ライフサイエンスコーパス: intracellularly

1 ting that the observed chemistry would occur intracellularly.

2 t protein folding or enzyme activity, or act intracellularly.

3 across the plasma membrane, and releasing it intracellularly.

4 chemical level, nor have they been localized intracellularly.

5 e parasitism that allows bacteria to persist intracellularly.

6 kinetics and amount of HIV epitopes produced intracellularly.

7 responses were assessed in supernatants and intracellularly.

8 , escaped into the cytoplasm, and replicated intracellularly.

9 penetrate the embryo and later are deposited intracellularly.

10 a single type of GluN2 subunit) are retained intracellularly.

11 report here that C3 activation also occurred intracellularly.

12 may be expressed both at the sarcolemma and intracellularly.

13 B system primarily sustain energy generation intracellularly.

14 lated KV1.2 channel, by trapping the channel intracellularly.

15 to the cell surface and instead accumulates intracellularly.

16 the phagosome is required for GBS to survive intracellularly.

17 preserve transport activity but are retained intracellularly.

18 to generate sustained nanomolar levels of NO intracellularly.

19 embrane coreceptors for transmitting signals intracellularly.

20 Mature ECs only express these ECM proteins intracellularly.

21 that serve to propagate glutamate responses intracellularly.

22 ion, strongly suggesting that magnesium acts intracellularly.

23 d some macrophage populations expressed C3aR intracellularly.

24 ted macrophages, leading to VCC accumulation intracellularly.

25 th cholesterol depletion, Bsep redistributed intracellularly.

26 proposed to carry out its antiviral activity intracellularly.

27 using inactive GDF11 precursor to accumulate intracellularly.

28 rgeting the NGF-TrkA pathway both extra- and intracellularly.

29 e etiological agent of TB, both in vitro and intracellularly.

30 ediates the unfolded protein response acting intracellularly.

31 s systems, with most receptors being trapped intracellularly.

32 VHHs that elicit a phenotype when expressed intracellularly.

33 dicating the demonstrated interaction occurs intracellularly.

34 here it is phosphorylated by TK1 and trapped intracellularly.

35 ptomycin, whether applied extracellularly or intracellularly.

36 synaptic transmission (EPSC(A)) when applied intracellularly.

37 and CaMKII-dependent phosphorylation of the intracellularly accessible regions of Na(V)1.5 using a s

38 stending toxins (CDTs) compose a subclass of intracellularly acting genotoxins produced by many Gram-

39 Anthrax toxin is an intracellularly acting toxin in which sufficient informa

40 Anthrax toxin is an intracellularly acting toxin where sufficient detail is

41 Intracellularly activated PCCAs ranged from 500nm to 6mu

42 2(Q390X) subunits accumulated and aggregated intracellularly, activated caspase 3 and caused widespre

43 We previously demonstrated that IL1R2 intracellularly activates the expression of several proi

44 al differences between serum circulating and intracellularly active complement and will describe and

45 udies confirmed that compound 16 accumulated intracellularly after 1 h of incubation with CCRF-CEM ce

46 cific markers but were not able to replicate intracellularly after infecting macrophages.

47 ctive for Gram-negative bacteria, which acts intracellularly after membrane translocation.

48 ion of caspase-1 extracellularly, as well as intracellularly after phagocytosis by surrounding macrop

49 s an inner-membrane motor complex that moves intracellularly along a right-handed helical path; when

50 nisms that enable this pathogen to replicate intracellularly also function when mammalian macrophages

51 Processing by endogenous furin occurs mostly intracellularly, although also extracellular processing

52 the MR1-ligand interaction and are degraded intracellularly, although some MR1 molecules acquire new

53 N249Q mutation) caused R345W F3 to aggregate intracellularly and adopt an altered secreted conformati

54 n the prefusion conformation interact with H intracellularly and at the cell surface, while destabili

55 lete model for Wnt signalosome assembly both intracellularly and at the membrane.

56 resulting monophosphate compound is trapped intracellularly and available for locality specific inhi

57 was confirmed using coimmunoprecipitation of intracellularly and bacterially expressed and endogenous

58 rotein C is predominantly performed by furin intracellularly and by all three proprotein convertases

59 Galectins can function intracellularly and can also be secreted to bind to cell

60 lic adaptations within the host to replicate intracellularly and cause disease.

