ライフサイエンスコーパス: intracellular retention

1 contained in this domain are unnecessary for intracellular retention.

2 as previously shown to be critical for GLUT4 intracellular retention.

3 tivation depends on EGFR internalization and intracellular retention.

4 tion of protein translation that exacerbated intracellular retention.

5 in domain of CLECSF8 was responsible for its intracellular retention.

6 he cell surface, resulting in their abnormal intracellular retention.

7 nship between vIL-6-calnexin interaction and intracellular retention.

8 G109R and R213W) secretion of mutant RS1 and intracellular retention.

9 ors and arrestin was not responsible for the intracellular retention.

10 lex-1 (AP-1) causes a delay in the return to intracellular retention after insulin withdrawal.

11 tation of the LL motif slows return to basal intracellular retention after insulin withdrawal.

12 c redistribution of Kv4.2, releasing it from intracellular retention and allowing plasma membrane exp

13 , whose product determines folate/antifolate intracellular retention and antifolate antitumor activit

14 trol from birth to P28 decreased mutant COMP intracellular retention and chondrocyte cell death, and

15 have in a dominant negative fashion, causing intracellular retention and degradation of wild-type cav

16 ding leading to an abnormal conformation and intracellular retention and elimination.

17 and provides an additional mechanism for the intracellular retention and insulin-stimulated release o

18 alpha(1D)-ARs) in most cell types results in intracellular retention and little or no functionality.

19 We examine here the requirements for intracellular retention and localization of vIL-6.

20 inges of C1r and C1s and are associated with intracellular retention and mild endoplasmic reticulum e

21 isrupted, thus alleviating both D469del-COMP intracellular retention and premature chondrocyte cell d

22 ically labeled cathepsin D indicated reduced intracellular retention and processing in the knockout c

23 protein stability, induced its high partial intracellular retention, and decreased its cell surface

24 resistance to degradation, and its enhanced intracellular retention are the major contributing facto

25 budding and forming particles, and hence its intracellular retention cannot be attributed to a cytoso

26 ric and heteromeric combinations that affect intracellular retention characteristics and protein stab

27 Attachment of MDDL to VSG results in intracellular retention confirming that MDDL is a trypan

28 ssion levels both in vitro and in vivo, with intracellular retention for p.P1824H.

29 Most XLRS-associated mutations cause intracellular retention, however a subset are secreted a

30 it to the plasma membrane are susceptible to intracellular retention in HIV-1 Nef-expressing cells.

31 Both mutant transporters exhibit enhanced intracellular retention in renal cells, an observation t

32 s distinct from WT) TNFRSF1A showed abnormal intracellular retention in the neutrophils of TRAPS pati

33 Intracellular retention is due to phosphorylation to ade

34 We assessed secretion/intracellular retention, multimerization, regulated stor

35 unchanged in infected cells, suggesting that intracellular retention occurred after peptide loading.

36 in Ig domains 0 and 1 (D0 and D1) causes the intracellular retention of 3DL1*004.

37 oncolysis increases over time, which limits intracellular retention of [(18)F]FHBG.

38 arboxyl terminus is the chief determinant of intracellular retention of a significant fraction of tot

39 -succinimidyl 3-iodobenzoate, SIPC increased intracellular retention of activity by up to 65%.

40 ecluded LTD and the underlying NMDAR-induced intracellular retention of AMPARs.

41 sm and H(2)O(2) production by decreasing the intracellular retention of As(2)O(3).

42 Intracellular retention of ATZ triggers a complex injury

43 terized p.R125C mutation, p.G257R results in intracellular retention of beta1B, generating a function

44 inting at role(s) for these complexes in the intracellular retention of CD4.

45 ow that the AP-3 complex is required for the intracellular retention of Chs3p.

46 lagen, causing VWD through dominant-negative intracellular retention of coexpressed wild-type (WT) VW

47 level was confirmed in both families by the intracellular retention of collagen XII in patient derma

48 PSACH is characterized by intracellular retention of COMP and other extracellular

49 hat an unpaired Cys1169 does not explain the intracellular retention of Cys1149Arg.

50 on of D469del-COMP in transgenic mice causes intracellular retention of D469del-COMP, thereby recapit

51 Here we tested whether intracellular retention of deltaR in sensory neurons con

52 ins cause MDR either by decreasing the total intracellular retention of drugs or redistributing intra

53 ated the first mouse model to show extensive intracellular retention of ECM proteins recapitulating t

54 es appear important for surface egression or intracellular retention of empty HLA-DR.

55 IFN-gamma increased the intracellular retention of fibrillar Abeta40 and Abeta42

56 erivatives, which are the forms required for intracellular retention of folates and are also the pref

57 human embryo kidney 293 cells, resulting in intracellular retention of gamma2.

58 mutants in COS-1 cells also resulted in the intracellular retention of GPIIb-IIIa, suggesting that i

59 eplacement with Glu, Lys, Pro, or Asn caused intracellular retention of GPIIb-IIIa.

60 Raji cells promoted the internalization and intracellular retention of HIV-1.

61 munofluorescence microscopy corroborated the intracellular retention of HLA-DR and revealed markedly

62 g that disulphide bonding contributes to the intracellular retention of I AAT.

63 nslational maturation of ULBP2, resulting in intracellular retention of immature ULBP2.

64 nduced AMPAR endocytosis, it is required for intracellular retention of internalized AMPARs.

