ライフサイエンスコーパス: intracellular receptor

1 nding of Ins(1,4,5)P3 to its Ca2+-mobilizing intracellular receptor.

2 ion of the minor receptor subunit, with some intracellular receptor.

3 grammed switch from cell surface receptor to intracellular receptor.

4 it is degraded to a product recognized by an intracellular receptor.

5 receptors and Usp4 failing to rescue another intracellular receptor.

6 ceived at the plasma membrane rather than by intracellular receptors.

7 acting on membrane receptors or by acting on intracellular receptors.

8 asma membrane and causes a redistribution of intracellular receptors.

9 ate transcriptional activation via different intracellular receptors.

10 ere believed to act only on cells containing intracellular receptors.

11 g motifs in the cytosolic tails (C-tails) of intracellular receptors.

12 EGULATORY COMPONENTS OF ABA RECEPTORS (RCAR) intracellular receptors.

13 g of pathogen-associated "danger" signals by intracellular receptors.

14 to select ligand peptides and identify their intracellular receptors.

15 s others, such as Eps8, were found only with intracellular receptors.

16 alent or cross-linking fusion protein led to intracellular receptor accumulation.

17 The aryl hydrocarbon receptor (AhR) is an intracellular receptor activated by ligands important in

18 e may modulate serotonergic function through intracellular receptors, alpha (ER alpha) and/or beta (E

19 bout the molecular mechanism of recycling of intracellular receptors and lipid raft-associated protei

20 s, our findings suggest that either L2 or an intracellular receptor are cleaved by gamma secretase as

21 ll context in which it is expressed and that intracellular receptors are capable of translocation to

22 The activities of intracellular receptors are regulated by their cognate l

23 protein 4 (NSP4) is known to function as an intracellular receptor at the endoplasmic reticulum (ER)

24 proteins by plants is typically mediated by intracellular receptors belonging to the nucleotide-bind

25 led by limiting the access of DNA and RNA to intracellular receptors, but the mechanisms by which end

26 us, agonists elicit up-regulation (mainly of intracellular receptors) by interacting with cell surfac

27 s a member of the highly conserved family of intracellular receptors called immunophilins.

28 Binding of calcium to its intracellular receptor calmodulin (CaM) activates a fami

29 Binding of the peptidoglycan product to the intracellular receptor causes a proinflammatory response

30 II binding to MELADL by binding to different intracellular receptors, cholesterol to Scap and oxyster

31 ta-fold hydrolase, that is a component of an intracellular receptor complex involved in the detection

32 product ComS, is thought to be sensed by an intracellular receptor, ComR, after uptake by oligopepti

33 We sought to determine whether intracellular receptors constitute a static pool or repr

34 Intracellular receptor DAF-12 regulates dauer formation

35 CR cell surface receptor to that from the GR intracellular receptor, demonstrate the importance of th

36 The RIG-like helicase (RLH) family of intracellular receptors detect viral nucleic acid and si

37 n of Notch receptors leads to release of the intracellular receptor domain (Notch IC), which transloc

38 begun to be unraveled, implicating specific intracellular receptor domains and protein kinases in th

39 This observation suggests that multiple intracellular receptor domains form a binding pocket for

40 ned by sequences other than those located in intracellular receptor domains.

41 family can be determined by different single intracellular receptor domains.

42 side chains and increased flexibility at the intracellular receptor face as features that coincide wi

43 ved assembly motif may exist between the two intracellular receptor families.

44 and are mediated via binding of RAPA to its intracellular receptor FK506-binding protein 12 (FKBP12)

45 The complex of rapamycin with its intracellular receptor, FKBP12, interacts with RAFT1/FRA

46 Calmodulin (CaM) is the major intracellular receptor for Ca2+ and is responsible for t

47 Calmodulin is the main intracellular receptor for calcium.

48 Because the R subunit of PKA is the only intracellular receptor for cAMP, the abnormal isozyme ki

49 NPC1 is also the intracellular receptor for Ebola virus (EBOV).

50 ght be through a direct interaction with the intracellular receptor for estrogen, estrogen receptor a

51 The intracellular receptor for inositol 1,4,5-trisphosphate

52 ivate the transcription factor PPARgamma, an intracellular receptor for LPA, in CV1 cells transfected

53 r-activated receptor gamma (PPARgamma) as an intracellular receptor for LPA.

54 we show that full-length PGRP-LE acted as an intracellular receptor for monomeric peptidoglycan, wher

55 ties of Pto, which appears to function as an intracellular receptor for the AvrPto signal molecule.

