ライフサイエンスコーパス: intraepithelial lymphocyte

1 e of gammadelta T cells and TCRgammadelta(+) intraepithelial lymphocytes.

2 ransforming growth factor beta production by intraepithelial lymphocytes.

3 d subepithelial collagen plate and increased intraepithelial lymphocytes.

4 -expressing cells, including most intestinal intraepithelial lymphocytes.

5 ymphoid tissues tested, including intestinal intraepithelial lymphocytes.

6 nction as a homing or retention molecule for intraepithelial lymphocytes.

7 lls including gammadelta TCR-positive (TCR+) intraepithelial lymphocytes.

8 cells, CD8+ T lymphocytes, and TCRgammadelta intraepithelial lymphocytes.

9 e in intimate contact with subepithelial and intraepithelial lymphocytes.

10 nducing proliferation of cultured intestinal intraepithelial lymphocytes.

11 FD promoted a decreased in the proportion of intraepithelial lymphocytes.

12 is spatially matched by Nkrp1g on subsets of intraepithelial lymphocytes.

13 fic CD8 T cells in comparison to gut mucosal intraepithelial lymphocytes.

14 uired a surface phenotype resembling that of intraepithelial lymphocytes.

15 Like adaptive TCR alphabeta+ T cells, intraepithelial lymphocytes, a subset enriched in TCR ga

16 to function in the regulation of intestinal intraepithelial lymphocyte activity.

17 mmune response in the small intestine and by intraepithelial lymphocytes after a single intraperitone

18 T cells, NKT cells, regulatory T cells, and intraepithelial lymphocytes all develop in the thymus an

19 beta(7)(+) DC (alphaE-DC) were distinct from intraepithelial lymphocytes and distinguishable from CD1

20 eraction between integrin alpha(E)beta(7) on intraepithelial lymphocytes and E-cadherin on epithelial

21 In the ileum, the proportion of intraepithelial lymphocytes and goblet cells reduced, an

22 lpha E beta 7 is highly expressed on colonic intraepithelial lymphocytes and has been suggested to fu

23 found predominantly within the intestine as intraepithelial lymphocytes and have been shown to be in

24 EATL derives from a clonal proliferation of intraepithelial lymphocytes and is often disseminated at

25 Here we show that small intestinal intraepithelial lymphocytes and lamina propria lymphocyt

26 opulations of anatomically distinct T cells, intraepithelial lymphocytes and lamina propria lymphocyt

27 D8alpha(+) T and natural killer cells in the intraepithelial lymphocytes and lamina propria lymphocyt

28 Aberrant intraepithelial lymphocytes and lymphoma cells are intra

29 d with excess interferon-gamma production by intraepithelial lymphocytes and Myd88 activity.

30 on most small intestinal lamina propria and intraepithelial lymphocytes and on a small subset of per

31 Immunohistochemical studies of the intraepithelial lymphocytes and PCR amplification reveal

32 illus blunting, increased lamina propria and intraepithelial lymphocytes, and epithelial apoptosis, l

33 neutrophils with occasional crypt abscesses, intraepithelial lymphocytes, and goblet cells in the int

34 , CD8alphaalphaTCRalphabeta small intestinal intraepithelial lymphocytes, and innate memory phenotype

35 , CD8alphaalphaTCRalphabeta small intestinal intraepithelial lymphocytes, and innate memory phenotype

36 Intraepithelial lymphocytes are decreased following smal

37 Gamma delta intraepithelial lymphocytes are thought to coordinate re

38 d 8), expressed predominantly by innate-like intraepithelial lymphocytes, as the ligand engaging epit

39 of CD8 alpha alpha homodimers in some of the intraepithelial lymphocytes, as well as low expression o

40 s, natural killer (NK) cells, and intestinal intraepithelial lymphocytes, as well as normalization of

41 significantly increased in cecal tonsil and intraepithelial lymphocytes at days 6 and 8, respectivel

42 ed IFN-gamma transcript levels in intestinal intraepithelial lymphocytes at this time.

43 These data demonstrate that gamma delta intraepithelial lymphocytes can protect the host from pa

44 is accompanied by a dramatic decrease in the intraepithelial lymphocyte CD8alpha(+)TCRgammadelta(+)/C

45 eta(+)CD4(-)CD8alpha(+)CD8beta(-) intestinal intraepithelial lymphocytes (CD8alphaalpha IELs) are an

46 2.0 afterward; P = .0007; density of CD3(+) intraepithelial lymphocytes changed from 61 to 91 cells/

47 ound in intestinal tissues, primarily in the intraepithelial lymphocyte compartment and lamina propri

48 secrete IL-4 and IFN-gamma is present in the intraepithelial lymphocyte compartment of the rat.

