ライフサイエンスコーパス: intracerebral haemorrhage

1 evere stroke increasing the absolute risk of intracerebral haemorrhage).

2 lth Stroke Scale >3) versus those with acute intracerebral haemorrhage.

3 ical deficits without infarction, seizure or intracerebral haemorrhage.

4 in and is associated with dementia and lobar intracerebral haemorrhage.

5 age-matched stroke service referrals without intracerebral haemorrhage.

6 specialty practice can improve outcome after intracerebral haemorrhage.

7 ial conservative treatment for patients with intracerebral haemorrhage.

8 ay be a risk factor for thrombolysis-related intracerebral haemorrhage.

9 weighted scans) and lacunar infarcts, but no intracerebral haemorrhage.

10 traventricular haemorrhage size and thalamic intracerebral haemorrhage.

11 , and loss of functional independence) after intracerebral haemorrhage.

12 idence of dementia and risk factors after an intracerebral haemorrhage.

13 es on long-term functional performance after intracerebral haemorrhage.

14 ally invasive surgery (MIS) in patients with intracerebral haemorrhage.

15 cal management as a therapeutic strategy for intracerebral haemorrhage.

16 or people taking antiplatelet therapy before intracerebral haemorrhage.

17 s, does not improve functional outcome after intracerebral haemorrhage.

18 complications and no increase in symptomatic intracerebral haemorrhage.

19 in patients with probable CAA without lobar intracerebral haemorrhage.

20 redict a poor outcome in patients with acute intracerebral haemorrhage.

21 controls, though none had major CAA-related intracerebral haemorrhages.

22 idence declined by more than 50% for primary intracerebral haemorrhage (0.47, 0.27-0.83, p=0.01) but

23 chaemic stroke (1.68, 95% CI 1.60-1.77), and intracerebral haemorrhage (1.24, 95% CI 1.07-1.44).

24 lic blood pressure was much lower than after intracerebral haemorrhage (158.5 mm Hg [SD 30.1] vs 189.

25 eeded the absolute increase in risk of fatal intracerebral haemorrhage (2.2% [1.5% to 3.0%]) and the

26 score 2 vs 1, p<0.001), and more often with intracerebral haemorrhage (20% vs 13%, p=0.002).

27 We included 114 patients with intracerebral haemorrhage (39 with clinically probable c

28 bsolute excess 3.1% [2.4-3.8]); and of fatal intracerebral haemorrhage (91 [2.7%] of 3391 vs 13 [0.4%

29 changes in the population-based incidence of intracerebral haemorrhage according to age and likely ae

30 Spontaneous supratentorial intracerebral haemorrhage accounts for 20% of all stroke

31 Intracerebral haemorrhage accounts for about 10-15% of a

32 mortality (1.6, 0.8-3.4; p=0.27) or rates of intracerebral haemorrhage after treatment with thromboly

33 ognised as an important cause of spontaneous intracerebral haemorrhage and cognitive impairment in th

34 l disease and a largely untreatable cause of intracerebral haemorrhage and contributor to age-related

35 ed cerebral small vessel disorder leading to intracerebral haemorrhage and dementia.

36 ploratory analyses to assess mortality after intracerebral haemorrhage and examine the absolute risks

37 gression models for association with primary intracerebral haemorrhage and ischaemic stroke subtypes.

38 Primary intracerebral haemorrhage and lacunar ischaemic stroke a

39 ar instability, leading to increased primary intracerebral haemorrhage and lacunar stroke risk.

40 loperoxidase levels increase risk of primary intracerebral haemorrhage and lacunar stroke, directly i

41 cerebrovascular permeability, development of intracerebral haemorrhage and neurovascular injury in ex

42 improve clinical management of patients with intracerebral haemorrhage and promise to reduce mortalit

43 t decreases in DBS complications, with fewer intracerebral haemorrhages and infections with general a

44 y participants or patients with non-CAA deep intracerebral haemorrhage) and patients with Alzheimer's

45 dwide (91.5% for ischaemic stroke, 87.1% for intracerebral haemorrhage), and were consistent across r

46 frequent but previously underestimated after intracerebral haemorrhage, and are three times more comm

47 of 14.2% (95% CI 10.0-19.3) at 1 year after intracerebral haemorrhage, and incidence reached 28.3% (

48 l burden of vascular-related brain damage in intracerebral haemorrhage, and may be a useful surrogate

49 have recently been described in spontaneous intracerebral haemorrhage, and may be important to under

50 separately for cerebral infarction, primary intracerebral haemorrhage, and subarachnoid haemorrhage.

