ライフサイエンスコーパス: intracytoplasmic

1 thmias and restrictive heart failure, and by intracytoplasmic accumulation of desmin-reactive deposit

2 he level of TNF receptor 1 or its associated intracytoplasmic adaptor complex.

3 or against neurodegeneration associated with intracytoplasmic aggregate-prone protein accumulation as

4 er characterized by progressive weakness and intracytoplasmic aggregates in muscle that exert reducin

5 is neuronal loss, astrocytosis, and neuronal intracytoplasmic aggregates of abnormal neuronal IFs tha

6 pose that Hsp70 can be used as a vehicle for intracytoplasmic and intranuclear delivery of proteins o

7 l laser scanning microscopic images revealed intracytoplasmic and intranuclear punctate patterns of i

8 The native CD39 protein has two intracytoplasmic and two transmembrane domains.

9 elop intestinal disease had increased T-cell intracytoplasmic antigen 1-positive cytotoxic T lymphocy

10 is no evidence of positive selection on the intracytoplasmic antigen PS120 despite low selective con

11 Rab11 was found to load onto the intracytoplasmic axonemes late in mitosis and to accumul

12 tron microscopy of invaded monolayers showed intracytoplasmic bacteria enclosed by membrane-bound vac

13 to IcsA-specific antibody on the surface of intracytoplasmic bacteria.

14 urine biosynthesis was unable to expand into intracytoplasmic bacterial communities over time, unless

15 e agent of epidemic typhus, is an obligately intracytoplasmic bacterium, a lifestyle that imposes sig

16 ettsia prowazekii, a slowly growing obligate intracytoplasmic bacterium, was investigated.

17 trated in Rickettsia prowazekii, an obligate intracytoplasmic bacterium.

18 g that platelet NO formation is triggered by intracytoplasmic Ca(++) elevation.

19 and these receptors were shown to induce an intracytoplasmic Ca(2+) flux and cellular chemotaxis fol

20 wild-type cells in order to produce the same intracytoplasmic Ca(2+) flux.

21 eotaxin caused a similar rise in eosinophil intracytoplasmic Ca2+ and complete cross-desensitization

22 The anti-sIgM-mediated free intracytoplasmic calcium ([Ca2+]i) responses were signif

23 two receptors produced a synergistic rise in intracytoplasmic calcium ([Ca2+]i) to levels not reached

24 eased and the TCR/CD3-induced increased free intracytoplasmic calcium concentration response was norm

25 /CD3 complex leads to a dramatic increase of intracytoplasmic calcium concentration, protein tyrosine

26 Overexpression of c-Jun led to increase in intracytoplasmic calcium flux following TCR stimulation.

27 3) CD3-mediated increases in free intracytoplasmic calcium occur specifically in lupus T c

28 aracterized by heightened TCR-initiated free intracytoplasmic calcium responses.

29 Maturation was monitored by the induction of intracytoplasmic casein and lipids and the membrane prot

30 ent of caspase-8 to the complex, followed by intracytoplasmic caspase cleavage of amyloid precursor p

31 These data suggest that intracytoplasmic CD95 mutations in ALPS impair apoptosis

32 throughout its external, transmembrane, and intracytoplasmic coding regions.

33 ated in the ectodomains, suggesting that the intracytoplasmic components that mediate G protein bindi

34 We estimated intracytoplasmic concentrations of paromomycin, using an

35 l contamination of surrounding structures by intracytoplasmic contents of the damaged hair cells.

36 catabolic process in which lysosomes degrade intracytoplasmic contents transported in double-membrane

37 tes after priming or prime-boosting by using intracytoplasmic cytokine staining and assays for cytoki

38 an mast cell line, HMC-1, as demonstrated by intracytoplasmic cytokine staining and flow cytometry, a

39 The intracytoplasmic cytokine staining assay showed that the

40 ction by activated NK cells was confirmed by intracytoplasmic cytokine staining by three-color immuno

41 Using intracytoplasmic cytokine staining in conjunction with H

42 Flow cytometry of intracytoplasmic cytokines in leukocyte subsets followin

43 family of molecules, containing a conserved intracytoplasmic "death domain" that indirectly activate

44 t E6 T lymphocytic leukaemia cells following intracytoplasmic delivery.

