ライフサイエンスコーパス: intracellular membrane

1 protein associating with or integrating into intracellular membrane.

2 to the molecular composition and function of intracellular membranes.

3 genomic RNA on the surface of virus-induced intracellular membranes.

4 ial in controlling the shape and dynamics of intracellular membranes.

5 t generates reactive oxygen species (ROS) at intracellular membranes.

6 the major determinants of its recruitment to intracellular membranes.

7 o increased alpha-synuclein sequestration on intracellular membranes.

8 stance to infection by pathogens that damage intracellular membranes.

9 tive regulator of ARP2/3 function present on intracellular membranes.

10 vation of caspase-8 on the cytosolic side of intracellular membranes.

11 ication complexes on the cytoplasmic face of intracellular membranes.

12 ontrolling the morphology and trafficking of intracellular membranes.

13 ents occurring within or near the plasma and intracellular membranes.

14 iably associated with extensively rearranged intracellular membranes.

15 essed mu1 induces apoptosis and localizes to intracellular membranes.

16 ably replicate their RNA genomes on modified intracellular membranes.

17 tafazzin, which was associated with multiple intracellular membranes.

18 xpressed protein was targeted extensively to intracellular membranes.

19 and KChIP3x all autonomously target eGFP to intracellular membranes.

20 1/2 < 1 min) between the plasma membrane and intracellular membranes.

21 ially active G protein betagamma subunits to intracellular membranes.

22 A and is restricted to a subset of host cell intracellular membranes.

23 to the capacity of micro1 to associate with intracellular membranes.

24 cytosol but also in the plasma membrane and intracellular membranes.

25 stable association of AP-1 with appropriate intracellular membranes.

26 t a wide range of substrates across cell and intracellular membranes.

27 vesicle exocytosis, but it is also found on intracellular membranes.

28 to assemble its RNA replication complexes on intracellular membranes.

29 he cell surface and rapidly redistributed to intracellular membranes.

30 ndicating association of these proteins with intracellular membranes.

31 us RNA replication requires association with intracellular membranes.

32 he transactivated Trk receptors are found in intracellular membranes.

33 domain may anchor the replication complex to intracellular membranes.

34 ted to participate in sterol distribution to intracellular membranes.

35 ining beta5 accumulated in the cytosol or on intracellular membranes.

36 led on the cytoplasmic surface of rearranged intracellular membranes.

37 ostasis leads to a dramatic rearrangement of intracellular membranes.

38 depends on the extensive remodeling of host intracellular membranes.

39 aquaporins from the plasma membrane (PM) to intracellular membranes.

40 otein found both in the cytosol and bound to intracellular membranes.

41 ion of vesicle trafficking and remodeling of intracellular membranes.

42 discrimination between surface-connected and intracellular membranes.

43 ycles to shuttle reducing equivalents across intracellular membranes.

44 f disease-associated changes to GM1-enriched intracellular membranes.

45 mble viral RNA replication complexes on host intracellular membranes, a process whose molecular detai

46 icity is compatible with simple necrosis and intracellular membrane accumulation.

47 her budding of DNA-containing HBV virions at intracellular membranes also involves MVB functions, we

48 ive liposome fusion and lysis, the fusion of intracellular membranes also requires Rab GTPases, Rab e

49 ndent genes, as gene fusions, or targeted to intracellular membranes, also demonstrate the potential

50 on complexes are universally associated with intracellular membranes, although different viruses use

51 wed that ERP5 is resident mainly on platelet intracellular membranes, although it is rapidly recruite

52 ses control vesicle formation from different intracellular membranes and are regulated by Arf guanine

53 All of the proteins were localized to intracellular membranes and detected as 42-kDa monomers

54 striking differences in the organization of intracellular membranes and in the assembly of mature vi

55 man endothelial cells, GPER was expressed on intracellular membranes and mediated eNOS activation and

56 have shown that Bcl-2 is present on several intracellular membranes and mitochondria may not be the

57 ule ends exert pulling and pushing forces on intracellular membranes and organelles.

