ライフサイエンスコーパス: intracerebroventricular

1 Intracerebroventricular (30 microg or 100 microg) or i.v

2 ession of each of the anti-Abeta scFvs after intracerebroventricular AAV serotype 1 delivery to P0 pu

3 eneficial effects is demonstrated here in an intracerebroventricular Abeta(42) infusion mouse model o

4 P (0.5-5 nmol) into the nTS and prevented by intracerebroventricular administration (20 nmol h(-1)) o

5 Finally, we demonstrate that BCAA intracerebroventricular administration ameliorates abnor

6 Finally, exogenous Dkk1 replacement via intracerebroventricular administration completely revers

7 55041 was soluble in an aqueous vehicle, and intracerebroventricular administration of 31 to 316 nmol

8 acological depletion of serotonin (5-HT) via intracerebroventricular administration of 5,7 dihydroxyt

9 Previous investigations show that intracerebroventricular administration of a potent inhib

10 Scavenging endogenous NPY by intracerebroventricular administration of anti-NPY antib

11 We found that repeated daily intracerebroventricular administration of BDNF attenuate

12 Furthermore, intracerebroventricular administration of BDNF triggered

13 Intracerebroventricular administration of beta-guanidino

14 Intracerebroventricular administration of BMP7 to mice l

15 Intracerebroventricular administration of CoPP in rats w

16 Intracerebroventricular administration of CSF3, 24 h aft

17 A 14-day intracerebroventricular administration of CYCLO to 8-mon

18 ally, the HPA-axis response to peripheral or intracerebroventricular administration of dexamethasone

19 Chronic intracerebroventricular administration of FGF9 increased

20 First, we showed that intracerebroventricular administration of glucose in rat

21 of Hap1 in the rodent hypothalamus, whereas intracerebroventricular administration of insulin downre

22 Intracerebroventricular administration of insulin increa

23 Intracerebroventricular administration of kisspeptin-10

24 Intracerebroventricular administration of KW-6002 into f

25 adrenoceptors directly in the brain (chronic intracerebroventricular administration of metoprolol) at

26 Intracerebroventricular administration of NPQ 53-70 prod

27 Since the intracerebroventricular administration of NPY increases

28 We found that intracerebroventricular administration of NPY inhibits b

29 cessary to mediate the stimulatory effect of intracerebroventricular administration of NPY on VLDL-TG

30 Intracerebroventricular administration of Rac1 antisense

31 Intracerebroventricular administration of saline, oxytoc

32 sgenic rat model of sporadic AD generated by intracerebroventricular administration of streptozotocin

33 A single intracerebroventricular administration of the antisense

34 Intracerebroventricular administration of the CRF antago

35 In Experiment 2 chronic intracerebroventricular administration of the selective

36 y determined that oral, intraperitoneal, and intracerebroventricular administration of this flavonoid

37 We previously reported that intracerebroventricular administration of three anti-Tau

38 me (1 microL) of pre-subarachnoid hemorrhage intracerebroventricular administration of two dosages (0

39 oximately 10 mg/kg/d, 4 months), followed by intracerebroventricular administration of vehicle or div

40 Intracerebroventricular administration to rats of a sing

41 teome), ex vivo (brain slices), and in vivo (intracerebroventricular administration) using activity-b

42 decreasing T(b) in rats than intrathecal or intracerebroventricular administration, indicating a per

43 ignificantly decreased feeding in mice after intracerebroventricular administration.

44 es, but this effect was modest compared with intracerebroventricular administration.

45 severe SMA mice, much more effectively than intracerebroventricular administration; subcutaneous inj

46 ed peripherally (intravenous) and centrally (intracerebroventricular and intra-PFC) (n = 10-12/experi

47 ts that the amnesia resulting from systemic, intracerebroventricular and intrahippocampal injections

48 protein administration (parenteral, central intracerebroventricular and intraparenchymal, intranasal

49 Intracerebroventricular and VMH injection of the nonsele

50 Intracerebroventricular apoE significantly decreased foo

51 a model, we established a unique protocol of intracerebroventricular application of diphtheria toxin

52 An intracerebroventricular application of insulin promoted

53 (MER) by disabling astrocytic functions via intracerebroventricular application of l-aminoadipic aci

54 The effects of intracerebroventricular application of Neuropeptide Y (N

55 Intracerebroventricular ASO injection in neonatal mice r

56 A single embryonic or neonatal intracerebroventricular ASO injection strikingly rescued

57 Chronic FGF-2 infusions (intracerebroventricular) blocked the deficit in SCT caus

58 e exhibited light aversion in response to an intracerebroventricular CGRP injection.