45 that afflict humans are associated with the intracytoplasmic deposition of aggregate-prone proteins

46 ential proteolytic cleavages that produce an intracytoplasmic domain called CD44-ICD.

47 with an atypical extracellular domain and an intracytoplasmic domain containing one typical ITIM and

48 ll, and Src-dependent phosphorylation of the intracytoplasmic domain of EphrinB.

49 These findings demonstrated that the intracytoplasmic domain of the transmembrane Env (Env-TM

50 residue in an artificial glycine and alanine intracytoplasmic domain was endocytosed and degraded in

51 e binds directly to a region within the Toll intracytoplasmic domain, providing the first evidence th

52 Within the hFcgammaRIIA intracytoplasmic domain, there are 2 conserved tyrosine

53 uitment of signaling adapter proteins to the intracytoplasmic domain.

54 I molecules lacking lysine residues in their intracytoplasmic domain.

55 mutations in the transmembrane protein (TM) intracytoplasmic domain.

56 ite, resulting in a frameshift and truncated intracytoplasmic domain.

57 but overlapping target sites within the CD4 intracytoplasmic domain.

58 ransmembrane proteins contain unusually long intracytoplasmic domains (ICD-TM).

59 d in the synaptic cleft, connected via their intracytoplasmic domains to the presynaptic web on one s

60 -zeta) signaling motifs (ITAMs) within their intracytoplasmic domains.

61 polar, tapered cell extension containing an intracytoplasmic, electron-dense core.

62 T cells being labeled with 1 to 3 pg/cell of intracytoplasmic endosomal iron and 15 to 20 pg/cell of

63 ion that this pathogen replicates within the intracytoplasmic environment facilitating delivery of Ag

64 At neurodegenerative sites, intracytoplasmic, eosinophilic, alpha-synuclein/ubiquiti

65 To assess the role of intracytoplasmic estrogen receptors in mediating suppres

66 Intracytoplasmic filamentous aggregates, such as neurofi

67 , 10.7% stained for IFN-gamma and/or IL-4 by intracytoplasmic flow analysis.

68 re determined by flow cytometry using stable intracytoplasmic fluorescent dye 5- and 6-carboxyfluores

69 or found in stress granules and P bodies, in intracytoplasmic foci.

70 gether, our data imply that the formation of intracytoplasmic Gag-RNA complexes is facilitated by YB-

71 l hallmarks of SPG11 in neurons that include intracytoplasmic granular lysosome-like structures mainl

72 method has been developed for the isolation intracytoplasmic (ICM) vesicles (chromatophores) from Rh

73 d HIV-1-induced IFN-alpha production; and 3) intracytoplasmic IFN-alpha was detected in CD14+ cells.

74 We confirmed this hypothesis by detecting intracytoplasmic IFN-gamma in macrophages activated with

75 n expansion of IFN-gamma-producing cells and intracytoplasmic IFN-gamma levels was found in pregnant

76 FACS analysis of intracytoplasmic IFN-gamma staining showed that some gra

77 and CD86 Ag by LC in overlying epidermis and intracytoplasmic IL-12 accumulation in a subpopulation o

78 the cell cycle expressed significantly more intracytoplasmic IL-2 as well as IL-2Rbeta and gamma pro

79 Intracytoplasmic inclusion bodies (ICI) have been identi

80 f the protein, leading to the development of intracytoplasmic inclusion bodies and eventually to neur

81 These antibodies identify intracytoplasmic inclusion bodies in acute KD tissues.

82 disorder characterized by the appearance of intracytoplasmic inclusions called Lewy bodies (LB) in d

83 Intracytoplasmic inclusions composed of alpha-synuclein

84 sease (PD) patients progressively accumulate intracytoplasmic inclusions formed by misfolded alpha-sy

85 tification, we used laser microdissection of intracytoplasmic inclusions identified in patient muscle

86 g beta-sheet-rich fibrils that accumulate as intracytoplasmic inclusions in Parkinson disease and cer

87 ntotemporal cortices and ubiquitin-positive, intracytoplasmic inclusions in the granule cells of the

88 llmark of the disease is the accumulation of intracytoplasmic inclusions known as Lewy bodies that co

89 substantia nigra pars compacta coupled with intracytoplasmic inclusions known as Lewy bodies.

