ライフサイエンスコーパス: intramembrane

1 MO-IgGs to AQP4 in separate tetramers versus intramembrane aggregates (orthogonal arrays of particles

2 ds, including the terminal most hydrophobic, intramembrane anchoring sequence.

3 ug.L(-1) concentration of c-SWNTs, was 4.74% intramembrane and 6.3% intermembrane.

4 These numbers suggest that intramembrane and intracellular proteins in isolated oxy

5 STRA6 has one intramembrane and nine transmembrane helices in an intri

6 Gamma-secretase is an intramembrane aspartyl protease complex that cleaves typ

7 nonproteolytic functions for members of the intramembrane aspartyl protease family.

8 ing metalloproteases and gamma-secretase, an intramembrane aspartyl protease involved in Alzheimer's

9 The gamma-secretase complex is an intramembrane aspartyl protease that cleaves its substra

10 Signal peptide peptidase (SPP) is an intramembrane aspartyl protease that cleaves remnant sig

11 gamma-Secretase is an intramembrane aspartyl protease that cleaves the amyloid

12 rticle, we investigate the role of SPPL3, an intramembrane aspartyl protease, in murine NK cell biolo

13 is region defines a functional domain for an intramembrane aspartyl protease.

14 The signal peptide peptidase (SPP)-related intramembrane aspartyl proteases are a homologous group

15 of NK cell maturation and expand the role of intramembrane aspartyl proteases in innate immunity.

16 tide peptidase (SPP) and gamma-secretase are intramembrane aspartyl proteases that bear similar activ

17 embrane receptors and lipids can result from intramembrane barriers, skeletal interactions, rafts, an

18 ual and ubiquitous aspartyl protease with an intramembrane catalytic site that cleaves many type-I in

19 tructure, surrounding a large, water-filled, intramembrane chamber, capped by a zinc metalloprotease

20 n (TMD) helices and residues involved in the intramembrane charge displacement remain unknown.

21 However, intramembrane charge movement was only reduced in fibers

22 e amplitude or the voltage-dependence of the intramembrane charge movement.

23 Ectodomain cleavage is followed by intramembrane cleavage (S2) to generate a soluble intrac

24 nhibitory factor binding to CD74 induces its intramembrane cleavage and the release of its cytosolic

25 Intramembrane cleavage by catalytically active SPP provi

26 in which ectodomain shedding and subsequent intramembrane cleavage by gamma-secretase leads to relea

27 L3 serves as a new substrate for consecutive intramembrane cleavage by SPPL2a/b.

28 sser extent, SPPL2b are responsible for this intramembrane cleavage event.

29 and a specific requirement for SPP-mediated intramembrane cleavage in protein turnover.

30 The intramembrane cleavage of APP by gamma-secretase occurs

31 Intramembrane cleavage of Bri2 is triggered by an initia

32 Thus, NPC remodeling by regulated intramembrane cleavage of p75(NTR) controls astrocyte-ne

33 By investigating the kinetics of intramembrane cleavage of the Alzheimer's disease-associ

34 gral membrane protein complex, catalyzes the intramembrane cleavage of the beta-amyloid precursor pro

35 c molecule in Alzheimer disease, through the intramembrane cleavage of the beta-carboxyl-terminal fra

36 This proteolysis was a prerequisite for the intramembrane cleavage of the C-terminal fragments of PT

37 of a GXXXG dimerization motif influences the intramembrane cleavage only to a minor extent.

38 Intramembrane cleavage sites are accessible and not part

39 teins via ectodomain shedding followed by an intramembrane cleavage.

40 ry structure of the Bri2 TMD and thereby its intramembrane cleavage.

41 main, followed by a gamma-secretase-mediated intramembrane cleavage.

42 gamma-Secretase is a multiprotein intramembrane cleaving aspartyl protease (I-CLiP) that c

43 The signal peptide peptidase (SPP) is an intramembrane cleaving aspartyl protease involved in rel

44 Signal peptide peptidase (SPP) is an intramembrane cleaving protease (I-CLiP) identified by i

45 ses that carry out these cleavages are named intramembrane cleaving proteases (I-CLips).

46 irst time the identification of five metallo-intramembrane cleaving proteases in Anabaena variabilis.

