ライフサイエンスコーパス: intracellular signal

1 balance, which may lead to the production of intracellular signals.

2 logies are driven by pheromone gradients and intracellular signals.

3 mbly of multiprotein complexes that transmit intracellular signals.

4 itions and produce homogeneous, steady-state intracellular signals.

5 r allosteric regulation of channel gating by intracellular signals.

6 gands and couple to G proteins that transmit intracellular signals.

7 riving polarization of membrane proteins and intracellular signaling.

8 surface receptors and subsequently activates intracellular signaling.

9 molecular events coupling ligand binding to intracellular signaling.

10 relationships between caveolae structure and intracellular signaling.

11 operties as an often-overlooked modulator of intracellular signaling.

12 since these receptors via ITAM contribute to intracellular signaling.

13 input into BAT and reduces beta3-adrenergic intracellular signaling.

14 enous participants in antigen processing and intracellular signaling.

15 living cells has revolutionized the study of intracellular signaling.

16 CypD), influenced endothelial metabolism and intracellular signaling.

17 fate commitment, depends almost entirely on intracellular signaling.

18 ich scavenges human chemokines and modulates intracellular signaling.

19 receptors (GPCRs) are intimately involved in intracellular signaling.

20 ard to G protein and beta-arrestin-dependent intracellular signaling.

21 ase, thereby serving as crucial mediators of intracellular signaling.

22 2)) levels; and RAGE, RAGE ligands, and RAGE intracellular signaling.

23 king FMRP show aberrant mRNA translation and intracellular signalling.

24 on but did not induce RANKL, suggesting that intracellular signaling activated by the low affinity in

25 be fully understood by genetic mutations or intracellular signaling alone.

26 n analog extracellular signal into a digital intracellular signal and that this conversion increases

27 te [PI(4,5)P2] is a well-known precursor for intracellular signaling and a bona fide regulator of act

28 ate how this MAPK-phosphatase might regulate intracellular signaling and cardiac growth dynamics in v

29 hange the fiber knob affinity to DSG2 or the intracellular signaling and DSG2 shedding in epithelial

30 ults show that total body irradiation alters intracellular signaling and epigenetic pathways regulati

31 tor protein (RKIP) is a seminal regulator of intracellular signaling and exhibits both antimetastatic

32 ction with TLRs, TIR serves to both initiate intracellular signaling and facilitate recruitment of si

33 omplications in the brain, thereby affecting intracellular signaling and gene expression that underli

34 ization of LAT by adapter complexes enhances intracellular signaling and is physiologically relevant.

35 P4pal-10 and FR900359 inhibited Gq-mediated intracellular signaling and primary human airway smooth

36 ipheral blood eosinophils were used to study intracellular signaling and protein translation in cells

37 7-expressing LNCaP cell clone showed altered intracellular signaling and reduced spheroid formation p

38 y (meSPIM) for imaging and quantification of intracellular signaling and submicrometer cellular struc

39 Phosphatidylinositol is critical for intracellular signalling and anchoring of carbohydrates

40 rentially responded to LTE4 when analysed by intracellular signalling and gene expression.

41 embrane 'Trigger' sequence therein, leads to intracellular signalling and rapid platelet clearance.

42 ane of most cells serve as key organizers of intracellular signalling and tethering points of cytoske

43 on and clustering is a prerequisite for TNFR intracellular signaling, and as m4-1BBL can only recruit

44 complex to phosphorylate the ITAMs, initiate intracellular signaling, and drive CD4(+) T cell fate de

45 n factors that are activated by receptor and intracellular signaling, and microRNAs which are small n

46 Dectin-1, a receptor that elicits TREM2-like intracellular signals, and cyclocreatine, a creatine ana

47 es and assimilates diverse environmental and intracellular signals, and it further transmits signals

48 Intracellular signaling antibody array analysis revealed

49 as metabolite exchange (Ca(2+) and lipids), intracellular signaling, apoptosis, and autophagy.

50 of genes involved in inflammatory responses, intracellular signalling, apoptosis and pathogen-induced

51 Mechanistically, ICAM-1-mediated intracellular signaling appeared to support neutrophil R

52 mechanically induced membrane damage and/or intracellular signaling are evaluated.

