ライフサイエンスコーパス: intraflagellar

1 ton extrusion via Hv1 channels should induce intraflagellar alkalinisation and activate CatSper ion c

2 Here we demonstrate that intraflagellar Ca(2+) elevations act to directly regulat

3 Gliding motility induces mechanosensitive intraflagellar Ca(2+) elevations in trailing (dragging)

4 Highly compartmentalized intraflagellar Ca(2+) elevations initiate retrograde tra

5 motor function in response to alterations in intraflagellar Ca2+ levels.

6 tion potentiates CatSper current to increase intraflagellar calcium and induce sperm hyperactivation.

7 lagellar motility is regulated by changes in intraflagellar calcium.

8 ortance, the mode of interaction between the intraflagellar ciliary transport (IFT) mechanism and its

9 usually result from disruption of retrograde intraflagellar (IFT) transport of the cilium.

10 her with dynein to bidirectionally transport intraflagellar particles, melanosomes, and neuronal vesi

11 cilia structural proteins, polycystin-1 and intraflagellar protein-88.

12 ial spokes are required for Ca(2+)-initiated intraflagellar signaling, resulting in modulation of inn

13 The PFR is an intraflagellar structure present alongside the axoneme a

14 oneme, which potentially mediates retrograde intraflagellar trafficking, runs through the entire axis

15 oducts from the flagellar tip is mediated by intraflagellar transport (IFT) , which is essential for

16 arrier at the base of the organelle [3-8] by intraflagellar transport (IFT) [9-18].

17 aintenance of all cilia and flagella require intraflagellar transport (IFT) along the axoneme.

18 semble from basal bodies by a process called intraflagellar transport (IFT) and are associated with s

19 ins in primary cilia is thought to depend on intraflagellar transport (IFT) and diffusion.

20 crotubule-based organelles that assemble via intraflagellar transport (IFT) and function as signaling

21 GFP-tagged alpha-tubulin enters cilia as an intraflagellar transport (IFT) cargo and by diffusion.

22 Mutations in several genes affecting intraflagellar transport (IFT) cause SRPS but they do no

23 rily of HEAT repeats, may not be part of the intraflagellar transport (IFT) complex and is not requir

24 IFT80, a protein component of intraflagellar transport (IFT) complex B, is required fo

25 unction of Ift27, which encodes a subunit of intraflagellar transport (IFT) complex B.

26 The intraflagellar transport (IFT) complex is an integral co

27 Binding protein (SLB), is a component of the intraflagellar transport (IFT) complex.

28 Intraflagellar transport (IFT) complexes A and B build a

29 Two intraflagellar transport (IFT) complexes, IFT-A and IFT-

30 ization (aCGH) covering 20 genes that encode intraflagellar transport (IFT) components and 74 ciliopa

31 ization of other ciliary proteins, including intraflagellar transport (IFT) components, sensory recep

32 very similar, but not identical, to that of intraflagellar transport (IFT) components.

33 aintenance of eukaryotic cilia and flagella, intraflagellar transport (IFT) consists of the bidirecti

34 Intraflagellar transport (IFT) depends on two evolutiona

35 Anterograde intraflagellar transport (IFT) employing kinesin-2 molec

36 Across eukaryotes, intraflagellar transport (IFT) facilitates cilia biogene

37 This is the first time an intraflagellar transport (IFT) gene is implicated in the

38 netic approach in mice identified a role for intraflagellar transport (IFT) genes in Shh signal trans

39 nal (anterograde and retrograde) motor-based intraflagellar transport (IFT) governs cargo transport a

40 least BBS1, -4, -5, -7, and -8 and undergoes intraflagellar transport (IFT) in association with a sub

41 n FLA15 and FLA17 show defects in retrograde intraflagellar transport (IFT) in Chlamydomonas.

42 Loss of TCTEX1D2 impairs retrograde intraflagellar transport (IFT) in humans and the protist

43 toplasmic dynein 2, the motor for retrograde intraflagellar transport (IFT) in primary cilia.

44 Eukaryotic cilia are assembled via intraflagellar transport (IFT) in which large protein pa

45 Intraflagellar transport (IFT) is a bidirectional proces

46 wn, but because the OS is a modified cilium, intraflagellar transport (IFT) is a candidate mechanism.