47 Peptide Peptidases (SPP) are members of the Intramembrane Cleaving Proteases, which are involved in

48 ty of a previously unknown function for this intramembrane-cleaving aspartic protease in dislocation

49 ne proteolysis, specifically cleavage by the intramembrane-cleaving aspartyl protease signal peptide

50 subunit of the gamma-secretase complex, are intramembrane-cleaving aspartyl proteases of the GxGD ty

51 SPPL) proteases are members of the family of intramembrane-cleaving aspartyl proteases of the GXGD-ty

52 combinant substrates for gamma-secretase, an intramembrane-cleaving enzyme, are critically important

53 ost proteases: signal peptidase (SP) and the intramembrane-cleaving protease signal peptide peptidase

54 gamma-Secretase is an intramembrane-cleaving protease that processes many type

55 gamma-Secretase is an intramembrane-cleaving protease that produces amyloid-be

56 Gamma-secretase is a multiprotein, intramembrane-cleaving protease with a growing list of p

57 the domain I was further processed by a host intramembrane-cleaving protease, signal peptide peptidas

58 One of the intramembrane-cleaving proteases (I-CLiPs), gamma-secret

59 the remaining stubs are further processed by intramembrane-cleaving proteases (I-CLiPs).

60 give deeper insights into the mechanisms of intramembrane-cleaving proteases and the impact on viral

61 sheds light on potential mechanisms by which intramembrane-cleaving proteases cleave their substrates

62 gamma-Secretases are a family of intramembrane-cleaving proteases involved in various sig

63 tark contrast to rhomboid--another family of intramembrane-cleaving proteases.

64 homboid family, which belong to the class of intramembrane-cleaving serine proteases.

65 The main intramembrane contact site is formed by a complex electr

66 within mitochondria to supply the Cu(A) and intramembrane Cu(B) sites of cytochrome oxidase, within

67 nal quality control scrutiny but displays an intramembrane defect.

68 orthologue) has the capacity for recognizing intramembrane degrons, expanding its spectrum of substra

69 mera with the glycophorin A TM domain causes intramembrane dimerization and consequently operon activ

70 Consequently, the strength of the intramembrane dimerization of the glycophorin A domain c

71 The intramembrane (dipole) potential (Psid) increased linear

72 saturating cytokine occupancy, we determined intramembrane dissociation constants (K(d,2D)) of 180 an

73 in the CD225 domain, consisting of the first intramembrane domain (intramembrane domain 1 [IM1]) and

74 onsisting of the first intramembrane domain (intramembrane domain 1 [IM1]) and a conserved intracellu

75 highlight the functional significance of the intramembrane domain and the CSD for defined caveolin-in

76 Substrates with misfolded intramembrane domains define a pathway (ERAD-M) that dif

77 ar vesicles (GUVs) leads to the formation of intramembrane domains.

78 We conclude that RH421 detects intramembrane electric field strength changes arising fr

79 as detected via fluorometric measurement of intramembrane electric fields.

80 The effect of pH on intramembrane electrical properties was examined by stud

81 om alterations in interfacial, as opposed to intramembrane, electrostatics.

82 Norfluoxetine binds within intramembrane fenestrations found in only one of these t

83 t gains access to the channel cavity through intramembrane fenestrations.

84 asure cholesterol intermembrane exchange and intramembrane flipping rates, in situ, without recourse

85 ported by previous studies, particularly for intramembrane flipping where our measured rates are seve

86 This effect is attributed to an amplified intramembrane friction.

87 e chain at a principal interface between the intramembrane-gated pore and the cytoplasmic gating ring

88 Analysis of intramembrane gating charge movements and ionic tail cur

89 The authors examined the significance of an intramembrane glutamic acid conserved in all P/rds prote

90 Surprisingly, only one of the four conserved intramembrane glycine residues significantly affects the

91 activate the ErbB2 receptors, suggesting an intramembrane-growth factor function for MUC4.