59 eritoneal CGRP injection, but was seen after intracerebroventricular CGRP injection.

60 In addition, as with intracerebroventricular CGRP, there was no general incre

61 dark only, similar to motility changes after intracerebroventricular CGRP.

62 Intracerebroventricular CNTF(Ax15) decreased 24 h food i

63 The findings demonstrate that intracerebroventricular CRF (5 microg) significantly inc

64 monstrated that reinstatement in response to intracerebroventricular CRF administration is heightened

65 Intracerebroventricular CRF impaired intradimensional se

66 Intracerebroventricular dAG also increased FM at the hig

67 Furthermore, intracerebroventricular dAG failed to regulate FM and in

68 erinsulinemic-euglycemic clamp suggests that intracerebroventricular dAG impairs glucose clearance wi

69 In addition, intracerebroventricular delivery of (Met)CCL5 interrupte

70 g inhibition of gliotransmission and because intracerebroventricular delivery of CPT to wild-type mic

71 Moreover, intracerebroventricular delivery of CRH rescued the cond

72 We tested the hypothesis that intracerebroventricular delivery of GAS6 directly into t

73 ich were significantly reduced after chronic intracerebroventricular delivery of losartan.

74 e reduced seizure frequency were mimicked by intracerebroventricular delivery of the NMDA receptor (N

75 treated beagle dogs using intracisternal or intracerebroventricular delivery.

76 Intracerebroventricular E(2) infusion also increased PI3

77 Intrahippocampal or intracerebroventricular E(2) infusion in middle-aged fem

78 as increased 5 min after intrahippocampal or intracerebroventricular E(2) infusion in middle-aged, bu

79 dial, nucleus of the amygdala reproduced the intracerebroventricular effect.

80 cerebroventricular Ex4 to GLP-1r antagonism, intracerebroventricular Ex4 failed to reduce food intake

81 Despite the insensitivity of intracerebroventricular Ex4 to GLP-1r antagonism, intrac

82 Intracerebroventricular Ex4 was 100-fold more potent tha

83 GLP-1r dependence of the anorectic effect of intracerebroventricular Ex4 was assessed in GLP-1r(-/-)

84 nchanged body fat content, rats treated with intracerebroventricular FGF21 displayed a robust increas

85 Intracerebroventricular GCV infusion for 28 days nearly

86 Chronic intracerebroventricular ghrelin (2.5 nmol/d) increased f

87 In rats, intracerebroventricular ghrelin decreased odor detection

88 Intracerebroventricular ghrelin treatment can influence

89 AND In this study, the anorectic effects of intracerebroventricular GLP-1 and Ex4, and the sensitivi

90 ere measured in MCT1-inhibited animals after intracerebroventricular glucose administration following

91 The anorectic effect of intracerebroventricular glucose and the insulin secretor

92 Intracerebroventricular glucose infusion reduced severe

93 required for intravenous (i.v.) but not for intracerebroventricular (i.c.v.) activity.

94 Intracerebroventricular (i.c.v.) administration of CDP-c

95 Intracerebroventricular (i.c.v.) administration of CGS-2

96 Following intracerebroventricular (i.c.v.) administration of GALC

97 We previously demonstrated that intracerebroventricular (i.c.v.) administration of prote

98 In lean mice, intraperitoneal (i.p.) or intracerebroventricular (i.c.v.) administration of SR-33

99 Intracerebroventricular (i.c.v.) administration of the t

100 ciception that was ~100-fold greater than by intracerebroventricular (i.c.v.) administration.