47 Intraflagellar transport (IFT) is a motility in which pa

48 Intraflagellar transport (IFT) is a motility process ope

49 Intraflagellar transport (IFT) is a process required for

50 Intraflagellar transport (IFT) is a rapid movement of mu

51 Intraflagellar transport (IFT) is an active event in whi

52 Intraflagellar transport (IFT) is an ancient, conserved

53 Intraflagellar transport (IFT) is an evolutionarily cons

54 Intraflagellar transport (IFT) is assumed to be the pred

55 Anterograde intraflagellar transport (IFT) is essential for photorec

56 Intraflagellar transport (IFT) is essential for the deve

57 Intraflagellar transport (IFT) is essential for the elon

58 Anterograde intraflagellar transport (IFT) is mediated by kinesin mo

59 Intraflagellar transport (IFT) is not essential for PKD-

60 Retrograde intraflagellar transport (IFT) is required for assembly

61 Intraflagellar transport (IFT) is required for proper fu

62 Intraflagellar transport (IFT) is required for the assem

63 Intraflagellar transport (IFT) is the bidirectional move

64 Intraflagellar transport (IFT) is the process by which p

65 a, tba-6 regulates velocities and cargoes of intraflagellar transport (IFT) kinesin-2 motors kinesin-

66 17 and kinesin-3 KLP-6 without affecting the intraflagellar transport (IFT) kinesin-II.

67 Sensory cilia are assembled by intraflagellar transport (IFT) kinesins, which transport

68 tmentalized ciliogenesis depends on the core intraflagellar transport (IFT) machinery and the associa

69 Intraflagellar transport (IFT) machinery is required for

70 ciliary membranes at rates comparable to the intraflagellar transport (IFT) machinery located between

71 Intraflagellar transport (IFT) machinery mediates the bi

72 kinesin-2 subunit Kif3a, a component of the intraflagellar transport (IFT) machinery used to generat

73 Cilia are assembled and maintained by the intraflagellar transport (IFT) machinery, which coordina

74 er centrioles, and IFT88, a component of the intraflagellar transport (IFT) machinery.

75 et-Biedl syndrome (BBS) proteins, and on the intraflagellar transport (IFT) machinery.

76 Intraflagellar transport (IFT) motors assemble and maint

77 Characterization of previously described intraflagellar transport (IFT) mouse mutants has led to

78 Intraflagellar transport (IFT) moves IFT trains carrying

79 This phenotype is much less pronounced in intraflagellar transport (IFT) mutants and reveals that

80 e during flagellar resorption, especially in intraflagellar transport (IFT) mutants, suggesting that

81 s neurons depends on the kinesin-2-dependent intraflagellar transport (IFT) of ciliary precursors ass

82 Cilia are assembled via intraflagellar transport (IFT) of ciliary precursors; ho

83 rated that kinesin-II drives the anterograde intraflagellar transport (IFT) of protein complexes alon

84 Cilia and flagella are assembled by intraflagellar transport (IFT) of protein complexes that

85 We used an improved procedure to analyze the intraflagellar transport (IFT) of protein particles in C

86 Moreover, intraflagellar transport (IFT) particle components accum

87 Intraflagellar transport (IFT) particle composition was

88 examine the role of the IFT20 subunit of the intraflagellar transport (IFT) particle in photoreceptor

89 Conserved intraflagellar transport (IFT) particle proteins and IFT

90 -3-kinesin, which cooperate to move the same intraflagellar transport (IFT) particles along microtubu

91 Intraflagellar transport (IFT) particles are multiprotei

92 Chlamydomonas reinhardtii intraflagellar transport (IFT) particles can be biochemi

93 hlamydomonas genes that encode components of intraflagellar transport (IFT) particles involved in cil

94 rate, and the rate of entry into flagella of intraflagellar transport (IFT) particles is increased.

95 Intraflagellar transport (IFT) particles of Chlamydomona

96 HYLS-1 compromises the docking and entry of intraflagellar transport (IFT) particles, ciliary gating

97 is molecular architecture, two reservoirs of intraflagellar transport (IFT) particles, correlating wi

98 y activity and interact genetically with the intraflagellar transport (IFT) pathway to play a role in

99 may traffic to the primary cilium through an intraflagellar transport (IFT) pathway.

