ライフサイエンスコーパス: intractable

1 neage-level differences when fine-mapping is intractable.

2 e to the loss of hair cells is permanent and intractable.

3 Fokker-Planck approach, the dynamic gain is intractable.

4 idity worldwide yet has remained genetically intractable.

5 f freedom that are otherwise computationally intractable.

6 of entry that had previously been relatively intractable.

7 ise for treating diseases that are currently intractable.

8 the Focus Level procedure is computationally intractable.

9 ssion in both tumor cells and T cells remain intractable.

10 namics in quantum systems that are otherwise intractable.

11 The latter are considered to be intractable.

12 ation-based approaches) that were previously intractable.

13 ufacture when cell culture adaptation proves intractable.

14 hes are essential, though often analytically intractable.

15 ucture between genes, or are computationally intractable.

16 effects, but these typically make the theory intractable.

17 tigations of sialoglycans in brain have been intractable.

18 in experimental settings typically viewed as intractable.

19 NP-complete, and so probably computationally intractable.

20 ted in favor of a simple but computationally intractable acid-base mechanism.

21 selective hERG-blocking torsadogen used for intractable AF, verapamil, a non-torsadogenic MICE compa

22 ert from their native functional states into intractable amyloid aggregates.

23 oteins from their soluble native states into intractable amyloid deposits is associated with a wide r

24 However, exact Bayesian inference is intractable and approximate methods such as Markov chain

25 However, these methods are computationally intractable and can be inaccurate when the number of reg

26 formation of bacteria and archaea considered intractable and difficult-to-transfect, while facilitati

27 ecially for genome engineering strategies of intractable and economically important microbial species

28 tic ductal adenocarcinoma is one of the most intractable and fatal cancer.

29 difficult to locate and are morphologically intractable and genetically divergent.

30 g the performance of PBT was computationally intractable and previous attempts succeeded only with sm

31 used, the reconstitution process is often an intractable and time-consuming trial-and-error procedure

32 nal immunoassays operated with expensive and intractable antibodies.

33 of such simulations also becomes classically intractable as system sizes increase.

34 over harmful drug seeking is one of the most intractable aspects of addiction, as human substance abu

35 mab provided a good clinical response for an intractable asthma.

36 terized by poor prognosis and remain largely intractable at the metastatic stage.

37 mputational barriers that made such analyses intractable at this scale.

38 Although historically a genetically intractable bacterium, Chlamydia is experiencing a renai

39 design problem is generally computationally intractable because of parametric uncertainties in the m

40 manual collection and curation are becoming intractable because of the large number of sequences in

41 to investigate many important and previously intractable bioelectric phenomena.

42 n of temporal lobe epilepsy (TLE), a common, intractable brain disorder, arises in children with febr

43 Epilepsy is one of the most common and intractable brain disorders.

44 ith a large number of degrees of freedom are intractable by classical computers, since their complexi

45 Metastatic melanoma is among the most intractable cancers to treat; patients show resistance t

46 s with CSU can be gradually improved even in intractable cases.

47 rocolitis (NEC), which remains a leading and intractable cause of mortality in preterm infants.

48 An intractable challenge in glaucoma treatment has been to

49 Treating obesity has proven to be an intractable challenge, in part, due to the difficulty of

50 egalencephaly (HME), are important causes of intractable childhood epilepsy.

51 ial, patients (aged 1-30 years) with severe, intractable, childhood-onset, treatment-resistant epilep

52 Neuropathic pain is a major, intractable clinical problem and its pathophysiology is

53 be staged as necessary, avoiding the almost intractable complexity apparent in even the simplest cur

54 Unfortunately, this model gives rise to an intractable computational problem: The computation of th

55 supercomputing resources to solve otherwise intractable computational tasks.

56 Fibrosis is a common and intractable condition associated with various pathologie

57 chronic itch, chronic itch remains an often intractable condition.

58 e systemic amyloidoses have been regarded as intractable conditions, but improvements in the understa

59 In societies involved in an intractable conflict, there are strong socio-psychologic

60 olence within the context of one of the most intractable conflicts in the world, the intervention led

61 The ability to infer intractable control models from sensor data opens new po

62 e potential to modify the natural history of intractable critical limb ischemia.

63 ype 1 (LAD1) had severe periodontitis and an intractable, deep, nonhealing sacral wound.

64 ntially inappropriate treatments that remain intractable despite intensive communication and negotiat

65 ce, opening a new strategy for treating this intractable developmental disorder.