92 s affecting reticulon or REEP proteins, with intramembrane hairpin domains that model ER membranes, c

93 PG33 protein protrudin contains hydrophobic, intramembrane hairpin domains, interacts with tubular ER

94 tary spastic paraplegia encode proteins with intramembrane hairpin loops that contribute to the curva

95 drophobic segments and are proposed to adopt intramembrane helical hairpins that stabilize membrane c

96 r is approximately 13 degrees , showing that intramembrane helix-helix association forces dominate ov

97 rved when ClC-7 was truncated after the last intramembrane helix.

98 Finally, two highly conserved intramembrane histidines (His-171 and His-197) within Ap

99 -terminal LPS transport slide, a hydrophobic intramembrane hole and the hydrophilic channel of the ba

100 were obtained at the N-terminal domain, the intramembrane hole, the lumenal gate, the lumen of LptD

101 ogen bonding is typically weakened in water, intramembrane hydrogen bonding between native lipids has

102 Both proteins bind SERCA through intramembrane interactions, impeding calcium translocati

103 Muc4 serves as an intramembrane ligand for the receptor tyrosine kinase Er

104 Intramembrane lipid transport reactions utilize P-type A

105 tracellular to the selectivity filter are an intramembrane loop and an arginine residue, both highly

106 An intramembrane loop is found immediately after the select

107 ransmembrane regions and the less structured intramembrane loops undergo restricted submicrosecond ti

108 Bacillus subtilis SpoIVFB is an intramembrane metalloprotease that cleaves Pro-sigma(K)

109 Intramembrane metalloproteases (IMMPs) are conserved fro

110 Intramembrane metalloproteases (IMMPs) control critical

111 of one large and diverse family of putative intramembrane metalloproteases are widely distributed in

112 Site-2 proteases (S2Ps) are intramembrane metalloproteases that cleave transmembrane

113 B are somewhat different from those of other intramembrane metalloproteases, perhaps reflecting diffe

114 odomain shedding at the juxtamembrane and/or intramembrane motif and to show that this is independent

115 mutagenesis demonstrated that similar polar intramembrane motifs are also important for assembly of

116 Electrogenic signals mediated by intramembrane movement of hydrophobic ions, such as hexy

117 helix (TM4) about a central hinge seals the intramembrane opening, preventing lipid block of the cav

118 n but not at lysines in the oligomerization, intramembrane, or C-terminal domains.

119 ing effects on vertical stacking and lateral intramembrane organization.

120 ged transmembrane proteins to indicate their intramembrane orientation.

121 appear inadequate to account for the size of intramembrane particles (IMPs) expressed in the OHC memb

122 the smallest and had the most densely packed intramembrane particles (IMPs), whereas the PF-CwC synap

123 oscopy revealed disruption of the strands of intramembrane particles connecting bicellular and tricel

124 s Type V, Type VI, PVC and a novel PrsW-like intramembrane peptidase-dependent mechanism.

125 s converge at the inner leaflet to create an intramembrane pocket with additional electron density co

126 The intramembrane processes regulate the establishment and e

127 s Abeta40, Abeta42, and AICD production, nor intramembrane processing of Notch and N-cadherin.

128 content of the transmembrane domain nor its intramembrane processing.

129 1 (Ras and a-factor converting enzyme 1), an intramembrane protease (IMP) of the endoplasmic reticulu

130 signal transduction system in which a single intramembrane protease cleaves three anti-sigma factor s

131 d range of papillomavirus types requires the intramembrane protease gamma secretase.

132 The intramembrane protease gamma-secretase is a key player i

133 Dysfunction of the intramembrane protease gamma-secretase is thought to cau

134 f the amyloid precursor protein (C99) by the intramembrane protease gamma-secretase.

135 raphic analysis of Escherichia coli GlpG, an intramembrane protease of the rhomboid family, has revea

136 t al. and Frezza et al. show that a rhomboid intramembrane protease PARL and a dynamin-related protei

137 This intramembrane protease plays a major role in converting

138 eric core complex that includes the aspartyl intramembrane protease presenilin (PS).

139 urther processing, which requires the site 2 intramembrane protease RasP.