51 dified Rankin scale [mRS]), the incidence of intracerebral haemorrhages, and technical observations.

52 cases [10 388 with ischaemic stroke and 3059 intracerebral haemorrhage] and 13 472 controls).

53 Delayed seizures after intracerebral haemorrhage are associated with different

54 of CAA in patients with thrombolysis-related intracerebral haemorrhage are required.

55 as on cognition in the context of ageing and intracerebral haemorrhage, as well as in Alzheimer's and

56 are alone, reduced death or dependence after intracerebral haemorrhage associated with antiplatelet t

57 n older age-groups, in part due to a rise in intracerebral haemorrhage associated with antithrombotic

58 7, 0.20-0.69; p=0.002), but the incidence of intracerebral haemorrhage associated with antithrombotic

59 The incidence of intracerebral haemorrhage associated with premorbid hype

60 29-0.95; p=0.03), but the number of cases of intracerebral haemorrhage at all ages were similar in OX

61 mplications (cerebrospinal fluid leakage and intracerebral haemorrhage) at days 3-7 after AAV2 gene t

62 published arteriovenous malformation-related intracerebral haemorrhage (AVICH) score showed better ou

63 alteplase seems to be safe in patients with intracerebral haemorrhage, but increased asymptomatic bl

64 embolic events outnumbered warfarin-related intracerebral haemorrhages by about 15-fold (280 vs 19),

65 Neither incidence of symptomatic intracerebral haemorrhage (by SITS-MOST definition, 1/52

66 If the incidence of intracerebral haemorrhage can be decreased, then in the

67 We used a discovery cohort of 1409 primary intracerebral haemorrhage cases and 1624 controls from t

68 d high-dose tinzaparin developed symptomatic intracerebral haemorrhage compared with one in the aspir

69 nd 138 controls (96 healthy elderly, 42 deep intracerebral haemorrhage controls) and 72 patients with

70 ulation aged under 75 years the incidence of intracerebral haemorrhage decreased substantially (rate

71 From the 560 patients with spontaneous intracerebral haemorrhage enrolled in the PITCH cohort b

72 n, 3/52 [6%] vs 4/51 [8%], p=0.59) nor total intracerebral haemorrhage events (8/52 [15%] vs 14/51 [2

73 We studied consecutive patients with intracerebral haemorrhage from four specialist stroke ce

74 al cohort study in patients with spontaneous intracerebral haemorrhage from the Prognosis of Intracer

75 though the number of hospital admissions for intracerebral haemorrhage has increased worldwide in the

76 preclinical and clinical studies focused on intracerebral haemorrhage has risen.

77 h systolic blood pressure were strongest for intracerebral haemorrhage (hazard ratio 1.44 [95% CI 1.3

78 Microbleeds are strongly associated with intracerebral haemorrhage, hypertension, lacunar stroke

79 Antithrombotic agents increase risks of intracerebral haemorrhage (ICH) and associated adverse o

80 mine the strength of the association between intracerebral haemorrhage (ICH) and cerebral amyloid ang

81 ERACT2 enrolled 2839 adults with spontaneous intracerebral haemorrhage (ICH) and high systolic blood

82 the relationship between laterality of acute intracerebral haemorrhage (ICH) and poor clinical outcom

83 onists oral anticoagulants (NOAC)-associated intracerebral haemorrhage (ICH) are largely unknown.

84 ilon2 and epsilon4 have an increased risk of intracerebral haemorrhage (ICH) in lobar regions, presum

85 study, we examined injury progression after intracerebral haemorrhage (ICH) induced by collagenase i

86 Intracerebral haemorrhage (ICH) is an acute neurological

87 of blood pressure (BP) at the acute phase of intracerebral haemorrhage (ICH) is beneficial.

