ライフサイエンスコーパス: intraflagellar transport

1 otein-coupled receptors GPCRs or by blocking intraflagellar transport.

2 t they show features of defective retrograde intraflagellar transport.

3 Shh signaling regulates this balance through intraflagellar transport.

4 ilia construction or maintenance, but not in intraflagellar transport.

5 lium morphology and provides a substrate for intraflagellar transport.

6 a novel ciliary gene required for retrograde intraflagellar transport.

7 ynein-2 complex are essential for retrograde intraflagellar transport.

8 nt data support a role in cilia function and intraflagellar transport.

9 on of genes associated with ciliogenesis and intraflagellar transport.

10 eviously in a subset of mutants defective in intraflagellar transport.

11 syndrome when mutated, in the triggering of intraflagellar transport.

12 (-/-) basal bodies, suggesting impairment of intraflagellar transport.

13 sting 9+2 axonemes associated with decreased intraflagellar transport.

14 t that a length-dependent feedback regulates intraflagellar transport.

15 eins transmit force for ciliary motility and intraflagellar transport.

16 ctural precursors delivered to their tips by intraflagellar transport.

17 n-2 family member best known for its role in intraflagellar transport.

18 ugh the degradation of proteins required for intraflagellar transport.

19 n three families, we identified mutations in Intraflagellar Transport 172 Homolog [IFT172 (Chlamydomo

20 Here, we identify intraflagellar transport 20 (IFT20) as a new target of t

21 nsport [kinesin family member 3A (Kif3a) and intraflagellar transport 88 (Ift88)] and Cre drivers tha

22 so known as polaris or Tg737), which encodes intraflagellar transport 88 homolog, and Kif3a, which en

23 remodeling and centrosome migration, whereas intraflagellar transport 88's role seems to be restricte

24 vely, a recent finding has revealed that the intraflagellar transport 88/polaris protein, which is re

25 INTU is essential for intraflagellar transport A complex assembly during cilio

26 ated that the TTC21B gene product IFT139, an intraflagellar transport-A component, mainly localizes a

27 Kinesin-2 motors, which are involved in intraflagellar transport and cargo transport along cytop

28 mselves, and show that crumbs genes modulate intraflagellar transport and cilia elongation.

29 esin II subunit Kif3A, which is required for intraflagellar transport and ciliogenesis.

30 KIF3A/B, a kinesin involved in intraflagellar transport and Golgi trafficking, is disti

31 Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human sk

32 Intraflagellar transport and kinesin-3 KLP-6 are require

33 nesin II motor complex, that is required for intraflagellar transport and the formation of cilia, was

34 Epistasis analyses indicate that DAF-6/intraflagellar transport and the OCR-2/OSM-9 TRPV channe

35 How might intraflagellar transport and the size of the trains be i

36 F3A/B, is a heterotrimeric motor involved in intraflagellar transport and vesicle motility in neurons

37 in the cytoplasm, transported into cilia by intraflagellar transport, and bound to specific sites on

38 in isotype regulates ciliary ultrastructure, intraflagellar transport, and ciliary functions of extra

39 equires an active transport process known as intraflagellar transport, and previous measurements sugg

40 s to predict the relation between length and intraflagellar transport, and then compare the predicted

41 length-dependent signal produced to regulate intraflagellar transport appropriately?

42 ptures and releases its single effector, the intraflagellar transport B holocomplex, from the large p

43 entify the role of kinesin-II in anterograde intraflagellar transport by photoreceptor-specific delet

44 affecting ciliary assembly, mutations in the intraflagellar transport complex A (IFT-A) paradoxically

45 ,5)P2)-dependent manner, ciliary delivery by intraflagellar transport complex A binding to the TULP3/

46 r characterization of specific components of Intraflagellar Transport complex A uncovered a cilia-ind

47 requiring the receptor cytoplasmic tail, the intraflagellar transport complex-B (IFT-B), and ciliary

48 which encodes a component of the anterograde intraflagellar transport complex.

