ライフサイエンスコーパス: intracellular signaling

1 surface receptors and subsequently activates intracellular signaling.

2 molecular events coupling ligand binding to intracellular signaling.

3 relationships between caveolae structure and intracellular signaling.

4 operties as an often-overlooked modulator of intracellular signaling.

5 since these receptors via ITAM contribute to intracellular signaling.

6 input into BAT and reduces beta3-adrenergic intracellular signaling.

7 enous participants in antigen processing and intracellular signaling.

8 living cells has revolutionized the study of intracellular signaling.

9 CypD), influenced endothelial metabolism and intracellular signaling.

10 molecular link between ERECTA activation and intracellular signaling.

11 g, endosomal pH sensing, membrane fusion and intracellular signaling.

12 tence of a GPBC in nAChRs serving to promote intracellular signaling.

13 fate commitment, depends almost entirely on intracellular signaling.

14 proteins involved in antigen presentation or intracellular signaling.

15 , but also on regulation of RISC assembly by intracellular signaling.

16 elin-13-induced G protein activation and its intracellular signaling.

17 cts of ligand concentration on EGFR-mediated intracellular signaling.

18 ng protein, implicated in actin assembly and intracellular signaling.

19 ich scavenges human chemokines and modulates intracellular signaling.

20 receptors (GPCRs) are intimately involved in intracellular signaling.

21 ard to G protein and beta-arrestin-dependent intracellular signaling.

22 ase, thereby serving as crucial mediators of intracellular signaling.

23 2)) levels; and RAGE, RAGE ligands, and RAGE intracellular signaling.

24 riving polarization of membrane proteins and intracellular signaling.

25 on but did not induce RANKL, suggesting that intracellular signaling activated by the low affinity in

26 be fully understood by genetic mutations or intracellular signaling alone.

27 te [PI(4,5)P2] is a well-known precursor for intracellular signaling and a bona fide regulator of act

28 rase 4 (PDE4) is an essential contributor to intracellular signaling and an important drug target.

29 ompounds toward insects and recently also as intracellular signaling and bacteriostatic molecules in

30 ate how this MAPK-phosphatase might regulate intracellular signaling and cardiac growth dynamics in v

31 hange the fiber knob affinity to DSG2 or the intracellular signaling and DSG2 shedding in epithelial

32 ults show that total body irradiation alters intracellular signaling and epigenetic pathways regulati

33 tor protein (RKIP) is a seminal regulator of intracellular signaling and exhibits both antimetastatic

34 ction with TLRs, TIR serves to both initiate intracellular signaling and facilitate recruitment of si

35 omplications in the brain, thereby affecting intracellular signaling and gene expression that underli

36 ization of LAT by adapter complexes enhances intracellular signaling and is physiologically relevant.

37 atial patterns of dopaminergic modulation of intracellular signaling and plasticity in Drosophila mus

38 P4pal-10 and FR900359 inhibited Gq-mediated intracellular signaling and primary human airway smooth

39 ipheral blood eosinophils were used to study intracellular signaling and protein translation in cells

40 7-expressing LNCaP cell clone showed altered intracellular signaling and reduced spheroid formation p

41 y (meSPIM) for imaging and quantification of intracellular signaling and submicrometer cellular struc

42 on and clustering is a prerequisite for TNFR intracellular signaling, and as m4-1BBL can only recruit

43 ated with gain of integrin-binding function, intracellular signaling, and cell pro-adhesive activity.

44 complex to phosphorylate the ITAMs, initiate intracellular signaling, and drive CD4(+) T cell fate de

45 n factors that are activated by receptor and intracellular signaling, and microRNAs which are small n

46 Intracellular signaling antibody array analysis revealed

47 d efficient inhibition of TF:FVIIa-dependent intracellular signaling, antibody-dependent cell-mediate

48 as metabolite exchange (Ca(2+) and lipids), intracellular signaling, apoptosis, and autophagy.

49 Mechanistically, ICAM-1-mediated intracellular signaling appeared to support neutrophil R

50 mechanically induced membrane damage and/or intracellular signaling are evaluated.

51 an important docking protein responsible for intracellular signaling assembly and transduction.