88 Poor prognosis after intracerebral haemorrhage (ICH) is related to haemorrhag

89 Intracerebral haemorrhage (ICH) is the most devastating

90 BACKGROUND AND Intraventricular extension of intracerebral haemorrhage (ICH) predicts poor outcome, b

91 Intraventricular extension of intracerebral haemorrhage (ICH) predicts poor outcome, b

92 Intracerebral haemorrhage (ICH) remains the most devasta

93 ith arteriovenous malformation (AVM)-related intracerebral haemorrhage (ICH) than other AVM or ICH sc

94 dictor of poor outcome only in patients with intracerebral haemorrhage (ICH) volumes </=30 cm(3) (OR

95 (CAA)) is an important cause of spontaneous intracerebral haemorrhage (ICH), a devastating and still

96 cible HO-1 to early brain injury produced by intracerebral haemorrhage (ICH).

97 (95% CI 57-64) in people with non-traumatic intracerebral haemorrhage (ICH).

98 no specific therapies improved outcome after intracerebral haemorrhage (ICH).

99 echanisms underlying brain injury induced by intracerebral haemorrhage (ICH).

100 health-related quality of life (HRQoL) after intracerebral haemorrhage (ICH).

101 ion rate may be a predictor of outcome after intracerebral haemorrhage (ICH).

102 health-related quality of life (HRQoL) after intracerebral haemorrhage (ICH).

103 id angiopathy (CAA) is associated with lobar intracerebral haemorrhage (ICH).

104 ut the long-term prognosis after spontaneous intracerebral haemorrhage (ICH).

105 subjects, including seizures in 5 (0.6%) and intracerebral haemorrhage in 4 (0.5%).

106 Patients with spontaneous supratentorial intracerebral haemorrhage in neurosurgical units show no

107 s, but not in the overall number of cases of intracerebral haemorrhage in older age-groups, in part d

108 transfusion after acute spontaneous primary intracerebral haemorrhage in people taking antiplatelet

109 aemorrhage and examine the absolute risks of intracerebral haemorrhage in the context of functional o

110 e interventions (seizure after discharge and intracerebral haemorrhage in the recreational activity g

111 ital with acute stroke (ischaemic or primary intracerebral haemorrhage) in England and Wales between

112 than two times higher in patients with lobar intracerebral haemorrhage (incidence at 1 year 23.4%, 14

113 14.6-33.3) than for patients with non-lobar intracerebral haemorrhage (incidence at 1 year 9.2%, 5.1

114 ke severity, but the absolute excess risk of intracerebral haemorrhage increased with increasing stro

115 Intracerebral haemorrhage is a complication of thromboly

116 Intracerebral haemorrhage is an important public health

117 prespecified subgroup analysis, according to intracerebral haemorrhage location.

118 s use, improved data collection, low rate of intracerebral haemorrhage, low technical complications,

119 ow age 75 years, absolute number of cases of intracerebral haemorrhage might increase in future.

120 bsolute effects of alteplase on the risks of intracerebral haemorrhage, mortality, and functional imp

121 stroke), and outnumbered disabling or fatal intracerebral haemorrhage (n=45 vs n=18), with an absolu

122 Late seizures after intracerebral haemorrhage occur after the initial acute

123 9-60) in 2013; symptomatic post-thrombolysis intracerebral haemorrhages occurred in 28 of 675 patient

124 or conscious patients with superficial lobar intracerebral haemorrhage of 10-100 mL and no intraventr

125 -80 years with a non-traumatic (spontaneous) intracerebral haemorrhage of 20 mL or higher to standard

126 tratified by trial, to model the log odds of intracerebral haemorrhage on allocation to alteplase, tr

127 patients with CAA versus patients with deep intracerebral haemorrhage or healthy controls.

128 early treatment did not increase the risk of intracerebral haemorrhage or other bleeding.