58 tiporters are located in the cytoplasmic and intracellular membranes and play crucial roles in regula

59 nction as dynamin-like proteins that bind to intracellular membranes and promote remodeling and traff

60 y extended SNARE sequences at the surface of intracellular membranes and prompting our development of

61 he non-vesicular transfer of sterols between intracellular membranes and the plasma membrane.

62 e enzyme in order to modify the structure of intracellular membranes and use them for the constructio

63 2C interacts with both intracellular membranes and virus-specific RNAs and has

64 he spatial contribution of the cytoskeleton, intracellular membranes, and ATP-dependent active forces

65 vivo, appears to be tightly associated with intracellular membranes, and can bind to specific phosph

66 PDE3A1, which is localized to intracellular membranes, and PDE3A2, which is cytosolic,

67 iruses, including herpesviruses, envelope at intracellular membranes, and the effect of tetherin on s

68 ion of hepatitis C virus (HCV) RNA occurs on intracellular membranes, and the replication complex (RC

69 Intracellular membranes are critical for replication of

70 During dengue virus infection of host cells, intracellular membranes are rearranged into distinct sub

71 -1-P may function to recruit cPLA(2)alpha to intracellular membranes as well as allosterically activa

72 and exit cells and have been shown to cross intracellular membranes as well.

73 In group 1 cells intracellular membranes associated with t-tubular struct

74 The NF2 tumor suppressor gene encodes an intracellular membrane-associated protein, called merlin

75 to purified D3 and D5 phosphoinositides, the intracellular membrane association of pleckstrin-2 and c

76 fect on protein A synthesis, degradation, or intracellular membrane association.

77 cturally and mechanistically analogous to an intracellular membrane-attached contractile phage tail.

78 3 charge neutralizing point mutations at the intracellular membrane border and characterized them ele

79 zed by fatty-acid amide hydrolase (FAAH), an intracellular membrane-bound enzyme that also cleaves AM

80 most of the visible biota coming to rely on intracellular membrane-bound organelles.

81 uring infection chlamydial pathogens form an intracellular membrane-bound replicative niche termed th

82 nd that the APP TM helix is disrupted at the intracellular membrane boundary near the epsilon-cleavag

83 ectly associated with the plasma membrane or intracellular membranes but instead colocalizes with int

84 In cells, BAX targets several intracellular membranes but notably does not target the

85 ulation of misfolded SOD1 and its binding to intracellular membranes, but the role of endogenous MIF

86 Hundreds of proteins are anchored in intracellular membranes by a single transmembrane domain

87 -gammaB families can influence the shape of intracellular membranes by mediating intraluminal intera

88 rred protection against subsequent damage to intracellular membranes caused by photooxidative chemist

89 charged O2 (-) is unable to diffuse through intracellular membranes, cells express distinct SOD isof

90 Ryanodine receptors (RyRs) are intracellular membrane channels playing key roles in man

91 They biomineralize magnetosomes, intracellular membrane-coated magnetic nanoparticles, th

92 es; (iii) Planctomycetes, which possesses an intracellular membrane compartment, is placed at the bas

93 lasma membrane, whereas GLUT4 is retained in intracellular membrane compartments and does not display

94 n-1/Vps34/UVRAG protein complex is formed in intracellular membrane compartments as it is found witho

95 lut4, but not of IRAP, to insulin-responsive intracellular membrane compartments in 3T3-L1 adipocytes

96 l, its channel activity may be restricted to intracellular membrane compartments in these cells.

97 onium chloride is routinely used to alkalize intracellular membrane compartments under the assumption

98 ence cross-correlation spectroscopy data for intracellular membrane compartments, we show that the co

99 ng different transport pathways that connect intracellular membrane compartments.

100 eins have higher raft affinity than those of intracellular membranes, consistent with raft-mediated p

101 eptides such as adiponectin and recycling of intracellular membranes containing GLUT4 glucose transpo

102 Poliovirus infection remodels intracellular membranes, creating a large number of memb

103 ause the accumulation of free cholesterol in intracellular membranes, deplete endoplasmic reticulum c

104 egument-associated capsids to bud through an intracellular membrane derived from the cell's secretory

105 cells transduced with 3AB protein displayed intracellular membrane disruption; specifically, the for

106 tin-like conjugation systems that reorganize intracellular membranes during canonical autophagy are n

107 uration, including vesicular trafficking and intracellular membrane dynamics.

