ライフサイエンスコーパス: intracrine

1 oducing a potential novel model of autocrine/intracrine action of S1P that still involves its GPCRs.

2 n-coupled PTH/PTHrP receptor, PTHrP also has intracrine actions mediated by a nuclear localization se

3 The intracrine activity of steroid metabolizing enzymes is i

4 he hypothesis that melatonin acts both as an intracrine and paracrine circadian signal of darkness, a

5 an also be produced within tissues to act in intracrine and paracrine fashions.

6 Intracrine androgen production and AR amplification, amo

7 Abiraterone acetate potently disrupts intracrine androgen receptor signalling pathways implica

8 ated with enzalutamide resistance; targeting intracrine androgens and AKR1C3 will overcome enzalutami

9 the current study highlights NPC2 as a novel intracrine/autocrine factor that controls adipocyte diff

10 y coexpression of DP1, suggesting a possible intracrine/autocrine signaling mechanism.

11 Intracrine biosynthesis of endometrial androgens during

12 rgeting complete suppression of systemic and intracrine contributions to the prostatic androgen micro

13 beta-adrenergic stimulation, arguing against intracrine control of respiration by NO within cardiac m

14 inct function of VEGF in mediating autocrine/intracrine CRC cell survival.

15 Endothelin-1 acts in an intracrine fashion on endolysosomal ET(B) to induce nitr

16 whether these can control respiration in an intracrine fashion.

17 coexist, allowing NO to work in an autocrine/intracrine fashion.

18 slation and influence cellular events in an "intracrine" fashion.

19 ed by endothelial NO in a paracrine, but not intracrine, fashion.

20 essenger in both the autocrine/paracrine and intracrine FGF-2 pathways.

21 Intracrine GH acts in pituitary cells as an apoptosis sw

22 11beta-HSD1) amplifies local intracellular ("intracrine") glucocorticoid action; in the brain it is h

23 by VEGF regulates differentiation through an intracrine mechanism that is distinct from the role of s

24 the efficacy of using this drug delivery and intracrine mechanism to control the fate of human MSCs a

25 of mesenchymal stem cells (MSCs) through an intracrine mechanism, suggesting a new strategy to promo

26 and independent, act through auto-, para- or intracrine mechanisms and can be modified by hormonal si

27 vern inflammatory and immune responses as an intracrine mediator of eosinophil cytokine secretion.

28 leukotrieneC4 acts through hitherto unknown intracrine mode to elicit store-independent Ca(2+) signa

29 ted in exogenous (paracrine), autocrine, and intracrine modes.

30 Thus, myocyte autocrine/intracrine NOS3 regulation in vivo can underlie key role

31 ght to establish if there are differences in intracrine, paracrine, and endocrine regulation of sex s

32 8 production in prostate cancer cells via an intracrine pathway independent of its classical nuclear

33 are nuclear and exert activities through an intracrine, perhaps nuclear, pathway.

34 decreased decidualization suggesting that an intracrine prostanoid pathway consisting of Cox-2, prost

35 Stanniocalcin-1 is an intracrine protein; it binds to the cell surface, is int

36 tory forms of PTHrP, the role of PTHrP as an intracrine regulator of cell growth and cell death; (b)

37 MAP3K1 is therefore the nexus of an intracrine regulatory loop connecting the TGF-alpha/EGFR

38 1beta-HSD1 provides lymphocytes with a novel intracrine regulatory mechanism that could influence suc

39 signaling has been extensively studied, its intracrine role has been largely attributed to interacti

40 Peripheral intracrine sex steroid synthesis from adrenal precursors

41 d whether cysteinyl leukotrienes (cysLT) are intracrine signal transducers that regulate human eosino

42 fected with HHV-8 in an autocrine manner via intracrine signaling and that these activities may contr

43 investigate the role of these regions in the intracrine signaling of HMW FGF-2, we produced stable tr

44 brane-anchoring domain converts autocrine to intracrine signaling.

45 In addition, intracellular (intracrine) sites of angiotensin action have been report

46 gical effects from the interior of the cell (intracrine), some of which are not inhibited by Ang rece

47 We conclude that intracrine steroidogenesis may permit tumors to circumve

48 l require novel agents capable of inhibiting intracrine steroidogenic pathways within the prostate tu

49 cate into the nucleus, thereby serving as an intracrine stimulator of smooth muscle proliferation.

50 these studies show how VEGF functions as an intracrine survival factor in colorectal cancer cells, d

51 steroids, AR overexpression, increased local intracrine synthesis of androgens, and upregulation of t

52 teroid sulfatase (STS) inhibitors confirming intracrine synthesis to estrogen.

53 pulmonary artery smooth muscle cells via an intracrine TGF-beta1 pathway in pulmonary hypertension.

54 In this study, we investigated the role of intracrine VEGF signaling in colorectal cancer cell surv

55 suggest that stromal-dependent paracrine and intracrine VEGF-A/VEGFR-1 signaling contributes to human

56 clear whether they control respiration in an intracrine way.