140 al fragment (NTF) of CD74 is mediated by the intramembrane protease signal peptide peptidase-like (SP

141 at mice with an inactivating mutation in the intramembrane protease signal peptide peptidase-like 2A

142 The mutation was mapped to the intramembrane protease signal peptide peptidase-like 2a

143 teases, including cathepsin S (CatS) and the intramembrane protease signal peptide peptidase-like 2a

144 Another intramembrane protease, signal peptide peptidase, predom

145 We investigate the folding of GlpG, an intramembrane protease, using perfectly funneled structu

146 vement of signal peptide peptidase (SPP), an intramembrane protease, which acts on substrates that ha

147 SP(UL40) by a signal peptide peptidase-type intramembrane protease.

148 Intramembrane proteases (IPs) cleave membrane-associated

149 sms and is carried out by different types of intramembrane proteases (IPs), including a large family

150 ins via the degradation of MucA by activated intramembrane proteases AlgW and/or MucP.

151 and the significance of rhomboids and other intramembrane proteases are discussed.

152 Intramembrane proteases are important enzymes in biology

153 The active sites of intramembrane proteases are positioned in the lipid bila

154 rol processes, but little is known about how intramembrane proteases are regulated.

155 Intramembrane proteases are responsible for a number of

156 Rhomboid intramembrane proteases are the enzymes that release act

157 ill facilitate the characterization of other intramembrane proteases as well as non-protease membrane

158 Our work demonstrates that intramembrane proteases can be sequence specific and tha

159 Intramembrane proteases catalyse the signal-generating s

160 Members of the widespread rhomboid family of intramembrane proteases cleave transmembrane domain (TMD

161 To address this limitation, here we focus on intramembrane proteases containing domains known to exer

162 gress on understanding this newest family of intramembrane proteases has been rapid.

163 n though a number of structures of different intramembrane proteases have been solved recently, funda

164 Intramembrane proteases hydrolyze peptide bonds within t

165 Rhomboid intramembrane proteases occur throughout the kingdoms of

166 Intramembrane proteases regulate diverse processes by cl

167 Intramembrane proteases signal by releasing proteins fro

168 Rhomboid proteases are intramembrane proteases that play key roles in various d

169 Rhomboids are intramembrane proteases that use a catalytic dyad of ser

170 Intramembrane proteases, which control many medically im

171 oof that rhomboid proteins function as novel intramembrane proteases, with a serine protease-like cat

172 omboids, belongs to a unique class of serine intramembrane proteases; little is known about its funct

173 , we propose that IFITM3 is predominantly an intramembrane protein where both the N and C termini fac

174 plasmic portion of membrane proteins control intramembrane protein-protein interactions.

175 Presenilins are ubiquitous, intramembrane proteins that function in Alzheimer's dise

176 he ERC and link ERC trafficking to regulated intramembrane proteolysis (RIP) and expression of megali

177 s the final step in the process of regulated intramembrane proteolysis (RIP) and has a significant im

178 on in B. subtilis is controlled by regulated intramembrane proteolysis (RIP) and requires the site 2

179 which requires DegS protease in a regulated intramembrane proteolysis (RIP) cascade to derepress the

180 ToxR undergoes regulated intramembrane proteolysis (RIP) during late stationary p

181 In addition, we found that a regulated intramembrane proteolysis (RIP) family pheromone precurs

182 Recently, regulated intramembrane proteolysis (RIP) has been recognized as a

183 Regulated intramembrane proteolysis (RIP) involves cleavage of a t

184 Regulated intramembrane proteolysis (RIP) involves cleavage of a t

185 Regulated intramembrane proteolysis (RIP) is a conserved mechanism

186 Regulated intramembrane proteolysis (RIP) is a mechanism of transm

187 Regulated intramembrane proteolysis (RIP) of endoplasmic reticulum

188 Here, we show that FGF1 induces regulated intramembrane proteolysis (RIP) of FGFR3.

189 ility, but impaired functioning in regulated intramembrane proteolysis (RIP) of OASIS, ATF6 and SREBP

190 mulate Notch receptors by inducing regulated intramembrane proteolysis (RIP) to produce a transcripti

191 -step proteolytic pathway known as regulated intramembrane proteolysis (RIP), thereby inactivating th

192 P) family of proteases involved in regulated intramembrane proteolysis (RIP), which plays a role in d

193 tress signals release sigma(22) by regulated intramembrane proteolysis (RIP).

