ライフサイエンスコーパス: intrachromosomal

1 e frequent over gene footprints and most are intrachromosomal.

2 Until recently, such stable intrachromosomal aberrations have been very hard to dete

3 t the detection and quantification of stable intrachromosomal aberrations in lymphocytes of healthy f

4 The control groups contained very few such intrachromosomal aberrations.

5 lu-quasipalindromes lead to the formation of intrachromosomal amplicons with large inverted repeats (

6 Intrachromosomal amplification of a region of chromosome

7 th acute lymphoblastic leukemia (ALL) and an intrachromosomal amplification of chromosome 21 (iAMP21)

8 Intrachromosomal amplification of chromosome 21 (iAMP21)

9 Intrachromosomal amplification of chromosome 21 (iAMP21)

10 sor acute lymphoblastic leukemia, defined by intrachromosomal amplification of chromosome 21 (iAMP21)

11 ssociated with an increased risk of relapse (intrachromosomal amplification of chromosome 21 [iAMP21]

12 ted with a poor outcome and characterized by intrachromosomal amplification of chromosome 21 includin

13 analysis of metaphase chromosomes showed an intrachromosomal amplification of the rrm1 locus.

14 t stalled replication forks lead to elevated intrachromosomal and ectopic recombination promoting sit

15 Both spontaneous intrachromosomal and heteroallelic gene conversion event

16 elp define how CTCF mediates both long-range intrachromosomal and interchromosomal interactions, and

17 tic increases in CAN1 duplication mutations, intrachromosomal and interchromosomal recombination, and

18 11 validated clustered breakpoints involving intrachromosomal and interchromosomal translocations bet

19 ous reciprocal exchanges, most of which were intrachromosomal as determined by fluorescence in situ h

20 These data suggest two related phenomena: an intrachromosomal association that holds the halves of a

21 First, intrachromosomal associations increase at longer distanc

22 CYREN allows cNHEJ to occur at telomeres and intrachromosomal breaks during the S and G2 phases, and

23 Such intrachromosomal contacts appear to be a general mechani

24 Fewer short-range intrachromosomal contacts are detected for the inactive

25 inactive X has two superdomains of frequent intrachromosomal contacts separated by a boundary region

26 anscription factories, multiscale loops, and intrachromosomal contacts that mimic those found in vivo

27 Insulators mediate inter- and intrachromosomal contacts to regulate enhancer-promoter

28 ize as they arise spontaneously by inter- or intrachromosomal crossover events within misaligned dupl

29 ult from translocation with the IGH locus or intrachromosomal deletion and is associated with poor ou

30 lass switch recombination (CSR) occurs by an intrachromosomal deletion requiring generation of double

31 lass switch recombination (CSR) occurs by an intrachromosomal deletion whereby the IgM constant regio

32 insertional chromosomal rearrangement or by intrachromosomal deletion.

33 downstream C(H) regions and functions via an intrachromosomal deletional event between the donor Smic

34 lass switch recombination (CSR) occurs by an intrachromosomal deletional process between switch (S) r

35 ombination (SR) occurs by a B cell-specific, intrachromosomal deletional process between switch regio

36 It occurs by a unique type of intrachromosomal deletional recombination within special

37 CSR generally occurs by an intrachromosomal deletional recombination within switch

38 in ATR(+/-)p53(+/-) mice was associated with intrachromosomal deletions and loss of wild-type p53.

39 wo alternative ways: (i) the creation of two intrachromosomal deletions or (ii) the formation of a pa

40 es varying from <100 kb to 66 Mb, indicating intrachromosomal deletions or inversions.

41 ty including the generation of chimeric L1s, intrachromosomal deletions, intrachromosomal duplication

42 ases with LOH limited to less than 9 Mb were intrachromosomal deletions.

43 formed approximately as often as the pair of intrachromosomal deletions.

44 or gene-targeting (plasmid-to-chromosome) or intrachromosomal (direct repeat) homologous recombinatio

45 onfirmed by microscopy by measurement of the intrachromosomal distances between two sites on one chro

46 ex chromosomes yet differ in copy number and intrachromosomal distribution.

47 lated mitochondrial cytochrome c release and intrachromosomal DNA fragmentation, which lead to apopto

48 in achieves this by setting up longer-range, intrachromosomal DNA interactions, which compact and ind

49 (CSR) is a late B cell process that involves intrachromosomal DNA rearrangement.