56 rase FKBP12 was originally identified as the intracellular receptor for the immunosuppressive drugs F

57 RACK1 is an intracellular receptor for the serine/ threonine protein

58 kappaB and functions downstream of RIG-I, an intracellular receptor for viral RNA.

59 Fatty acid-binding proteins (FABPs) act as intracellular receptors for a variety of hydrophobic com

60 of the lysosomal proteins NPC1 and LAMP1 as intracellular receptors for Ebola virus and Lassa virus,

61 Cytoplasmic lipid-binding proteins are the intracellular receptors for hydrophobic ligands, deliver

62 e conditions led to the description of novel intracellular receptors for infectious and noninfectious

63 oteins 12 and 12.6 (FKBP12 and FKBP12.6) are intracellular receptors for the immunosuppressant drug F

64 Immunophilins are intracellular receptors for the immunosuppressants cyclo

65 in is a member of the "non-protein kinase C" intracellular receptors for the second messenger diacylg

66 amma-secretase leads to release of a soluble intracellular receptor fragment with functional activity

67 We selectively targeted the intracellular receptor-G protein interface by using cell

68 /Dvl proteins to interpret distinct types of intracellular, receptor-generated stimuli and transmit t

69 their many biological effects by binding an intracellular receptor (GR) that, in turn, translocates

70 In the intracellular receptor half, the bulkier L310(6.37) side

71 al CC chemokine receptor 1 pool (surface and intracellular receptors), however, showed no significant

72 ignaling pathway, and PPARgamma is the first intracellular receptor identified for LPA.

73 nals through TLR13; however, the most likely intracellular receptor in human subjects is TLR8.

74 ding and Western blot analyses indicate that intracellular receptor in normal rat kidney cells is fun

75 structural glycoprotein NSP4 functions as an intracellular receptor in the ER membrane, and it has be

76 d by the interaction of N-propeptide with an intracellular receptor in the secretory pathway, because

77 ing immunogold labeling was used to quantify intracellular receptors in segments of apical and basal

78 To find intracellular receptors involved in the JH response, we

79 Hsp90 and p23, interact with members of the intracellular receptor (IR) family.

80 rved in the zinc-binding region (ZBR) of the intracellular receptor (IR) superfamily; when it was mut

81 For example, hormone-bound intracellular receptors (IRs) nucleate formation of tran

82 e findings indicate that the distribution of intracellular receptors is related to that of synaptic r

83 ly characterized as an endoplasmic reticulum intracellular receptor, is a multifunctional viral enter

84 ted quisqualate or glutamate from activating intracellular receptors leading to Ca2+ responses.

85 alternative treatment approaches targeted to intracellular receptors might be of benefit in controlli

86 n is proteolytically primed and bound to its intracellular receptor, Niemann-Pick C1.

87 sults show a role for the microbiota and the intracellular receptor Nod2 in promoting the mucosal adj

88 rom memory T cells through activation of the intracellular receptor NOD2.

89 binding oligomerization domain (NOD) 2 is an intracellular receptor of bacterial peptidoglycan produc

90 Because protein kinase C (PKC) is the intracellular receptor of phorbol ester tumor promoters

91 Immunophilins are intracellular receptors of the immunosuppressants cyclos

92 The T6.34(279)K mutant displayed a higher intracellular receptor pool than the wild type.

93 endocytic exchange of surface receptors with intracellular receptor pools, and the lateral diffusion

94 ion, which quenches the pHluorin signal from intracellular receptor pools.

95 ent with rapid exchange of extracellular and intracellular receptor pools.

96 The large intracellular receptor population, and potential for fun

97 Importantly, the agonists also stabilized intracellular receptor precursors, possibly via their ph

98 regulates reproductive function through two intracellular receptors, progesterone receptor-A (PR-A)

99 The aryl hydrocarbon receptor (AhR) is an intracellular receptor protein that regulates gene trans

100 The modular nature of intracellular receptor proteins has allowed the recent d

101 he actions of these hormones are mediated by intracellular receptor proteins that act as ligand-activ

102 In metazoans, intracellular receptors recognize these molecules.

103 well as that IFN-inducible protein 16 is the intracellular receptor recognizing transfected DNA.

104 ivation of Janus kinases (Jaks) bound at the intracellular receptor region.

105 mined by recruitment of specific proteins to intracellular receptor signaling complexes.