100 Highly conserved intraflagellar transport (IFT) protein complexes direct

101 -1 product (CMG-1), a human homologue of the intraflagellar transport (IFT) protein IFT-71 in Chlamyd

102 the transport adaptor ODA16, as well as the intraflagellar transport (IFT) protein IFT46, but the mo

103 lishing the first association of a defective intraflagellar transport (IFT) protein with human diseas

104 We show that in mice mutant for a cilia intraflagellar transport (IFT) protein, IFT88/polaris, S

105 ealed moderately altered expression of known intraflagellar transport (IFT) protein-encoding loci in

106 The highly conserved intraflagellar transport (IFT) proteins are essential fo

107 Intraflagellar transport (IFT) proteins are essential fo

108 gulators of animal development and depend on intraflagellar transport (IFT) proteins for their format

109 The intraflagellar transport (IFT) proteins Ift172/Wimple an

110 d and maintained by evolutionarily conserved intraflagellar transport (IFT) proteins that are involve

111 Intraflagellar transport (IFT) proteins were first ident

112 ODA16 localization resembles that seen for intraflagellar transport (IFT) proteins, and flagellar a

113 Disruption of intraflagellar transport (IFT) results in loss of flagel

114 are unusual in that they do not require the intraflagellar transport (IFT) system for assembly of th

115 The intraflagellar transport (IFT) system is required for bu

116 Ciliogenesis is accomplished by the intraflagellar transport (IFT) system, a set of proteins

117 Cilia use microtubule-based intraflagellar transport (IFT) to organize intercellular

118 he kinesin-2-driven anterograde transport of intraflagellar transport (IFT) trains has long been susp

119 Intraflagellar transport (IFT) underpins many of the imp

120 Intraflagellar transport (IFT) uses kinesin II to carry

121 s are required to establish sensory cilia by intraflagellar transport (IFT) where KIF3 and KIF17 coop

122 hog (Hh) signaling in vertebrates depends on intraflagellar transport (IFT) within primary cilia.

123 rved moving anterogradely at 0.7 microm/s by intraflagellar transport (IFT) within sensory cilia of c

124 ntenance of primary cilia are facilitated by intraflagellar transport (IFT), a bidirectional protein

125 asm into the cilium and flagellum axoneme by intraflagellar transport (IFT), a conserved process comm

126 e assembled and maintained by the process of intraflagellar transport (IFT), a highly conserved mecha

127 Assembly of cilia and flagella requires intraflagellar transport (IFT), a highly regulated kines

128 Ciliary assembly requires intraflagellar transport (IFT), a motile system that del

129 axonemal subunits at the tip are mediated by intraflagellar transport (IFT), a motility process essen

130 Sensory cilia and intraflagellar transport (IFT), a pathway essential for

131 m Caenorhabditis elegans that is involved in intraflagellar transport (IFT), a process essential for

132 of proteins within the cilia is governed by intraflagellar transport (IFT), a process that facilitat

133 Cilia assembly is mediated by intraflagellar transport (IFT), and cilia defects disrup

134 Cilia formation requires intraflagellar transport (IFT), and mutations disrupting

135 y opsin to test whether the highly conserved intraflagellar transport (IFT), as driven by heterotrime

136 alcium levels and requires kinesin-II-driven intraflagellar transport (IFT), as well as BBS- and RAB8

137 oth the frequency and velocity of retrograde intraflagellar transport (IFT), but it does not eliminat

138 ined by kinesin-2 motors in a process termed intraflagellar transport (IFT), but they exhibit great v

139 rs that act jointly to carry out anterograde intraflagellar transport (IFT), ferrying cargo along mic

140 Kif3a, a component of intraflagellar transport (IFT), is important in cilia ma

141 ve been classified as putatively involved in intraflagellar transport (IFT), the bidirectional moveme

142 Intraflagellar transport (IFT), the bidirectional moveme

143 onstruction of cilia and flagella depends on intraflagellar transport (IFT), the bidirectional moveme

144 ance of eukaryotic flagella are regulated by intraflagellar transport (IFT), the bidirectional traffi

145 activator for an anterograde motor OSM-3 of intraflagellar transport (IFT), the ciliogenesis-require

146 Intraflagellar transport (IFT), the motor-dependent move

147 g flagellar shortening and in the absence of intraflagellar transport (IFT), the predominant protein

