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1 (SUV) analysis was performed, and the total intrahepatic (18)F-fluoroethylcholine positive tumor vol
3 sed case-control study, 2395 CCA cases (1169 intrahepatic, 995 perihilar, and 231 distal) seen at the
4 t that abnormal AAT protein conformation and intrahepatic accumulation have broad effects on metaboli
5 e and hepatic steatosis, consistent with the intrahepatic accumulation of glucocorticoids, and predis
6 lectrin-mediated cross-presentation supports intrahepatic adaptive antiviral immune responses and may
7 Moreover, the renal excretion kinetic and intrahepatic albumin binding affinity of CyG can further
10 was associated with decreased activation of intrahepatic and blood NK cells; it was followed by rest
12 ility of invasion and migration in vitro and intrahepatic and distal lung metastasis in vivo of HCC c
13 elial cells, named cholangiocytes, that line intrahepatic and extrahepatic bile ducts, contribute sub
14 ession levels were measured in the following intrahepatic and extrahepatic cholangiocarcinoma (CCA) c
18 gh the CSC profile was similar between mucin-intrahepatic and mucin-perihilar subtypes, CD13(+) CSCs
19 erosing cholangitis was associated with both intrahepatic and perihilar CCA, with similar AORs of 14.
20 in centers from Asia were more likely to be intrahepatic and were less frequently invasive compared
21 cular density, portosystemic shunting (PSS), intrahepatic angiogenesis, and fibrosis without affectin
22 itial activation, but was maintained by high intrahepatic antigen load during the early phase of the
24 h perihilar (AOR = 453, 95% CI 104-999) than intrahepatic (AOR = 93.4, 95% CI 27.1-322) or distal (AO
27 erozygous mice (Jag1(+/-) ) exhibit impaired intrahepatic bile duct (IHBD) development, decreased SOX
30 of cirrhotic patients with tumors exhibiting intrahepatic bile duct differentiation remains controver
34 ry proliferation was evaluated by changes in intrahepatic bile duct mass and the expression of prolif
36 ivo and in vitro knockdown of GnRH decreased intrahepatic bile duct mass/cholangiocyte proliferation
37 hepatoblasts into cholangiocytes, premature intrahepatic bile duct morphogenesis, and biliary hyperp
39 ithout these infections: cancer of liver and intrahepatic bile duct; fibrosis, cirrhosis, and other l
40 adolinium administration = 1 x dilatation of intrahepatic bile ducts + 2 x dysmorphy + 1 x portal hyp
41 the characteristic phenotype of high-density intrahepatic bile ducts and enlarged liver in Rosa(NICD/
43 bile ducts, and its expression is reduced in intrahepatic bile ducts of patients with cholestatic dis
45 isease characterised by destruction of small intrahepatic bile ducts, leading to fibrosis and potenti
48 ompensatory proliferation of hepatocytes and intrahepatic biliary cells, thus impeding HCC developmen
50 mixtures found in primary cultures of human intrahepatic biliary epithelial cells (HiBEC), human ren
51 , human bronchial epithelial cells, isolated intrahepatic biliary epithelial cells from explanted pri
54 inistration of GnRH to normal rats increased intrahepatic biliary mass (IBDM) and hepatic fibrosis.
55 in increased cholangiocyte proliferation and intrahepatic biliary mass, liver damage, and inflammatio
56 the clinico-radiological characteristics of intrahepatic biliary mucinous cystic neoplasms and to es
59 e produced a crowded branching defect in the intrahepatic biliary network and influenced actin dynami
67 limp-1(hi)Hobit(lo) T cells found within the intrahepatic but not the circulating memory CD8 T cell p
68 olesterolemia induced the differentiation of intrahepatic, but not intrasplenic, Th17 cells in wild-t
69 zation of these pathways was sought in human intrahepatic CC, in vivo, using multiplex labeling and s
70 iated with shorter survival of patients with intrahepatic CCA (HR, 4.2; 95% CI: 1.1-14.1; P = 0.04).
