ライフサイエンスコーパス: intracellular protein

1 However, WT1 is a currently undruggable, intracellular protein.

2 ng possibility that NKG2E may function as an intracellular protein.

3 n (IFN)-alpha/beta-inducible, ubiquitin-like intracellular protein.

4 ubiquitous detection of MR1 transcripts and intracellular protein.

5 responsible for the regulated degradation of intracellular proteins.

6 ck copolymer formulation as a tool to target intracellular proteins.

7 inked beta-N-acetylglucosamine (O-GlcNAc) on intracellular proteins.

8 ator for quantification of other surface and intracellular proteins.

9 identification of AX-mediated haptenation of intracellular proteins.

10 interactions, and/or trafficking of numerous intracellular proteins.

11 that involves the recruitment and fusion of intracellular proteins.

12 C-terminus (GIPC) link RGS19 to a variety of intracellular proteins.

13 me pathway for the controlled degradation of intracellular proteins.

14 s single-cell measurement of 30+ surface and intracellular proteins.

15 to glial cells and cause the aggregation of intracellular proteins.

16 vealed 67 GalNAz-labeled proteins, including intracellular proteins.

17 oteasome system catalyzes the degradation of intracellular proteins.

18 ly regulated by a number of cell surface and intracellular proteins.

19 ciated proteins, cell membrane proteins, and intracellular proteins.

20 on of peptides derived from a limited set of intracellular proteins.

21 S-nitrosylates cysteine residues in diverse intracellular proteins.

22 of the proteasome is targeted degradation of intracellular proteins.

23 channels via modification of thiol groups of intracellular proteins.

24 e acetylation status of histones and various intracellular proteins.

25 age between integrins' cytoplasmic tails and intracellular proteins.

26 or NACHT-leucine-rich repeat (NLR) family of intracellular proteins.

27 igase involved in proteasomal degradation of intracellular proteins.

28 ain (tail) serves as a scaffold for numerous intracellular proteins.

29 beta has the capacity to interact with other intracellular proteins.

30 hat are classically associated with immature intracellular proteins.

31 apacity versus proteasome load of undegraded intracellular proteins.

32 tures, T-cell receptors (TCRs) can recognize intracellular proteins.

33 ignals from the extracellular environment to intracellular proteins.

34 without knowledge of cell-surface markers or intracellular proteins.

35 main conformations that selectively activate intracellular proteins.

36 responsible for the regulated degradation of intracellular proteins.

37 activity of DAT are regulated by a number of intracellular proteins.

38 de correlated signaling information on total intracellular protein abundance and subcellular protein

39 ation, lower autophagic capacity, and higher intracellular protein abundance phenotypes of aged and S

40 However, because temporal changes in intracellular protein abundances cannot be measured dire

41 cylation) integrates glucose metabolism with intracellular protein activity and localization.

42 on of the targeted mRNA and of corresponding intracellular protein activity was achieved.

43 UMO (small ubiquitin-like modifier) to other intracellular proteins affects a broad range of nuclear

44 e CHMP2B, resulting in autophagy impairment, intracellular protein aggregate accumulation, unfolded p

45 Reactivation of intracellular protein aggregates after a severe stress i

46 Intracellular protein aggregates are a pathological hall

47 hibit reduced mitotic potential, and display intracellular protein aggregates as compared to cells fr

48 Healthy metazoan cells effectively eliminate intracellular protein aggregates, indicating that effici

49 To avoid the build-up of potentially toxic intracellular protein aggregates, the timing and locatio

50 ation due to the rapid accumulation of large intracellular protein aggregates.

51 Intracellular protein aggregation is a common pathologic

52 n of wild-type, but not mutant, LSS prevents intracellular protein aggregation of various cataract-ca

53 s possible that any therapeutic that reduces intracellular protein aggregation will benefit all.

54 o digest the polyQ tract, which can initiate intracellular protein aggregation, preventing polyQ pept

55 is a well characterized system for degrading intracellular proteins, although many aspects remain poo

56 ve system to screen for molecules inhibiting intracellular protein amyloidogenesis in vivo, by testin

57 ll penetrating peptide applicable to achieve intracellular protein and gene delivery.