61 Glycan degradation mainly occurs intracellularly and depends on the import of oligosaccha

62 It exists as a free molecule, intracellularly and extracellularly, and conjugated to t

63 lter the fatty acid synthesis and metabolism intracellularly and extracellularly, but also in the mac

64 Active MMP-1 was found in CCh fibroblasts intracellularly and extracellularly, whereas only proMMP

65 the ubiquitous sources of DNA damage present intracellularly and in the external environment.

66 GPR30 was localized both intracellularly and in the plasma membrane and subject t

67 st advanced ochronosis, pigment was observed intracellularly and in the territorial matrix of individ

68 deliver the OMV-associated virulence factors intracellularly and induce caspase-9-mediated apoptosis

69 suggest that P2X receptors are also present intracellularly and involved in vesicle fusion with the

70 l complement system and initially functioned intracellularly and on the membrane of single-celled org

71 Additionally, UFPs can penetrate intracellularly and potentially cause DNA damage.

72 riments confirmed that xylose is transported intracellularly and reduced to the dead-end metabolite x

73 wed that murine spleen NK cells express TLR9 intracellularly and respond to CpG oligodeoxynucleotide

74 to form dimers, was still able to replicate intracellularly and retained virulence in mice.

75 that both cell types survived and replicated intracellularly and that both ultimately established a s

76 the C-terminus of the prodomain is retained intracellularly and that sequences within the N-terminus

77 lar signals have to be precisely interpreted intracellularly and translated into diverse cellular beh

78 Hh pathway activation occurred intracellularly and triggered Rac1 synthesis.

79 d upon redox triggering by glutathione (GSH) intracellularly and was actually observed upon redox tri

80 ial fraction of Clr-a molecules are retained intracellularly, and analyses of Clr-a/Clr-f hybrids att

81 CrVI is rapidly converted to CrIII intracellularly, and can induce apoptosis through differ

82 IgM was produced, since it was detected intracellularly, and impaired secretion was not due to a

83 bacteria to escape from endosomes, replicate intracellularly, and induce apoptosis.

84 egrin-mediated process, releases its payload intracellularly, and is a highly potent inhibitor of bra

85 recording Purkinje neuron membrane potential intracellularly, and motor neuron spikes extracellularly

86 to the extracellular space but is localized intracellularly, and only the short C terminus is extrac

87 Mutants lacking RNS2 activity accumulate RNA intracellularly, and rRNA in these mutants has a longer

88 e assay for the ability to invade, replicate intracellularly, and spread to adjacent epithelial cells

89 CA IV contributes robust catalytic activity intracellularly, and that this activity participates in

90 transmission, the causative agent replicates intracellularly, and the disease is fundamentally a vasc

91 transmission, the causative agent replicates intracellularly, and the disease is fundamentally a vasc

92 oxo-2-oxetanyl]methyl]dodecyl ester], or the intracellularly applied Ca(2+) chelator BAPTA in CA1 pyr

93 e-channel currents using extracellularly and intracellularly applied methanethiosulfonate (MTS) reage

94 tracellularly applied MTS probes, but not to intracellularly applied reagents.

95 ce; therefore, we transiently expressed them intracellularly as "intrabodies" to test their effects o

96 tire Factor VIII (FVIII)-amino-acid sequence intracellularly as 2 non-secreted polypeptides and have

97 ione S-transferase P1 (GSTP1) protein exists intracellularly as a dimer in reversible equilibrium wit

98 Iron oxide nanoparticles are synthesized intracellularly as a GFP-tagged ferritin heavy and light

99 coupled receptor (GPCR) that is found mainly intracellularly as most GPCRs.

100 neumocytes, where it is assembled and stored intracellularly as multilayered organelles known as lame

101 We show that LytA is mainly localized intracellularly, as only a small fraction was found atta

102 drimers to a multitude of smaller thiols was intracellularly assessed as a means to disrupt the balan

103 drenergic receptor (alpha2C-AR) is localized intracellularly at physiologic temperature.