49 lia and flagella, and recent work shows that intraflagellar transport complexes - or trains - fall in

50 stern blots revealed that the bulges contain intraflagellar transport complexes, a defect reported pr

51 We observe sub-complexes in exocyst and intraflagellar transport complexes, which we validate bi

52 The intraflagellar transport component polaris localized to

53 imilarly, knockdown of ift22, an anterograde intraflagellar transport component, also suppresses the

54 In mutant OSNs, cilia base-anchoring of intraflagellar transport components IFT88, the kinesin-I

55 Mutants of daf-6 or intraflagellar transport constitutively upregulate tph-1

56 Ciliary dysfunction caused by intraflagellar transport defects results in branching de

57 mbrane attachments before or coinciding with intraflagellar transport-dependent axoneme extension and

58 ioles at the plasma membrane but not for the intraflagellar transport-dependent extension of the cili

59 n et al. describe the necessity of Ift88 and intraflagellar transport for signal reception of the son

60 cription factors, foxj1 and rfx2, and of the intraflagellar transport gene ift88 (also known as polar

61 ephros fluid output through knockdown of the intraflagellar transport gene ift88, was not associated

62 ing ciliopathies and argue that mutations in intraflagellar transport genes cause their phenotypes be

63 ecause endothelial-specific re-expression of intraflagellar transport genes in respective mutants res

64 Embryos expressing mutant intraflagellar transport genes, which are essential and

65 oducts from the flagellar tip is mediated by intraflagellar transport (IFT) , which is essential for

66 arrier at the base of the organelle [3-8] by intraflagellar transport (IFT) [9-18].

67 aintenance of all cilia and flagella require intraflagellar transport (IFT) along the axoneme.

68 semble from basal bodies by a process called intraflagellar transport (IFT) and are associated with s

69 ins in primary cilia is thought to depend on intraflagellar transport (IFT) and diffusion.

70 crotubule-based organelles that assemble via intraflagellar transport (IFT) and function as signaling

71 GFP-tagged alpha-tubulin enters cilia as an intraflagellar transport (IFT) cargo and by diffusion.

72 Mutations in several genes affecting intraflagellar transport (IFT) cause SRPS but they do no

73 rily of HEAT repeats, may not be part of the intraflagellar transport (IFT) complex and is not requir

74 IFT80, a protein component of intraflagellar transport (IFT) complex B, is required fo

75 unction of Ift27, which encodes a subunit of intraflagellar transport (IFT) complex B.

76 The intraflagellar transport (IFT) complex is an integral co

77 Binding protein (SLB), is a component of the intraflagellar transport (IFT) complex.

78 Intraflagellar transport (IFT) complexes A and B build a

79 Two intraflagellar transport (IFT) complexes, IFT-A and IFT-

80 ization (aCGH) covering 20 genes that encode intraflagellar transport (IFT) components and 74 ciliopa

81 ization of other ciliary proteins, including intraflagellar transport (IFT) components, sensory recep

82 very similar, but not identical, to that of intraflagellar transport (IFT) components.

83 aintenance of eukaryotic cilia and flagella, intraflagellar transport (IFT) consists of the bidirecti

84 Intraflagellar transport (IFT) depends on two evolutiona

85 Anterograde intraflagellar transport (IFT) employing kinesin-2 molec

86 Across eukaryotes, intraflagellar transport (IFT) facilitates cilia biogene

87 This is the first time an intraflagellar transport (IFT) gene is implicated in the

88 netic approach in mice identified a role for intraflagellar transport (IFT) genes in Shh signal trans

89 nal (anterograde and retrograde) motor-based intraflagellar transport (IFT) governs cargo transport a

90 least BBS1, -4, -5, -7, and -8 and undergoes intraflagellar transport (IFT) in association with a sub

91 n FLA15 and FLA17 show defects in retrograde intraflagellar transport (IFT) in Chlamydomonas.

92 Loss of TCTEX1D2 impairs retrograde intraflagellar transport (IFT) in humans and the protist

93 toplasmic dynein 2, the motor for retrograde intraflagellar transport (IFT) in primary cilia.

94 Eukaryotic cilia are assembled via intraflagellar transport (IFT) in which large protein pa

95 Intraflagellar transport (IFT) is a bidirectional proces

96 wn, but because the OS is a modified cilium, intraflagellar transport (IFT) is a candidate mechanism.