58 In this article, we show that Itfg2 is an intracellular protein and it plays a critical role in B

59 ane sorting principle that may contribute to intracellular protein and lipid sorting and trafficking.

60 ved cellular process for bulk degradation of intracellular protein and organelles in lysosomes.

61 ication, web morphology, the distribution of intracellular protein and PI(4)P, along with cholesterol

62 oplasm inflicting hydroxyl radical attack on intracellular proteins and DNA.

63 The E3-ubiquitin ligase parkin ubiquitinates intracellular proteins and induces mitophagy.

64 ) plays a critical role in removing unwanted intracellular proteins and is involved in protein qualit

65 ain as well as by its interaction with other intracellular proteins and lipids.

66 l extraction and quantitative measurement of intracellular proteins and mRNA from a variety of cell t

67 induced by starvation to capture and degrade intracellular proteins and organelles in lysosomes, whic

68 athway that captures, degrades, and recycles intracellular proteins and organelles in lysosomes.

69 s the induction of autophagy, which delivers intracellular proteins and organelles sequestered in dou

70 hanisms, including physical association with intracellular proteins and post-translational modificati

71 tem has a central role in the degradation of intracellular proteins and regulates a variety of functi

72 rowth and survival autonomously by recycling intracellular proteins and/or organelles.

73 onoacylglycerols are required to be bound to intracellular proteins and/or to be rapidly converted to

74 The 14-3-3 family of intracellular proteins are dimeric, multifunctional adap

75 ne localization, yet it is unclear how these intracellular proteins are targeted to sites of synaptic

76 two main routes that cells use for degrading intracellular proteins are the ubiquitin-proteasome and

77 P3, of the NOD-like receptor (NLR) family of intracellular proteins, are expressed in innate immune c

78 These studies document major intracellular proteins associated with the cell surface

79 specific, live-cell, fluorescent labeling of intracellular proteins at high density for super-resolut

80 In this study, we identified intracellular protein ATP-binding cassette subfamily F m

81 up new opportunities for the development of intracellular protein-based anticancer treatment.

82 (CaMKII) in neuronal cells and recognize the intracellular protein biomarker tubulin.

83 riminate the extracellular proteins from the intracellular proteins by improving detection of activel

84 inciple, with refined extraction techniques, intracellular proteins can potentially be extracted with

85 he role of mammalian thioredoxin (Trx) as an intracellular protein cofactor is widely appreciated, it

86 kine is activated identically to IL-18 by an intracellular protein complex known as the inflammasome;

87 Intracellular protein complexes containing nucleic acids

88 Inflammasomes are intracellular protein complexes that drive the activatio

89 yeast strains by attenuating the changes in intracellular protein composition caused by aneuploidy.

90 MHC-I molecules expose the intracellular protein content on the cell surface, allow

91 following necrosis, GAPDH and numerous other intracellular proteins convert into an insoluble disulfi

92 ition of 300 mOsm mannitol), which increases intracellular protein crowding.

93 Here we show that intracellular protein degradation and endosomal acidific

94 ellular composition of the immune system and intracellular protein degradation contribute to impaired

95 Facile control of targeted intracellular protein degradation has many potential use

96 em represents the major pathway of selective intracellular protein degradation in eukaryotes.

97 ypothesis that AMPK serves as a modulator of intracellular protein degradation in the heart.

98 A major fraction of intracellular protein degradation is mediated by the pro

99 ysosome-autophagy pathways are the two major intracellular protein degradation systems that work coop

100 system is the major pathway of non-lysosomal intracellular protein degradation, playing an important

101 y important role for p97/VCP is facilitating intracellular protein degradation.

102 teasome system (UPS) is a major mechanism of intracellular protein degradation.

103 noacrylate nanoparticles are thus useful for intracellular protein delivery in vitro and have potenti

104 One type of intracellular protein detected specifically in RA joints

105 ut ways in which neurotransmission regulates intracellular protein disposition.