104 and DAP12 but that the complex was retained intracellularly at the endoplasmic reticulum instead of

105 We show that CAT processes Cm intracellularly but not extracellularly.

106 omerase A (PPIA), as a foldase is beneficial intracellularly, but extracellularly has detrimental fun

107 ion reaction, whereas the second is produced intracellularly by a pathway enzyme that converts exogen

108 helial cells forms AJs, which are stabilized intracellularly by binding of p120-catenin and cortical

109 TSG-6 was constitutively expressed intracellularly by both resting normal and CCh fibroblas

110 Stress-internalized EGFR is retained intracellularly by continued p38 activity in a mechanism

111 These organisms succeed intracellularly by effecting remarkable changes in a bro

112 was processed into a shorter form of ANGPTL3 intracellularly by furin only, and extracellularly mainl

113 strate that this truncated form is generated intracellularly by limited proteolysis mediated by propr

114 a adjusts its metabolism in order to survive intracellularly by modulating central carbon metabolism.

115 elial cells that 3OC12 is rapidly hydrolyzed intracellularly by PON2 to 3OC12 acid, which becomes tra

116 ve oligomeric forms and are rapidly degraded intracellularly by the endoplasmic reticulum-associated

117 nificant membrane permeability to be applied intracellularly by whole-cell dialysis.

118 ancer agents were synthesized simultaneously intracellularly, by two totally different mechanisms (in

119 en alkaline earth metals was not inherent to intracellularly calcifying cyanobacteria but was likely

120 Here we develop a technique for intracellularly calibrated superresolution microscopy th

121 box-amide-1-beta-D-ribofuranoside (AICAR) is intracellularly converted to the AMP analog ZMP, which a

122 Intracellularly, CSPG-LAR interaction mediates axonal gr

123 Intracellularly, dCIRL quenches cAMP levels upon mechani

124 Overexpression of AID intracellularly decreased surface expression of gp96 cli

125 an E3/19K molecule that was largely retained intracellularly despite having a mutated ER retrieval mo

126 Because homocysteine, which accumulates intracellularly during folate deficiency, stimulated int

127 we demonstrate that EAG2 protein is confined intracellularly during interphase but is enriched in the

128 to KCNE1 and KCNE2 retaining Kv1.4 and Kv3.4 intracellularly, early in the secretory pathway.

129 that necessitates involvement of VCP, since intracellularly expressed IgG Fc is degraded in a VCP-in

130 extracellularly applied PSA or PSA-NCAM and intracellularly expressed MARCKS-GFP are in close contac

131 Interactome analysis of intracellularly expressed monobodies revealed that they

132 rsion as demonstrated by the ability for the intracellularly expressed nanobodies to selectively bind

133 When coexpressed with a recombinase, these intracellularly expressed ssDNAs target specific genomic

134 tivation of TLR2 led to the up-regulation of intracellularly expressed TLR2 and inflammatory mediator

135 Both molecules were intracellularly expressed, confined to the late endosoma

136 -STP was unable to cause apoptosis even when intracellularly expressed.

137 orescent latex microspheres and subsequently intracellularly filled with biotinylated lucifer yellow

138 CC18 C. acnes ATCC6919 isolate could survive intracellularly for at least 96 hours.

139 To redress this we here record intracellularly from a higher order visual neuron in the

140 Adenosine may be formed intracellularly from adenine nucleotides or extracellula

141 We recorded intracellularly from CC neurons in the locust Schistocer

142 -one, whether added exogenously or generated intracellularly from cholesterol, inhibits the growth of

143 By recording intracellularly from dissociated neurons and intact gang

144 To answer these questions, we recorded intracellularly from hippocampal CA1 of awake, behaving

145 We have recorded intracellularly from lagged cells in the cat LGN and fou

146 We recorded intracellularly from motoneurons in a reduced preparatio

147 Here, by recording intracellularly from Purkinje neurons in unanesthetized

148 tate impacts cortical circuitry, we recorded intracellularly from the same neurons, under anesthesia

149 es a Cre recombinase interaction reporter to intracellularly fuse the coding sequences of two interac

150 an antiviral strategy that is applicable to intracellularly fusing viruses, including known and emer

151 ange inside cells, and the probe responds to intracellularly generated (1) O2 with an increase in flu

152 As markers for antioxidative activity, the intracellularly generated ROS levels, oxidative DNA dama

153 Intracellularly, heterotrimeric molecules associate to f

154 elial cells of normal corneas expressed TLR4 intracellularly; however, DED significantly increased th

155 uch as using CRISPR/cas9, offer the prospect intracellularly immunized T cells in HIV+ patients.