97 Intraflagellar transport (IFT) is a motility in which pa

98 Intraflagellar transport (IFT) is a motility process ope

99 Intraflagellar transport (IFT) is a process required for

100 Intraflagellar transport (IFT) is a rapid movement of mu

101 Intraflagellar transport (IFT) is an active event in whi

102 Intraflagellar transport (IFT) is an ancient, conserved

103 Intraflagellar transport (IFT) is an evolutionarily cons

104 Intraflagellar transport (IFT) is assumed to be the pred

105 Anterograde intraflagellar transport (IFT) is essential for photorec

106 Intraflagellar transport (IFT) is essential for the deve

107 Intraflagellar transport (IFT) is essential for the elon

108 Anterograde intraflagellar transport (IFT) is mediated by kinesin mo

109 Intraflagellar transport (IFT) is not essential for PKD-

110 Retrograde intraflagellar transport (IFT) is required for assembly

111 Intraflagellar transport (IFT) is required for proper fu

112 Intraflagellar transport (IFT) is required for the assem

113 Intraflagellar transport (IFT) is the bidirectional move

114 Intraflagellar transport (IFT) is the process by which p

115 a, tba-6 regulates velocities and cargoes of intraflagellar transport (IFT) kinesin-2 motors kinesin-

116 17 and kinesin-3 KLP-6 without affecting the intraflagellar transport (IFT) kinesin-II.

117 Sensory cilia are assembled by intraflagellar transport (IFT) kinesins, which transport

118 tmentalized ciliogenesis depends on the core intraflagellar transport (IFT) machinery and the associa

119 Intraflagellar transport (IFT) machinery is required for

120 ciliary membranes at rates comparable to the intraflagellar transport (IFT) machinery located between

121 Intraflagellar transport (IFT) machinery mediates the bi

122 kinesin-2 subunit Kif3a, a component of the intraflagellar transport (IFT) machinery used to generat

123 Cilia are assembled and maintained by the intraflagellar transport (IFT) machinery, which coordina

124 er centrioles, and IFT88, a component of the intraflagellar transport (IFT) machinery.

125 et-Biedl syndrome (BBS) proteins, and on the intraflagellar transport (IFT) machinery.

126 Intraflagellar transport (IFT) motors assemble and maint

127 Characterization of previously described intraflagellar transport (IFT) mouse mutants has led to

128 Intraflagellar transport (IFT) moves IFT trains carrying

129 This phenotype is much less pronounced in intraflagellar transport (IFT) mutants and reveals that

130 e during flagellar resorption, especially in intraflagellar transport (IFT) mutants, suggesting that

131 s neurons depends on the kinesin-2-dependent intraflagellar transport (IFT) of ciliary precursors ass

132 Cilia are assembled via intraflagellar transport (IFT) of ciliary precursors; ho

133 rated that kinesin-II drives the anterograde intraflagellar transport (IFT) of protein complexes alon

134 Cilia and flagella are assembled by intraflagellar transport (IFT) of protein complexes that

135 We used an improved procedure to analyze the intraflagellar transport (IFT) of protein particles in C

136 Moreover, intraflagellar transport (IFT) particle components accum

137 Intraflagellar transport (IFT) particle composition was

138 examine the role of the IFT20 subunit of the intraflagellar transport (IFT) particle in photoreceptor

139 Conserved intraflagellar transport (IFT) particle proteins and IFT

140 -3-kinesin, which cooperate to move the same intraflagellar transport (IFT) particles along microtubu

141 Intraflagellar transport (IFT) particles are multiprotei

142 Chlamydomonas reinhardtii intraflagellar transport (IFT) particles can be biochemi

143 hlamydomonas genes that encode components of intraflagellar transport (IFT) particles involved in cil

144 rate, and the rate of entry into flagella of intraflagellar transport (IFT) particles is increased.