90 Here we report cellular models of intracytoplasmic inclusions of alpha-synuclein, generate

91 Intracytoplasmic inclusions resembling Lewy bodies were

92 yn by nitration can promote the formation of intracytoplasmic inclusions that constitute the hallmark

93 y demonstrated pale pink, oval to crescentic intracytoplasmic inclusions with a predilection for peri

94 , and endomysial fibrosis, in the absence of intracytoplasmic inclusions, rimmed vacuoles, or any evi

95 On routine staining, there were numerous intracytoplasmic inclusions, which ranged from eosinophi

96 ar to represent a unique form of prokaryotic intracytoplasmic inclusions.

97 e first step in the formation of fibrils and intracytoplasmic inclusions.

98 ons diminish microtubule binding and lead to intracytoplasmic inclusions.

99 functional, as shown by fertilization after intracytoplasmic injection into mouse oocytes.

100 asmic endosomal iron and 15 to 20 pg/cell of intracytoplasmic iron in mesenchymal stem cells compared

101 The correlation of increased intracytoplasmic levels of bcl-2 with high levels of cel

102 hologically characterized by the presence of intracytoplasmic Lewy bodies, the major component of whi

103 hologically characterized by the presence of intracytoplasmic Lewy bodies, the major components of wh

104 hologically characterized by the presence of intracytoplasmic Lewy bodies.

105 gical evidence of neurodegeneration and rare intracytoplasmic Lewy body-like inclusions in spinal ant

106 As with viral vectors, this intracytoplasmic life cycle provides a means for introdu

107 Clear cells with intracytoplasmic lipid and glycogen were focally present

108 onic epithelial cells a striking increase in intracytoplasmic lipid droplets (LDs), a dynamic organel

109 pted mitochondria and caused accumulation of intracytoplasmic lipid droplets.

110 organization and interstitial fibrosis, with intracytoplasmic lipid vacuoles identifiable by electron

111 e clear cells additionally revealed abundant intracytoplasmic lipid.

112 tide or a peptide corresponding to the third intracytoplasmic loop of the TXA2 receptor.

113 within the AtMTP1 N-segment of the His-rich intracytoplasmic loop that confines specificity to Zn(2+

114 6 gene there is bio-assimilated synthesis of intracytoplasmic magnetic nanoparticles which can be ima

115 e ability was not associated with surface or intracytoplasmic markers or secretion of cytokines.

116 A functional proteomic analysis of the intracytoplasmic membrane (ICM) development process was

117 gnized ultrastructural complexity within the intracytoplasmic membrane (ICM) housing the photosynthet

118 The Rhodobacter sphaeroides intracytoplasmic membrane (ICM) is an inducible membrane

119 Chromatophore membrane and intracytoplasmic membrane (ICM) prepared from these muta

120 hototrophic bacteria elaborate a specialized intracytoplasmic membrane (ICM) system for the conversio

121 ytochrome b and ISP is detected in membrane (intracytoplasmic membrane and air-aged chromatophore), a

122 pable of phototrophic growth and impaired in intracytoplasmic membrane formation.

123 Atomic force microscopy studies of the intracytoplasmic membrane have revealed the overall spat

124 s defining a heretofore unknown mechanism of intracytoplasmic membrane heme transport in Haemophilus.

125 Both FtsZ and MinD readily assembled on intracytoplasmic membrane surfaces, and we propose that

126 acultatively phototrophic bacterium forms an intracytoplasmic membrane that houses the photochemical

127 the LH2 complexes, which assembles spherical intracytoplasmic membrane vesicles of approximately 53 n

128 ns correlated with the presence of elaborate intracytoplasmic membrane-bound compartments, including

129 for assembly of the RC and highly developed intracytoplasmic membrane.