50 Isotype switching occurs by intrachromosomal DNA recombination between switch (S) re

51 effector functions to antibodies through an intrachromosomal DNA recombination process at the heavy-

52 We explore the role of 53BP1 in intrachromosomal DNA repair using I-SceI to introduce pa

53 Intrachromosomal domains are formed by chromatin anchori

54 We observed that intrachromosomal DSB repair is accomplished with nearly

55 53BP1 facilitates joining of intrachromosomal DSBs but only at distances correspondin

56 st that CSR exploits a general propensity of intrachromosomal DSBs separated by several hundred kilob

57 Among intrachromosomal duplicates, however, there is no correl

58 However, a minimum of three independent intrachromosomal duplication events have resulted in >37

59 t the positional candidate locus D15S122, an intrachromosomal duplication of proximal 15q was detecte

60 However, intrachromosomal duplications also have been reported.

61 e locus for the formation of the majority of intrachromosomal duplications blocks on human chromosome

62 mic sequence stretches and by long segmental intrachromosomal duplications in which highly homologous

63 We find that most of the intrachromosomal duplications seem to share a common anc

64 that show a 12-fold excess of recent (>98%) intrachromosomal duplications when compared with duplica

65 gene family evolved by transchromosomal and intrachromosomal duplications within the human genome.

66 region also contains seven out of the eight intrachromosomal duplications within the sequence, inclu

67 of chimeric L1s, intrachromosomal deletions, intrachromosomal duplications, and intra-L1 rearrangemen

68 de further evidence of gene formation within intrachromosomal duplications, but indicate that recent

69 gest human chromosomes and contains numerous intrachromosomal duplications, yet it has one of the low

70 show evidence of extensive, species-specific intrachromosomal duplications.

71 redominantly as tandem and tightly clustered intrachromosomal duplications.

72 romosomal duplications occurred prior to the intrachromosomal duplications.

73 Analysis of intrachromosomal end joining in individual DSBR survivor

74 n DNA and is involved in the formation of an intrachromosomal enhancer/promoter loop.

75 and R2 eliminations appear to occur by large intrachromosomal events (i.e., loop-out events) that inv

76 We describe 36 novel PDL SRs, including 17 intrachromosomal events (inversions, duplications, delet

77 ngements occur via both interchromosomal and intrachromosomal exchange events between the proximal an

78 Two of the recurrent transcripts involved an intrachromosomal fusion between RCC1 and HENMT1 located

79 Spectral karyotype analysis showed frequent intrachromosomal fusions and fragmentations 26 hours aft

80 erentially mapped to certain chromosomes and intrachromosomal gene clusters.

81 ctive and nonproductive pathways, whereas in intrachromosomal gene conversion and mating-type switchi

82 ery generation, a process accomplished by an intrachromosomal gene conversion between an expressor lo

83 A specific intrachromosomal gene conversion event between two compl

84 The induction of intrachromosomal gene conversion in Arabidopsis by HO re

85 We could establish intrachromosomal gene conversion in the male germline as

86 a high degree of similarity, suggesting that intrachromosomal gene conversion is frequent, perhaps pr

87 d for interhomologue gene conversion but not intrachromosomal gene conversion.

88 ses indicated high wheat-specific inter- and intrachromosomal gene duplication activities that are po

89 separate sets of cooperating loci exist for intrachromosomal genomic instability in human colorectal

90 oncerted evolution of the tandem U2 genes is intrachromosomal homogenization; interchromosomal geneti

91 d by an 8-bp XhoI linker insertion; rates of intrachromosomal homologous recombination between the ma

92 nterchromosomal mating-type switching and on intrachromosomal homologous recombination but not on int

93 on from one allele to the other is caused by intrachromosomal homologous recombination mediated by se

94 Intrachromosomal homologous recombination, manifest as r

95 creased rates of chromosomal aberrations and intrachromosomal homologous recombinational events in th

96 ed a ?selectable marker system to screen for intrachromosomal illegitimate recombination events in or

97 short direct repeats, a unique signature of intrachromosomal illegitimate recombination.

98 age, 10 cM apart to quantitate the extent of intrachromosomal instability in 59 human sporadic colore

99 ficient GH1 expression requires a long-range intrachromosomal interaction between remote enhancer seq

100 Thus, BN analysis of large intrachromosomal interaction datasets is a useful tool f

101 TNF gene regulation thus reveals a mode of intrachromosomal interaction that combines a looped gene

102 wn of IRAIN lncRNA with shRNA abolishes this intrachromosomal interaction.

103 n BN modeling indicates that the strength of intrachromosomal interactions (hic_strength) is directly

104 nation (CSR) is regulated through long-range intrachromosomal interactions between germline transcrip

105 ortantly, poly(ADP-ribosyl)ation facilitates intrachromosomal interactions between insulator sites me

106 ked Rad50 gene, but it did reduce long-range intrachromosomal interactions between the locus control

107 en by long-range protein-mediated inter- and intrachromosomal interactions have been reported to infl

108 Intrachromosomal interactions in the T(H)2 cytokine locu

109 We propose that short-range intrachromosomal interactions may form the basis of coor

110 We demonstrate that numerous intrachromosomal interactions occur along both parental

111 interaction but otherwise a predominance of intrachromosomal interactions over interchromosomal inte

112 Long-range intrachromosomal interactions play an important role in

113 r biological functions, and are enriched for intrachromosomal interactions with synchronized promoter

114 ng TH2-cell-related cytokines and diminished intrachromosomal interactions within that locus.