148 During intraflagellar transport (IFT), the regulation of motor

149 IFT88, essential for anterograde intraflagellar transport (IFT), was significantly reduce

150 ney disease 2 (PKD2) and its relationship to intraflagellar transport (IFT), we cloned the gene encod

151 Primary cilia are built and maintained by intraflagellar transport (IFT), whereby the two IFT comp

152 and down the flagella in a process known as intraflagellar transport (IFT), which is essential for a

153 Intraflagellar transport (IFT), which is the bidirection

154 n this category are known to be required for intraflagellar transport (IFT), which is the bidirection

155 he assembly of primary cilia is dependent on intraflagellar transport (IFT), which mediates the bidir

156 system consists of three subcomplexes [i.e., intraflagellar transport (IFT)-A, IFT-B, and the BBSome]

157 ins besides a possible role for motor-driven Intraflagellar Transport (IFT).

158 luding BBS4, that is cycled through cilia by intraflagellar transport (IFT).

159 Kif3a, a subunit of Kinesin II essential for intraflagellar transport (IFT).

160 equires an active transport process known as intraflagellar transport (IFT).

161 d to require both anterograde and retrograde intraflagellar transport (IFT).

162 Cilia are assembled via intraflagellar transport (IFT).

163 ssembled and maintained by the bidirectional intraflagellar transport (IFT).

164 cause B tubule defects that further disrupt intraflagellar transport (IFT).

165 ctural cores assembling from basal bodies by intraflagellar transport (IFT).

166 eostasis and are assembled and maintained by intraflagellar transport (IFT).

167 ed through a highly conserved process called intraflagellar transport (IFT).

168 cilia and flagella depends on bidirectional intraflagellar transport (IFT).

169 mbrane and the axoneme in a process known as intraflagellar transport (IFT).

170 embly portion of the turnover is mediated by intraflagellar transport (IFT).

171 flagella of Chlamydomonas reinhardtii called intraflagellar transport (IFT).

172 large protein complexes in a process termed intraflagellar transport (IFT).

173 siRNA inhibition of anterograde intraflagellar transport (IFT88) reduced cilia length an

174 n three families, we identified mutations in Intraflagellar Transport 172 Homolog [IFT172 (Chlamydomo

175 Here, we identify intraflagellar transport 20 (IFT20) as a new target of t

176 nsport [kinesin family member 3A (Kif3a) and intraflagellar transport 88 (Ift88)] and Cre drivers tha

177 so known as polaris or Tg737), which encodes intraflagellar transport 88 homolog, and Kif3a, which en

178 remodeling and centrosome migration, whereas intraflagellar transport 88's role seems to be restricte

179 vely, a recent finding has revealed that the intraflagellar transport 88/polaris protein, which is re

180 conditional alleles for genes essential for intraflagellar transport [kinesin family member 3A (Kif3

181 INTU is essential for intraflagellar transport A complex assembly during cilio

182 Kinesin-2 motors, which are involved in intraflagellar transport and cargo transport along cytop

183 mselves, and show that crumbs genes modulate intraflagellar transport and cilia elongation.

184 esin II subunit Kif3A, which is required for intraflagellar transport and ciliogenesis.

185 KIF3A/B, a kinesin involved in intraflagellar transport and Golgi trafficking, is disti

186 Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human sk

187 Intraflagellar transport and kinesin-3 KLP-6 are require

188 nesin II motor complex, that is required for intraflagellar transport and the formation of cilia, was

189 Epistasis analyses indicate that DAF-6/intraflagellar transport and the OCR-2/OSM-9 TRPV channe

190 How might intraflagellar transport and the size of the trains be i

191 F3A/B, is a heterotrimeric motor involved in intraflagellar transport and vesicle motility in neurons

192 length-dependent signal produced to regulate intraflagellar transport appropriately?

193 ptures and releases its single effector, the intraflagellar transport B holocomplex, from the large p

194 entify the role of kinesin-II in anterograde intraflagellar transport by photoreceptor-specific delet

195 affecting ciliary assembly, mutations in the intraflagellar transport complex A (IFT-A) paradoxically

196 ,5)P2)-dependent manner, ciliary delivery by intraflagellar transport complex A binding to the TULP3/

197 r characterization of specific components of Intraflagellar Transport complex A uncovered a cilia-ind

198 requiring the receptor cytoplasmic tail, the intraflagellar transport complex-B (IFT-B), and ciliary

199 which encodes a component of the anterograde intraflagellar transport complex.