49 cells, which are abundant in the intestinal intraepithelial lymphocyte compartment.

50 n of CD8 T cells into the lamina propria and intraepithelial lymphocyte compartments.

51 Intraepithelial lymphocytes constitute a group of T cell

52 , a population of wild-type CD8alphaalpha(+) intraepithelial lymphocytes constitutively expressed gra

53 ion of the integrin CD103alpha(E)/beta(7) by intraepithelial lymphocytes controls the retention of ly

54 umed oats, 0.24; 95% CI, 0.01-4.8; P = .35), intraepithelial lymphocyte counts (standardized mean dif

55 tween groups, morphologic changes and CD3(+) intraepithelial lymphocyte counts differed significantly

56 ased intraepithelial lymphocytes, markers of intraepithelial lymphocyte cytotoxicity, gliadin-specifi

57 Intestinal intraepithelial lymphocyte-derived interferon-gamma prot

58 e dendritic epidermal T cells are prototypic intraepithelial lymphocytes, displaying an almost monocl

59 tains CD4(+)CD8alphaalpha(+) double-positive intraepithelial lymphocytes (DP IELs), which originate f

60 chronic inflammation, lymphocyte aggregates, intraepithelial lymphocytes, eosinophils, and villous bl

61 In contrast, most CD8 intraepithelial lymphocytes exhibited 2B4 but not NKG2A.

62 at CD8+ T-cell receptor alphabeta intestinal intraepithelial lymphocytes express and secrete this cyt

63 addition, all intestinal lamina propria and intraepithelial lymphocytes express GPR-9-6.

64 A subpopulation of isolated human intestinal intraepithelial lymphocytes expressed the fractalkine re

65 In addition, analysis of intestinal intraepithelial lymphocytes following feeding of OVA did

66 pha) and gamma interferon (IFN-gamma), while intraepithelial lymphocytes from calves with cryptospori

67 x vivo reverse transcriptase PCR of RNA from intraepithelial lymphocytes from control calves showed a

68 ce within the intestine through retention of intraepithelial lymphocytes, functional redistribution o

69 Here we show that gammadelta intraepithelial lymphocytes (gammadelta IEL) of the smal

70 Gammadelta intraepithelial lymphocytes (gammadelta IEL) reside at t

71 Although intestinal intraepithelial lymphocytes have a distinct localization

72 In the gut, the Thy-1(+)TCRalphabeta(+) intraepithelial lymphocyte (IEL) compartment is surprisi

73 tinal mucosa was significantly lower and the intraepithelial lymphocyte (IEL) count (x 100 enterocyte

74 both exhibit abnormal thymic and intestinal intraepithelial lymphocyte (IEL) development, but the de

75 ion, results in marked changes in intestinal intraepithelial lymphocyte (IEL) function and phenotype.

76 (CD103)beta 7 is thought to be important for intraepithelial lymphocyte (IEL) localization or functio

77 The function of the intraepithelial lymphocyte (IEL) network of T cell recep

78 The intraepithelial lymphocyte (IEL) network possibly compos

79 An early and rapid increase of the intraepithelial lymphocyte (IEL) population of orally in

80 mice appear normal, we demonstrated that the intraepithelial lymphocyte (IEL) populations of small (S

81 st selection of TCRalphabeta(+)CD8alphaalpha intraepithelial lymphocyte (IEL) progenitors (IELps), ev

82 D4(+) T helper functions and induction of an intraepithelial lymphocyte (IEL) program that included e

83 e reported that the pathogens induce a rapid intraepithelial lymphocyte (IEL) response important for

84 Peyer's patch (PP), lamina propria (LP), and intraepithelial lymphocyte (IEL) T cell populations were

85 To understand the relevance of intraepithelial lymphocyte (IEL)-derived KGF expression

86 We reveal a local intestinal intraepithelial lymphocyte (IEL)-GLP-1 receptor (GLP-1R)

87 is crucial for the development of intestinal intraepithelial lymphocytes (IEL) and delivery is mediat

88 aracterize the phenotype of large intestinal intraepithelial lymphocytes (IEL) and lamina propria leu

89 Intraepithelial lymphocytes (IEL) are a critical effecto

90 ro studies have demonstrated that intestinal intraepithelial lymphocytes (IEL) are constitutively cyt