53 We show that intracellular signals are observed in motile and stabili

54 anoikis resistance pathway, focusing on the intracellular signals associated with integrins that mod

55 2, ErbB3/HER3, and ErbB4/HER4, which trigger intracellular signals at the origin of essential cellula

56 vents such as polarization, endocytosis, and intracellular signaling, but challenging to quantify usi

57 ted that efficient HIV entry also depends on intracellular signaling, but this remains controversial.

58 LPS-induced NF-kappaB reporter activity and intracellular signaling by NF-kappaB and MAPK pathways w

59 on in three of seven donors, suggesting that intracellular signaling by p17 may lead to genomic insta

60 myr-Akt mouse model for GBM are enriched for intracellular signaling cascade proteins (GO: 0007242) a

61 acellular domain of RAGE initiates a complex intracellular signaling cascade, resulting in the produc

62 , and CSF3), silencing of major inflammatory intracellular signaling cascades (STAT1, STAT3, STAT5, p

63 alpha (TNF-alpha) by initiating a variety of intracellular signaling cascades and is considered to be

64 hemical signals via adhesion, and integrates intracellular signaling cascades associated with cytoske

65 y to assess the role of KORs and KOR-coupled intracellular signaling cascades on reinstatement of nic

66 However, the intracellular signaling cascades that mediate the osteob

67 rs receptors (FGFRs) are thought to initiate intracellular signaling cascades upon ligand-induced dim

68 mbrane receptors P2Y1 and P2Y12, stimulating intracellular signaling cascades, leading to integrin al

69 ract with extracellular ligands to transduce intracellular signaling cascades, modulate target gene e

70 both lineage-specifying and cell-polarizing intracellular signaling cascades, Wnts can polarize cell

71 ive conformations to regulate a multitude of intracellular signaling cascades.

72 lar immunoglobulin (TrkAIg2) domain triggers intracellular signaling cascades.

73 nstream of cell-surface receptors to control intracellular signaling cascades.

74 The inflammasome is an intracellular signaling complex, which on recognition of

75 n these split receptors, antigen-binding and intracellular signaling components assemble only in the

76 tification of many recognition receptors and intracellular signaling components of efferocytosis, its

77 tributions of neurotransmitter receptors and intracellular signaling components.

78 g an unexpected specificity of selected GPCR intracellular signalling components.

79 geted" kinase inhibitors that interfere with intracellular signaling contributing to tumor progressio

80 Vascular endothelial (VE)-cadherin transfers intracellular signals contributing to vascular hemostasi

81 Initially, starvation-induced intracellular signals direct changes in gene expression.

82 ric cytokine receptors as a key regulator of intracellular signaling discrimination.

83 ta signaling domain (CAR) and one lacking an intracellular signaling domain (DeltaCAR).

84 nsgenic knock-in mice, where the IL-15Ralpha intracellular signaling domain was replaced with the int

85 This allows SPRY2 to inhibit intracellular signaling downstream of other receptor tyr

86 Intracellular signaling during oxidative stress is compl

87 However, the intracellular signaling effectors transducing its activa

88 at bud off from the cell surface to generate intracellular signaling endosomes.

89 membrane depolarization into precisely timed intracellular signaling events in the mammalian brain.

90 ortant role in controlling receptor-mediated intracellular signaling events, which have a central rol

91 ufficient to couple extracellular stimuli to intracellular signaling events.

92 , including neuronal damage, to induction of intracellular signaling events.

93 oss talk between extracellular ATP and JA in intracellular signaling events.

94 gnal transduction by controlling the fate of intracellular signaling factors.

95 cell polarity determinant, orchestrates the intracellular signaling for normal forgetting.

96 nd G-protein-coupled receptors and propagate intracellular signals for growth, survival, proliferatio

97 o suitable to convert synaptic activity into intracellular signals for synaptic modification.