200 lia and flagella, and recent work shows that intraflagellar transport complexes - or trains - fall in

201 stern blots revealed that the bulges contain intraflagellar transport complexes, a defect reported pr

202 We observe sub-complexes in exocyst and intraflagellar transport complexes, which we validate bi

203 The intraflagellar transport component polaris localized to

204 imilarly, knockdown of ift22, an anterograde intraflagellar transport component, also suppresses the

205 In mutant OSNs, cilia base-anchoring of intraflagellar transport components IFT88, the kinesin-I

206 Mutants of daf-6 or intraflagellar transport constitutively upregulate tph-1

207 Ciliary dysfunction caused by intraflagellar transport defects results in branching de

208 n et al. describe the necessity of Ift88 and intraflagellar transport for signal reception of the son

209 cription factors, foxj1 and rfx2, and of the intraflagellar transport gene ift88 (also known as polar

210 ephros fluid output through knockdown of the intraflagellar transport gene ift88, was not associated

211 ing ciliopathies and argue that mutations in intraflagellar transport genes cause their phenotypes be

212 ecause endothelial-specific re-expression of intraflagellar transport genes in respective mutants res

213 Embryos expressing mutant intraflagellar transport genes, which are essential and

214 ata suggest a tantalizing connection between intraflagellar transport in cilia and brain development.

215 Intraflagellar transport in cilia has been proposed as a

216 ns and implicate the molecular components of intraflagellar transport in degenerative disorders of th

217 ptor cells of the retina, we have focused on intraflagellar transport in photoreceptor sensory cilia.

218 Intraflagellar transport is a conserved delivery system

219 Intraflagellar transport is essential for the assembly a

220 Intraflagellar transport is involved in the assembly of

221 Anterograde intraflagellar transport is sped up in lengthened cilia,

222 Intraflagellar transport is the rapid, bidirectional mov

223 e different measurements: 1) the quantity of intraflagellar transport machinery as a function of leng

224 We find that the quantity of intraflagellar transport machinery is independent of len

225 The intraflagellar transport machinery is required for the a

226 ecent identification in Chlamydomonas of the intraflagellar transport machinery that assembles cilia

227 loading onto the constitutively trafficking intraflagellar transport machinery.

228 Hh receptor Patched-related factor DAF-6 and intraflagellar transport modulate serotonin production i

229 vation of the Kif3a subunit of the kinesin-2 intraflagellar transport motor in mesenchymal skeletal p

230 The Chlamydomonas anterograde intraflagellar transport motor, kinesin-2, is isolated a

231 mediate chain associated with the retrograde intraflagellar transport motor.

232 required for the functional coordination of intraflagellar transport motors and their cargoes.

233 lia and that Gli3 processing is defective in intraflagellar transport mutants.

234 nance and signaling via Tulp3, essential for intraflagellar transport of ciliary signaling receptors.

235 This plus end-directed motor carries intraflagellar transport particles from the base to the

236 hancement of fluorescence signal in tracking intraflagellar transport particles, or reduction of phot

237 to an opening well suited for the passage of intraflagellar transport particles.

238 ignaling and adhesion molecules, and ciliary intraflagellar transport particles.

239 ivity to PIFTC3, encoding a component of the intraflagellar transport pathway.

240 tes cilia length through an Fgf8/Fgf24-Fgfr1-intraflagellar transport pathway.

241 tructural components of flagella, kinesin-II/intraflagellar transport plays a role in sensory transdu

242 ssociation of RPGR-ORF15 isoform(s) with the intraflagellar transport polypeptide IFT88 as well as mi

243 wo recent studies have shown that defects in intraflagellar transport prevent assembly of sensory cil

244 Unlike zebrafish intraflagellar transport protein (IFT) mutants, cyst for

245 icing variants in WDR35, encoding retrograde intraflagellar transport protein 121 (IFT121), in three

246 of open brain (sopb), a null allele of mouse Intraflagellar transport protein 122 (Ift122).

