domain (NICD).

176 ed form of the Notch receptor (cleaved Notch intracellular domain, NICD)].

177 ieved by increased recruitment of the NOTCH1 intracellular domain (NICD1) to nuclear and mitochondria

178 in, which facilitates the cleavage of NOTHC1 intracellular domain (NICD1).

179 hat requires nearly all available free Notch intracellular domains (NICDs) but could not identify the

180 overexpressing a version missing part of the intracellular domain (NL1DeltaC).

181 Upon ligand binding, the Notch intracellular domain (NOTCH ICD) translocates into the n

182 ating S3-specific Val-1744 cleavage of Notch intracellular domain (Notch intracellular domain) to tot

183 y gamma-secretase, which releases the active intracellular domain (Notch1(NIC)).

184 We constructed functional mimetics of the intracellular domain of a model GPCR, the thyrotropin re

185 nsertion of a gephyrin-binding site into the intracellular domain of alpha6 and delta subunits brough

186 a global conformational change in the B30.2 intracellular domain of BTN3A1 induced by pAg binding.

187 Here we report that the intracellular domain of Caenorhabditis elegans BMP type

188 e mediated via the gamma-secretase-regulated intracellular domain of CD44, which promoted aggressive

189 s or by mutation of cysteine 1102 within the intracellular domain of CHL1 reduces endocytosis of CHL1

190 of a highly conserved serine cluster in the intracellular domain of E-Cadherin is essential for bind

191 Cleaved intracellular domain of ErbB4 directly interacted with H

192 at App promotes growth by palmitoylating the intracellular domain of Fat, and that palmitoylation neg

193 Multiple regions of the intracellular domain of Ft have been implicated in regul

194 All 10 cysteines in the intracellular domain of IA-2 were modified to serine by

195 Receptors with the intracellular domain of IGF1R show increased activation

196 Conversely, receptors with the intracellular domain of IR display higher IRS-1 phosphor

197 he IQ region of IQGAP1 binds directly to the intracellular domain of IR.

198 Mutation of tyrosine 1138 in the intracellular domain of LepRb that mediates signaling th

199 ts are mediated via interactions between the intracellular domain of LOX-1 and AT1 that activate AT1.

200 We show that the intracellular domain of Lrp1 interacts with the nuclear

201 lation of a chimeric receptor containing the intracellular domain of Mer fused to the extracellular d

202 lar hair cells was found to interact with an intracellular domain of microfibril interface-located pr

203 MPL and that 3 tyrosine residues within the intracellular domain of MPL are required to activate sig

204 port that CaMKII robustly phosphorylates the intracellular domain of NL-1.

205 nd binding, a proteolytic event releases the intracellular domain of Notch, which translocates to the

206 enewal by Notch1 cleavage, and the generated intracellular domain of Notch1 (NICD) induced the expres

207 of OS based on conditional expression of the intracellular domain of Notch1 (NICD).

208 t mice constitutively expressing the active, intracellular domain of NOTCH1 (NICD1) in Sertoli cells.

209 er overexpression of a constitutively active intracellular domain of NOTCH1.

210 nts harbor gain-of-function mutations in the intracellular domain of Notch1.

211 e show that liver-specific expression of the intracellular domain of Notch2 (N2ICD) in mice is suffic

212 that expression of the constitutively active intracellular domain of Notch4 (N4ICD) in melanoma cells

213 ee-dimensional NMR solution structure of the intracellular domain of p45 and characterized its intera

214 Thus, although the intracellular domain of sortilin does not contribute to

215 er sST2 levels in the GWAS and mapped to the intracellular domain of ST2, which is absent in sST2.

216 response begins with sensing of pAg via the intracellular domain of the butyrophilin 3A1 (BTN3A1) mo

217 Posttranslational modifications to the intracellular domain of the EGFR are known to regulate E

218 s kinase 1 (JAK1) bound to a fragment of the intracellular domain of the interferon-lambda receptor 1

219 A prominent example is the intracellular domain of the Notch receptor (NICD), which

220 mediates phosphorylation of residues in the intracellular domain of the protease, and it coincides w

221 d by Box1 and Box2 motifs located within the intracellular domain of the receptor chains.

222 We now show that the N-terminal intracellular domain of the type II transmembrane protei

223 n mammalian cells as a factor that binds the intracellular domain of the unactivated epidermal growth

224 ath domain regulates RIP1 recruitment to the intracellular domain of TNFR1.

225 ite long-standing evidence that the specific intracellular domains of AMPA-type glutamate receptor (A

226 ring was modulated by both extracellular and intracellular domains of ApoER2.

227 CD28, whereas T cell functions depend on the intracellular domains of both CD28 and CD3epsilon, with

228 rgic receptor (alpha2AAR) that occurs at the intracellular domains of both proteins.

229 e various studies is that the association of intracellular domains of CCR5 with the signaling machine

230 rs of Notch signaling that interact with the intracellular domains of DLL1 and DLL4.