71 NAFLD and CCA, stratifying by its subtypes; intrahepatic CCA (iCCA), and extrahepatic CCA (eCCA).
72 Noninvasive differential diagnosis between intrahepatic CCA and hepatocellular carcinoma (HCC) is s
75 tabolism in NAFLD causes a selective loss of intrahepatic CD4(+) but not CD8(+) T lymphocytes, leadin
76 increased frequency of IL-17(+) cells among intrahepatic CD4(+) T cells and higher Th17/rTreg and Th
79 Liver disease elicits alterations in the intrahepatic CD4(+) T-cell compartment that suppress T-c
89 7F secretion in vitro and in vivo; IL-17F(+) intrahepatic cells expanded more vigorously in IL-17A kn
93 rom combined hepatocellular liver cancer and intrahepatic cholangiocarcinoma (ICC) has increased and
97 on and aggressive malignancy of mass-forming intrahepatic cholangiocarcinoma (ICC), we modeled ICC de
100 er comprises hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (iCCA), and other rare t
101 Standard therapies for localized inoperable intrahepatic cholangiocarcinoma (IHCC) are ineffective.
102 e to enrich for cell surface proteins of the intrahepatic cholangiocarcinoma cell line CC-SW-1 was de
103 ondary glioblastoma, acute myeloid leukemia, intrahepatic cholangiocarcinoma, and chondrosarcomas, le
104 cers, including hepatocellular carcinoma and intrahepatic cholangiocarcinoma, are leading causes of c
105 ly encompassing hepatocellular carcinoma and intrahepatic cholangiocarcinoma, has become the second l
108 102 hepatocellular carcinomas (HCCs), three intrahepatic cholangiocarcinomas (ICCs), one neuroendocr
110 itized both EHCs and the otherwise resistant intrahepatic cholangiocytes to the toxin, whereas replen
111 inotransferase (1239 vs 2065 U/L, P = 0.02), intrahepatic cholangiopathy (0% vs 22%, P = 0.015), bili
113 before procurement causes injuries including intrahepatic cholangiopathy, which may lead to graft los
116 holangiopathies such as progressive familial intrahepatic cholestasis and primary sclerosing cholangi
117 diagnosis, 14 age-appropriate subjects with intrahepatic cholestasis as diseased controls and seven
120 nagement and pregnancy outcome in women with intrahepatic cholestasis of pregnancy (ICP) and treatmen
124 pruritus of the skin is an early symptom of intrahepatic cholestasis of pregnancy (ICP) or due to be
127 f clinical evolution in progressive familial intrahepatic cholestasis type 2 patients and how they re
131 ary diseases, including progressive familial intrahepatic cholestasis type 3 (PFIC3), a rare disease
135 tations in ATP8B1 cause progressive familial intrahepatic cholestasis type1 in humans, which is chara
136 hildhood liver disease, progressive familial intrahepatic cholestasis, but cause and effect is less c
137 fferent genes can cause progressive familial intrahepatic cholestasis, but known genes cannot account
139 h Alagille syndrome (ALGS), 16 with familial intrahepatic cholestasis-1 (FIC1), 18 with bile salt exp
140 asis characterized by a progressive familial intrahepatic cholestasis-like phenotype with normal seru
141 s in five patients with progressive familial intrahepatic cholestasis-like phenotype with normal seru
143 spectrum from intermittent (benign recurrent intrahepatic cholestasis; BRIC) to progressive familial
146 andheld imaging device was then performed on intrahepatic colorectal metastases after the administrat
148 of murine liver with adenovirus, a model for intrahepatic cross-presentation, confirms hepatocytes di
149 tment hour 10 (P = .023) and peak (P = .034) intrahepatic CXCL10 levels were also higher in these pat
150 eatment hour 6 and day 2, while induction of intrahepatic CXCL10 mRNA peaked (mean fold-induction [+/
158 examined changes in serum lipid profiles and intrahepatic expression of lipid-related genes during in
161 ther adjusted for weight loss, losing VAT or intrahepatic fat was independently associated with impro
163 eased hepatic de novo lipogenesis, decreased intrahepatic fatty acid oxidation, and inadequate increa