130 c bacteria synthesize an extensive system of intracytoplasmic membranes (ICM) in order to increase th

131 R. rubrum puf interposon mutants do not form intracytoplasmic membranes and are phototrophically inco

132 appear to be required for the maintenance of intracytoplasmic membranes and cell survival in late sta

133 ically and show no bc(1) complex activity in intracytoplasmic membranes prepared from these mutant ce

134 of R. capsulatus cyt c(y) was purified from intracytoplasmic membranes to homogeneity.

135 asma membrane but instead was mistargeted to intracytoplasmic membranes.

136 are unique in that they regularly mature at intracytoplasmic membranes.

137 Downregulated genes corresponded to an intracytoplasmic microcompartment for disposal of methyl

138 basal pole lipid vacuoles, with perinuclear-intracytoplasmic migration of the inclusions promoting a

139 The TCR complex signals through a set of 10 intracytoplasmic motifs, termed immunoreceptor tyrosine-

140 rse eukaryotic cells within vacuoles without intracytoplasmic multiplication.

141 Intracytoplasmic nanoparticles were stained with Prussia

142 These animals accumulate age-dependent intracytoplasmic neuronal alpha-syn inclusions that para

143 These animals developed age-dependent intracytoplasmic neuronal alpha-synuclein inclusions par

144 igomerization domain (Nod)1, a member of the intracytoplasmic Nod-like receptor family, induced poten

145 hat wild-type Beclin 1 colocalizes with both intracytoplasmic organelles and nuclei in COS7 monkey ki

146 ic agent of epidemic typhus, is an obligate, intracytoplasmic, parasitic bacterium.

147 oximately 200-fold higher than the estimated intracytoplasmic paromomycin concentration, suggestive o

148 When ferumoxides-TA or MION-46L-TA was used, intracytoplasmic particles stained with Prussian blue st

149 The obligate intracytoplasmic pathogen Rickettsia prowazekii relies o

150 s currently known regarding how professional intracytoplasmic pathogens, including Shigella, mediate

151 ear the NH2 and COOH termini with very short intracytoplasmic peptides at either end.

152 Electron microscopy findings confirmed intracytoplasmic, perinuclear uptake of liposomes in tum

153 an attenuated cell wall, and less extensive intracytoplasmic (photosynthetic) membrane system compar

154 We found herein that the intracytoplasmic pool of the low-molecular-weight (LMW)

155 der that is associated with the formation of intracytoplasmic protein aggregates (Lewy-body inclusion

156 CD79 alpha is a subunit of an intracytoplasmic protein reported to be specific for B l

157 in are a major component of Lewy bodies, the intracytoplasmic proteinaceous inclusions that are a pat

158 Intracytoplasmic proteinaceous inclusions, primarily com

159 rimary locus of CRAMP activity appears to be intracytoplasmic, rather than at the outer membrane, sug

160 uencing unexpectedly revealed that the third intracytoplasmic region (3ICR) of the sheep receptor has

161 covered, polyubiquitination of Lys225 in the intracytoplasmic region and subsequent endocytosis and p

162 FCV formation required intracytoplasmic replication of bacteria.

163 hich assemble virus-like particles (VLPs) in intracytoplasmic ribonucleoprotein (RNP) complexes.

164 The actin tail associated with intracytoplasmic rickettsiae remained stationary in the

165 Intracytoplasmic rickettsial morulae were detected on pe

166 n linked to domains 3 and 4 of human CD4 and intracytoplasmic sequence from either CD4 or human P-sel

167 Two forms, alpha-1 and alpha-2, have intracytoplasmic sequences that are identical within a m

168 negatively regulates osteoclast formation by intracytoplasmic sequestration of FHL2 to blunt RANK act

169 , and NK cells may be influenced by distinct intracytoplasmic signaling cascades that are activated b

170 CD74, CD44, and a truncated CD44 lacking its intracytoplasmic signaling domain.

171 CI, 0.90 to 1.26), and the odds ratios with intracytoplasmic sperm injection (ICSI) (139 defects, 9.

172 Using intracytoplasmic sperm injection (ICSI) and standard in

173 We report two children who were conceived by intracytoplasmic sperm injection (ICSI) and who develope

174 hildren born after in-vitro fertilisation by intracytoplasmic sperm injection (ICSI) are at increased