98 Here we sought to investigate the intracellular signaling from cannabinoid 2 receptor (CB2

99 iverse immune cell functions by transmitting intracellular signals from Ag, costimulatory receptors,

100 assembly has been suggested to be induced by intracellular signals from CD36, similar to integrin ins

101 cal functions as, epidermal differentiation, intracellular signal function, transcriptional factors c

102 s including cell motility, intercellular and intracellular signaling, gene expression, and membrane i

103 anismal functions such as neuronal activity, intracellular signaling, gene expression, cell prolifera

104 e, but it is poised to rapidly assemble into intracellular signal-generating complexes as well.

105 nase (RLK or TXK) are essential mediators of intracellular signaling in both normal and neoplastic T-

106 ical microenvironment, contact guidance, and intracellular signaling in cell decision making.

107 e modulation of spatiotemporal regulation of intracellular signaling in intact cells and multicellula

108 lation of MsrB1 did not preclude LPS-induced intracellular signaling in macrophages, but resulted in

109 ity and female-specific resilience impacting intracellular signaling in the brain.

110 In response to intracellular signals in Gram--negative bacteria, transl

111 f electrical activity and the propagation of intracellular signals in neuronal networks.

112 esponse to a wide range of extracellular and intracellular signals, including cell-cell contact, cell

113 nteractions only turn productive by specific intracellular signal-induced intracellular domain modifi

114 ytic degradation of extracellular matrix and intracellular signaling initiated upon its binding to uP

115 We propose that this inter- and intracellular signaling is involved in triggering the re

116 sive dissociation of polyplexes triggered by intracellular signals is demonstrated.

117 Mac-1-dependent cell spreading and initiated intracellular signaling manifested in phosphorylation of

118 The intracellular signaling mechanisms involved in different

119 A presynaptic mechanism mediated by distinct intracellular signaling mechanisms may account for this

120 Understanding the intracellular signaling mechanisms that govern growth co

121 Little is known about intracellular signaling mechanisms that persistently exc

122 Our results identify a novel intracellular signaling module that synergistically regu

123 These data position CD2AP as a major intracellular signaling molecule coordinating NGF signal

124 lr), Apolipoprotein receptor 2 (Apoer2), and intracellular signaling molecule Disabled-1 (Dab1).

125 The intracellular signaling molecule Dishevelled (Dvl) media

126 ) is characterized by underexpression of the intracellular signaling molecule RhoH.

127 nosine monophosphate (c-di-GMP) is a dynamic intracellular signaling molecule that plays a central ro

128 as a result of variegated surface receptor, intracellular signaling molecule, and transcription fact

129 Moreover, we identified a novel intracellular signaling molecule, cAMP-response element

130 Very few studies addressed how intracellular signaling molecules differentially specify

131 TGFBIp also induced phosphorylation of intracellular signaling molecules SRC, FAK, AKT, JNK and

132 ween an epigenetic regulator, WHSC1, and key intracellular signaling molecules, AKT, RICTOR, and Rac1

133 eta through the timed activation of discrete intracellular signaling molecules, suggesting pathways i

134 n multiple stimuli, including the binding of intracellular signaling molecules.

135 through membrane-bound receptors and related intracellular signaling molecules.

136 phate (cGMP) are now recognized as important intracellular signalling molecules that modulate cardiac

137 Calcium ions are well-known intracellular signalling molecules.

138 n of approximately 50 pseudokinases, control intracellular signaling networks by catalyzing the phosp

139 of the kinetics, cellular distribution, and intracellular signaling networks of cosignaling molecule

140 Atrial function is regulated by a variety of intracellular signaling networks that facilitate rapid c

141 or human cancer cells is largely mediated by intracellular signaling networks that regulate viral rep

142 Migratory immune cells use intracellular signaling networks to generate and orient

143 The activation of complex intracellular signaling networks underlies these respons

144 horylation analysis may provide insight into intracellular signaling networks underlying tumor behavi

145 ersible fashion, hold promise for modulating intracellular signaling networks with high spatial and t

146 GF receptor and previously indistinguishable intracellular signaling networks, only TGF-alpha stimula

147 Despite its central position in oncogenic intracellular signaling networks, the role of mTORC1 in

148 Spatio-temporal regulation of intracellular signalling networks is key to normal cellu

149 Additive/competitive assays indicate that intracellular signaling-networks for multiple ligands ut

150 ic response based on a mathematical model of intracellular signaling of activator and inhibitor.