106 alized by nanofabrication, a method to track intracellular protein dynamics in real-time, in situ and

107 ceptor (GPCR) causes recruitment of multiple intracellular proteins, each of which can activate disti

108 al tags that can be used to covalently label intracellular proteins efficiently in living cells.

109 ss I molecules present peptides derived from intracellular proteins, enabling immune surveillance by

110 cell populations based upon the presence of intracellular protein epitopes would enable many types o

111 otease complex that degrades a wide range of intracellular proteins, especially those modified with u

112 TMEM176B is an intracellular protein expressed in ATDCs and initially i

113 P311, a conserved 8-kDa intracellular protein expressed in brain, smooth muscle,

114 precise mechanisms by which deficiency of an intracellular protein expressed primarily in the differe

115 discrete groups on the basis of high or low intracellular protein expression and virion release.

116 ant TGF-beta1 increased PAI-1 transcription, intracellular protein expression, and secretion.

117 However, unlike intracellular protein fate, intrinsic factors determinin

118 We show that Dact1, an intracellular protein, forms a complex with Vangl2.

119 mediated proteolytic cleavage, releasing the intracellular protein fragment CD44-ICD, which transloca

120 that electroporation is capable of releasing intracellular proteins from adherent Chinese hamster ova

121 Extraction of intracellular proteins from cells is often an important

122 This is a unique mechanism for inhibiting an intracellular protein function and the structural contus

123 Hs, can serve as inhibitors or activators of intracellular protein function, but functional testing o

124 reversible, and dose-dependent control over intracellular protein function.

125 Additionally, while several intracellular proteins function as c-di-AMP receptors in

126 Intracellular protein gradients are significant determin

127 Intracellular protein gradients underlie essential cellu

128 patial control of division site placement by intracellular protein gradients, under simplified condit

129 t to the application of 5ECdsAP1 aptamer for intracellular protein-guided imaging and modulation of g

130 The Kindlin family of intracellular proteins has recently emerged as key regul

131 poly-(ADP-ribose) polymerase 14 (PARP14), an intracellular protein highly expressed in lymphoid cells

132 The intracellular protein HMGB1 is released from cells and a

133 ranslational stress response to maintain the intracellular protein homeostasis.

134 ptor is not secreted but is maintained as an intracellular protein in B cells where it interacts with

135 her, we provide mechanistic insights of this intracellular protein in matrix mineralization.

136 association of GPIbbeta with an unidentified intracellular protein in mediating regulation of GPIbalp

137 or elucidating the structure and function of intracellular proteins in cell biology.

138 These numbers suggest that intramembrane and intracellular proteins in isolated oxygenic photosynthet

139 e showed that the probe specifically labeled intracellular proteins in live cells without and with wa

140 d extracellular spaces, and association with intracellular proteins in liver and kidney.

141 half-life and can readily label a variety of intracellular proteins in living cells.

142 In this review, I highlight a series of intracellular proteins in quiescent T cells that functio

143 Matrix metalloproteinase-2 proteolyzes intracellular proteins in the heart and induces acute my

144 ng the relative phosphorylation levels of 39 intracellular proteins in untreated, cetuximab, dasatini

145 ariable levels of specificity to hundreds of intracellular proteins in vitro.

146 adducts enhance metal-catalyzed oxidation of intracellular proteins in vivo by use of live cell imagi

147 foundly affect interactions between ASOs and intracellular proteins in ways that are only beginning t

148 hock proteins are known to stabilize several intracellular proteins, including defense-related signal

149 he ubiquitin-proteasome system degrades most intracellular proteins, including misfolded proteins.

150 Here we investigate the intracellular protein interaction network of the transme

151 pSITE-BiFC and pSITEII vectors for studying intracellular protein interaction, localization and move

152 aryotic cells and involved in a multitude of intracellular protein interactions.

153 y 3 domain-bearing protein Intersectin 1, an intracellular protein involved in synaptic vesicle cycli

154 omerization domain-like receptors (NLRs) are intracellular proteins involved in innate-driven inflamm

155 ity to alter the basal expression of various intracellular proteins involved in regulating cell growt

156 eracting protein 1 (TRIP-1), a predominantly intracellular protein is localized in the ECM of bone.