101 Intracerebroventricular (i.c.v.) angiotensin (ANG) II ca

102 In Experiment 1, intracerebroventricular (i.c.v.) infusion of leptin (0.5

103 e assessed Fos-expression in rat brain after intracerebroventricular (i.c.v.) injection of a newly de

104 Intracerebroventricular (i.c.v.) injection of an adipone

105 emic administration of hypertonic saline and intracerebroventricular (i.c.v.) injection of Ang-II inc

106 aluated the effect of intrathecal (i.t.) and intracerebroventricular (i.c.v.) injection of HE in a ra

107 f action of these growth factors, we perform intracerebroventricular (i.c.v.) injections of recombina

108 Generalized glutamate receptor blockade with intracerebroventricular (i.c.v.) kynurenate eliminated P

109 Here, we show that intracerebroventricular (i.c.v.) leptin increases lumbar

110 In addition, intracerebroventricular (i.c.v.) NPS evoked a significan

111 , we assessed the safety and tolerability of intracerebroventricular (i.c.v.) rhPDGF-BB administratio

112 Here, we compared the effects of prolonged intracerebroventricular (i.c.v.) versus systemic deliver

113 essor with IL-1 receptor antagonist (10 mug, intracerebroventricular (i.c.v.), 24 and 48 h after the

114 hen administered by three parenteral routes [intracerebroventricular (i.c.v.), intrathecal, and subcu

115 Intracerebroventricular (i.c.v.)-GnRH restores mating in

116 3 mg/kg s.c.) as well as central (0.3-3 nmol intracerebroventricular, i.c.v.) administration of this

117 e in SMA mice, either by intravenous (IV) or intracerebroventricular (ICV) administration at very ear

118 We found that intracerebroventricular (icv) administration of TTR in n

119 ly blocked the effects of morphine following intracerebroventricular (icv) administration.

120 d in the RVLM of normal rabbits infused with intracerebroventricular (ICV) Ang II.

121 e 5CSRTT and then each was implanted with an intracerebroventricular (ICV) cannula.

122 Expression of BDNF and noggin via intracerebroventricular (ICV) delivery in an adenoviral

123 Inhibition of the enzyme by intracerebroventricular (icv) delivery of AUDA further i

124 By using intracerebroventricular (icv) delivery of the mitotic ma

125 Here, we show that periodic intracerebroventricular (ICV) delivery of this AO result

126 Intracerebroventricular (icv) improgan (40-80 mug) produ

127 First, intracerebroventricular (icv) infusion (5 mul/10 min) of

128 This was followed by leptin intracerebroventricular (ICV) infusion and bone histomor

129 The approach of intracerebroventricular (ICV) infusion of cytosine arabi

130 Intracerebroventricular (ICV) infusion of IGF-I during t

131 Here, we report that intracerebroventricular (icv) infusion of leptin reverse

132 Intracerebroventricular (icv) infusion of NPY (1 nmol/2

133 ract (NTS) preproglucagon (PPG), and chronic intracerebroventricular (ICV) infusion of the GLP-1 rece

134 tral Glp1r stimulates HGP, we tested whether intracerebroventricular (ICV) infusion of the Glp1r anta

135 Male rats subjected to bilateral intracerebroventricular (icv) infusions of EtOH (0-240 n

136 nce stable responding was observed, received intracerebroventricular (ICV) infusions of the KOR agoni

137 Using intracerebroventricular (ICV) infusions, we examine the

138 Intracerebroventricular (icv) injection of ANG II into n

139 mice, Sim1 neuron ablation was performed by intracerebroventricular (ICV) injection of diphtheria to

140 In vivo, intracerebroventricular (icv) injection of IL1beta or TN

141 We report that intracerebroventricular (ICV) injection of leptin, conco

142 s of PK2 on the regulation of food intake by intracerebroventricular (ICV) injection of PK2 and anti-

143 SMA pups (Smn-/-, SMN2+/+, SMNDelta7+/+) by intracerebroventricular (ICV) injection.

144 n antibody to mouse GM-CSF was introduced by intracerebroventricular (ICV) injections into the brains

145 urons via actions on CRF2 receptors, we gave intracerebroventricular (icv) injections of mouse Ucn 2

146 g-induced (3 to 4 weeks) CHF (n=5), CHF with intracerebroventricular (ICV) losartan treatment (n=5),

147 nal populations following either systemic or intracerebroventricular (icv) prolactin administration.

148 lts show that the effects of intravenous and intracerebroventricular IL-1 are mediated by endothelial

149 Finally, EAE mice treated with intracerebroventricular IL-1ra showed normal glutamaterg

150 aged 11beta-HSD1(-/-) mice before and during intracerebroventricular infusion (10 d) of spironolacton

151 smalemmal disruption, rats (n = 21) received intracerebroventricular infusion 2 h before DTBI of a no

152 in treatment by intraperitoneal injection or intracerebroventricular infusion could normalize myocard

153 ist, leptin (0.62 microg/h) was added to the intracerebroventricular infusion for 10 days.