52 s perceived and transduced into asymmetrical intracellular signaling at the LRO remains controversial

53 vents such as polarization, endocytosis, and intracellular signaling, but challenging to quantify usi

54 ted that efficient HIV entry also depends on intracellular signaling, but this remains controversial.

55 LPS-induced NF-kappaB reporter activity and intracellular signaling by NF-kappaB and MAPK pathways w

56 on in three of seven donors, suggesting that intracellular signaling by p17 may lead to genomic insta

57 , ATF2, and TCFs are required to connect the intracellular signaling cascade elicited by activation o

58 ctivates cell surface receptors to elicit an intracellular signaling cascade leading to enhancement o

59 Thus, we here identified an intracellular signaling cascade linking extrinsic integr

60 myr-Akt mouse model for GBM are enriched for intracellular signaling cascade proteins (GO: 0007242) a

61 gical concentrations of DHEA activate a GPER intracellular signaling cascade that increases pri-miR-2

62 acellular domain of RAGE initiates a complex intracellular signaling cascade, resulting in the produc

63 , and CSF3), silencing of major inflammatory intracellular signaling cascades (STAT1, STAT3, STAT5, p

64 s an intricately regulated process involving intracellular signaling cascades and gene transcription.

65 alpha (TNF-alpha) by initiating a variety of intracellular signaling cascades and is considered to be

66 hemical signals via adhesion, and integrates intracellular signaling cascades associated with cytoske

67 TNF activates three distinct intracellular signaling cascades leading to cell surviva

68 y to assess the role of KORs and KOR-coupled intracellular signaling cascades on reinstatement of nic

69 However, the intracellular signaling cascades that mediate the osteob

70 rs receptors (FGFRs) are thought to initiate intracellular signaling cascades upon ligand-induced dim

71 mbrane receptors P2Y1 and P2Y12, stimulating intracellular signaling cascades, leading to integrin al

72 ract with extracellular ligands to transduce intracellular signaling cascades, modulate target gene e

73 protein-coupled opioid receptor, initiating intracellular signaling cascades, such as protein kinase

74 both lineage-specifying and cell-polarizing intracellular signaling cascades, Wnts can polarize cell

75 ive conformations to regulate a multitude of intracellular signaling cascades.

76 lar immunoglobulin (TrkAIg2) domain triggers intracellular signaling cascades.

77 nstream of cell-surface receptors to control intracellular signaling cascades.

78 tenin-dependent and beta-catenin-independent intracellular signaling cascades.

79 s between cell surface receptors and several intracellular signaling cascades.

80 regulation of immune-inflammatory activity, intracellular signaling, cell survival and protein and l

81 The inflammasome is an intracellular signaling complex, which on recognition of

82 n these split receptors, antigen-binding and intracellular signaling components assemble only in the

83 tification of many recognition receptors and intracellular signaling components of efferocytosis, its

84 tributions of neurotransmitter receptors and intracellular signaling components.

85 geted" kinase inhibitors that interfere with intracellular signaling contributing to tumor progressio

86 ric cytokine receptors as a key regulator of intracellular signaling discrimination.

87 ta signaling domain (CAR) and one lacking an intracellular signaling domain (DeltaCAR).

88 nsgenic knock-in mice, where the IL-15Ralpha intracellular signaling domain was replaced with the int

89 ike proteins, which do not exhibit any known intracellular signaling domain.

90 This allows SPRY2 to inhibit intracellular signaling downstream of other receptor tyr

91 Intracellular signaling during oxidative stress is compl

92 ferase reporter assays to test HARE-mediated intracellular signaling during the uptake of eight ligan

93 However, the intracellular signaling effectors transducing its activa

94 at bud off from the cell surface to generate intracellular signaling endosomes.

95 membrane depolarization into precisely timed intracellular signaling events in the mammalian brain.

96 ortant role in controlling receptor-mediated intracellular signaling events, which have a central rol

97 , including neuronal damage, to induction of intracellular signaling events.

98 initiated by [Ca(2+)]o and amino acids into intracellular signaling events.

99 oss talk between extracellular ATP and JA in intracellular signaling events.

100 ufficient to couple extracellular stimuli to intracellular signaling events.