157 ound on the serine and threonine residues of intracellular proteins is an inducible post-translationa

158 Alterations in O-GlcNAc modification of intracellular proteins is linked to diabetes, and the in

159 Post-translational palmitoylation of intracellular proteins is mediated by protein palmitoylt

160 Coupling of cellular prion protein to these intracellular proteins is modified by soluble amyloid-be

161 ivator of canonical WNT signaling and, as an intracellular protein, it helps to maintain precursor ce

162 ound that taurine enhanced K(V) channels via intracellular protein kinase C-mediated pathways.

163 extracytoplasmic domain (ectodomain) and an intracellular protein kinase domain involved in downstre

164 Focal adhesion kinase is an intracellular protein kinase that plays critical roles i

165 eins, generating hypotheses for differential intracellular protein kinases A and C signaling pathways

166 the LPS-elicited phosphorylation of multiple intracellular protein kinases.

167 iotensin II activation of Tyk2 increased the intracellular protein level of Cx43 via STAT3.

168 e absence of TF oscillations under same mean intracellular protein level of TF.

169 Intracellular protein levels of diverse transcription fa

170 two-component systems and used them to drive intracellular protein levels to match user-defined refer

171 he technologies available for the control of intracellular protein levels with small molecules and co

172 the extracellular domain of integrins and to intracellular proteins like paxillin and FAK, suggesting

173 In this protocol, surface and intracellular protein markers can also be stained with f

174 d with iTRAQ labeling, SNO-RAC revealed that intracellular proteins may undergo rapid denitrosylation

175 is was used to quantify changes in levels of intracellular proteins, measure reactive oxygen species

176 d-beta oligomer-triggered phosphorylation of intracellular protein mediators and impairment of synapt

177 r (Abetao) regulates the association between intracellular protein mediators and the synaptic recepto

178 e metabotropic glutamate receptor 5 with the intracellular protein mediators Homer1b/c, calcium/calmo

179 ond to environmental cues while also sensing intracellular protein misfolding.

180 The intracellular proteins MMACHC and MMADHC play important

181 that functions in innate immunity both as an intracellular protein modifier and as an extracellular s

182 Intracellular protein motors have evolved to perform spe

183 However, little is known about the intracellular proteins necessary for channel function.

184 he novel markers identified in our study are intracellular proteins not previously identified in the

185 em are conformational epitopes of ubiquitous intracellular proteins not specific to brain tissue.

186 logous to protein phosphorylation; increased intracellular protein O-GlcNAc modification has been obs

187 fuel an indispensable dynamic regulation of intracellular protein O-GlcNAcylation at key stages of T

188 r concentrations of UDP-GlcNAc and increased intracellular protein O-GlcNAcylation controlled by the

189 (GlcNAc) to serine and threonine residues of intracellular proteins (O-GlcNAc), regulates food intake

190 Intracellular proteins of interest were labeled with flu

191 Plants and animals use intracellular proteins of the nucleotide-binding domain,

192 signals from various membrane receptors and intracellular proteins onto the actin cytoskeleton.

193 nsduction domain (PTD), to achieve effective intracellular protein or gene delivery in clinical pract

194 The intracellular protein p120 catenin aids in maintenance o

195 Association of GPCRs with intracellular protein partners might be one of the mecha

196 e extension and retraction processes through intracellular protein phosphorylation of numerous cytosk

197 PAMP responses include changes in intracellular protein phosphorylation, including the act

198 lent attachment of ubiquitin (Ub) to various intracellular proteins plays important roles in altering

199 Lipin1, an intracellular protein, plays critical roles in controlli

200 the pMHC I repertoire is a reflection of the intracellular protein pool.

201 osphorylation and OGlcNAcylation are dynamic intracellular protein post-translational modifications t

202 onspecific weak attractive interactions with intracellular proteins prior to substrate recognition.

203 Surprisingly, despite these differences in intracellular protein processing, the T cell and antibod

204 tor-sensed input signals affect and modulate intracellular protein-protein interactions (PPIs).