115 In addition to these intrachromosomal interactions, we now describe interchro

116 fect gene expression by mediating inter- and intrachromosomal interactions.

117 g to analyze publicly available datasets for intrachromosomal interactions.

118 TNF gene, which undergo activation-dependent intrachromosomal interactions.

119 angements (translocations or insertions) and intrachromosomal inversions that contain long (1-4000 kb

120 ps, nested insertion of rice linkage groups, intrachromosomal inversions, and a nonreciprocal translo

121 With the use of an intrachromosomal inverted repeat as a recombination repo

122 With the use of an intrachromosomal inverted-repeat as a recombination repo

123 d to be similar in structure to conventional intrachromosomal joints.

124 tial proximity of potentially recombinogenic intrachromosomal loci.Oncogene advance online publicatio

125 g repair of a single site-specific DSB at an intrachromosomal locus.

126 This inter- or intrachromosomal long-range regulation does not require

127 H19 imprinting domain and forms a long-range intrachromosomal loop to interact with the three cluster

128 tion capture (3C) analysis indicated that an intrachromosomal loop was formed by CTCF self-dimerisati

129 , we demonstrate that upon T cell activation intrachromosomal looping occurs in the TNF locus.

130 CSR occurs via an intrachromosomal looping out and deletion mechanism that

131 nscriptional start site of the CA12 gene via intrachromosomal looping upon hormone treatment.

132 The intrachromosomal loops detected in genomic studies conta

133 Here we show that each opsin gene forms intrachromosomal loops in the appropriate photoreceptor

134 , indicating that it arises predominantly by intrachromosomal misalignment during meiosis.

135 with Y chromosomes that evidently formed by intrachromosomal NAHR between inverted repeat pairs comp

136 ght the recombinogenic nature of the MSY, as intrachromosomal NAHR occurs for nearly all Y-chromosome

137 We utilized an intrachromosomal NHEJ substrate in which DSBs are genera

138 n Y chromosome (MSY) and provide targets for intrachromosomal non-allelic homologous recombination (N

139 suggested that the inversions were caused by intrachromosomal nonhomologous recombination.

140 nteractions are apparently lost in favour of intrachromosomal ones upon gene activation.

141 hyroid carcinoma (PTC) typically have either intrachromosomal or extrachromosomal rearrangements that

142 Haplotype analysis indicated an intrachromosomal origin for the duplication.

143 significance, LD was found among 8 of the 34 intrachromosomal pairs of loci.

144 One intrachromosomal rearrangement was detected in this link

145 , the human sequence has undergone extensive intrachromosomal rearrangement, whereas the mouse sequen

146 Comparative genome analyses support intrachromosomal rearrangements across the phylum, dispr

147 Thus, intrachromosomal rearrangements and inversions appear to

148 Both inter- and intrachromosomal rearrangements are facilitated by the p

149 angement scenario, and provide evidence that intrachromosomal rearrangements are more frequent than i

150 nts are more often interchromosomal, whereas intrachromosomal rearrangements are more prominent in ra

151 enome allowed an assessment of the number of intrachromosomal rearrangements between it and the chick

152 o) genome it has become possible to describe intrachromosomal rearrangements between these three impo

153 there was a greater than expected degree of intrachromosomal rearrangements compared to the chicken,

154 Only one interchromosomal and two intrachromosomal rearrangements differentiated both S. o

155 nd DeltaN599) were identified as products of intrachromosomal rearrangements fusing the 3' coding por

156 This shows that intrachromosomal rearrangements have been fixed more fre

157 These results suggest that intrachromosomal rearrangements may be a common mechanis

158 We studied intrachromosomal rearrangements of the syntenic block 3/

159 Intrachromosomal rearrangements or deletions are produce

160 frequent occurrence of inversions and other intrachromosomal rearrangements since the divergence of

161 eran autosomes; in contrast, higher rates of intrachromosomal rearrangements support a special role o

162 A number of intrachromosomal rearrangements were detected by mapping

163 firmed, but a larger than expected number of intrachromosomal rearrangements were reported; (2) to hy

164 Intrachromosomal rearrangements, as shown here, make up

165 oci on 12 chromosomes, and only DAs mediated intrachromosomal rearrangements, based on our reconstruc

166 a finch and chicken, but they differ in many intrachromosomal rearrangements, lineage-specific gene f

167 In contrast to several intrachromosomal rearrangements, only two evolutionary t

168 le the felid lineage has primarily undergone intrachromosomal rearrangements.

169 lthy plutonium workers contain large (>6 Mb) intrachromosomal rearrangements.