154 rotein-CIP (AAV9-GFP-CIP) to brain cells via intracerebroventricular infusion in amyloid precursor pr

155 bitor, delivered directly to the brain using intracerebroventricular infusion in an aged transgenic m

156 for in vivo imaging of myelination following intracerebroventricular infusion in the rat brain.

157 IgG brain distribution after intrathecal or intracerebroventricular infusion into the cerebrospinal

158 body weight were retained at least 1 d after intracerebroventricular infusion into the left ventricle

159 Finally, intracerebroventricular infusion of 5-HT stimulated base

160 In Experiment 1, pups receiving intracerebroventricular infusion of 50 ng of the anti-in

161 Direct intracerebroventricular infusion of a dominant-negative

162 In OVX rats, 5-min intracerebroventricular infusion of a PAK inhibitor pept

163 nt with the in vitro findings, we found that intracerebroventricular infusion of a specific PPARdelta

164 Direct activation of TLR3 by intracerebroventricular infusion of a TLR3 ligand impair

165 d memory impairment in mice that received an intracerebroventricular infusion of AbetaOs.

166 As expected, intracerebroventricular infusion of AG in mice increased

167 Chronic intracerebroventricular infusion of AG or dAG increased

168 Intracerebroventricular infusion of an adenosine A1 rece

169 food intake without causing malaise, whereas intracerebroventricular infusion of apoE antiserum stimu

170 Results showed that long-term intracerebroventricular infusion of BDNF accelerated the

171 acute carbon monoxide poisoning followed by intracerebroventricular infusion of brain-derived neurot

172 oxygen on hippocampal neurogenesis; whereas intracerebroventricular infusion of brain-derived neurot

173 A1 and mPFC spine density observed 2 h after intracerebroventricular infusion of E2 was blocked by DH

174 In parallel, mice were given an intracerebroventricular infusion of farnesoid X receptor

175 monoxide + hyperbaric oxygen with additional intracerebroventricular infusion of Fc fragment of tyros

176 , aged (24-month-old) rats were treated with intracerebroventricular infusion of FGF-2 or vehicle for

177 Compared with vehicle, continuous intracerebroventricular infusion of FGF21 increased both

178 Intracerebroventricular infusion of GDNF improved behavi

179 Intracerebroventricular infusion of GLP-1 in mice direct

180 WH therapy begun 3 weeks after initiation of intracerebroventricular infusion of human Abeta decrease

181 Intracarotid or intracerebroventricular infusion of hypertonic NaCl evok

182 Antagonizing the NPY1 receptors by intracerebroventricular infusion of its antagonist large

183 -administration paradigm to demonstrate that intracerebroventricular infusion of NPS reinstates extin

184 Similarly, an intracerebroventricular infusion of OLZ resulted in a tr

185 Furthermore, intracerebroventricular infusion of PF4800567 increased

186 n-derived neurotrophic factor signaling with intracerebroventricular infusion of recombinant human Tr

187 nd then blocked central EC signaling with an intracerebroventricular infusion of rimonabant while ass

188 allenged with a brief high-fat diet or acute intracerebroventricular infusion of saturated fatty acid

189 Intracerebroventricular infusion of the BACE1 inhibitor

190 Intracerebroventricular infusion of the CRF-sub-2 recept

191 To accomplish these goals, intracerebroventricular infusion of the KOR antagonist n

192 -sODN-Ran; we then delivered these probes by intracerebroventricular infusion or intraperitoneal inje

193 In this study, we discovered that intracerebroventricular infusion or local OVLT injection

194 (1 microg Fe in 2 microl) was delivered via intracerebroventricular infusion to the left cerebral ve

195 tudy, we examined the effect of BDNF chronic intracerebroventricular infusion versus K252a (a Trk rec

196 rats, we examined if PACAP (.25-1.0 microg, intracerebroventricular infusion) affects motivation as

197 The effects of recombinant sAPP, applied by intracerebroventricular infusion, on hippocampal and cor

198 ipopolysaccharide and later provided IL-4 by intracerebroventricular infusion.