175 Using the outcome of intracytoplasmic sperm injection (ICSI) as a readout, we

176 st was IVF, categorized according to whether intracytoplasmic sperm injection (ICSI) for male inferti

177 Intracytoplasmic sperm injection (ICSI) has been used in

178 Intracytoplasmic sperm injection (ICSI) is a more invasi

179 Intracytoplasmic sperm injection (ICSI) is a technique t

180 Intracytoplasmic sperm injection (ICSI) is increasingly

181 rm or somatic cell chromatin within 5 min of intracytoplasmic sperm injection (ICSI) or somatic cell

182 Examination of embryos generated by intracytoplasmic sperm injection (ICSI) revealed that ma

183 Intracytoplasmic sperm injection (ICSI) was initially de

184 ls from adult mice generated with the use of intracytoplasmic sperm injection (ICSI), a type of ART.

185 We previously demonstrated that intracytoplasmic sperm injection (ICSI), a type of assis

186 s, such as in-vitro fertilisation (IVF) with intracytoplasmic sperm injection (ICSI), can be used as

187 Intracytoplasmic sperm injection (ICSI), however, can en

188 Using a combination of intracytoplasmic sperm injection (ICSI), in vitro fertil

189 e past 10 years has been the introduction of intracytoplasmic sperm injection (ICSI).

190 rmatozoon into an oocyte, the process called intracytoplasmic sperm injection (ICSI).

191 e oocytes similar to what is observed during intracytoplasmic sperm injection (ICSI).

192 s treated by in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI).

193 ction testicular sperm extraction (TESE) and intracytoplasmic sperm injection (ICSI).

194 uss two major advances in the ART laboratory-intracytoplasmic sperm injection and extended embryo cul

195 The development of intracytoplasmic sperm injection and its successful appl

196 rocedures such as in vitro fertilization and intracytoplasmic sperm injection are generally considere

197 e first births of rhesus monkeys produced by intracytoplasmic sperm injection at rates greater or equ

198 specifically sperm retrieval techniques for intracytoplasmic sperm injection coupled with in-vitro f

199 rian tissue and the continued development of intracytoplasmic sperm injection for men with poor sperm

200 The use of in vitro fertilization and intracytoplasmic sperm injection has added to the viabil

201 icular sperm extraction (TESE) combined with intracytoplasmic sperm injection has allowed many men wi

202 Intracytoplasmic sperm injection has begun an era of con

203 The advent of intracytoplasmic sperm injection has revolutionized the

204 able of producing normal offspring following intracytoplasmic sperm injection into wild-type ova and

205 Because intracytoplasmic sperm injection is increasingly used as

206 These irregularities indicate that the intracytoplasmic sperm injection itself might lead to th

207 Intracytoplasmic sperm injection may be considered as th

208 r amplitude of Ca(2+) oscillations following intracytoplasmic sperm injection or expression of phosph

209 h any other cause, but treatment with either intracytoplasmic sperm injection or sperm donation remov

210 eved with both conventional and piezo-driven intracytoplasmic sperm injection procedures.

211 Intracytoplasmic sperm injection resulted in abnormal sp

212 The introduction of IVF and intracytoplasmic sperm injection revolutionized the trea

213 Intracytoplasmic sperm injection suggested that the DNA

214 maintained, embryos can be generated by the intracytoplasmic sperm injection technique (ICSI) from s

215 age and functional sperm that can be used in intracytoplasmic sperm injection to produce chromosomall

216 uration (primary outcome), and fertilized by intracytoplasmic sperm injection with subsequent transfe

217 ng a treatment cycle of IVF (with or without intracytoplasmic sperm injection).