108 ranes of their own, disrupt or perforate the intracellular, membrane-enclosed compartment into which

109 While intracellular membrane expression of Abeta1-42 in APP48

110 activated only when H2O2 was present at the intracellular membrane face.

111 provide a mechanism to regulate the rate of intracellular membrane flow.

112 her enteroviruses, initiates a remodeling of intracellular membrane for genomic replication, the regu

113 ansfected cells demonstrated localization to intracellular membranes for E-Syt1 and to plasma membran

114 CIRV is more restricted in utilizing various intracellular membranes for replication.

115 describes a procedure to prepare a raft-like intracellular membrane fraction enriched for the trans-G

116 eticulum stress but was not found within the intracellular membrane fractions and may represent a new

117 , consistent with indiscriminate sampling of intracellular membranes from the cytosol rather than tra

118 SNARE proteins play a critical role in intracellular membrane fusion by forming tight complexes

119 y adapted to investigation of other types of intracellular membrane fusion by using appropriate alter

120 Our results suggest that the intracellular membrane fusion complex is designed to fus

121 complexes play essential roles in catalyzing intracellular membrane fusion events although the assemb

122 interact specifically to control and mediate intracellular membrane fusion events.

123 N-ethylmaleimide-sensitive factor (NSF), an intracellular membrane fusion factor.

124 s collectively suggest that the mechanism of intracellular membrane fusion induced by peripherin-2 an

125 Intracellular membrane fusion is mediated by the concert

126 ein receptors (SNAREs) form part of the core intracellular membrane fusion machinery, but it is uncle

127 e two universally required components of the intracellular membrane fusion machinery, SNARE and SM (S

128 Intracellular membrane fusion mediates diverse processes

129 tive factor (NSF) is known to be crucial for intracellular membrane fusion processes, but its role in

130 on machinery and mediate virtually all known intracellular membrane fusion reactions on which exocyto

131 syts might contribute to the specificity of intracellular membrane fusion reactions.

132 ns into SNARE complexes is required for many intracellular membrane fusion reactions.

133 Intracellular membrane fusion requires R-SNAREs and Q-SN

134 Intracellular membrane fusion requires SNARE proteins in

135 Sec1/Munc18 (SM) proteins activate intracellular membrane fusion through binding to cognate

136 nd target (t)-SNAREs play essential roles in intracellular membrane fusion through the formation of c

137 The SNARE complex acts centrally for intracellular membrane fusion, an essential process for

138 hment protein receptor) assembly may promote intracellular membrane fusion, an essential process for

139 achment protein receptors) are essential for intracellular membrane fusion, but the general mechanism

140 (SM) proteins are required for every step of intracellular membrane fusion, but their molecular mecha

141 SNAREs constitute the core machinery of intracellular membrane fusion, but vesicular SNAREs loca

142 ARE proteins and tethering complexes mediate intracellular membrane fusion, fission requires the pres

143 lies, and SM SNARE-binding proteins catalyze intracellular membrane fusion.

144 , likely underlying a universal mechanism of intracellular membrane fusion.

145 ein receptors (SNAREs) play central roles in intracellular membrane fusion.

146 SNARE complex formation is essential for intracellular membrane fusion.

147 physically link two apposed membranes before intracellular membrane fusion.

148 nesis of small seamless tubes occurs through intracellular membrane growth and directed vesicle fusio

149 Accumulation of misfolded proteins on intracellular membranes has been implicated in neurodege

150 of the endoplasmic reticulum (ER) and other intracellular membranes have important functions in cell

151 part explaining the association of AP-3 with intracellular membranes having less acidic phosphoinosit

152 tion efflux that would follow a titration of intracellular membrane-impermeant anions by the intracel

153 nd E(m) to the mean charge valency (z(x)) of intracellular membrane-impermeant anions, X(-)(i).