66 ongenital sodium diarrhea (CSD) refers to an intractable diarrhea of intrauterine onset with high fec

67 d to mutations in the MYO5B gene, leading to intractable diarrhea often necessitating intestinal tran

68 rentiation characterized by life-threatening intractable diarrhea.

69 ovides recommendations to prevent and manage intractable disagreements about the use of such treatmen

70 Malignant mesothelioma (MM), is an intractable disease with limited therapeutic options and

71 nd therapeutic strategies for this otherwise intractable disease.

72 ell-type specific intervention in this often intractable disease.

73 ial fraction of patients diagnosed with this intractable disease.

74 ell-targeted therapies in patients with this intractable disease.

75 ritical to developing new therapies for this intractable disease.

76 for patients suffering from EB, a currently intractable disease.

77 Intractable diseases such as cancer are associated with

78 in clinical trials, including in previously intractable diseases such as melanoma.

79 s potential for cell-based therapies against intractable diseases such as those that affect the centr

80 f the world's most debilitating, costly, and intractable diseases.

81 novel class of drugs to combat the hitherto intractable disorder of chronic asthma.

82 promising route to treating these otherwise intractable disorders than seeking to adjust levels of o

83 nd treatment development for these currently intractable disorders.

84 gets for drug development in these currently intractable disorders.

85 ies can target the underlying cause of these intractable disorders.

86 pment of durable therapy for these currently intractable disorders.

87 ebrafish findings, we treated five medically intractable Dravet syndrome patients with a clinically-a

88 ylase (ACC), an attractive but traditionally intractable drug target.

89 ration of other enzymes previously viewed as intractable drug targets.

90 rmore, manual annotation of the data remains intractable due to the large number of samples in the ar

91 heterogeneous catalysts, a problem typically intractable due to the multiplicity of coordination envi

92 ized arterial calcification of infancy is an intractable ectopic mineralization disorder caused by mu

93 cessary for pre-existing glaucoma cases with intractable elevated IOP with or without INV.

94 IL-10/IL-10R-deficient patients had intractable enterocolitis, perianal disease, and fistula

95 The remaining patients had intractable epilepsies of different causes and type.

96 (SUDEP) is the most common cause of death in intractable epilepsies, but physiological mechanisms tha

97 l migration, severe intellectual disability, intractable epilepsy and early death.

98 pe of severe neurological symptoms including intractable epilepsy and profound neurocognitive impairm

99 We recorded from patients with chronically intractable epilepsy as they performed a task that requi

100 Dravet syndrome (DS) is an infantile-onset intractable epilepsy caused by heterozygous loss-of-func

101 phic (ECoG) data from 15 human patients with intractable epilepsy during a word completion task and e

102 study a research participant with medically intractable epilepsy who had extensive bilateral frontot

103 l EEG data from rare patients with medically intractable epilepsy, and found evidence for respiratory

104 order associated with mental retardation and intractable epilepsy, and Miller-Dieker syndrome (MDS) i

105 This approach is of therapeutic interest for intractable epilepsy, as it spares cortical function bet

106 racterized by abnormal brain development and intractable epilepsy, caused similar defects in Golgi lo

107 haly, movement disorders, and/or early-onset intractable epilepsy.

108 injury (TBI) is one of the leading causes of intractable epilepsy.

109 on of dysplastic cortex for the treatment of intractable epilepsy.

110 pic cortex, and is generally associated with intractable epilepsy.

111 ng seizures in people with pharmacologically intractable epilepsy.

112 injury (TBI) and a common cause of medically-intractable epilepsy.

113 wer antiepileptic drugs for the treatment of intractable epilepsy.

114 es in 11 patients for surgical evaluation of intractable epilepsy.

115 3% accurate on a dataset of 16 patients with intractable epilepsy.

116 y is a valuable option for pharmacologically intractable epilepsy.

117 most common cause of death in patients with intractable epilepsy.

118 parent-offspring trios with fever-sensitive, intractable epileptic encephalopathy, leading to the dis

119 y presented to the emergency department with intractable epistaxis.

120 They can be computationally intractable even for mining a dataset containing just a

121 robed directly and revealing computationally intractable features that rely on the long-range interac

122 r converting self-limited tissue repair into intractable fibrosis.

123 anguage dominance in patients with medically intractable focal epilepsies against the results of an i

124 Intractable focal epilepsy is a devastating disorder wit

125 Data in 23 patients with medically intractable focal epilepsy were retrospectively analyzed

126 n holds promise as a novel approach to treat intractable focal epilepsy while minimizing disruption o

127 nguage laterality in patients with medically intractable focal epilepsy.