101 gnal transduction by controlling the fate of intracellular signaling factors.

102 cell polarity determinant, orchestrates the intracellular signaling for normal forgetting.

103 Here we sought to investigate the intracellular signaling from cannabinoid 2 receptor (CB2

104 s including cell motility, intercellular and intracellular signaling, gene expression, and membrane i

105 anismal functions such as neuronal activity, intracellular signaling, gene expression, cell prolifera

106 nase (RLK or TXK) are essential mediators of intracellular signaling in both normal and neoplastic T-

107 ical microenvironment, contact guidance, and intracellular signaling in cell decision making.

108 G proteins are molecular switches that relay intracellular signaling in eukaryotes.

109 e modulation of spatiotemporal regulation of intracellular signaling in intact cells and multicellula

110 lation of MsrB1 did not preclude LPS-induced intracellular signaling in macrophages, but resulted in

111 y, we determined that CD4 activation induces intracellular signaling in monocytes and that inhibition

112 ity and female-specific resilience impacting intracellular signaling in the brain.

113 tagamma-, Galpha(s)-, and Galpha(q)-mediated intracellular signaling in the mouse STHdh(Q7/Q7) cell c

114 ytic degradation of extracellular matrix and intracellular signaling initiated upon its binding to uP

115 osphatidylserine on apoptotic cells, and the intracellular signaling intermediates engulfment cell mo

116 The intracellular signaling involved in NET formation is com

117 We propose that this inter- and intracellular signaling is involved in triggering the re

118 Activated TLR4 induces intracellular signaling leading to activation of transcr

119 Mac-1-dependent cell spreading and initiated intracellular signaling manifested in phosphorylation of

120 ification could play an important role as an intracellular signaling mechanism.

121 controversial and little is known about the intracellular signaling mechanisms by which cytokines in

122 The intracellular signaling mechanisms involved in different

123 A presynaptic mechanism mediated by distinct intracellular signaling mechanisms may account for this

124 Understanding the intracellular signaling mechanisms that govern growth co

125 Little is known about intracellular signaling mechanisms that persistently exc

126 The functional neuroanatomy and intracellular signaling mechanisms underlying the impact

127 s, revealing the critical roles they play in intracellular signaling, metabolism, the trafficking of

128 Our results identify a novel intracellular signaling module that synergistically regu

129 These data position CD2AP as a major intracellular signaling molecule coordinating NGF signal

130 lr), Apolipoprotein receptor 2 (Apoer2), and intracellular signaling molecule Disabled-1 (Dab1).

131 The intracellular signaling molecule Dishevelled (Dvl) media

132 ) is characterized by underexpression of the intracellular signaling molecule RhoH.

133 nosine monophosphate (c-di-GMP) is a dynamic intracellular signaling molecule that plays a central ro

134 as a result of variegated surface receptor, intracellular signaling molecule, and transcription fact

135 Moreover, we identified a novel intracellular signaling molecule, cAMP-response element

136 Very few studies addressed how intracellular signaling molecules differentially specify

137 There is static information on the intracellular signaling molecules involved in these resp

138 TGFBIp also induced phosphorylation of intracellular signaling molecules SRC, FAK, AKT, JNK and

139 ing prenylation of RhoA and effects on other intracellular signaling molecules such as NF-kappaB and

140 ween an epigenetic regulator, WHSC1, and key intracellular signaling molecules, AKT, RICTOR, and Rac1

141 mulates breast tumorigenesis via a number of intracellular signaling molecules, including PI3K/AKT an

142 eta through the timed activation of discrete intracellular signaling molecules, suggesting pathways i

143 xpression and ability to form complexes with intracellular signaling molecules.

144 through membrane-bound receptors and related intracellular signaling molecules.

145 n multiple stimuli, including the binding of intracellular signaling molecules.