231 OsSERK2 interacts with the intracellular domains of each immune receptor in the yea

232 Ras-related protein 5A) bind directly to the intracellular domains of GABAARs, validating our proteom

233 Upon activation, intracellular domains of GPCRs mediate signaling to G-pr

234 The intracellular domains of KCNH channels are structurally

235 Analysis of the extracellular and intracellular domains of Kirrel2 revealed that it is cle

236 The intracellular domains of many ion channels are important

237 Moreover, none of the intracellular domains of p75NTR demonstrated a propensit

238 Switching the intracellular domains of the gamma2 and gamma1 subunits

239 The core domains of vav2 bound to the intracellular domains of the PTHR independent of recepto

240 ial: the scissor-like rotation separates the intracellular domains of the two receptor molecules to m

241 reating chimeras using the extracellular and intracellular domains of three different Drosophila repu

242 the PDGF receptor and the transmembrane and intracellular domains of TrkA, the downstream TrkA-induc

243 Analogous "anchor" peptides within intracellular domains of vertebrate KCNQ2, KCNQ3, and Na

244 cade to release its transcriptionally active intracellular domain, on force to unfold a protective do

245 In human CRC specimens, CD133 and Notch intracellular domain-positive CRC cells colocalized in p

246 on of a vector encoding for the active Notch intracellular domain prevented H19-induced mineralizatio

247 These data demonstrate that soluble ErbB4 intracellular domain promotes HIF-1alpha stability and s

248 ly complex fluorescence changes within these intracellular domains, providing clues as to how posttra

249 ion and reporter assays revealed that Notch1 intracellular domain regulates CD133 expression at the t

250 risingly, a single lysine residue within the intracellular domain rescues shedding of Tim-3.

251 M and I338T, located in the transmembrane or intracellular domain, respectively, have no influence on

252 in-of-function transgene encoding the Notch1 intracellular domain resulted in lymphoproliferation, ex

253 ther show that ILK interacted with the CD103 intracellular domain, resulting in protein kinase B (PKB

254 ar domains and transducing signals via their intracellular domains, resulting in changes in direction

255 ments or expression of membrane-tethered APP intracellular domain results in adenylate cyclase-depend

256 se cleavage and nuclear translocation of its intracellular domain (Ryk-ICD).

257 laced between the Rosa26 promoter and Notch1 intracellular domain sequences.

258 Chromatin immunoprecipitation of the NOTCH intracellular domain showed increased binding to two spe

259 them at the extracellular domain, it, at its intracellular domain, signals activation of the C-termin

260 ed by two distinct, structurally disordered, intracellular domains spanning amino acids 584-734 ("mid

261 than wild-type tumors on the basis of Notch1 intracellular domain staining ( P = .004).

262 e component of the WAVE complex, through its intracellular domain, suggesting a role in the control o

263 expressing either full-length Dchs1b or its intracellular domain, suggesting that Dchs1b affects mic

264 enhance the repulsive activity of all three intracellular domains, suggesting that repulsion by Unc5

265 ific gamma-secretase complexes following the intracellular domain swap.

266 we examined the responses elicited by their intracellular domains systematically.

267 cells expressing truncated forms of the CD30 intracellular domain that allowed us to identify the key

268 alysis showed that only a core region of the intracellular domain that exhibits at least some conserv

269 domain, a transmembrane (TM) domain, and an intracellular domain that includes a juxtamembrane (JM)

270 1 induces a conformational change within the intracellular domain that involves the JM region and is

271 cellular domain and with a region of the Fat intracellular domain that is essential for controlling H

272 ression in Fat1(KO) cells of a modified Fat1 intracellular domain that localizes exclusively to mitoc

273 or transmembrane helix 5 (TM5), TM6, and TM7 intracellular domains that are essential elements for GP

274 lly primary sequence determinants within the intracellular domain, the transmembrane domain and the l

275 ffects the NSC fate by signaling through its intracellular domain to regulate beta-catenin signaling

276 nuclear localization of the activated NOTCH4 intracellular domain to the apical cytoplasm of neoplast

277 water channels and their redistribution from intracellular domains to the plasma membrane via vesicul

278 leavage of Notch intracellular domain (Notch intracellular domain) to total Notch intracellular domai

279 We have demonstrated that N1-ICD (Notch1 intracellular domain) transactivated the mouse Kruppel-l

280 roviding evidence that signaling via the DCC intracellular domain triggers DCC recruitment to the pla

281 and TACE (ADAM17), which releases the Trop2 intracellular domain (Trop2 ICD).

282 The butyrophilin 3A1 intracellular domain undergoes a conformational change i

283 Conformational coupling between membrane and intracellular domains via poorly understood mechanisms i

284 The MERTK intracellular domain was expressed as a 6xHis-fusion pro

285 0) of the stalk region and Tim-3 lacking the intracellular domain was not efficiently cleaved after P

286 the N-glycosylation dependence, whereas the intracellular domain was not involved.

287 xpression of a mutant E-cadherin lacking the intracellular domain was sufficient for efficient L. mon

288 Truncated Sema6B lacking the intracellular domain was unable to rescue the loss-of-fu

289 llele 008, with an altered transmembrane and intracellular domain, was not affected by mutation of th

290 n SHP-2 and phosphorylated forms of the LRP1 intracellular domain, we utilized an ELISA with purified

291 Minimal amounts of the Notch intracellular domain were sufficient for rescue, which w

292 t dimer interfaces in the BTN3A1 full-length intracellular domain, which are stable in MD simulations

293 rface results in the generation of the Notch intracellular domain, which associates with several tran

294 luence the cytoskeleton directly through its intracellular domain, which can bind and localize Ena/VA

295 5a stimulates the release of the tagged Ptk7 intracellular domain, which can translocate into the nuc

296 ger is regulated by binding of Ca(2+) to its intracellular domain, which contains two structurally ho

297 ulting in the cytoplasmic release of a Notch intracellular domain, which translocates to the nucleus

298 sing mutations localize to these specialized intracellular domains, which underlie the unique gating

299 g of chromogenic duplex IHC for HER2 ECD and intracellular domain with advanced image analysis.

300 DCC dominant negative that replaces the DCC intracellular domain with mCherry, consistent with netri