91 Intestinal intraepithelial lymphocytes (IEL) are mostly CD8 single

92 Intestinal intraepithelial lymphocytes (IEL) bear a partially activ

93 TCR alpha beta+ intestinal intraepithelial lymphocytes (IEL) can express either the

94 In this context, intestinal intraepithelial lymphocytes (IEL) compose a large, highl

95 Previous studies have found that intraepithelial lymphocytes (IEL) contain virus-specific

96 Cytotoxic CD8alphabeta(+) intraepithelial lymphocytes (IEL) contribute to the deve

97 ntrol mice, TCR gammadelta and TCR alphabeta intraepithelial lymphocytes (IEL) developed efficiently

98 TCR agonist-driven CD8alphaalpha intestinal intraepithelial lymphocytes (IEL) development.

99 estinal lamina propria lymphocytes (LPL) and intraepithelial lymphocytes (IEL) during primary SIV inf

100 xpress CD8 alphabeta, whereas TCR alphabeta+ intraepithelial lymphocytes (IEL) express CD8 alpha alph

101 Previous analysis of intestinal intraepithelial lymphocytes (IEL) from nude mice and a v

102 The importance of intraepithelial lymphocytes (IEL) in immunoprotection ag

103 tead, there were twice as many CD8alphaalpha intraepithelial lymphocytes (IEL) in mice that were reco

104 ession of IL-10 was produced specifically by intraepithelial lymphocytes (IEL) in the small intestine

105 Although homing of intraepithelial lymphocytes (IEL) into intestinal epithe

106 aggregates in the development of intestinal intraepithelial lymphocytes (IEL) is a matter of controv

107 TCR alphabeta(+), CD8alphabeta(+) intestinal intraepithelial lymphocytes (IEL) is dependent on MHC cl

108 Intraepithelial lymphocytes (IEL) of the intestine repre

109 The differentiation of intestinal intraepithelial lymphocytes (IEL) remains controversial,

110 The intestinal intraepithelial lymphocytes (IEL) represent multi-lineag

111 Analysis of engrafted intraepithelial lymphocytes (IEL) showed that they had a

112 Mouse small intestine intraepithelial lymphocytes (IEL) that express alphabeta

113 eaks, intervillous spaces, and the number of intraepithelial lymphocytes (IEL) were measured before a

114 enriched lamina propria lymphocytes (LPL) or intraepithelial lymphocytes (IEL) were transferred into

115 both GCT and CD11c on PP lymphocytes (PPL), intraepithelial lymphocytes (IEL), and lamina propria ly

116 development of naive CD8 T cells, intestinal intraepithelial lymphocytes (IEL), and natural killer (N

117 ion of T cell receptor gammadelta-expressing intraepithelial lymphocytes (IEL), but these changes wer

118 opment occurs in the thymus, some intestinal intraepithelial lymphocytes (IEL), including TCR gamma d

119 ls and in extrathymically derived intestinal intraepithelial lymphocytes (IEL).

120 d the hypothesis that they behave like other intraepithelial lymphocytes (IEL).

121 The number of intraepithelial lymphocytes (IELs) and immune phenotypes

122 Cell-to-cell interactions between intraepithelial lymphocytes (IELs) and intestinal epithe

123 dramatic decrease in extrathymic intestinal intraepithelial lymphocytes (IELs) and natural killer 1.

124 Intestinal intraepithelial lymphocytes (IELs) are a large and diver

125 Intestinal intraepithelial lymphocytes (IELs) are located at the cr

126 gammadelta intraepithelial lymphocytes (IELs) are located beneath o

127 Intraepithelial lymphocytes (IELs) are located between e

128 nt of TCRalphabeta+CD8alphaalpha+ intestinal intraepithelial lymphocytes (IELs) are not thoroughly un

129 Locally resident intraepithelial lymphocytes (IELs) are primarily T cells

130 Murine small intestine intraepithelial lymphocytes (IELs) bear properties of bo

131 Intraepithelial lymphocytes (IELs) bearing the gammadelt

132 amined the effects of interleukin (IL)-15 on intraepithelial lymphocytes (IELs) because they resemble

133 e show that, although mouse small intestinal intraepithelial lymphocytes (IELs) expressed the CD43 co

134 Intraepithelial lymphocytes (IELs) from human intestinal

135 D134) in the activation of CD8(+) intestinal intraepithelial lymphocytes (IELs) has been studied usin

136 Intestinal intraepithelial lymphocytes (IELs) in mice include two m

137 e of an enlarged clonal population of innate intraepithelial lymphocytes (IELs) lacking classical B-,