145 Intraflagellar transport (IFT) particles of Chlamydomona

146 HYLS-1 compromises the docking and entry of intraflagellar transport (IFT) particles, ciliary gating

147 is molecular architecture, two reservoirs of intraflagellar transport (IFT) particles, correlating wi

148 y activity and interact genetically with the intraflagellar transport (IFT) pathway to play a role in

149 may traffic to the primary cilium through an intraflagellar transport (IFT) pathway.

150 Highly conserved intraflagellar transport (IFT) protein complexes direct

151 -1 product (CMG-1), a human homologue of the intraflagellar transport (IFT) protein IFT-71 in Chlamyd

152 the transport adaptor ODA16, as well as the intraflagellar transport (IFT) protein IFT46, but the mo

153 lishing the first association of a defective intraflagellar transport (IFT) protein with human diseas

154 We show that in mice mutant for a cilia intraflagellar transport (IFT) protein, IFT88/polaris, S

155 ealed moderately altered expression of known intraflagellar transport (IFT) protein-encoding loci in

156 The highly conserved intraflagellar transport (IFT) proteins are essential fo

157 Intraflagellar transport (IFT) proteins are essential fo

158 gulators of animal development and depend on intraflagellar transport (IFT) proteins for their format

159 The intraflagellar transport (IFT) proteins Ift172/Wimple an

160 d and maintained by evolutionarily conserved intraflagellar transport (IFT) proteins that are involve

161 Intraflagellar transport (IFT) proteins were first ident

162 ODA16 localization resembles that seen for intraflagellar transport (IFT) proteins, and flagellar a

163 Disruption of intraflagellar transport (IFT) results in loss of flagel

164 are unusual in that they do not require the intraflagellar transport (IFT) system for assembly of th

165 The intraflagellar transport (IFT) system is required for bu

166 Ciliogenesis is accomplished by the intraflagellar transport (IFT) system, a set of proteins

167 Cilia use microtubule-based intraflagellar transport (IFT) to organize intercellular

168 he kinesin-2-driven anterograde transport of intraflagellar transport (IFT) trains has long been susp

169 Intraflagellar transport (IFT) underpins many of the imp

170 Intraflagellar transport (IFT) uses kinesin II to carry

171 s are required to establish sensory cilia by intraflagellar transport (IFT) where KIF3 and KIF17 coop

172 hog (Hh) signaling in vertebrates depends on intraflagellar transport (IFT) within primary cilia.

173 rved moving anterogradely at 0.7 microm/s by intraflagellar transport (IFT) within sensory cilia of c

174 ntenance of primary cilia are facilitated by intraflagellar transport (IFT), a bidirectional protein

175 asm into the cilium and flagellum axoneme by intraflagellar transport (IFT), a conserved process comm

176 e assembled and maintained by the process of intraflagellar transport (IFT), a highly conserved mecha

177 Assembly of cilia and flagella requires intraflagellar transport (IFT), a highly regulated kines

178 Ciliary assembly requires intraflagellar transport (IFT), a motile system that del

179 axonemal subunits at the tip are mediated by intraflagellar transport (IFT), a motility process essen

180 Sensory cilia and intraflagellar transport (IFT), a pathway essential for

181 m Caenorhabditis elegans that is involved in intraflagellar transport (IFT), a process essential for

182 of proteins within the cilia is governed by intraflagellar transport (IFT), a process that facilitat

183 Cilia assembly is mediated by intraflagellar transport (IFT), and cilia defects disrup

184 Cilia formation requires intraflagellar transport (IFT), and mutations disrupting

185 y opsin to test whether the highly conserved intraflagellar transport (IFT), as driven by heterotrime

186 alcium levels and requires kinesin-II-driven intraflagellar transport (IFT), as well as BBS- and RAB8

187 oth the frequency and velocity of retrograde intraflagellar transport (IFT), but it does not eliminat

188 ined by kinesin-2 motors in a process termed intraflagellar transport (IFT), but they exhibit great v

189 rs that act jointly to carry out anterograde intraflagellar transport (IFT), ferrying cargo along mic

190 Kif3a, a component of intraflagellar transport (IFT), is important in cilia ma

191 ve been classified as putatively involved in intraflagellar transport (IFT), the bidirectional moveme