151 t defense mediated through activation of the intracellular signaling of jasmonate (JA), a well-charac

152 ermore, we found that the fumarase-dependent intracellular signaling of the B. subtilis DDR is achiev

153 the endosomal residence time and subsequent intracellular signaling of the beta2AR.

154 a receptors (FcgammaRs) classically modulate intracellular signaling on binding of the Fc region of I

155 d within AKT1, a member of the PI3K/AKT/MTOR intracellular signaling pathway activated in endometrial

156 g IGF-1R expression is sufficient to restore intracellular signaling pathway activation profile lying

157 ufficient to initiate the complex pattern of intracellular signaling pathway and gene expression prof

158 h levels of misfolded proteins in the ER, an intracellular signaling pathway called the unfolded prot

159 The ERK/MAPK intracellular signaling pathway is hypothesized to be a

160 The Nox2/TRX-1/NF-kappaB intracellular signaling pathway is involved in the patho

161 ging secretory needs, cells employ a dynamic intracellular signaling pathway known as the unfolded pr

162 lthough dependent on CD44, is mediated by an intracellular signaling pathway rather than as a competi

163 CD2AP with TrkA and p85 suggests a distinct intracellular signaling pathway regulating growth of non

164 There is decreased expression of the intracellular signaling pathway spleen tyrosine kinase (

165 entify a hitherto unrecognized Nox2-mediated intracellular signaling pathway that contributes to hype

166 The effects of these proteins converge on an intracellular signaling pathway that depends on a protei

167 ntegrated stress response (ISR), a universal intracellular signaling pathway that responds to a varie

168 However, the intracellular signaling pathway that senses dietary fat

169 However, the intracellular signaling pathway triggering Src activatio

170 permits the design of rational cytokine and intracellular signaling pathway-targeted therapeutics, r

171 Akt is an intracellular signalling pathway that serves as an essen

172 l transducer and activator of transcription) intracellular signalling pathway.

173 NFR ligands, CD70 has been shown to initiate intracellular signaling pathways (CD70 reverse signaling

174 ecent achievements in using light to control intracellular signaling pathways and discuss future pros

175 ssion, particularly in genes involved in key intracellular signaling pathways and genes mediating fea

176 pecific biological effects through different intracellular signaling pathways and has a complex prote

177 rTMD23 markedly suppressed the activation of intracellular signaling pathways and the production of i

178 h for new therapeutics aimed at manipulating intracellular signaling pathways and/or transcriptional

179 pes depending on their environment and which intracellular signaling pathways are activated.

180 Cytokine-mediated intracellular signaling pathways are fundamental for the

181 nisms connecting cell polarity proteins with intracellular signaling pathways are largely unknown.

182 out the molecular components involved in the intracellular signaling pathways by which [CO2] controls

183 Conversely, activation of intracellular signaling pathways coupled to mGluRI in D1

184 receptors on myelin, and the integration of intracellular signaling pathways emanating downstream fr

185 d understanding of the complex regulation of intracellular signaling pathways in CLL, currently a maj

186 stablished, and the molecular mechanisms and intracellular signaling pathways involved are not known.

187 However, the intracellular signaling pathways involved are unknown.

188 Although many of the intracellular signaling pathways involved in the proinfl

189 guanylate cyclase (NO-GC, sGC) and triggers intracellular signaling pathways involving cGMP.

190 l studies on MOR gene have not addressed how intracellular signaling pathways mediate extracellular m

191 homeostasis and, consequently, in modulating intracellular signaling pathways remains unclear.

192 by miR-200/Zeb1-dependent EMT that activate intracellular signaling pathways responsible for tumor c

193 -activated protein kinase 1 (MSK1)-ranges of intracellular signaling pathways similar to those activa

194 at is largely regulated by extracellular and intracellular signaling pathways that are central to cel

195 the gene targets of which were enriched for intracellular signaling pathways that are important to c

196 However, the intracellular signaling pathways that control these proc

197 ression of MOR gene requires the activity of intracellular signaling pathways that have been implicat

198 identified an RvD2/DRV2 axis that activates intracellular signaling pathways that increase phagocyto

199 ognize the secreted interferons and activate intracellular signaling pathways that induce the express

200 ly relevant mechanical signal that regulates intracellular signaling pathways throughout the tumor.