106 R) plays a central role in the regulation of intracellular receptor signaling pathways by acting as a

107 ays a central role in the regulation of many intracellular receptor signalling pathways and can media

108 stimulates cGMP synthesis by activating its intracellular receptor, soluble guanylyl cyclase (sGC).

109 transported into the cell, can also activate intracellular receptors such as mGluR5.

110 ein interaction studies and the discovery of intracellular receptors, such as affinity-capture comple

111 Taking the intracellular receptor superfamily as a whole revealed a

112 nic factor 1 (SF-1), an orphan member of the intracellular receptor superfamily, plays an essential r

113 pronounced structural reorganization of the intracellular receptor surface.

114 nanobodies bind to epitopes displayed on the intracellular receptor surface; therefore, we transientl

115 Detecting pathogenic DNA by intracellular receptors termed "sensors" is critical tow

116 active complexes with members of a family of intracellular receptors termed the FK506 binding protein

117 tocyte nuclear factor 4 (HNF-4) is an orphan intracellular receptor that appears to be a key factor i

118 avirus nonstructural glycoprotein NSP4 is an intracellular receptor that mediates the acquisition of

119 omerization domain-containing 2 (NOD2) is an intracellular receptor that plays an essential role in i

120 r for the Toxoplasma protein profilin, is an intracellular receptor that resides in the endoplasmic r

121 e mitochondrial KATP channel is an important intracellular receptor that should be taken into account

122 Steroid hormones bind and activate intracellular receptors that are ligand-regulated transc

123 eproduction through stimulation of classical intracellular receptors that bind DNA and regulate gene

124 We hypothesized that VAPs serve as intracellular receptors that couple lipid homeostasis th

125 cAMP-dependent protein kinase (PKA) are two intracellular receptors that mediate the effects of the

126 Hippocampal GC actions are mediated by intracellular receptors that modulate the transcription

127 Nod proteins are intracellular receptors that play key roles in innate im

128 (NOD)-like receptors (NLRs) are a family of intracellular receptors that recognize conserved pattern

129 The inflammasome contains intracellular receptors that recognize various pathogen-

130 erentiation-associated gene 5 (MDA5) are key intracellular receptors that recognize virus infection t

131 receptors (NLRs) are a specialized group of intracellular receptors that represent a key component o

132 species involved a pH-dependent switch to an intracellular receptor, the lysosome-resident protein LA

133 n antagonist to progesterone's action at its intracellular receptor, these results support the involv

134 ow CpG ODN are captured and delivered to the intracellular receptor TLR9, however, has been elusive.

135 phosphate (Ins[1,4,5]P3), which binds to its intracellular receptor to mobilize intracellular calcium

136 icroscopy or cause obvious redistribution of intracellular receptor to the surface, suggesting that t

137 Inositol 1,4,5-trisphosphate (InsP3) acts on intracellular receptors to cause liberation of Ca2+ ions

138 Estradiol acts through both membrane and intracellular receptors to influence neuronal activity a

139 y an oligopeptide permease and interact with intracellular receptors to modulate gene expression.

140 ssically, progesterone acts through specific intracellular receptors to regulate gene expression.

141 xin was revealed to be due to recruitment of intracellular receptors to the cell surface upon agonist

142 synthesis inhibitors caused translocation of intracellular receptors to the cell surface, as shown by

143 CXCR2 plays an essential role in both proper intracellular receptor trafficking and efficient cellula

144 receptor by more than 85%, without affecting intracellular receptor trafficking back to the cell surf

145 es have been implicated in the regulation of intracellular receptor trafficking, and are known to bin

146 ted in the physiological function of RhoB in intracellular receptor trafficking, and these findings w

147 the central nervous system are mediated via intracellular receptor/transcription factors that intera

148 the central nervous system are mediated via intracellular receptor/transcription factors that intera

149 This suggests that ligand-specific intracellular receptor transport is required for chemoki

150 xtracellular (growth factor and insulin) and intracellular (receptor tyrosine kinases, Ras and Src) o

151 t impair hormone-dependent activation of the intracellular receptor tyrosine kinase (contained within

152 llular N-terminal ligand binding domains and intracellular receptor tyrosine kinase activity but reta

153 At the same time, the level of intracellular receptor was maintained at a constant leve

154 is assembly in the zinc binding domains from intracellular receptors, we systematically analyzed the

155 d no evidence for the existence of a pool of intracellular receptors, which could represent a recepto

156 mmals, drosophila use both extracellular and intracellular receptors, which have conserved signaling

157 its derivative, everolimus, act on specific intracellular receptors within lymphocytes, whereas othe