128 for arbitrary circulant quantum circuits is intractable for a classical computer, assuming conjectur

129 Since exact inference in this model is intractable for all the scale of the datasets, we develo

130 ak transient complexes have remained largely intractable for crystallographic studies.

131 ommunity approach; however, SI models can be intractable for examining species-diverse, spatially str

132 tomistic description remains computationally intractable for fully quantum mechanical approaches.

133 Tripedalia cystophora, a species previously intractable for gene transfer, although no clear evidenc

134 often renders direct ab initio calculations intractable for large or complex systems.

135 in memory to start their workflows, which is intractable for mammalian genomes.

136 l and basic research applications previously intractable for potentiometric dyes.

137 lzheimer's and Parkinson's, are particularly intractable for structure-targeted therapeutic design.

138 Dravet Syndrome is an intractable form of childhood epilepsy associated with d

139 pective optimization of crystallographically intractable fragment hits into more potent binders.

140 ther tau reduction may also be of benefit in intractable genetic epilepsies.

141 apeutic benefit in Dravet syndrome and other intractable genetic epilepsies.

142 or prospectively according to mathematically intractable genetic models, and to assist the validation

143 pioneer TF Sox2 to facilitate its binding to intractable genomic loci in embryonic stem cells.

144 ey feature of other pioneer TFs operating at intractable genomic loci.

145 HZ is a particularly intractable GI and its detection represents a significan

146 oscope; endoscopic cyclophotocoagulation for intractable glaucoma; endoscopic trimming of a retropros

147 atin derivative (6OTD), limits the growth of intractable glioblastoma (grade IV glioma) and glioma st

148 dex, 28 kg/m(2) [range, 20-35 kg/m(2)]) with intractable groin pain were included.

149 ovel treatment modalities for this currently intractable group of disorders.

150 e revealed many new species in taxonomically intractable groups, but unbiased studies of previously w

151 le alternative strategy for the treatment of intractable heroin addiction, particularly in individual

152 We represent three cases of intractable high-volume diarrhea associated with combine

153 53 mutations are observed frequently in most intractable human cancers and establish dependency for t

154 ve attribution asymmetry," driving seemingly intractable human conflict.

155 dous promise for the treatment of previously intractable human diseases but to exert their effects on

156 tion and deposition are associated with many intractable human diseases.

157 opener diazoxide is used clinically to treat intractable hypoglycemia caused by excessive insulin sec

158 nhibitors as a generalized strategy to treat intractable hypoxic cancer cells found widely in most so

159 owever, existing methods are computationally intractable in large cohorts and may not optimize power.

160 with severe neurodevelopmental delay and an intractable infantile-onset seizure disorder.

161 2 patients (75%) had high-risk features (ie, intractable infections and autoinflammation), 25 (45%) w

162 Microbial persisters can cause recurrent or intractable infections, and, like resistant mutants, the

163 these drugs is their inability to target the intractable infectious stage of the parasite.

164 Findings suggest that in cases of intractable intergroup conflict, top-down control mechan

165 g for the millions of people who suffer from intractable itch.

166 ion and partitioning--to generate previously intractable large metagenome assemblies.

167 ted the search for alternative therapies for intractable liver diseases.

168 imaging might be considered in children with intractable localized pruritus of unknown etiology of th

169 e: Chronic critical limb ischemia, marked by intractable lower extremity ischemic rest pain and tissu

170 rgery can be a last resort for patients with intractable, medically refractory epilepsy.

171 on and surgical specimens from patients with intractable Meniere's disease.

172 is an effective treatment for patients with intractable mesial temporal lobe epilepsy (mTLE), a thir

173 orm discharges and seizures in patients with intractable mesial temporal lobe epilepsy, without affec

174 orm discharges and seizures in patients with intractable mesial temporal lobe epilepsy.

175 An intractable model of immune recognition with close to a

176 vances in Bayesian statistical inference for intractable models, we fitted a nonlinear control model

177 y be therapeutic for patients with otherwise intractable mood, anxiety and pain syndromes.

178 78 patients with intractable mTLE and unilateral hippocampal sclerosis un

179 or of postoperative outcome in patients with intractable mTLE.

180 ear-old man with intellectual disability and intractable multifocal epilepsy presented to a neurologi

181 with ptosis, optic atrophy, and recent-onset intractable myoclonic epilepsy.