247 howed that avc1 is a hypomorphic mutation of intraflagellar transport protein 172 (Ift172), required

248 Here, we provide evidence that intraflagellar transport protein 20 (IFT20) interacts wi

249 We showed previously that the intraflagellar transport protein 20 (IFT20), a component

250 icrotubule nucleation, Golgi distribution of intraflagellar transport protein 20 homologue, and cilio

251 Effect of the variant observed in the gene Intraflagellar Transport Protein 43 (IFT43) was studied

252 We show that SDCCAG3 interacts with the intraflagellar transport protein 88 (IFT88), a crucial c

253 kinesin family member 3A) or Ift88 (encoding intraflagellar transport protein 88), genes required for

254 iption requires kinesin family member 3a and intraflagellar transport protein 88, proteins that are e

255 recent examples include the demonstration of intraflagellar transport protein and hedgehog contributi

256 ions in TTC21B, which encodes the retrograde intraflagellar transport protein IFT139, cause both isol

257 gastric cilia, we conditionally deleted the intraflagellar transport protein Ift88 (Ift88(-/fl)).

258 ough mice with a hypomorphic mutation in the intraflagellar transport protein IFT88 (Ift88Tg737Rpw mi

259 formation and centriolar recruitment of the intraflagellar transport protein Ift88.

260 Elimination of the intraflagellar transport protein Kif3a leads to excessiv

261 T52, encoding a homolog of the Chlamydomonas intraflagellar transport protein, IFT52.

262 Intraflagellar transport proteins (IFT) are required for

263 performed shRNA-mediated knockdown of seven intraflagellar transport proteins (IFTs) and conditional

264 ges were associated with increased levels of intraflagellar transport proteins and accelerated ciliog

265 This pathway also includes genes encoding intraflagellar transport proteins and cyclic nucleotide

266 rotein content, including abnormal levels of intraflagellar transport proteins and proteins associate

267 germline stem cell populations, and require intraflagellar transport proteins for their formation.

268 C2cd3 is also required for recruiting the intraflagellar transport proteins Ift88 and Ift52 to the

269 The unanticipated involvement of several intraflagellar transport proteins in the mammalian Hedge

270 ncluding removal of CP110 and recruitment of intraflagellar transport proteins.

271 localization, in tight coordination with the intraflagellar transport system and vesicular traffickin

272 sport protein 20 (IFT20), a component of the intraflagellar transport system, controls polarized traf

273 the base of mature cilia and is required for intraflagellar transport trafficking.

274 in the cytoplasm, transported into cilia by intraflagellar transport, and bound to specific sites on

275 in isotype regulates ciliary ultrastructure, intraflagellar transport, and ciliary functions of extra

276 equires an active transport process known as intraflagellar transport, and previous measurements sugg

277 s to predict the relation between length and intraflagellar transport, and then compare the predicted

278 ent due to the inherent length dependence of intraflagellar transport, whereas disassembly is length

279 ated that the TTC21B gene product IFT139, an intraflagellar transport-A component, mainly localizes a

280 mbrane attachments before or coinciding with intraflagellar transport-dependent axoneme extension and

281 ioles at the plasma membrane but not for the intraflagellar transport-dependent extension of the cili

282 complete removal of cilia by inactivation of intraflagellar transport-related proteins.

283 ugh the degradation of proteins required for intraflagellar transport.

284 otein-coupled receptors GPCRs or by blocking intraflagellar transport.

285 t they show features of defective retrograde intraflagellar transport.

286 Shh signaling regulates this balance through intraflagellar transport.

287 ilia construction or maintenance, but not in intraflagellar transport.

288 lium morphology and provides a substrate for intraflagellar transport.

289 a novel ciliary gene required for retrograde intraflagellar transport.

290 ynein-2 complex are essential for retrograde intraflagellar transport.

291 nt data support a role in cilia function and intraflagellar transport.

292 on of genes associated with ciliogenesis and intraflagellar transport.

293 eviously in a subset of mutants defective in intraflagellar transport.

294 syndrome when mutated, in the triggering of intraflagellar transport.

295 (-/-) basal bodies, suggesting impairment of intraflagellar transport.

296 sting 9+2 axonemes associated with decreased intraflagellar transport.

297 t that a length-dependent feedback regulates intraflagellar transport.

298 eins transmit force for ciliary motility and intraflagellar transport.

299 ctural precursors delivered to their tips by intraflagellar transport.

300 n-2 family member best known for its role in intraflagellar transport.