201 small molecules and dramatically stimulating intracellular signaling pathways to determine cell fate.

202 eptors on target cells, stimulating specific intracellular signaling pathways to facilitate appropria

203 tage-activated calcium (Cav) channels couple intracellular signaling pathways to membrane potential b

204 ive oxygen species, autophagy activation and intracellular signaling pathways were analyzed in Mincle

205 sequent activation of inhibitory (Gi-linked) intracellular signaling pathways within the basolateral

206 Eukaryotic cells evolved a set of intracellular signaling pathways, collectively termed th

207 mbination with agents that target oncogenic, intracellular signaling pathways, diagnostic pathologist

208 erabilities in receptor tyrosine kinases and intracellular signaling pathways, epigenetics, metabolis

209 increasing the capacity of IL-13 to activate intracellular signaling pathways, such as signal transdu

210 ell-specific manipulations through canonical intracellular signaling pathways, they are easy and cost

211 ow and fast neurotransmitter systems through intracellular signaling pathways-and may unify a number

212 ansmitted through the glycocalyx to initiate intracellular signaling pathways.

213 by the host innate immune system and related intracellular signaling pathways.

214 e and polarity to coordinate the activity of intracellular signaling pathways.

215 by aberrant activation of several well-known intracellular signaling pathways.

216 ss, cells must activate a series of adaptive intracellular signaling pathways.

217 portant second messengers in many inter- and intracellular signaling pathways.

218 xecution of these functions through multiple intracellular signaling pathways.

219 FRs reside and how they control such diverse intracellular signaling pathways.

220 tochondria are key integrators of convergent intracellular signaling pathways.

221 ulate a truly astonishing number of critical intracellular signaling pathways.

222 SR, which was associated with alterations in intracellular signaling pathways.

223 mes play critical roles in a wide variety of intracellular signaling pathways.

224 ial firing as critical components regulating intracellular signalling pathways and gene expression in

225 receptor expression and/or interactions with intracellular signalling pathways in native environments

226 s demonstrates that therapeutic targeting of intracellular signalling pathways that regulate the swit

227 nsed by lung cells and can activate specific intracellular signalling pathways, and thus have physiol

228 nstrates the potential of (31)P-NMR to probe intracellular signalling pathways.

229 ntegrins, this trafficking can also regulate intracellular signalling pathways.

230 not affect protein phosphorylation in other intracellular signalling pathways.

231 ating the extracellular microenvironment and intracellular signalling pathways.

232 aptor molecules that also activate different intracellular signalling pathways.

233 and neuromodulators, mitochondria behave as intracellular signal-processing networks.

234 hat mechanical cues and the diffusion of the intracellular signal produced by focal adhesions are det

235 How intracellular signals promote talin binding to the integ

236 and tight junctions and function to scaffold intracellular signaling protein complexes.

237 The intracellular signaling protein regulator of presynaptic

238 l evidence of an Eph receptor-class-specific intracellular signaling protein that is required for app

239 immune-inflammatory control, cell survival, intracellular signaling, protein and lipid homeostasis,

240 zinc finger (PLZF), as well as expression of intracellular signaling proteins FcepsilonRgamma, spleen

241 Post-translational modification of intracellular signaling proteins in these pathways is a

242 actor-beta (TGF-beta) network of ligands and intracellular signaling proteins is a subject of intense

243 or homologous factors (FHFs) are a family of intracellular signaling proteins linked with Nav channel

244 sing mass cytometry, we profiled surface and intracellular signaling proteins simultaneously in milli

245 ed many extracellular guidance molecules and intracellular signaling proteins that regulate axonal ou

246 face marker expression, activation states of intracellular signaling proteins, and cytokine productio

247 monoamine modulation with phosphorylation of intracellular signaling proteins.

248 APOL1 risk variant-induced dysregulation of intracellular signaling relevant for cell survival.

249 e extracellular TCR-pMHC interaction into an intracellular signal remains unknown.