218 ale DNA decondensation that occurs following intracytoplasmic sperm injection, an assisted reproducti

219 re, embryo transfer, in vitro fertilization, intracytoplasmic sperm injection, and round spermatid in

220 rates were observed among women who received intracytoplasmic sperm injection, and who received AH wh

221 Standard IVF treatment, intracytoplasmic sperm injection, embryo biopsy, single-

222 rility of TAL(-/-) sperm was circumvented by intracytoplasmic sperm injection, indicating that TAL de

223 fetuses produced by in vitro fertilization, intracytoplasmic sperm injection, or round spermatid inj

224 y fivefold compared with conventional PNI or intracytoplasmic sperm injection-mediated transgenesis.

225 after ART-five of whom were conceived after intracytoplasmic sperm injection.

226 stes were able to generate normal pups after intracytoplasmic sperm injection.

227 ogy but complete fertilization failure after intracytoplasmic sperm injection.

228 4 mature rhesus oocytes, later fertilized by intracytoplasmic sperm injection.

229 SCs were injected into 85 rhesus oocytes via intracytoplasmic sperm injection.

230 he purpose of subsequent or simultaneous IVF/intracytoplasmic sperm injection.

231 in the 2B domain severely disrupted the fine intracytoplasmic staining of desmin, causing clumping of

232 with progressive multiple sclerosis by using intracytoplasmic staining.

233 f the postsynaptic regions or in relation to intracytoplasmic structures.

234 (IL-3), and IL-5 (GMRbetaC) with a truncated intracytoplasmic tail caused by deletion of a 104-bp exo

235 ole for even minor sequence variation of the intracytoplasmic tail in modulating the antigenicity of

236 te that mutations selected in Gag and Env TM intracytoplasmic tail influence the replication and cyto

237 We also provide evidence that the intracytoplasmic tail of CCR5 does not play an important

238 , was abrogated by deleting the NH2-terminal intracytoplasmic tail of CD4, or by mutating the two cri

239 itination required a cysteine residue in the intracytoplasmic tail of MHC I molecules.

240 el mechanism by which point mutations in the intracytoplasmic tail of the transmembrane component (gp

241 highly conserved structural motif within the intracytoplasmic tail resulted in decreased binding of n

242 nce is provided for minor differences in the intracytoplasmic tail sequences of WC1.1 and WC1.2 that

243 ng feature of these isoforms: their distinct intracytoplasmic tails (FcgammaRIIa with an immunorecept

244 ation, prominent frontotemporal neuron loss, intracytoplasmic tau aggregates, paired helical tau fila

245 Both CD27+ and CD27- B cells up-regulated intracytoplasmic TLR-9 following CpG DNA activation.

246 , even though these cells contained abundant intracytoplasmic TLR9.

247 Intracytoplasmic TNF levels were increased in normal tis

248 ing that this protein may be involved in the intracytoplasmic transport of the viral genome.

249 This beta intracytoplasmic truncated chain (betaIT) has a predicte

250 binding was localized to the pellicle and an intracytoplasmic tubulovesicular network in sporozoites.

251 This receptor associates with intracytoplasmic tyrosine kinases, essentially janus kin

252 of dopaminergic neurons and the presence of intracytoplasmic-ubiquitinated inclusions (Lewy bodies).

253 The pathological hallmark of the disease is intracytoplasmic vacuoles containing autophagic material

254 (0.5 and 1.0 mg/kg) induced the formation of intracytoplasmic vacuoles in pyramidal neurons in layers

255 adipophilin expression, a greater number of intracytoplasmic vacuoles, and larger vacuoles.

256 PPT of aged cats which included somata with intracytoplasmic vacuoles, darkened mitochondria, deplet

257 In addition, immunohistochemistry showed intracytoplasmic VEGF in polyploid megakaryocytes.

258 , within which virus buds predominantly into intracytoplasmic vesicles, in contrast to the plasmalemm

259 e cell membrane, resulting in ferritin-lined intracytoplasmic vesicles.

260 e endothelial cells showed a large number of intracytoplasmic vesicles.

261 ed a distinct population of NUCB2-containing intracytoplasmic vesicles.

262 ns compared to POKA; extensive aggregates of intracytoplasmic viral particles were also observed.

263 MMTV), a mammalian retrovirus that assembles intracytoplasmic virus particles, commandeers the cellul