65 expression systems and primary neurons, the intracellular retention of KA2 is not caused by subunit

66 rmore, TCR downmodulation is mediated by the intracellular retention of ligated complexes and degrada

67 stitution and showed that it resulted in the intracellular retention of malfolded alphaIIb beta3 hete

68 In conclusion, these data indicate that intracellular retention of mutant alpha1-ATZ is associat

69 This dysplasia results from the intracellular retention of mutant COMP protein and prema

70 ling of mutant receptors resulted in reduced intracellular retention of occupied EGF receptors and de

71 lar peptide binding, but is not required for intracellular retention of open conformers.

72 and little efflux after paclitaxel removal; intracellular retention of paclitaxel may contribute to

73 VWF, and the mutation was proposed to cause intracellular retention of pro-VWF heterodimers.

74 Internalization assays demonstrated that intracellular retention of radioactivity was up to 1.5-f

75 To identify factors that may function in the intracellular retention of rVWFR273W, we investigated th

76 s confirmed impaired secretion and increased intracellular retention of TE, and insoluble elastin ass

77 hibition appears to be mediated by increased intracellular retention of the CCR5 coreceptor- AOP-RANT

78 UL141 binding promotes intracellular retention of the DRs, thus protecting viru

79 t in cells becomes translated into prolonged intracellular retention of the drug.

80 de collection of yeast mutants for defective intracellular retention of the ER chaperone, Kar2p.

81 ing, it is not sufficient to account for the intracellular retention of the heterodimer.

82 Although intracellular retention of the majority of mutant matril

83 ts indicate the pathological basis of RS1 is intracellular retention of the majority of mutant protei

84 uption of the proximal region results in the intracellular retention of the MaxiK channel without aff

85 ell surface expression of ferroportin due to intracellular retention of the mutant protein.

86 l TRMA truncations are clustered resulted in intracellular retention of the mutant protein.

87 fluorescence analysis demonstrated increased intracellular retention of the mutant proteins.

88 ntified as mediating drug resistance, causes intracellular retention of the mutant proteins.

89 nd -4 (NL3 and NL4), respectively, result in intracellular retention of the mutant proteins.

90 nd these changes were weakly correlated with intracellular retention of the mutant receptors.

91 brane localization of the mK44 N-termini and intracellular retention of the pore-forming C-termini.

92 be shown to participate in MOR export by the intracellular retention of the receptor after small inte

93 show that mutations of the rLHR which cause intracellular retention of the receptor result in a decr

94 in misfolding of the D1 domain and complete intracellular retention of the receptor.

95 sociated heterozygous MC4R mutations lead to intracellular retention of the receptor.

96 on of AS160 and Na(+),K(+)-ATPase led to the intracellular retention of the sodium pump.

97 peptidase (IRAP), and ACBD3 was required for intracellular retention of these cargos in unstimulated

98 erologous cells show that there is prolonged intracellular retention of these mutants even though the

99 The intracellular retention of these protein complexes is me

100 restoration of BCR-ABL signaling mediated by intracellular retention of TKIs above a quantifiable thr

101 or disruption of bile production and causes intracellular retention of toxic bile constituents, incl

102 ysosomal fusion rates after invasion and the intracellular retention of trypomastigotes.

103 h elevated HIF1alpha levels, cell death, and intracellular retention of types II and X collagen.

104 ytoplasmic domains of UL16 are important for intracellular retention of UL16, whereas the ectodomain

105 ow that tumor cell-associated CEACAM1 causes intracellular retention of various NKG2D ligands in mous

106 Pathogenic intracellular retention of VWF lacking exons 33-34 cause

107 tive manner, causing the mislocalization and intracellular retention of WT Cav-1.

108 CD46 down-regulation was not attributable to intracellular retention or a global or specific shutdown

109 intersection of mechanisms that include: (1) intracellular retention or degradation of VWF, (2) defec

110 t increased membrane permeability, increased intracellular retention, or modulation of melphalan's me

111 e were used to test the local absorption and intracellular retention patterns of selected probes, in

112 -3/-7 from the C terminus that functions in intracellular retention prior to assembly with other Fce

113 In line with their intracellular retention, remaining currents of TRPC1 and

114 redistribution of this gelatinase, in which intracellular retention resulted in reciprocal extracell

115 o epilepsy through a mechanism that includes intracellular retention resulting in aberrant neuronal p

116 sociated with NKG2D(FL), which led to forced intracellular retention, resulting in decreased surface

117 he abundance of aquaporin 2 and enhanced its intracellular retention, suggesting impaired sensitivity

118 Some mutations resulted in intracellular retention, suggesting that the receptors w

119 , we decided to use 111In, which has greater intracellular retention than iodine.

120 nd analyses of Clr-a/Clr-f hybrids attribute intracellular retention to both the stalk region and par

121 se decreased Ca(2+) sensitivity or increased intracellular retention, traits that would not easily ex

122 estricted pool of peptides, resulting in its intracellular retention under normal conditions.

123 To understand what governs mutant intracellular retention, we generated a series of R345 m

124 h of the mutant proteins exhibit substantial intracellular retention when expressed in mammalian rena

125 s, FABP binding of EETs may facilitate their intracellular retention whereas the lack of FABP affinit

126 S is associated with a defect in biogenesis, intracellular retention, which is similar to but milder

127 86 in 3DL1*004 is the principal cause of its intracellular retention, with a secondary and additive c