146 sented here show that the simplistic view of intracellular signaling networks being made up of activa

147 n of approximately 50 pseudokinases, control intracellular signaling networks by catalyzing the phosp

148 of the kinetics, cellular distribution, and intracellular signaling networks of cosignaling molecule

149 To understand how intracellular signaling networks process such multidimen

150 Atrial function is regulated by a variety of intracellular signaling networks that facilitate rapid c

151 or human cancer cells is largely mediated by intracellular signaling networks that regulate viral rep

152 Migratory immune cells use intracellular signaling networks to generate and orient

153 The activation of complex intracellular signaling networks underlies these respons

154 horylation analysis may provide insight into intracellular signaling networks underlying tumor behavi

155 ersible fashion, hold promise for modulating intracellular signaling networks with high spatial and t

156 GF receptor and previously indistinguishable intracellular signaling networks, only TGF-alpha stimula

157 Despite its central position in oncogenic intracellular signaling networks, the role of mTORC1 in

158 Additive/competitive assays indicate that intracellular signaling-networks for multiple ligands ut

159 the role of the cell of origin, deregulated intracellular signaling, non-neoplastic cells in the tum

160 ic response based on a mathematical model of intracellular signaling of activator and inhibitor.

161 t defense mediated through activation of the intracellular signaling of jasmonate (JA), a well-charac

162 ermore, we found that the fumarase-dependent intracellular signaling of the B. subtilis DDR is achiev

163 the endosomal residence time and subsequent intracellular signaling of the beta2AR.

164 a receptors (FcgammaRs) classically modulate intracellular signaling on binding of the Fc region of I

165 on channel variants that alter regulation by intracellular signaling or cytoskeletal proteins.

166 d within AKT1, a member of the PI3K/AKT/MTOR intracellular signaling pathway activated in endometrial

167 g IGF-1R expression is sufficient to restore intracellular signaling pathway activation profile lying

168 ufficient to initiate the complex pattern of intracellular signaling pathway and gene expression prof

169 h levels of misfolded proteins in the ER, an intracellular signaling pathway called the unfolded prot

170 activate inflammation and cell death and its intracellular signaling pathway involves necrosome forma

171 The ERK/MAPK intracellular signaling pathway is hypothesized to be a

172 The Nox2/TRX-1/NF-kappaB intracellular signaling pathway is involved in the patho

173 ging secretory needs, cells employ a dynamic intracellular signaling pathway known as the unfolded pr

174 lthough dependent on CD44, is mediated by an intracellular signaling pathway rather than as a competi

175 CD2AP with TrkA and p85 suggests a distinct intracellular signaling pathway regulating growth of non

176 There is decreased expression of the intracellular signaling pathway spleen tyrosine kinase (

177 entify a hitherto unrecognized Nox2-mediated intracellular signaling pathway that contributes to hype

178 The effects of these proteins converge on an intracellular signaling pathway that depends on a protei

179 One rapid intracellular signaling pathway that has not yet been ex

180 ntegrated stress response (ISR), a universal intracellular signaling pathway that responds to a varie

181 However, the intracellular signaling pathway that senses dietary fat

182 However, the intracellular signaling pathway triggering Src activatio

183 permits the design of rational cytokine and intracellular signaling pathway-targeted therapeutics, r

184 NFR ligands, CD70 has been shown to initiate intracellular signaling pathways (CD70 reverse signaling

185 ecent achievements in using light to control intracellular signaling pathways and discuss future pros

186 ssion, particularly in genes involved in key intracellular signaling pathways and genes mediating fea

187 pecific biological effects through different intracellular signaling pathways and has a complex prote

188 rTMD23 markedly suppressed the activation of intracellular signaling pathways and the production of i

189 h for new therapeutics aimed at manipulating intracellular signaling pathways and/or transcriptional

190 nt indicated that no recognized CO-sensitive intracellular signaling pathways appeared to mediate CO

191 pes depending on their environment and which intracellular signaling pathways are activated.

192 Cytokine-mediated intracellular signaling pathways are fundamental for the

193 nisms connecting cell polarity proteins with intracellular signaling pathways are largely unknown.

194 Activation of various intracellular signaling pathways by gut-derived bacteria

195 out the molecular components involved in the intracellular signaling pathways by which [CO2] controls

196 Conversely, activation of intracellular signaling pathways coupled to mGluRI in D1

197 is the third in a series of Perspectives on intracellular signaling pathways coupled to proliferatio

198 receptors on myelin, and the integration of intracellular signaling pathways emanating downstream fr

199 to focus on understanding how to harness key intracellular signaling pathways for therapeutic human b

200 rs, and interventions aimed at disruption of intracellular signaling pathways have shown promise in p

201 Analysis of the intracellular signaling pathways implicated in this proc

202 d understanding of the complex regulation of intracellular signaling pathways in CLL, currently a maj

203 stablished, and the molecular mechanisms and intracellular signaling pathways involved are not known.