156 pathway, such as when poly(I:C) is delivered intracellularly in a complex with liposomes or via nucle

157 e light or dark in HEp2 cells and accumulate intracellularly in a time-dependent manner, mainly in th

158 eolar macrophages in the lung and replicates intracellularly in a vacuolar compartment with endoplasm

159 ever, we show here that it also participates intracellularly in activation of the NF-kappaB pathway.

160 FR-targeted PCCAs were observed intracellularly in both cell lines, but uptake was signi

161 are present in infected cells or accumulate intracellularly in certain tumor cells.

162 ne A production was enhanced both extra- and intracellularly in Deltagpy2 mutants.

163 steine (SPARC) is up-regulated and expressed intracellularly in developing muscle, during regeneratio

164 LR10 was found to be predominantly expressed intracellularly in epithelia, and activation required vi

165 sensitively in a partial aqueous medium and intracellularly in HeLa cells.

166 er strips, in protein medium (like BSA), and intracellularly in HeLa cells.

167 8 expression revealed that PfMSP8 is present intracellularly in late schizonts and merozoites.

168 Here, we show that CB(2)Rs are located intracellularly in layer II/III pyramidal cells of the r

169 xpression, mammalian P2X4 was also localized intracellularly in lysosomes.

170 B. cenocepacia can survive intracellularly in macrophages by altering the maturatio

171 Leishmania replicates intracellularly in macrophages, a process that is essent

172 The bacteria replicate intracellularly in macrophages, and the restriction of b

173 here that IL-1alpha and -beta were degraded intracellularly in murine bone marrow-derived DC and tha

174 animals that causes disease by proliferating intracellularly in muscle and the central nervous system

175 acellularly, whereas only proMMP-1 was found intracellularly in normal fibroblasts.

176 ifestyle for the chlamydia, which were found intracellularly in Onychodromopsis-like ciliates.

177 at the sarcolemma but also could accumulate intracellularly in some patients with inclusion body myo

178 Ubc13 accumulates intracellularly in the absence of STAT3.

179 cases analyzed in detail (n = 39) Hi resided intracellularly in the core tonsillar tissue.

180 We show that immature RET9 accumulates intracellularly in the Golgi, whereas RET51 is efficient

181 ul conditions and reduced ability to survive intracellularly in the host plant.

182 helial cells and to its inability to survive intracellularly in these cells as well as in MH-S murine

183 s GLUT4-containing vesicles and tethers them intracellularly in unstimulated cells and in which insul

184 Yeast-derived VLPs (yVLPs) assemble intracellularly in vivo during recombinant protein produ

185 hetized cats and spiny stellates were filled intracellularly in vivo with horseradish peroxidase.

186 ne also has little or no effect when applied intracellularly in whole-cell recording, but blocks effe

187 ch allow for coordinated protein homeostasis intracellularly, in between cells and even across organs

188 but the deferrated siderophores accumulated intracellularly, indicating a blockade of siderophore re

189 As with HPV pseudoviruses (PsV) generated intracellularly, infection by cell-free particles assemb

190 disease-causing myocilin variants aggregate intracellularly instead of being secreted to the trabecu

191 W) expressed in Escherichia coli can arrange intracellularly into highly stable macro-structures thro

192 MeV envelope glycoproteins preassemble intracellularly into tightly associated hetero-oligomers

193 e death signal mediated by DR6 is transduced intracellularly is not known.

194 other required signaling molecules and acts intracellularly is unknown.

195 After QAQ accumulates intracellularly, it blocks voltage-gated ion channels in

196 ch a truncated SLRP protein core is retained intracellularly, its accumulation triggering endoplasmic

197 Intracellularly labeled DAO expression by basophils meri

198 Intracellularly labeled DAO(+) and surface expression of

199 CD63, CD203c (P = 0.0086, P = 0.04205), and intracellularly labeled diamine oxidase (P = 0.0003, P =

200 s were physiologically identified in slices, intracellularly labeled, processed for light microscopic

201 done on 22 electrophysiologically identified intracellularly labelled neurons in cats and on 80 neuro

202 Depletion of zinc intracellularly leads to apoptosis by an unknown mechani

203 ered by difficulties in detecting CO release intracellularly, limited understanding of the biological

204 genous lipidation activity, the substrate is intracellularly lipidated.