154 s set point of Vc was then determined by the intracellular membrane-impermeant solute content (X-i) a

155 the negative electrostatic surface charge of intracellular membranes in a way that renders the cell l

156 s the close contact between cell surface and intracellular membranes in muscle cells ensuring efficie

157 HID-1 is essential for its association with intracellular membranes in nematodes and PC12 cells.

158 C. elegans neuronal HID-1 resides on intracellular membranes in neuronal cell somas; however,

159 becomes accessible on the cytosolic side of intracellular membranes in order to interact with cytoso

160 ack a chaperone that precludes mSOD1 binding intracellular membranes in other cells.

161 pid for the translocation of cPLA(2)alpha to intracellular membranes in response to inflammatory agon

162 n light chain 3 (LC3), which are enriched at intracellular membranes in response to proteotoxic stres

163 luR5), is expressed on both cell surface and intracellular membranes in striatal neurons.

164 assembly of the viral replicase complexes on intracellular membranes in the host cells.

165 and its association with lipid droplets and intracellular membranes in transfected cells were abroga

166 cross contamination with other PM domains or intracellular membranes, in marked contrast to DRM that

167 The proteins localize to intracellular membranes including vacuoles that contain

168 dance of mGluR5 both on the cell surface and intracellular membranes, including the endoplasmic retic

169 Ras have revealed signaling on a variety of intracellular membranes, including the Golgi apparatus.

170 CV NS3/4A serine protease is associated with intracellular membranes, including the MAM, through memb

171 on of K-Ras from the PM and association with intracellular membranes, including the outer membrane of

172 (PAM) around the fungal arbuscule creates an intracellular membrane interface between the symbionts.

173 functions of C3 in all four locations (i.e. intracellular, membrane, interstitium and circulation) a

174 The assembly of RNA replication complexes on intracellular membranes is an essential step in the life

175 nionic porphyrins (for example, haem) across intracellular membranes is crucial to many biological pr

176 The fusion of intracellular membranes is driven by the formation of a

177 studies suggest that copper movement across intracellular membranes is mechanistically similar to th

178 However, the phospholipid asymmetry across intracellular membranes is not known.

179 imary phosphate group, acts only through the intracellular membrane leaflet and depends on the presen

180 th anionic lipids that are restricted to the intracellular membrane leaflet.

181 changer slc24a5 (nckx5) that localizes to an intracellular membrane, likely the melanosome or its pre

182 ligands, sortilin is primarily localized to intracellular membranes, limiting the formation of a cel

183 Replication, intracellular membrane localization, and packaging chara

184 r the mRNA untranslated regions or protein A intracellular membrane localization.

185 . recently propose in Cell that expansion of intracellular membrane microdomains induced by saturated

186 owth, RNA synthesis, protein expression, and intracellular membrane modifications.

187 suggests a model in which the SM content of intracellular membranes modulates the secretion of nasce

188 h PLCdelta(4) protein localized primarily to intracellular membranes mostly to the endoplasmic reticu

189 rain mGluR5 is localized on cell surface and intracellular membranes, neither the presence nor physio

190 rans-Golgi network and are a key part of the intracellular membrane network.

191 Positive-strand RNA viruses reshape the intracellular membranes of cells to form a compartment w

192 ons in which DAG is evenly distributed among intracellular membranes of HEK293 cells.

193 s in which DAG is randomly distributed among intracellular membranes of HEK293 cells.

194 which hijack this cellular enzyme to remodel intracellular membranes of infected cells to set up the

195 To determine whether mGluR5 signals from intracellular membranes of other cell types, such as exc

196 was functionally competent and localized to intracellular membranes of yeast, suggesting that Ca(2+)

197 RNA [(+)RNA] viruses replicate their RNA on intracellular membranes, often in association with spher

198 mical probes with targeted affinity for DNA, intracellular membranes or the plasma membrane.

199 proteomic analysis provided a global view of intracellular membrane organization.

200 oinositides play important roles in numerous intracellular membrane pathways.

201 d redistribution of endogenous ergosterol to intracellular membranes, phenotypes that are Kes1p depen

202 confluent cell cultures, PTPmu resides in an intracellular membrane pool; however, as culture density

203 lation, beta-NAD and ATP were compared using intracellular membrane potential and force measurements.