138 selection of CD8alphaalpha and CD8alphabeta intraepithelial lymphocytes (IELs) of the intestine, whi

139 Intraepithelial lymphocytes (IELs) play an important rol

140 Because intraepithelial lymphocytes (IELs) produce a number of c

141 Intraepithelial lymphocytes (IELs) represent a significa

142 The development of intestinal intraepithelial lymphocytes (IELs) requires the movement

143 his model of intestinal inflammation, CD8(+) intraepithelial lymphocytes (IELs) secrete transforming

144 lial cells (ECs) is a population of resident intraepithelial lymphocytes (IELs) that provide host-pro

145 termine the contribution Vgamma1+ intestinal intraepithelial lymphocytes (IELs) vs systemic Vgamma1+

146 , no expansion of CD8 alpha alpha intestinal intraepithelial lymphocytes (IELs) was observed, despite

147 elta T cells isolated from murine intestinal intraepithelial lymphocytes (IELs) were separated into g

148 , CD8alphaalpha(+)TCRalphabeta(+) intestinal intraepithelial lymphocytes (IELs), arose from a unique

149 uding natural killer (NK) cells, NK T cells, intraepithelial lymphocytes (IELs), CD8 T cells, and gam

150 such as TCRalphabeta((+))CD8alphaalpha((+)) intraepithelial lymphocytes (IELs), require full-agonist

151 isolation and purification of rat intestinal intraepithelial lymphocytes (IELs), we previously identi

152 ion requirements of TCR-alphabeta intestinal intraepithelial lymphocytes (IELs), we utilized the 2C t

153 pulated by CD8(+) alpha beta and gamma delta intraepithelial lymphocytes (IELs), which monitor the in

154 Specialized intraepithelial lymphocytes (IELs), which reside at thes

155 s, and distinct subpopulations of intestinal intraepithelial lymphocytes (IELs).

156 cularly for T cell receptor (TCR)-gammadelta intraepithelial lymphocytes (IELs).

157 n is different in colon and small intestinal intraepithelial lymphocytes (IELs).

158 re T cells, and subpopulations of intestinal intraepithelial lymphocytes (IELs).

159 l (CD8alphabeta and CD4) T cells, designated intraepithelial lymphocytes (IELs).

160 pha and were sequestered as CD8alphaalpha(+) intraepithelial lymphocytes (IELs).

161 rface of T lymphocytes, including intestinal intraepithelial lymphocytes (IELs).

162 celiac disease were villous atrophy with 40 intraepithelial lymphocytes (IELs)/100 enterocytes (ECs)

163 Human small intestinal intraepithelial lymphocytes (iIEL) are a unique populati

164 However, intestinal intraepithelial lymphocytes (iIEL) of CD3zeta eta(null)

165 ole of IL-2 in the development of intestinal intraepithelial lymphocytes (iIEL), we evaluated IL-2(-/

166 Murine intestinal intraepithelial lymphocytes (iIELs) are made up of a het

167 Hence, intestinal intraepithelial lymphocytes (iIELs) are potentially the

168 in lymphoid organs as well as in intestinal intraepithelial lymphocytes (iIELs) is dependent on the

169 T cell receptor (TCR) alpha beta intestinal intraepithelial lymphocytes (iIELs) using the 2C transge

170 o recycling into intestinal CD4(-)CD8beta(-) intraepithelial lymphocytes (iIELs).

171 We demonstrate that virus-specific intraepithelial lymphocytes in gut resemble neither cent

172 sease, can result from expansion of aberrant intraepithelial lymphocytes in refractory celiac disease

173 T cells but constitute a major proportion of intraepithelial lymphocytes in the gastrointestinal muco

174 but not in the maintenance of CD8alphaalpha intraepithelial lymphocytes in the intestine.

175 h) mice had normal numbers of TCR gammadelta intraepithelial lymphocytes in the intestines and did no

176 ming growth factor beta(1) production by the intraepithelial lymphocytes increased, as did Smad2 expr

177 ss-linking of the T cell receptor complex on intraepithelial lymphocytes increases the avidity of alp

178 y stage NSCLC patient survival and increased intraepithelial lymphocyte infiltration.