164 nt was also associated with replenishment of intrahepatic glucose due to enhanced gluconeogenesis and
167 upport the prognostic importance of treating intrahepatic HCC even in patients with metastatic diseas
168 ular carcinoma (HCC) is mainly determined by intrahepatic HCC progression, local treatment with TACE
169 essful treatment options, several aspects of intrahepatic HCV infection dynamics are still poorly und
171 INT-747), a potent selective FXR agonist, on intrahepatic hemodynamic dysfunction and signaling pathw
172 infection, during or shortly before maximal intrahepatic IFN-stimulated gene expression, but disappe
173 clearance of HCV is associated with loss of intrahepatic immune activation by IFNalpha, which is ind
175 e important causes of human disease, but the intrahepatic immune response to hepatitis viruses is poo
176 ge of TCPTP by NS3/4A induces a shift of the intrahepatic immune response toward a nonantiviral Th2-d
177 nic hepatitis C virus infection activates an intrahepatic immune response, leading to increased expre
178 gt1 and gt3 infections do not elicit innate intrahepatic immune responses and remain highly sensitiv
180 ms of liver tolerance limit the magnitude of intrahepatic immune responses, allowing the liver to rec
184 , we postulated that Mincle signaling drives intrahepatic inflammation and liver injury in Con A hepa
186 hat inflammatory monocytes contribute to the intrahepatic inflammatory response during the early phas
187 RIF) was a central mediator of the resulting intrahepatic inflammatory response that was independent
188 n vitro or in xenografted mice after s.c. or intrahepatic injection in normal and cirrhotic (carbon t
189 Herein, we describe an original method of intrahepatic injection into adult NOD.Cg-Prkdc(scid)Il2r
190 t of severe amebic liver abscesses following intrahepatic injection of E. histolytica by a combined r
192 -mediated clearance of senescent cells after intrahepatic injection of NRAS (Figures 2I, 3B, 3C, and
195 iled to induce viremia in tamarins following intrahepatic inoculation, nor did they lead to progeny v
196 EV infections in humanized mice and modelled intrahepatic interferon stimulated gene (ISG) responses.
197 s superior to the low-fat diet in decreasing intrahepatic, intrapericardial, and pancreatic fats (P<0
198 lycemia, these results provide evidence that intrahepatic islet transplantation can restore glucose c
199 rpose of this study was to determine whether intrahepatic islet transplantation improves endogenous g
200 , disease duration before and 6 months after intrahepatic islet transplantation using stepped hyperin
202 flow during respiration in the upper part of intrahepatic IVC proximal to a large collateral vein as
205 crosis factor alpha and interleukin 2 at the intrahepatic level significantly more than HCV-specific
206 onsiveness to IFNalpha therapy, as are lower intrahepatic levels of HBV pregenomic RNA and pre-activa
208 ally, the lack of stabilin-1 led to elevated intrahepatic levels of the profibrogenic chemokine CCL3
210 antly greater visceral adipose tissue (VAT), intrahepatic lipid (IHL), plasma free fatty acids, adipo
211 estriction to allow an effective decrease of intrahepatic lipid component, and despite that evidence
213 For colorectal liver metastasis (CRLM), intrahepatic lymph invasion and lymph node metastasis ar
216 ) iMPhi by the CCL2 inhibitor, mNOX-E36, the intrahepatic macrophage equilibration shifted toward the
217 th sofosbuvir and velpatasvir, we found that intrahepatic MAIT cells are activated by monocyte-derive
218 re further supported by the analysis of such intrahepatic markers of WHV infection as replicative int
219 n results in rapid changes in peripheral and intrahepatic metabolic pathways, implicating a direct ef
224 ens, especially in portal vein metastasis or intrahepatic metastasis, compared to normal tissues.