182 res (limited recovery from ON, bilateral ON, intractable nausea, progressive course of disability), l

183 Multiple-system atrophy is an intractable neurodegenerative disease characterized by a

184 0A as a possible therapeutic target for this intractable neurological disease.

185 esponsible for approximately 40% of cases of intractable neuropathic pain after spinal cord injury (S

186 Chronic, intractable neuropathic pain is a common and debilitatin

187 used cancer drug which induces a serious and intractable neuropathy.

188 Select cases of intractable obsessive-compulsive disorder (OCD) have und

189 psulotomy benefitted patients with otherwise intractable OCD and thus appears to be an alternative to

190 randomized clinical trial, 16 patients with intractable OCD were randomized to active (n = 8) or sha

191 ventral gamma capsulotomy for patients with intractable OCD.

192 treatment options for this most serious and intractable of conditions.

193 for treating infections caused by this most intractable of drug resistant pathogens.

194 blastoma multiforme (GBM) is one of the most intractable of human cancers, principally because of the

195 fficiently solve important problems that are intractable on a conventional computer.

196 ions, but with genomes previously considered intractable or too expensive to undertake.

197 oscopic BCAs and subarray threshold CNVs are intractable, or cryptic, to both CMA and karyotyping.

198 t an innovative pharmacological strategy for intractable organ fibrosis.

199 oteins in both model species and genetically intractable organisms.

200 ate gene expression in otherwise genetically intractable organisms; and (iv) can be tailored to a nar

201 cal cortical dysplasia, are common causes of intractable paediatric epilepsy.

202 ) is safe and effective in the management of intractable pain associated with chronic pancreatitis (C

203 not because of secondary complications like intractable pain or secondary glaucoma.

204 n and calcium channel blockers for otherwise intractable pain states; and drugs which show promise in

205 e role of topical agents in the treatment of intractable pain syndromes.

206 xcellent candidate for treatment of chronic, intractable pain via spinal administration.

207 The most common indication for surgery was intractable pain, and all patients had undergone endosco

208 onic pain, persistent pain, pain management, intractable pain, and refractory pain to identify Englis

209 imension of 8 cm or smaller that was causing intractable pain.

210 is secondary to pancreas divisum [CPPD]) and intractable pain.

211 le combination of choices is computationally intractable, particularly for longer multistep decisions

212 ugs for novel therapeutic effects with often intractable pathological scenarios.

213 This retrospective analysis included seven intractable PCE patients.

214 nue for effective anti-epileptic therapy for intractable pediatric epilepsy patients.

215 cortical dysplasia, the most common cause of intractable pediatric epilepsy.

216 n a biological sample by rescuing previously intractable peptide species and applying additional evid

217 and efficacy of autologous cell therapy for intractable peripheral arterial disease/critical limb is

218 log-barrier function to compute analytically intractable, positively constrained Beta parameters.

219 60 patients with medically intractable primary or secondary generalised dystonia we

220 eigenvalues of certain operators is one such intractable problem and remains a fundamental challenge.

221 concentrations are therefore likely to be an intractable problem during the treatment of red mud leac

222 tinence (FI) is a severe, underreported, and intractable problem in many patients for which limited p

223 of obesity has called attention to the near-intractable problem of sustained weight reduction and it

224 Network comparison is a computationally intractable problem with important applications in syste

225 n the developing mammalian brain has been an intractable problem, in part because it has not been pos

226 given target is therefore a computationally intractable problem.

227 se is known to be a complexity-theoretically intractable problem.

228 on is generally a very difficult, not to say intractable, problem.

229 amic ocean management can address previously intractable problems at scales associated with coactive

230 biomarkers have failed clinically because of intractable problems such as highly variable background

231 ted its effectiveness for a variety of other intractable problems.

232 n was referred to our hospital because of an intractable productive cough.

233 design will enable the solution of currently intractable protein structures.

234 ons for therapeutically targeting previously intractable proteins.

235 d girl who presented with signs of localized intractable pruritus of 6 months' duration on the left s

236 was characterized by intermittent jaundice, intractable pruritus, increased serum bile acid (BA) lev

237 After several months of localized intractable pruritus, magnetic resonance imaging of the

238 d a preliminary genetic architecture of this intractable psychiatric disorder and yielded new hypothe

239 Child stunting and anemia are intractable public health problems in developing countri

240 and allow experimentalists to ask otherwise intractable questions about chromosome structure, functi

241 eviously been characterized as "analytically intractable"--readily comprehensible to theoreticians an

242 Patients with intractable refractory arrhythmic storm and cardiogenic

243 spid valve (TV) is increasing and results in intractable right heart failure.