199 and memory impairment in mice that received intracerebroventricular infusions of AbetaOs.

200 id fluxes in male Sprague-Dawley rats during intracerebroventricular infusions of either WIN55,212-2

201 ularly concentrated in the hypothalamus, and intracerebroventricular infusions of nanomolar amounts o

202 Similarly, intracerebroventricular infusions of oligomeric Abeta pr

203 After UVN and one-month intracerebroventricular infusions of saline, GABA(A)R ag

204 y the eIF4E-transgenic mice are corrected by intracerebroventricular infusions of the cap-dependent t

205 lateral ventricle of Sprague-Dawley rats for intracerebroventricular infusions, and arterial and veno

206 Finally, both DOI and estrogen (intracerebroventricular) inhibited feeding in ovariectom

207 t, ghrelin (1 nmol) was administered through intracerebroventricular injection at 5 hrs after CLP.

208 When administered by an intracerebroventricular injection in mice, M119 caused 1

209 ), AgRP, and ghrelin were investigated after intracerebroventricular injection in neural-specific POM

210 A single intracerebroventricular injection in the relatively seve

211 ed reinstatement behavior was measured after intracerebroventricular injection of 10 nM oxytocin in d

212 ped an in vivo model using CD-1 mice with an intracerebroventricular injection of 17-AAG for 24 h.

213 Intracerebroventricular injection of 26RFa and its C-ter

214 It has been reported that intracerebroventricular injection of a mu receptor antag

215 Finally, we report that intracerebroventricular injection of a soluble Fn14-Fc d

216 Importantly, intracerebroventricular injection of Abeta oligomers tri

217 Intracerebroventricular injection of Abeta1-42 oligomers

218 d restored the neuroprotection of gAD, while intracerebroventricular injection of AdipoR1 small inter

219 One intracerebroventricular injection of amylin induces a mo

220 In addition, intracerebroventricular injection of an IL-6 neutralizin

221 Changes in feeding behavior after intracerebroventricular injection of apoE, the regulatio

222 ubdivided into groups either administered an intracerebroventricular injection of artificial cerebros

223 Intracerebroventricular injection of C75 appears to rapi

224 versive behavior that is greatly enhanced by intracerebroventricular injection of CGRP and blocked by

225 METHODS AND Selective depletion of PVM using intracerebroventricular injection of clodronate abrogate

226 In addition, intracerebroventricular injection of DRB not only signif

227 of estrogens or their synthesis by a single intracerebroventricular injection of estrogen receptor a

228 We report that a single intracerebroventricular injection of FGF1 at a dose one-

229 Intracerebroventricular injection of ghrelin decreased s

230 Oral and intracerebroventricular injection of glycine elevated cu

231 Intracerebroventricular injection of Gpr17 agonists indu

232 Intracerebroventricular injection of GPR17 agonists indu

233 Intracerebroventricular injection of IL-1 induced leukoc

234 obtained following social defeat stress, and intracerebroventricular injection of IL-1 receptor antag

235 We found that a single intracerebroventricular injection of IL-1beta caused anx

236 , and global microglia activation induced by intracerebroventricular injection of IL-1beta were not o

237 Intracerebroventricular injection of insulin led to a gr

238 and cellular inflammatory changes induced by intracerebroventricular injection of interleukin-1beta w

239 at toll-like receptor 2 (TLR2) activation by intracerebroventricular injection of its ligand, Pam3CSK

240 A single intracerebroventricular injection of LMW AbetaOs (10 pmo

241 Intracerebroventricular injection of mu-p75-sap produced

242 Intracerebroventricular injection of NPQ/spexin produced

243 A single intracerebroventricular injection of NPY increased TG se

244 (NPY) signaling in the CNS was modulated by intracerebroventricular injection of NPY, receptor antag

245 Intracerebroventricular injection of PGDPs reduces body

246 hesis, we examined the therapeutic effect of intracerebroventricular injection of plasminogen activat

247 After intracerebroventricular injection of poly(I:C), microgli

248 Intracerebroventricular injection of thrombin (20U) was

249 In vivo, intracerebroventricular injection of VEGF increased brai

250 After delivery by intracerebroventricular injection to ATXN2-Q127 mice, AS

251 ce coupled with flow cytometric analyses and intracerebroventricular injection to determine the contr

252 stores SMN expression in motor neurons after intracerebroventricular injection.