230 omas (CCAs) comprise a mucin-secreting form, intrahepatic or perihilar, and a mixed form located peri
231 transcriptome analysis of a large number of intrahepatic, perihilar and distal cholangiocarcinomas a
232 0.27-0.42), and 0.29 (95% CI 0.19-0.44) for intrahepatic, perihilar, and distal CCA, respectively (P
234 nd pharmacologic measures, with transjugular intrahepatic portal-systemic shunt (TIPS) performed when
235 e the feasibility and safety of transjugular intrahepatic portosystemic shunt (TIPS) as a treatment f
236 <12 mm Hg after placement of a transjugular intrahepatic portosystemic shunt (TIPS) correlates with
237 early liver failure (ELF) after transjugular intrahepatic portosystemic shunt (TIPS) creation in pati
238 e efficacy and complications of transjugular intrahepatic portosystemic shunt (TIPS) creation perform
239 covered stent and bare stent in transjugular intrahepatic portosystemic shunt (TIPS) for cirrhotic po
240 hnical success, and efficacy of transjugular intrahepatic portosystemic shunt (TIPS) in a series of p
241 The efficacy and safety of transjugular intrahepatic portosystemic shunt (TIPS) in this populati
243 veloped PV recanalization (PVR)-transjugular intrahepatic portosystemic shunt (TIPS) to potentiate LT
244 ta are available on the role of transjugular intrahepatic portosystemic shunt (TIPS) with covered ste
248 ative portal vein embolization, transjugular intrahepatic portosystemic shunt placement, balloon retr
249 controversy over the ability of transjugular intrahepatic portosystemic shunts (TIPS) to increase sur
250 controversy over the ability of transjugular intrahepatic portosystemic shunts (TIPS) to increase sur
252 to groups given a small covered transjugular intrahepatic portosystemic stent-shunt (TIPS) (8 mm; n =
253 6; HR, 0.15; 95% CI, 0.03-0.69), and time to intrahepatic progression (P = 0.010; HR, 0.16; 95% CI, 0
254 2 largest liver metastases predicted time to intrahepatic progression (P = 0.013; HR, 0.21; 95% CI, 0
255 ival, progression-free survival, and time to intrahepatic progression after radioembolization for liv
256 ival, progression-free survival, and time to intrahepatic progression were among other factors correl
258 roscopic RFA (L-RFA) have been used to treat intrahepatic recurrent small hepatocellular carcinoma (H
259 erved that hypercholesterolemia elevated the intrahepatic regulatory T (Treg) cell population and inc
260 c infection, characterized by high levels of intrahepatic regulatory T cells and expression of inhibi
261 CC in male mice with substantially increased intrahepatic retention of hydrophobic BAs and decreased
264 ables were compared between tumors that were intrahepatic, small (<7 cm), and solitary (ISS) and thos
268 en primary human cholangiocytes and isolated intrahepatic T cells ex vivo and in vivo using the Ova-b
269 ot CD160, TIM-3, or LAG-3) were increased on intrahepatic T cells from healthy and diseased liver tis
271 id not induce a predominant Th17 response in intrahepatic T cells, given that hepatic cremtg CD4+ T c
272 ults elucidate a new mechanism that controls intrahepatic T-cell differentiation during atheroscleros
273 n hypercholesterolemic Ldlr(-/-) mice led to intrahepatic Th1 cell differentiation and CD11b(+)CD11c(
276 ys, a number comparable to that required for intrahepatic transplantation; in the absence of oxygen t
278 ected 4 years after HCV clearance shows that intrahepatic Tregs are still present in all patients, su
281 ciated with insulin resistance and increased intrahepatic triglyceride (IHTG) content, both of which
282 eks or a eucaloric control diet and measured intrahepatic triglyceride content (IHTG) using proton ma
284 eight gain is associated with an increase in intrahepatic triglycerides (IHTGs), and is the primary c
287 CI: 18, 47) of 40 completely ablated tumors, intrahepatic tumor recurrence was observed at 2-18 month
289 of (90)Y radioembolization in patients with intrahepatic tumors from pretherapeutic baseline paramet
292 nts, which were mainly mediated by increased intrahepatic tumour-growth factor (TGF)-beta because blo
294 lular mechanisms that regulate the increased intrahepatic vascular resistance (IHVR) in cirrhosis.
296 n contributes significantly to the increased intrahepatic vascular resistance that is the primary cau
298 l resolution provides a means for monitoring intrahepatic virological events in chronic HBV infection
299 r subtypes, CD13(+) CSCs characterized mixed-intrahepatic, whereas LGR5(+) characterized mucin-CCA su
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