244 ral lobe epilepsy is a common and frequently intractable seizure disorder.

245 calization of epileptogenic brain regions in intractable-seizure patients being considered for epilep

246 neuropathy 1 and microcephaly, early-onset, intractable seizures and developmental delay.

247 Because recurrent intractable seizures are a common feature of FCDs, epile

248 Intractable seizures are invariable in children with ISO

249 cephalopathies characterized by early onset, intractable seizures, and poor developmental outcomes.

250 lays, intellectual disability, microcephaly, intractable seizures, and progressive brain atrophy.

251 itive deficits, a more severe phenotype with intractable seizures, and the potential for sudden unexp

252 dly progressive postnatal encephalopathy and intractable seizures, leading to severe disability and e

253 ual disability and are often associated with intractable seizures.

254 ute-onset confusion, opsoclonus, chorea, and intractable seizures.

255 tical twins affected with autism and severe, intractable seizures.

256 hy, ptosis, and encephalomyopathy leading to intractable seizures.

257 isability, progressive cerebral atrophy, and intractable seizures.

258 h spiking regions of patients suffering from intractable seizures.

259 characterized by microcephaly; early-onset, intractable seizures; and developmental delay (MCSZ).

260 e a broad range of previously challenging or intractable separations.

261 ference genome, adding 1.03 Mb of previously intractable sequence.

262 nities to design inhibitors for an otherwise intractable set of PPIs.

263 g the possibility DBS might be used to treat intractable SIB associated with ASDs.

264 sibility of deep brain stimulation (DBS) for intractable SIB seen in some patients with an ASD, we ut

265 ffer the potential of developing classically intractable simulations with currently accessible quantu

266 increase their accuracy and enable hitherto intractable simulations.

267 ract allows nnAA incorporation at previously intractable sites of an IgG1 and at multiple sites in th

268 arisons between networks are computationally intractable, so new methodologies are sought.

269 Due to the genetically intractable status of C. trachomatis at that time, this

270 demand-based and automated; computationally intractable subnetworks are further divided until the en

271 ition metal dopants that ordinarily would be intractable, such as Cu(3+), as well as demonstrating a

272 n (DTS), which is increasingly used to treat intractable symptoms at the end of life.

273 ctors, which have been classically viewed as intractable targets using small-molecule inhibitor appro

274 oximation algorithms to many computationally intractable tasks.

275 lobe is an effective treatment for medically intractable temporal lobe epilepsy, but can cause memory

276 o a problem might be easy to define and also intractable to compute upon.

277 ly, cnidarians have thus far been relatively intractable to electrophysiological and genetic techniqu

278 sequence and structure diversity and proved intractable to existing methods.

279 subtle changes in collagen fibre orientation intractable to existing techniques.

280 Notoriously, the MHC region has been intractable to high-throughput analysis at complete sequ

281 ny new protein families that were previously intractable to homology based fold recognition methods.

282 is leads to a vast combinatorial complexity, intractable to mass spectrometry and requiring large amo

283 tract obstruction (47+/-11 years, 63% male) intractable to maximal medical therapy, who were referre

284 tive intestinal Firmicutes bacterium that is intractable to molecular genetic manipulation.

285 ee human pri-miRNAs, focusing on the regions intractable to previous high-throughput analyses.

286 tions should implement strategies to prevent intractable treatment conflicts, including proactive com

287 of catalysts for the synthesis of previously intractable Trp analogues.

288 e) 19-56 years old with severe and medically intractable TS were treated with high-frequency DBS of t

289 Glioblastoma multiforme (GBM) is an intractable tumor despite therapeutic advances, principa

290 r patients requiring emergency operation for intractable ulcer bleeding, vagotomy/drainage is associa

291 Vidian neurectomy had been applied mainly in intractable vasomotor rhinitis and severe perennial alle

292 and safe approach to rapidly treat severe or intractable viral infections after stem cell transplanta

293 n, had concurrent or prior optic neuritis or intractable vomiting episodes more frequently, had short

294 <1 month after LVAD implantation because of intractable VT.

295 w positive and negative selection options to intractable weed problems.

296 These problems become intractable when the dimensionality of the data is large

297 omically important, but many are genetically intractable which limits our understanding of their mole

298 g of quantum systems that is computationally intractable with a classical computer.

299 able-range interactions, which are generally intractable with classical methods.

300 pression via the TRPC3-NFkB axis, leading to intractable wound contracture.