205 To determine whether intracellularly localized channels are similarly "inacti

206 , we report that novel signaling through the intracellularly localized D2R long isoform (D2LR) elicit

207 The intracellularly located C-terminal domains (CTDs) make a

208 Our data support a model in which the intracellularly located prodomain affects the final conf

209 Sigma(1) receptors (sigma(1)Rs) are intracellularly mobile chaperone proteins implicated in

210 ellular M. tb bacterial growth only, or both intracellularly on infected macrophages as well as extra

211 We establish that Mn(2+) accumulates intracellularly on injection into the living Aplysia and

212 on was not affected by the presence of VEGFA intracellularly or extracellularly.

213 not due to a failure to invade, to replicate intracellularly, or to polymerize actin via IcsA for mov

214 lized by Sn-expressing cells, and accumulate intracellularly over time.

215 In contrast, miR-494 accumulated intracellularly (P < 0.05).

216 Intracellularly, pDox nanoparticles are transported to t

217 vealed that while giant obscurin-B localizes intracellularly, possessing dual kinase activity, a smal

218 PrfA-regulated genes are activated intracellularly (PrfA 'ON') but shut down outside the ho

219 , morbillivirus glycoproteins first assemble intracellularly prior to receptor binding, raising the q

220 , while destabilized F mutants interact only intracellularly, prior to F maturation.

221 fluid is insignificant and that glutamate is intracellularly produced.

222 r, much of the PtdIns(4,5)P(2) was localized intracellularly, rather than at the plasma membrane as i

223 t our vertical nanowire electrode arrays can intracellularly record and stimulate neuronal activity i

224 attachment and 1 year later motoneurons were intracellularly recorded and filled with neurobiotin to

225 Comparison with intracellularly recorded EPSCs revealed that most proper

226 nd releasing a functional nucleic acid cargo intracellularly remains a formidable challenge.

227 The intracellularly replicating lung pathogen Legionella pne

228 umulation of endoglycosidase H-sensitive IgM intracellularly, resembling the trafficking block in ane

229 Internalization assays indicated that intracellularly retained radioactivity for (18)F-RL-I-5F

230 This mutant protein was intracellularly retained, incompletely glycosylated, and

231 Intracellularly, S1P is dephosphorylated by the actions

232 Cleavage liberates intracellularly sequestered GLUT4 glucose transporters f

233 lecule important in transducing signals from intracellularly signaling Toll-like receptor 3 (TLR3) an

234 Intracellularly, SN reduced Ca(2+)/calmodulin (CaM)-depe

235 Identified splenius motoneurons were intracellularly stained with Neurobiotin.

236 in concentrations 1000-fold lower than found intracellularly, suggesting the dominance of specific in

237 In parallel, APP accumulated intracellularly, suggestive of a putative dysfunction of

238 Small microbes triggered ROS intracellularly, suppressing IL-1beta expression to limi

239 of McC imported from the cultured medium and intracellularly synthesized antibiotic.

240 ugs, can be used to mediate the secretion of intracellularly synthesized model isoprenoid biofuel com

241 ogated by the GDP analog GDP-beta-S (applied intracellularly), the phospholipase C inhibitor U-73122,

242 3 suggest that urea is hydrolyzed to ammonia intracellularly, then a portion is lost to the dissolved

243 ome replication to be specifically localised intracellularly, thereby helping the virus to avoid host

244 These events occur when VacA is not detected intracellularly, therefore do not require the direct int

245 TRPM8 retains Rap1 intracellularly through direct protein-protein interacti

246 ur extracellularly via external receptors or intracellularly through GAP junctions.

247 s (TCSs) sense stimuli and transduce signals intracellularly through phosphotransfer between cognate

248 Intracellularly, TIP110 regulated CMYC and GATA2 express

249 roposed to function both extracellularly and intracellularly to activate oncogenic signaling pathways

250 plasmalemmal uPAS complex and directly acts intracellularly to alter uPAS endocytotic trafficking.