204 However, the intracellular signaling pathways involved are unknown.

205 As intracellular signaling pathways involved in iIC-induced

206 Although many of the intracellular signaling pathways involved in the proinfl

207 guanylate cyclase (NO-GC, sGC) and triggers intracellular signaling pathways involving cGMP.

208 thways transducing matrix mechanical cues to intracellular signaling pathways linked to lineage speci

209 l studies on MOR gene have not addressed how intracellular signaling pathways mediate extracellular m

210 homeostasis and, consequently, in modulating intracellular signaling pathways remains unclear.

211 by miR-200/Zeb1-dependent EMT that activate intracellular signaling pathways responsible for tumor c

212 -activated protein kinase 1 (MSK1)-ranges of intracellular signaling pathways similar to those activa

213 at is largely regulated by extracellular and intracellular signaling pathways that are central to cel

214 the gene targets of which were enriched for intracellular signaling pathways that are important to c

215 However, the intracellular signaling pathways that control these proc

216 ression of MOR gene requires the activity of intracellular signaling pathways that have been implicat

217 with fibroblast activation via a network of intracellular signaling pathways that include focal adhe

218 identified an RvD2/DRV2 axis that activates intracellular signaling pathways that increase phagocyto

219 ognize the secreted interferons and activate intracellular signaling pathways that induce the express

220 the importance and complexity of a number of intracellular signaling pathways that present unique opp

221 Unraveling the network of beta-cell intracellular signaling pathways that promote beta-cell

222 ly relevant mechanical signal that regulates intracellular signaling pathways throughout the tumor.

223 small molecules and dramatically stimulating intracellular signaling pathways to determine cell fate.

224 eptors on target cells, stimulating specific intracellular signaling pathways to facilitate appropria

225 tage-activated calcium (Cav) channels couple intracellular signaling pathways to membrane potential b

226 ive oxygen species, autophagy activation and intracellular signaling pathways were analyzed in Mincle

227 sequent activation of inhibitory (Gi-linked) intracellular signaling pathways within the basolateral

228 MITF is regulated by multiple intracellular signaling pathways, although the exact mec

229 egrates and regulates extracellular cues and intracellular signaling pathways, both at the plasma mem

230 are caused by mutations in genes involved in intracellular signaling pathways, cell cycle regulation,

231 Eukaryotic cells evolved a set of intracellular signaling pathways, collectively termed th

232 mbination with agents that target oncogenic, intracellular signaling pathways, diagnostic pathologist

233 erabilities in receptor tyrosine kinases and intracellular signaling pathways, epigenetics, metabolis

234 ible cytokine receptor that engages multiple intracellular signaling pathways, including nuclear fact

235 epsilon and Cgamma1) in coordinating certain intracellular signaling pathways, such as calcium mobili

236 increasing the capacity of IL-13 to activate intracellular signaling pathways, such as signal transdu

237 ell-specific manipulations through canonical intracellular signaling pathways, they are easy and cost

238 ow and fast neurotransmitter systems through intracellular signaling pathways-and may unify a number

239 e and polarity to coordinate the activity of intracellular signaling pathways.

240 by aberrant activation of several well-known intracellular signaling pathways.

241 ss, cells must activate a series of adaptive intracellular signaling pathways.

242 portant second messengers in many inter- and intracellular signaling pathways.

243 xecution of these functions through multiple intracellular signaling pathways.

244 FRs reside and how they control such diverse intracellular signaling pathways.

245 tochondria are key integrators of convergent intracellular signaling pathways.

246 ulate a truly astonishing number of critical intracellular signaling pathways.

247 rtant roles as second messengers to regulate intracellular signaling pathways.

248 r intracellular) AA availability upstream of intracellular signaling pathways.

249 (FcgammaRs) and activation of the associated intracellular signaling pathways.

250 mprises adaptors and scaffolds that regulate intracellular signaling pathways.