204 potential timing is in contrast to the large intracellular membrane potential depolarizations observe

205 with vascular hyperpolarization, as shown by intracellular membrane potential measurements.

206 hybrid model, demonstrate that it generates intracellular membrane potential profiles that closely m

207 Here we combined intracellular membrane potential recordings in cat V1 wi

208 During dilation, the intracellular membrane potential was desynchronized, sen

209 anoelectrodes, and can simultaneously record intracellular membrane potentials from hundreds of conne

210 tors mediate docking, the initial contact of intracellular membranes preceding bilayer fusion.

211 seases, including type 1 diabetes (T1D), are intracellular membrane proteins, whose initial encounter

212 asmic tail of the ligand Jagged1, one in the intracellular membrane proximal region and the other nea

213 Ibbeta, and GPIX subunits, revealed that the intracellular membrane-proximal calmodulin-binding regio

214 inus of both alpha(IIb) and beta(3) TMs, the intracellular membrane-proximal regions, and the whole c

215 ytokine-receptor interactions are modulating intracellular membrane-proximal signaling events.

216 and may play a 2BL role in the induction of intracellular membrane rearrangements associated with po

217 arker for caveolae, in both cell-surface and intracellular membrane regions.

218 has been implicated in a variety of distinct intracellular membrane remodeling events.

219 have emerged: defects in (i) sarcolemmal and intracellular membrane remodelling and excitation-contra

220 n of cells with poliovirus induces a massive intracellular membrane reorganization to form vesicle-li

221 Intracellular membrane reorganization to support viral R

222 sembly of viral RNA replication complexes on intracellular membranes represents a critical step in th

223 iferative phase followed by expansion of the intracellular membrane secretory network to support Ig p

224 ic residues with the lipid headgroups at the intracellular membrane-solution interface reduce the mem

225 These findings indicate that functions at intracellular membranes, specifically those of the endop

226 In most of the group 2 cells, a faint intracellular membrane staining was observed.

227 y mobilizing Glut4 glucose transporters from intracellular membrane storage sites to the plasma membr

228 s infection results in the disintegration of intracellular membrane structures and formation of speci

229 crophages, HIV-1 Gag localizes to convoluted intracellular membrane structures termed virus-containin

230 Dengue virus induces several distinct intracellular membrane structures within the endoplasmic

231 ation, likely through signal transduction on intracellular membrane structures.

232 ution of c-Src, causing it to partition into intracellular membrane subdomains, where it likely becom

233 their genomes in association with rearranged intracellular membranes such as single- or double-membra

234 occurrence of preBCR signal propagation from intracellular membranes such as the endoplasmic reticulu

235 presence of PDZ domain proteins attached to intracellular membranes suggests that PDZ-type interacti

236 er leading to an open activation gate at the intracellular membrane surface and the intracellular C-t

237 its form a 350-kilodalton gating ring at the intracellular membrane surface.

238 tric charge density on the extracellular and intracellular membrane surfaces.

239 expression in a prokaryotic host lacking any intracellular membrane system drives the formation of cy

240 in form and function is displayed among the intracellular membrane systems of different eukaryotes.

241 The pathway between canalicular and intracellular membranes that BSEP constitutively cycles

242 uires recruitment of rab11a and myosin Vb to intracellular membranes that contain apical ABC transpor

243 in-lipid interaction between this enzyme and intracellular membranes that inhibits catalytic activity

244 anes exposed to the extracellular space from intracellular membranes; the second interrogated the ori

245 eases in Golgi diacylglycerol, allowing this intracellular membrane to serve as a platform for signal

246 f large cytoplasmic DNA viruses, rely on the intracellular membranes to develop their envelope, and p

247 endomembranes to maintain G protein pools in intracellular membranes to establish direct communicatio

248 Positive-sense RNA viruses remodel intracellular membranes to generate specialized membrane

249 Many RNA viruses remodel intracellular membranes to generate specialized sites fo

250 they need to translocate from the cytosol to intracellular membranes to participate in glycerolipid s

251 slocation of GLUT4 glucose transporters from intracellular membranes to the cell surface.

252 distributing GLUT4 glucose transporters from intracellular membranes to the cell surface.