205 loping cyclic peptides for the inhibition of intracellular protein-protein interactions and of direct

206 ed a peptide-based therapy aimed at blocking intracellular protein-protein interactions during EGFR s

207 We hypothesize that intracellular protein-protein interactions mediated via

208 nstrate robust and quantitative detection of intracellular protein-protein interactions.

209 de MCoTI-I an optimal scaffold for targeting intracellular protein-protein interactions.

210 n their target proteins, and thereby mediate intracellular protein-protein interactions.

211 ptides into potential therapeutics targeting intracellular protein-protein interactions.

212 of the alpha/beta-peptide approach to target intracellular protein-protein interactions.

213 ologs function directly with 20S to maintain intracellular protein quality control.

214 nucleotide exchange factor system assists in intracellular protein (re)folding.

215 performed to assess changes in the levels of intracellular proteins, reactive oxygen species (ROS), a

216 Consistent with this pattern of intracellular protein redistribution, impaired nucleocyt

217 nsequence of impaired phosphorylation of key intracellular proteins responsible for regulating the SR

218 rane integrins link extracellular matrix and intracellular proteins, resulting in bidirectional signa

219 anide to determine that under our conditions intracellular protein RSNO formation occurs from reactio

220 onical secreted subtilase [SBT5.2(a)] and an intracellular protein [SBT5.2(b)].

221 for single-cell studies to reliably identify intracellular proteins, secondary messengers, or metabol

222 tes with several transmembrane receptors and intracellular proteins serving as an anchoring molecule.

223 purpose of that technique was to reconstruct intracellular protein signaling networks.

224 x networks of biochemical reactions, such as intracellular protein signaling pathways and genetic net

225 Membrane fusion is essential for intracellular protein sorting, cell growth, hormone secr

226 xpression of IIp45 significantly reduces the intracellular protein stability of endogenous HDAC6, ind

227 first tier involves a genetic selection for intracellular protein stability that is based on the fol

228 Three-dimensional colocalization of intracellular protein structures and the cell surface wi

229 tively, of N-acetylglucosamine (GlcNAc) from intracellular protein substrates.

230 all proteins, danger signaling proteins, and intracellular proteins such as heat shock proteins and p

231 Covalent modifications of intracellular proteins, such as phosphorylation, are gen

232 n fluorescent protein (GFP) as a reporter of intracellular protein synthesis and degradation.

233 Y dye moiety as a component of probes for an intracellular protein target and highlight the importanc

234 and synucleinopathies, the normally soluble intracellular proteins tau and alpha-synuclein become in

235 This phenomenon was more pronounced for intracellular proteins than for connective tissue.

236 PRAME is an intracellular protein that cannot currently be drugged.

237 cytokine signaling 3 (SOCS3) is an important intracellular protein that inhibits cytokine signaling i

238 Talin is an intracellular protein that is critical for linking integ

239 P311 is an 8-kDa intracellular protein that is highly conserved across sp

240 Mammalian Nod2 is an intracellular protein that is implicated in the innate i

241 ain-containing protein 2 (NOD2/Card15) is an intracellular protein that is involved in the recognitio

242 Cyclophilin A (CypA) is an intracellular protein that is proinflammatory when relea

243 hough it can be secreted, vIL-6 is mainly an intracellular protein that is retained in the endoplasmi

244 Filamin A, an intracellular protein that stabilizes the actin cytoskel

245 olyamines is one of the few modifications of intracellular proteins that add positive charges.