170 abundance and splicing, and both inter- and intrachromosomal rearrangements.

171 usion oncogenes that arose primarily through intrachromosomal rearrangements.

172 ome, revealing a surprisingly high number of intrachromosomal rearrangements.

173 th genomes have been extensively reshaped by intrachromosomal rearrangements.

174 ne families or palindromes that might enable intrachromosomal recombination and repair.

175 Ab class switching occurs by an intrachromosomal recombination and requires generation o

176 chromosome pairing reduces the frequency of intrachromosomal recombination and thus decreases, but d

177 ar to those in higher eukaryotes, and MMR on intrachromosomal recombination between highly diverged (

178 hat expression of HO in Arabidopsis enhances intrachromosomal recombination between inverted repeats

179 omal circular DNA molecule that results from intrachromosomal recombination between long terminal rep

180 Intrachromosomal recombination between repeated elements

181 system to show that the molecules excised by intrachromosomal recombination between tandem FLP recomb

182 Previous studies have shown that the rate of intrachromosomal recombination between tandem repeats is

183 Homologous intrachromosomal recombination between the repeated regi

184 ly unique IgH locus in every B cell clone by intrachromosomal recombination between two switch (S) re

185 showed antimutagenic effects in deletion and intrachromosomal recombination events against ethyl meth

186 We investigated the inducibility of such intrachromosomal recombination events at different stage

187 distant control elements and to orchestrate intrachromosomal recombination events by pairing appropr

188 In contrast, intrachromosomal recombination events in the progeny dec

189 me and the plasmid was generally higher than intrachromosomal recombination except for two loci, araA

190 Interplasmidic and intrachromosomal recombination in Deinococcus radioduran

191 We designed DNA substrates to study intrachromosomal recombination in mammalian chromosomes.

192 icity assays that score for DNA deletions by intrachromosomal recombination in vivo and in vitro.

193 Thus, the observed high intrachromosomal recombination is due to meiotic recombi

194 hree-generation families showed that meiotic intrachromosomal recombination mediated the deletion.

195 n repair and are also defective in a mitotic intrachromosomal recombination pathway.

196 The frequency of intrachromosomal recombination reaches a value of 3.1%,

197 determine whether UV damage-induced mitotic intrachromosomal recombination relies on damage-induced

198 lts in a significantly elevated frequency of intrachromosomal recombination resulting in deletion eve

199 -specific double-strand breaks (DSBs) within intrachromosomal recombination substrates in Schizosacch

200 Furthermore, spontaneous intrachromosomal recombination that gives rise to deleti

201 substrates and tk(+) segregants produced via intrachromosomal recombination were recovered.

202 substrate that can report triplex-stimulated intrachromosomal recombination were transfected with a s

203 The production of rDNA circles depends upon intrachromosomal recombination within the rDNA tandem ar

204 plore the effects of chromosomal topology on intrachromosomal recombination, distinct loop geometries

205 a rad50S mutation does not diminish meiotic intrachromosomal recombination, similar to the mutant ph

206 When separated from the active centromere by intrachromosomal recombination, the inactive centromere

207 elevated frequencies of spontaneous mitotic intrachromosomal recombination, which is a phenotype sha

208 of the parental chromosomes and were due to intrachromosomal recombination.

209 active-capable of influencing the course of intrachromosomal recombination.

210 rates is relaxed for both gene targeting and intrachromosomal recombination.

211 eptibility, telomere length maintenance, and intrachromosomal recombination.

212 c systems and the generation of deletions by intrachromosomal recombination.

213 ng displaced synapsis and crossing over, and intrachromosomal recombination.

214 suggest that RAD59 functions specifically in intrachromosomal recombination.

215 he processing of double-strand breaks during intrachromosomal recombination.

216 e greater impact from natural selection than intrachromosomal regions.

217 uggest that homologous recombination between intrachromosomal repeats can be specifically initiated b

218 e-breakage-fusion cycles that generate large intrachromosomal repeats; these are ultimately trimmed b

219 re there is no meiotic recombination map and intrachromosomal repetitive sequences are abundant.

220 verified variant sites localized to areas of intrachromosomal segmental duplication within the human

221 hat the rapid expansion and fixation of some intrachromosomal segmental duplications during great-ape

222 Our analysis suggests that both inter- and intrachromosomal segmental duplications have impacted on

223 iated with the presence of highly homologous intrachromosomal segmental duplications.

224 We suggest the increase in intrachromosomal SSA reflects an opportunistic default r

225 hroughout the genome and are associated with intrachromosomal telomere repeats.

226 An intrachromosomal telomere-telomere fusion resulting in a

227 ged as a result of inversions and inter- and intrachromosomal translocations.

228 heavy chain (IGH) locus consisting of either intrachromosomal (VDJ) rearrangements or interchromosoma