192 Intraflagellar transport (IFT), the bidirectional moveme

193 onstruction of cilia and flagella depends on intraflagellar transport (IFT), the bidirectional moveme

194 ance of eukaryotic flagella are regulated by intraflagellar transport (IFT), the bidirectional traffi

195 activator for an anterograde motor OSM-3 of intraflagellar transport (IFT), the ciliogenesis-require

196 Intraflagellar transport (IFT), the motor-dependent move

197 g flagellar shortening and in the absence of intraflagellar transport (IFT), the predominant protein

198 During intraflagellar transport (IFT), the regulation of motor

199 IFT88, essential for anterograde intraflagellar transport (IFT), was significantly reduce

200 ney disease 2 (PKD2) and its relationship to intraflagellar transport (IFT), we cloned the gene encod

201 Primary cilia are built and maintained by intraflagellar transport (IFT), whereby the two IFT comp

202 and down the flagella in a process known as intraflagellar transport (IFT), which is essential for a

203 Intraflagellar transport (IFT), which is the bidirection

204 n this category are known to be required for intraflagellar transport (IFT), which is the bidirection

205 he assembly of primary cilia is dependent on intraflagellar transport (IFT), which mediates the bidir

206 system consists of three subcomplexes [i.e., intraflagellar transport (IFT)-A, IFT-B, and the BBSome]

207 ins besides a possible role for motor-driven Intraflagellar Transport (IFT).

208 luding BBS4, that is cycled through cilia by intraflagellar transport (IFT).

209 Kif3a, a subunit of Kinesin II essential for intraflagellar transport (IFT).

210 equires an active transport process known as intraflagellar transport (IFT).

211 d to require both anterograde and retrograde intraflagellar transport (IFT).

212 Cilia are assembled via intraflagellar transport (IFT).

213 ssembled and maintained by the bidirectional intraflagellar transport (IFT).

214 cause B tubule defects that further disrupt intraflagellar transport (IFT).

215 ctural cores assembling from basal bodies by intraflagellar transport (IFT).

216 eostasis and are assembled and maintained by intraflagellar transport (IFT).

217 ed through a highly conserved process called intraflagellar transport (IFT).

218 cilia and flagella depends on bidirectional intraflagellar transport (IFT).

219 mbrane and the axoneme in a process known as intraflagellar transport (IFT).

220 embly portion of the turnover is mediated by intraflagellar transport (IFT).

221 flagella of Chlamydomonas reinhardtii called intraflagellar transport (IFT).

222 of Chlamydomonas flagella, is referred to as intraflagellar transport (IFT).

223 mber of rafts, the particles translocated by intraflagellar transport (IFT).

224 large protein complexes in a process termed intraflagellar transport (IFT).

225 siRNA inhibition of anterograde intraflagellar transport (IFT88) reduced cilia length an

226 ata suggest a tantalizing connection between intraflagellar transport in cilia and brain development.

227 Intraflagellar transport in cilia has been proposed as a

228 ns and implicate the molecular components of intraflagellar transport in degenerative disorders of th

229 ptor cells of the retina, we have focused on intraflagellar transport in photoreceptor sensory cilia.

230 Intraflagellar transport is a conserved delivery system

231 Intraflagellar transport is essential for the assembly a

232 Intraflagellar transport is involved in the assembly of

233 Anterograde intraflagellar transport is sped up in lengthened cilia,

234 Intraflagellar transport is the rapid, bidirectional mov

235 conditional alleles for genes essential for intraflagellar transport [kinesin family member 3A (Kif3

236 e different measurements: 1) the quantity of intraflagellar transport machinery as a function of leng

237 We find that the quantity of intraflagellar transport machinery is independent of len

238 The intraflagellar transport machinery is required for the a

239 ecent identification in Chlamydomonas of the intraflagellar transport machinery that assembles cilia

240 loading onto the constitutively trafficking intraflagellar transport machinery.

241 Hh receptor Patched-related factor DAF-6 and intraflagellar transport modulate serotonin production i

242 vation of the Kif3a subunit of the kinesin-2 intraflagellar transport motor in mesenchymal skeletal p

243 The Chlamydomonas anterograde intraflagellar transport motor, kinesin-2, is isolated a

244 mediate chain associated with the retrograde intraflagellar transport motor.