251 apable of infecting S2 cells and replicating intracellularly to high levels, an unusual feature of th

252 microscale, we delivered electrical stimuli intracellularly to individual cells while simultaneously

253 e its monophosphate is not further converted intracellularly to its triphosphate derivative to a dete

254 d that can function both extracellularly and intracellularly to mediate a variety of cellular process

255 r its major metabolite norketamine could act intracellularly to produce some behavioral effects.

256 te receptor-mediated endocytosis and cleaved intracellularly to reconstitute the active drug.

257 e that matures extracellularly but functions intracellularly to regulate virulence.

258 Parasites transform intracellularly to the amastigote stage.

259 The prototypical agonist nicotine acts intracellularly to upregulate many nAChR subtypes, a phe

260 des self-assemble pericellularly, as well as intracellularly, to result in cell death.

261 Most tested TrOCs are quickly taken up and intracellularly transformed.

262 epithelium-lined lumens, and how chloride is intracellularly transported to phagosomes remain largely

263 The intracellularly trapped misprocessed protein associates

264 UCD38B intracellularly triggers endocytosis, causing 40-50% of

265 ages, with MINCLE and MCL proteins localized intracellularly under resting conditions.

266 ococcus neoformans can survive and replicate intracellularly unless the macrophages become classicall

267 h are revealed by blocking action potentials intracellularly using QX314 during swimming and struggli

268 SSA in A1, we recorded neural activity in A1 intracellularly using sharp electrodes.

269 2, either in the medium of Neuro-2A cells or intracellularly via adenoviral 7B2 overexpression, block

270 The BMP signal is transduced intracellularly via C-terminal phosphorylation of the BM

271 atterns of activation to drive these neurons intracellularly, we further demonstrated that activating

272 hat perturbs the ability of EGFR to dimerize intracellularly, we showed that a modest drug-induced in

273 for surface expression, CLECSF8 is retained intracellularly when expressed in non-myeloid cells.

274 plasma membrane, whereas CaV1.1 is retained intracellularly when Stac3 is absent.

275 he presynaptic membrane and then translocate intracellularly, where the light-chain endopeptidase cle

276 ntial for M. tuberculosis (Mtb) to replicate intracellularly while protecting it from antibiotic trea

277 ENaC extracellularly after being secreted or intracellularly, while ENaC is present in the Golgi or i

278 d fermentation enzymes were highly expressed intracellularly, while tricarboxylic acid (TCA) cycle ox

279 c transmembrane glycoproteins that associate intracellularly with a polypeptide known as the invarian

280 Procollagen was retained intracellularly with concomitant dilation of ER cisterna

281 CCR5 also interacts intracellularly with G proteins, as part of its signal t

282 inactive, unable to dimerize, and complexed intracellularly with the endoplasmic reticulum chaperone

283 landin D2 (PGD2) synthase (L-PGDS) interacts intracellularly with the GPCR DP1 in an agonist-independ

284 sma membrane continued as the BCR trafficked intracellularly with the sequential phosphorylation of k

285 DAF-FM we find that all blood cells form NO intracellularly, with a rank order of monocytes > neutro

286 spiratory drive potentials (CRDPs), recorded intracellularly, with action potentials blocked with the

287 ndocytose together and only become separated intracellularly, with NRP1 becoming associated with endo

288 Most mature ADAM17 is localised intracellularly, with only a small amount at the cell su

289 howed that 98% of compound 10 was hydrolyzed intracellularly within 48 h and released doxorubicin.

290 lence is related to its capacity to multiply intracellularly within a membrane-bound compartment, the

291 cultative bacterial pathogen that replicates intracellularly within a variety of cell types and is th

292 rosymbionts, called bacteroids, are confined intracellularly within highly specialized symbiotic host

293 lioside GM2 and other glycolipids accumulate intracellularly within lysosomes.

294 he nonmineralized collagen matrix or located intracellularly within neutrophils.

295 This sequential accumulation occurred mostly intracellularly within polyphosphate and carbonate granu

296 m an arbuscular mycorrhizal (AM) association intracellularly within the roots of more than 80% of lan

297 chemical route by which magnetite is formed intracellularly within the so-called magnetosomes has re

298 loaded with MV ex vivo, and MV was amplified intracellularly, without toxicity.

299 In myocytes, prion aggregates accumulate intracellularly, yet little is known about clearance pat

300 tly, even single nanoparticles could cluster intracellularly, yet their clustering state and subseque