253 es, ex vivo as tissue explants or in vivo by intracerebroventricular injection.

254 r to aversion seen previously after central (intracerebroventricular) injection.

255 Intracerebroventricular injections of both Ucn 1 (0.2 mi

256 t all neurons, a result that was verified by intracerebroventricular injections of colchicine into ad

257 volume in mature adult female is reversed by intracerebroventricular injections of IGF-1 receptor ant

258 Using acute intracerebroventricular injections of specific agonists

259 We determined here, by acute intracerebroventricular injections of specific agonists

260 ical studies in mice exposed to stress or to intracerebroventricular injections of this inflammatory

261 Bilateral intracerebroventricular injections of UBP304 (2.0 microl

262 c-Fos levels were elevated by intracerebroventricular injections of Ucn 1 (0.2 microg)

263 reement with UII activation of MPCh neurons, intracerebroventricular injections of UII significantly

264 Obese rodents were treated by intracerebroventricular injections, with immunoneutraliz

265 cogenesis in vivo, we performed transuterine intracerebroventricular injections.

266 tivation and neuroinflammation in the CNS by intracerebroventricular inoculation of TLR7 and/or TLR8

267 (CpG-ODN) to induce neuroinflammation after intracerebroventricular inoculation.

268 asured in response to fasting and refeeding, intracerebroventricular insulin and leptin, and Tub anti

269 Irs1 or Irs2 mediated suppression of HGP by intracerebroventricular insulin infusion.

270 Intracerebroventricular kainate administration in rat, a

271 late alcohol consumption and the efficacy of intracerebroventricular KOR antagonism to reduce such dy

272 Locus coeruleus activation was eliminated by intracerebroventricular kynurenic acid.

273 potent glucose-lowering effect of continuous intracerebroventricular leptin infusion was not impacted

274 Cell-specific gene deletion experiments and intracerebroventricular leptin infusions reveal that ser

275 rts and was normalized by intraperitoneal or intracerebroventricular leptin.

276 gh-fat (HF)-diet had no anorexic response to intracerebroventricular leptin.

277 f COX-1 in the neuroinflammatory response to intracerebroventricular lipopolysaccharide (LPS) was inv

278 nervous system beta1-adrenoceptor blockade (intracerebroventricular metoprolol, 25 microg) to achiev

279 ion of the conserved brain CDC42 activity by intracerebroventricular ML141 injection caused acute anx

280 response, and excessive grooming induced by intracerebroventricular NMU administration were abolishe

281 nsequence of these differences revealed that intracerebroventricular NPS reversed the hyperanxiety of

282 ts received an intravenous (OLZ-IV group) or intracerebroventricular (OLZ-ICV group) infusion of OLZ

283 Three days later, animals received daily intracerebroventricular or intra-VMN injections of eithe

284 We first demonstrated that intracerebroventricular or intrahippocampal E(2) infusio

285 Here, we show that intracerebroventricular or intraperitoneal administratio

286 We found that intracerebroventricular PACAP treatment induced anxiety-

287 ed NO during sleep deprivation (SD), we used intracerebroventricular perfusion in rats of the cell me

288 hetized rats: central cold, ambient cold, or intracerebroventricular prostaglandin E2 (PGE2) injectio

289 Vagotomy, systemic haloperidol, or intracerebroventricular raclopride (a type 2 dopamine re

290 Additionally, we report that intracerebroventricular resistin increased plasma FGF21

291 We show that chronic intracerebroventricular resistin infusion downregulated

292 is effect is abolished in CB1-KO mice and by intracerebroventricular rimonabant treatment, suggesting

293 time of injury or 3 days after injury by the intracerebroventricular route at a dose of 0.29 mg/kg/da

294 al of SPION-labeled fosB probe delivered via intracerebroventricular route was elevated in both acute

295 Intraperitoneal vs. intracerebroventricular routes of IL-18 administration h

296 nzyme replacement therapy via intrathecal or intracerebroventricular routes or with fusion proteins,

297 Intraperitoneal and intracerebroventricular treatment also normalized circul

298 The combined acute and repeated intracerebroventricular treatment with FGF2 and 8-OH-DPA

299 Furthermore, intracerebroventricular treatment with neuronostatin inc

300 compared as young adults for spontaneous or intracerebroventricular urocortin 2 administration-induc