245 required for the functional coordination of intraflagellar transport motors and their cargoes.

246 lia and that Gli3 processing is defective in intraflagellar transport mutants.

247 nance and signaling via Tulp3, essential for intraflagellar transport of ciliary signaling receptors.

248 This plus end-directed motor carries intraflagellar transport particles from the base to the

249 hancement of fluorescence signal in tracking intraflagellar transport particles, or reduction of phot

250 to an opening well suited for the passage of intraflagellar transport particles.

251 ignaling and adhesion molecules, and ciliary intraflagellar transport particles.

252 ivity to PIFTC3, encoding a component of the intraflagellar transport pathway.

253 tes cilia length through an Fgf8/Fgf24-Fgfr1-intraflagellar transport pathway.

254 tructural components of flagella, kinesin-II/intraflagellar transport plays a role in sensory transdu

255 ssociation of RPGR-ORF15 isoform(s) with the intraflagellar transport polypeptide IFT88 as well as mi

256 wo recent studies have shown that defects in intraflagellar transport prevent assembly of sensory cil

257 Unlike zebrafish intraflagellar transport protein (IFT) mutants, cyst for

258 icing variants in WDR35, encoding retrograde intraflagellar transport protein 121 (IFT121), in three

259 of open brain (sopb), a null allele of mouse Intraflagellar transport protein 122 (Ift122).

260 howed that avc1 is a hypomorphic mutation of intraflagellar transport protein 172 (Ift172), required

261 Here, we provide evidence that intraflagellar transport protein 20 (IFT20) interacts wi

262 We showed previously that the intraflagellar transport protein 20 (IFT20), a component

263 icrotubule nucleation, Golgi distribution of intraflagellar transport protein 20 homologue, and cilio

264 Effect of the variant observed in the gene Intraflagellar Transport Protein 43 (IFT43) was studied

265 We show that SDCCAG3 interacts with the intraflagellar transport protein 88 (IFT88), a crucial c

266 kinesin family member 3A) or Ift88 (encoding intraflagellar transport protein 88), genes required for

267 iption requires kinesin family member 3a and intraflagellar transport protein 88, proteins that are e

268 recent examples include the demonstration of intraflagellar transport protein and hedgehog contributi

269 ions in TTC21B, which encodes the retrograde intraflagellar transport protein IFT139, cause both isol

270 gastric cilia, we conditionally deleted the intraflagellar transport protein Ift88 (Ift88(-/fl)).

271 ough mice with a hypomorphic mutation in the intraflagellar transport protein IFT88 (Ift88Tg737Rpw mi

272 formation and centriolar recruitment of the intraflagellar transport protein Ift88.

273 Elimination of the intraflagellar transport protein Kif3a leads to excessiv

274 T52, encoding a homolog of the Chlamydomonas intraflagellar transport protein, IFT52.

275 Intraflagellar transport proteins (IFT) are required for

276 performed shRNA-mediated knockdown of seven intraflagellar transport proteins (IFTs) and conditional

277 ges were associated with increased levels of intraflagellar transport proteins and accelerated ciliog

278 This pathway also includes genes encoding intraflagellar transport proteins and cyclic nucleotide

279 rotein content, including abnormal levels of intraflagellar transport proteins and proteins associate

280 germline stem cell populations, and require intraflagellar transport proteins for their formation.

281 C2cd3 is also required for recruiting the intraflagellar transport proteins Ift88 and Ift52 to the

282 The unanticipated involvement of several intraflagellar transport proteins in the mammalian Hedge

283 ncluding removal of CP110 and recruitment of intraflagellar transport proteins.

284 complete removal of cilia by inactivation of intraflagellar transport-related proteins.

285 localization, in tight coordination with the intraflagellar transport system and vesicular traffickin

286 sport protein 20 (IFT20), a component of the intraflagellar transport system, controls polarized traf

287 the base of mature cilia and is required for intraflagellar transport trafficking.

288 ent due to the inherent length dependence of intraflagellar transport, whereas disassembly is length