129 ia in dementia-free survivors of spontaneous intracerebral haemorrhage; our results suggest that unde

130 substantial fall in hypertension-associated intracerebral haemorrhage over the past 25 years, but no

131 sus 6/75 (8%) in the remaining patients with intracerebral haemorrhage (P = 0.024); no diffusion-weig

132 ients with infection at onset, patients with intracerebral haemorrhage (p=0.014), dysphagia (p=0.003)

133 racerebral haemorrhage from the Prognosis of Intracerebral Haemorrhage (PITCH) cohort who were admitt

134 l haemorrhage survivors for association with intracerebral haemorrhage recurrence.

135 creased steeply in the days and weeks before intracerebral haemorrhage (regression p<0.0001) but not

136 eria were pure intraventricular haemorrhage; intracerebral haemorrhage resulting from intracranial va

137 k (odds ratio, 1.07, P = 0.04) and recurrent intracerebral haemorrhage risk (hazards ratio, 1.45, P =

138 ase levels were associated with both primary intracerebral haemorrhage risk (odds ratio, 1.07, P = 0.

139 djusted for stratification variables and the Intracerebral Haemorrhage Score.

140 In patients with intracerebral haemorrhage seen within 90 min, the highes

141 CAAH and thrombolysis-related intracerebral haemorrhage share some clinical features,

142 ture clinical trials including patients with intracerebral haemorrhage should assess cognitive endpoi

143 odels in a prospective cohort of 174 primary intracerebral haemorrhage survivors for association with

144 ective longitudinal follow-up of consecutive intracerebral haemorrhage survivors presenting to a sing

145 enrolled adults within 6 h of supratentorial intracerebral haemorrhage symptom onset if they had used

146 ommon in cerebral amyloid angiopathy-related intracerebral haemorrhage than in other intracerebral ha

147 Hypertension was more associated with intracerebral haemorrhage than with ischaemic stroke, wh

148 ever, the risk of dementia after spontaneous intracerebral haemorrhage that accounts for about 15% of

149 th increasing stroke severity: for SITS-MOST intracerebral haemorrhage the absolute excess risk range

150 ubarachnoid haemorrhages and, of all primary intracerebral haemorrhages, they are responsible for 4%

151 ified assessment of three classifications of intracerebral haemorrhage: type 2 parenchymal haemorrhag

152 ated intracerebral haemorrhage than in other intracerebral haemorrhage types.

153 magnetic resonance imaging (<3 months after intracerebral haemorrhage) using diffusion-weighted imag

154 probable cerebral amyloid angiopathy-related intracerebral haemorrhage versus 6/75 (8%) in the remain

155 tensive care unit with stable, non-traumatic intracerebral haemorrhage volume less than 30 mL, intrav

156 Primary intracerebral haemorrhage was excluded by computed tomog

157 The incidence of primary intracerebral haemorrhage was increased at low temperatu

158 e-phase blood pressure reading after primary intracerebral haemorrhage was more likely than after isc

159 owever defined, the proportional increase in intracerebral haemorrhage was similar irrespective of tr

160 the mean first systolic blood pressure after intracerebral haemorrhage was substantially higher than

161 ajor ischaemic stroke and those with primary intracerebral haemorrhage, we compared acute-phase and p

162 owever, alteplase also increases the risk of intracerebral haemorrhage; we aimed to determine the pro

163 only and those with frontal infarcts and/or intracerebral haemorrhage were both significantly more l

164 A total of 872 survivors of intracerebral haemorrhage were enrolled and followed for

165 d compared with usual premorbid levels after intracerebral haemorrhage, whereas acute-phase systolic

166 ) to investigate changes in the incidence of intracerebral haemorrhage with time, above and below age

167 While the association between CAA and lobar intracerebral haemorrhage (with its high recurrence risk

168 Intraventricular haemorrhage is a subtype of intracerebral haemorrhage, with 50% mortality and seriou

169 st an association with a high risk of future intracerebral haemorrhage, with potential implications f

170 s of Health Stroke Scale [NIHSS]); and fatal intracerebral haemorrhage within 7 days.

171 ge for patients with spontaneous superficial intracerebral haemorrhage without intraventricular haemo