251 SR, which was associated with alterations in intracellular signaling pathways.

252 mes play critical roles in a wide variety of intracellular signaling pathways.

253 ansmitted through the glycocalyx to initiate intracellular signaling pathways.

254 by the host innate immune system and related intracellular signaling pathways.

255 and tight junctions and function to scaffold intracellular signaling protein complexes.

256 The intracellular signaling protein regulator of presynaptic

257 l evidence of an Eph receptor-class-specific intracellular signaling protein that is required for app

258 immune-inflammatory control, cell survival, intracellular signaling, protein and lipid homeostasis,

259 bosomal proteins, transcription factors, and intracellular signaling proteins are overrepresented amo

260 zinc finger (PLZF), as well as expression of intracellular signaling proteins FcepsilonRgamma, spleen

261 Post-translational modification of intracellular signaling proteins in these pathways is a

262 actor-beta (TGF-beta) network of ligands and intracellular signaling proteins is a subject of intense

263 or homologous factors (FHFs) are a family of intracellular signaling proteins linked with Nav channel

264 sing mass cytometry, we profiled surface and intracellular signaling proteins simultaneously in milli

265 ed many extracellular guidance molecules and intracellular signaling proteins that regulate axonal ou

266 Whether RSPO-LGR4 is coupled to intracellular signaling proteins to regulate Wnt pathway

267 face marker expression, activation states of intracellular signaling proteins, and cytokine productio

268 the cell by binding and activating different intracellular signaling proteins, such as G proteins (Ga

269 monoamine modulation with phosphorylation of intracellular signaling proteins.

270 APOL1 risk variant-induced dysregulation of intracellular signaling relevant for cell survival.

271 nslate extracellular semaphorin binding into intracellular signaling remains unclear.

272 nding events trigger receptor activation and intracellular signaling remains unclear.

273 d differences in PDE activity and associated intracellular signaling responsible for the efficacy and

274 Moreover, engagement of this intracellular signaling route was functionally active in

275 Integrin-mediated changes of the intracellular signaling significantly affected the kinet

276 en the orthosteric drug binding site and the intracellular signaling surface, revealing strong intera

277 DSG2 with its fiber knob domain and triggers intracellular signaling that culminates in the cleavage

278 Here, we define the intracellular signaling that links ERalpha, mGluRs, and

279 -in" signal contributes to receptor-mediated intracellular signaling that regulates the kinetics of g

280 e cleavage events are partially regulated by intracellular signaling through an unknown allosteric me

281 ltikinase (HsIPMK) critically contributes to intracellular signaling through its inositol-1,4,5-trisp

282 Attachment triggers intracellular signaling to change gene expression from t

283 ogical synapse affects synapse formation and intracellular signaling to impact the downstream T cell

284 a RGD-independent manner and is involved in intracellular signaling via interacting with integrin be

285 This reduction required intracellular signaling via second messengers-cytosolic

286 Activating FcgammaRs elicit intracellular signaling via the ITAM domain of the assoc

287 ls EGFR protein levels, thereby impinging on intracellular signaling, viability, and response to targ

288 Sema3E-mediated intracellular signaling was investigated with fluorescen

289 Inhibition of intracellular signaling was measured by Western blot ana

290 Using activators and inhibitors of intracellular signaling, we demonstrated that A2B recept

291 To explore the role of intracellular signaling, we performed a kinome screen us

292 hesis and degradation, chromatin remodeling, intracellular signaling), which are linked to alteration

293 1 channels leaked Ca(2+), resulting in lower intracellular signaling, which is required for proper mu

294 ovel role for the ESCRT pathway in promoting intracellular signaling, which may begin to identify the

295 e ROP1 Rho GTPase signaling and coordinating intracellular signaling with cell wall mechanics.

296 ated factors (TRAFs) are key facilitators of intracellular signaling with roles in innate and adaptiv

297 of aging and oxidative stress on chondrocyte intracellular signaling, with a specific focus on oxidat

298 Altered intracellular signaling within the immune system may int

299 nternalized by endothelial cells, leading to intracellular signaling without the need for priming as

300 Despite the variations in intracellular signaling, Wnt pathways share the effector