246 ally described as self-peptides derived from intracellular proteins that are expressed at the cell su

247 ved that IL-32 is also able to interact with intracellular proteins that are involved in integrin and

248 t was used to label and subsequently isolate intracellular proteins that become exposed on the surfac

249 associated with the plant biomass releasing intracellular proteins that contaminate the metasecretom

250 -polymerase (PARP)-14 belongs to a family of intracellular proteins that generate ADP-ribose posttran

251 involved in folding and stabilizing multiple intracellular proteins that have roles in cell activatio

252 ransmembrane integrin adhesion receptors and intracellular proteins that link integrins to the actin

253 nown about the interactions between ASOs and intracellular proteins that may alter cellular localizat

254 Fatty acid-binding proteins (FABPs) are intracellular proteins that mediate AEA transport to its

255 enewing divisions, but the extracellular and intracellular proteins that regulate this process are la

256 ands were synthesized to selectively deliver intracellular protein therapeutics into tumor cells via

257 Previously, we developed an intracellular protein therapy that uses a recombinant ce

258 The glutathionylation of intracellular protein thiols can protect against irrever

259 trolled in vivo bioconjugation of a targeted intracellular protein to semiconductor quantum dots (QDs

260 understand the contributions of secreted and intracellular protein to the VSV-induced immune response

261 ave been proposed that link the mechanics of intracellular proteins to cell shape maintenance.

262 rstand what determines the susceptibility of intracellular proteins to degradation by the UPS, we dev

263 y interact with a relatively small number of intracellular proteins to induce profound physiological

264 Defective endosomal intracellular protein trafficking due to biallelic mutat

265 functional studies of Rpgr suggest a role in intracellular protein trafficking through the connecting

266 regulator of axonal morphology as well as of intracellular protein trafficking to the lysosome compar

267 Intracellular protein trafficking was pharmacologically

268 ike 1 (LEPROTL1) (two proteins that regulate intracellular protein trafficking) reduces GH receptor c

269 they participate in cell signaling including intracellular protein trafficking, cytoskeletal dynamics

270 nticipated role of physiological epoxides in intracellular protein trafficking.

271 cularly rich source of information regarding intracellular protein trafficking.

272 ated in NF-kappaB activation and possibly in intracellular protein trafficking.

273 er a distinct role of LRP6 as a platform for intracellular protein trafficking.

274 cyclotides inside live yeast cells by using intracellular protein trans-splicing in combination with

275 two species triggered calcium signaling and intracellular protein translocation events, respectively

276 t may have a vertebrate-specific function in intracellular protein transport and synaptic vesicle exo

277 s a coatomer protein complex responsible for intracellular protein transport between the endoplasmic

278 otein with dual functions, being involved in intracellular protein transport, as well as cellular sig

279 s I-II-III oxidative maturation required for intracellular protein transport.

280 nteraction controls different aspects of the intracellular protein triage decision, extending the fun

281 Spleen tyrosine kinase (SYK) is an intracellular protein tyrosine kinase involved in cell s

282 a microglial surface receptor that triggers intracellular protein tyrosine phosphorylation.

283 ions by phosphorylating tyrosine residues of intracellular proteins upon extracellular ligand binding

284 amic and inducible enzymatic modification to intracellular proteins utilizes the end product of the n

285 thought to play a role in cilia function and intracellular protein/vesicle trafficking.

286 We report that LRP1 binds intracellular proteins via its extracellular domain and

287 s is primarily ensured by the degradation of intracellular proteins via the ubiquitin-proteasome syst

288 the amplitude of the thermal denaturation of intracellular proteins was practically independent of fi

289 ase (p = 0.009), although levels of mRNA and intracellular protein were similar in aSS and healthy co

290 Synthesis and processing of viral intracellular proteins were largely unaltered in most co

291 in interactome has lagged far behind that of intracellular proteins, where mass spectrometry and yeas

292 p120-catenin is a multidomain intracellular protein, which mediates a number of cellul

293 rk paves the way to extracting and analyzing intracellular proteins while keeping cells live.

294 ) revealed that 6AzGlcNAc exclusively labels intracellular proteins, while GlcNAz and GalNAz are inco

295 Intracellular proteins whose expression is altered by th

296 m and integrin binding protein 1) is a small intracellular protein with numerous interacting partners

297 ly, we presented evidence that suggests that intracellular proteins with high expression in cancer ce

298 Intracellular proteins with long lifespans have recently

299 samine (O-GlcNAc) transferase (OGT) modifies intracellular proteins with N-acetylglucosamine.

300 OGT and AMPK target a multitude of intracellular proteins, with the net effect to protect c