253 icles, is well characterized for its role in intracellular membrane traffic and endocytosis from the

254 smitter release with those of other types of intracellular membrane traffic and, in turn, support a r

255 ort the emerging recognition that defects in intracellular membrane traffic are a significant cause o

256 simian immunodeficiency virus (SIV) subvert intracellular membrane traffic as part of their replicat

257 Rab guanosine triphosphatases regulate intracellular membrane traffic by binding specific effec

258 These data point to a role for spastin in intracellular membrane traffic events and provide furthe

259 Clathrin plays important roles in intracellular membrane traffic including endocytosis of

260 machinery have homologues in other types of intracellular membrane traffic, likely underlying a univ

261 function to dissect the role of clathrin in intracellular membrane traffic.

262 ransport is a general mechanism that governs intracellular membrane trafficking along the endocytic a

263 ularly the endoplasmic reticulum, as well as intracellular membrane trafficking and distribution as p

264 otein functioning in membrane tubulation for intracellular membrane trafficking and specific organell

265 ylinositol 3-kinase Vps34 complexes regulate intracellular membrane trafficking in endocytic sorting,

266 Intracellular membrane trafficking of glutamate receptor

267 transferase, plays a significant role in the intracellular membrane trafficking of Wnt3 and subsequen

268 a cellular degradation process involving an intracellular membrane trafficking pathway that recycles

269 Circumstantial evidence suggests that intracellular membrane trafficking pathways diversified

270 4 is involved in the control of multiple key intracellular membrane trafficking pathways including en

271 Intracellular membrane trafficking requires correct and

272 It plays an essential role in most intracellular membrane trafficking through its binding t

273 provide evidence that cholesterol regulates intracellular membrane trafficking via modulation of the

274 measures, provides a novel tool for studying intracellular membrane trafficking, and presents a new p

275 Neurons require highly specialized intracellular membrane trafficking, especially at synaps

276 at 18 degrees C, which blocks some forms of intracellular membrane trafficking, inhibited PKC- and P

277 esses such as receptor-mediated endocytosis, intracellular membrane trafficking, pro-hormone processi

278 play a fundamental role in multiple steps of intracellular membrane trafficking.

279 specific type(s) and/or specific step(s) in intracellular membrane trafficking.

280 mes to evaluate the impact of cholesterol on intracellular membrane trafficking.

281 ptors) are two key protein components of the intracellular membrane-trafficking machinery.

282 Autophagy, a unique intracellular membrane-trafficking pathway, is initiated

283 icking events and their integration with the intracellular membrane transport machinery are virtually

284 roton pump (H(+),K(+)-ATPase) from a pool of intracellular membranes (tubulovesicles) to the apical p

285 with the notion that mGluR5 can signal from intracellular membranes, uncaging glutamate on a CA1 den

286 trand RNA viruses replicate their genomes on intracellular membranes, usually in conjunction with vir

287 in muscle and adipose tissues by recruiting intracellular membrane vesicles containing the glucose t

288 Intracellular membrane vesicles containing the GLUT4 glu

289 zing virus-derived RNAs and are localized to intracellular membranes via an unknown mechanism.

290 ion, active Rab proteins need to localize to intracellular membranes via posttranslationally attached

291 When intracellular membranes were separated over a linear suc

292 roscopy reveals the accumulation of aberrant intracellular membranes when LpxB is overexpressed.

293 amate receptor, mGlu5, are also localized on intracellular membranes where they can mediate both over

294 tor 5 (mGluR5), are also highly expressed on intracellular membranes where they serve unknown functio

295 L to move from the cytosol to the plasma and intracellular membranes, where it directly disrupts memb

296 PV16 L2 are exposed on the cytosolic side of intracellular membranes, whereas an epitope within resid

297 mu-opioid receptors in both sarcolemmal and intracellular membranes, whereas M2-mAChR were detected

298 , image PLD activity in disease, and remodel intracellular membranes with new functionality.

299 tween the FAC1 globular catalytic domain and intracellular membranes, with N-terminal transmembrane a

300 In D. discoideum, the receptor was found on intracellular membranes, with prominent localization to