250 nding events trigger receptor activation and intracellular signaling remains unclear.

251 sduce mechanical forces from blood flow into intracellular signals required for vascular homeostasis.

252 Moreover, engagement of this intracellular signaling route was functionally active in

253 Integrin-mediated changes of the intracellular signaling significantly affected the kinet

254 en the orthosteric drug binding site and the intracellular signaling surface, revealing strong intera

255 The calcium-based intracellular signalling system is used ubiquitously to

256 tects extracellular glucose and transmits an intracellular signal that induces expression of HXT gene

257 DSG2 with its fiber knob domain and triggers intracellular signaling that culminates in the cleavage

258 Here, we define the intracellular signaling that links ERalpha, mGluRs, and

259 equires the integration of extracellular and intracellular signals that converge on a competition bet

260 terial, fungal or viral components, activate intracellular signals that lead to protective inflammato

261 a costimulatory molecule on T cells, induces intracellular signals that mediate cellular activation,

262 core is one of the basic building blocks in intracellular signalling, the dual phosphorylation-depho

263 T-cell receptor (TCR) and LFA-1 can generate intracellular signals, the immune cell adaptor protein l

264 ltikinase (HsIPMK) critically contributes to intracellular signaling through its inositol-1,4,5-trisp

265 s, showing that BcR immunoglobulins initiate intracellular signalling through homotypic interactions

266 y mediators that propagate extracellular and intracellular signals through to changes in gene express

267 Attachment triggers intracellular signaling to change gene expression from t

268 ogical synapse affects synapse formation and intracellular signaling to impact the downstream T cell

269 cues of the underlying matrix geometry into intracellular signals to extend spreading, which endows

270 Cells integrate environmental stimuli into intracellular signals to motility machineries to direct

271 plex 1 (mTORC1) integrates environmental and intracellular signals to regulate cell growth.

272 PCRs that are widely expressed and transduce intracellular signals to regulate cellular behavior, suc

273 To examine the role of intracellular signal transducer and activator of transcr

274 ace cadherin protein complex that acts as an intracellular signal transducer in the WNT signaling pat

275 the local extracellular environment mediate intracellular signal transduction and direct cell fate.

276 Endosomes have important roles in intracellular signal transduction as a sorting platform.

277 To allow simultaneous correlation between intracellular signal transduction events and extracellul

278 odds ratio, 2.15; P = 2.63 x 10(-8)) with an intracellular signal transduction mechanism and in ACOT4

279 Restraint of intracellular signal transduction pathways that promote

280 NPM-ALK co-opts several intracellular signal transduction pathways, foremost bei

281 rst during defence response) and GO:0035556 (intracellular signal transduction) were significantly ov

282 luding their physical and chemical triggers, intracellular signal transduction, and effector mechanis

283 to detachment of myocytes and alteration of intracellular signal transduction.

284 mic, multimolecular structures and sites for intracellular signal transduction.

285 more diversified than genes associated with intracellular signal transduction.

286 proteins constitutes a central mechanism of intracellular signal transduction.

287 lly neuropeptides, which serve as inter- and intracellular signal transmitters, is key in understandi

288 s voltage-coupled calcium influx to transmit intracellular signals, typically studied in neurons and

289 a RGD-independent manner and is involved in intracellular signaling via interacting with integrin be

290 This reduction required intracellular signaling via second messengers-cytosolic

291 ls EGFR protein levels, thereby impinging on intracellular signaling, viability, and response to targ

292 Inhibition of intracellular signaling was measured by Western blot ana

293 To explore the role of intracellular signaling, we performed a kinome screen us

294 RvD2-DRV2-initiated intracellular signals were investigated using mass cytom

295 hesis and degradation, chromatin remodeling, intracellular signaling), which are linked to alteration

296 ovel role for the ESCRT pathway in promoting intracellular signaling, which may begin to identify the

297 e ROP1 Rho GTPase signaling and coordinating intracellular signaling with cell wall mechanics.

298 of aging and oxidative stress on chondrocyte intracellular signaling, with a specific focus on oxidat

299 Altered intracellular signaling within the immune system may int

300 nternalized by endothelial cells, leading to intracellular signaling without the need for priming as