179 ration and cytokine secretion in the spleen, intraepithelial lymphocyte inflammatory cytokines, and i

180 Intestinal intraepithelial lymphocyte interferon-gamma protein expr

181 ively expressed granzyme B and GzmB(-/-) cre intraepithelial lymphocytes likewise expressed granzyme

182 ace proteins that are involved in intestinal intraepithelial lymphocyte localization or function, cul

183 Germ-free mice developed increased intraepithelial lymphocytes, markers of intraepithelial

184 In RCD, the immunophenotype of intraepithelial lymphocytes may be normal and polyclonal

185 r and of abnormal morphology, and intestinal intraepithelial lymphocytes, normally containing a large

186 Subepithelial and intraepithelial lymphocytes of human adenoids and tonsil

187 Analysis of colonic intraepithelial lymphocytes of PDK1-deficient mice revea

188 The intraepithelial lymphocytes of the small intestine conta

189 Furthermore, intraepithelial lymphocytes or transfected JY' cells exp

190 organization, and regulation of the adaptive intraepithelial lymphocytes, or IEL, which are key playe

191 villous height:crypt depth ratio, numbers of intraepithelial lymphocytes, or serologic markers of cel

192 a homodimers, populations consistent with an intraepithelial lymphocyte phenotypic profile.

193 CD8alphaalpha TCRalphabeta(+) intestinal intraepithelial lymphocytes play a critical role in prom

194 lts indicate that changes occur in the ileal intraepithelial lymphocyte population coincidently with

195 ble-positive cells present in the intestinal intraepithelial lymphocytes population can suppress T he

196 istics of regulatory cells in the intestinal intraepithelial lymphocytes population.

197 vious studies have suggested that intestinal intraepithelial lymphocytes prevent spontaneous intestin

198 of intestinal alphabeta(+) and gammadelta(+) intraepithelial lymphocytes purified from germ-free mice

199 gands for intestinal NK cell, T cell, and/or intraepithelial lymphocyte receptors.

200 ma to 'educate' the natural, skin-associated intraepithelial lymphocyte repertoire to be of physiolog

201 Intraepithelial lymphocytes represent a substantial frac

202 Secondary end points included numbers of intraepithelial lymphocytes, serology test results (for

203 Intraepithelial lymphocytes, such as gammadelta T cells

204 serum, nor did it induce IL-2R expression by intraepithelial lymphocytes, suggesting that GL3 inhibit

205 An important component of the disease is the intraepithelial lymphocyte that might become clonally ex

206 receptor (TCR)alphabeta+ cells and resident intraepithelial lymphocytes that are commonly enriched i

207 The enhancer also functions in gut intraepithelial lymphocytes that express CD8alpha but no

208 Intraepithelial lymphocytes that express the gammadelta

209 is role involves cell-cell interactions with intraepithelial lymphocytes that may also play a role in

210 In the epithelium, interleukin-15 activates intraepithelial lymphocytes that promote destruction of

211 eir anatomic location within the epithelium (intraepithelial lymphocytes), the interstitium between t

212 -gamma is produced by both stromal cells and intraepithelial lymphocytes through all stages of the me

213 owel transplant, the number and the ratio of intraepithelial lymphocytes to enterocytes, as well as c

214 AM-15 is involved in heterotypic adhesion of intraepithelial lymphocytes to IEC as well as in homotyp

215 In vitro exposure of colonic intraepithelial lymphocytes to IL-10 resulted in downreg

216 response and participate in the licensing of intraepithelial lymphocytes to kill intestinal epithelia

217 cell receptor alphabeta(+) CD4(-)CD8beta(-) intraepithelial lymphocytes (unconventional iIELs), a ma

218 pithelium, long-term retention of intestinal intraepithelial lymphocytes was also alphaEbeta7 indepen

219 e gamma-region gene repertoire of intestinal intraepithelial lymphocytes was regulated by interleukin

220 Extrathymic development of intestinal intraepithelial lymphocytes was studied using a reconsti

221 elta T cells or gammadelta TCR(+) intestinal intraepithelial lymphocytes, we hypothesized that activa

222 Tonsillar intraepithelial lymphocytes were also enriched in B cell

223 Although lymphocyte aggregates and intraepithelial lymphocytes were not predictive, termina

224 illus height to crypt depth and densities of intraepithelial lymphocytes were the primary end points.

225 d Mucida discuss development and function of intraepithelial lymphocytes, which are found within the

226 CR alpha- and beta-chain usage by intestinal intraepithelial lymphocytes, which are predominantly CD8

227 BY55 was expressed on all intestinal intraepithelial lymphocytes, which were predominantly CD

228 Is, biopsies showed significant increases in intraepithelial lymphocytes, which were predominantly T

229 owed by Peyer's patches, lamina propria, and intraepithelial lymphocyte yield with respiratory and in