194 al transduction mechanism known as regulated intramembrane proteolysis (RIP).

195 ecretase complex, a process called regulated intramembrane proteolysis (RIP).

196 ficking of ATF6 from the ER to the Golgi for intramembrane proteolysis and activation of ATF6.

197 n intracellular domain in p75(NTR)-regulated intramembrane proteolysis and apoptosis.

198 yroid signaling pathway that is regulated by intramembrane proteolysis and disrupted in cancer.

199 to the growing list of proteins that undergo intramembrane proteolysis and may shed light on the regu

200 main of an engineered receptor is cleaved by intramembrane proteolysis and releases a protein fragmen

201 o-Golgi trafficking and diminished regulated intramembrane proteolysis and transcriptional activity;

202 mbrane topology for the astrotactins, reveal intramembrane proteolysis as a feature of astrotactin ma

203 e present results validate S2P and regulated intramembrane proteolysis as novel therapeutic targets f

204 , as the critical determinants for efficient intramembrane proteolysis at the gamma-site.

205 The intramembrane proteolysis by gamma-secretase of the amyl

206 vation of Notch receptor is executed through intramembrane proteolysis by gamma-secretase, which is a

207 elope protein (FVenv) as a new substrate for intramembrane proteolysis by human SPPL3 and SPPL2a/b.

208 Regulated intramembrane proteolysis by members of the site-2 prote

209 at Bri2 (itm2b) is a substrate for regulated intramembrane proteolysis by SPPL2a and SPPL2b.

210 bifurcate sorting in the inner membrane and intramembrane proteolysis by the rhomboid protease Pcp1p

211 Subsequent intramembrane proteolysis catalysed by the gamma-secreta

212 little PAM-1/H3A was subjected to regulated intramembrane proteolysis followed by release of a small

213 evelopment through gamma-secretase-dependent intramembrane proteolysis followed by transcription of t

214 Intramembrane proteolysis governs many cellular control

215 Intramembrane proteolysis has emerged as a key mechanism

216 e demonstrate that LRP1B undergoes regulated intramembrane proteolysis in a gamma-secretase-dependent

217 was cleaved to nuclear CREB3L2 by regulated intramembrane proteolysis in normal thyroid cells that e

218 Our results identify a crucial role for intramembrane proteolysis in the life cycle of this path

219 Regulated intramembrane proteolysis is a central cellular process

220 Intramembrane proteolysis is a core regulatory mechanism

221 Regulated intramembrane proteolysis is a method for transducing si

222 Regulated intramembrane proteolysis is a widely accepted concept d

223 Regulated intramembrane proteolysis is initiated by shedding, and

224 Astn2 intramembrane proteolysis is insensitive to replacement

225 proteins via ectodomain shedding followed by intramembrane proteolysis is involved in a wide variety

226 Intramembrane proteolysis is now firmly established as a

227 Intramembrane proteolysis is thought to require local un

228 Rhomboid intramembrane proteolysis is thus a slow, kinetically co

229 atability class II complex (MHCII) undergoes intramembrane proteolysis mediated by SPPL2a.

230 terior pharynx-defective 1 that mediates the intramembrane proteolysis of a large number of proteins

231 gamma-secretase protein complex executes the intramembrane proteolysis of amyloid precursor protein (

232 sease-linked gene presenilin is required for intramembrane proteolysis of amyloid-beta precursor prot

233 strate of Sppl2a and suggests that regulated intramembrane proteolysis of CD74 by Sppl2a contributes

234 whether cerebral ischemia induces regulated intramembrane proteolysis of LRP and whether this proces

235 cate that gamma-secretase-mediated regulated intramembrane proteolysis of LRP results in cell death u

236 It mediates the intramembrane proteolysis of many type 1 proteins, plays

237 Regulated intramembrane proteolysis of membrane-embedded substrate

238 rtyl protease, is required for the regulated intramembrane proteolysis of Notch and APP, pathways tha

239 reveals its functional role in the regulated intramembrane proteolysis of p75 catalyzed by the gamma-

240 Thus, hypoxia-induced intramembrane proteolysis of p75(NTR) constitutes an api

241 e signal transduction that functions through intramembrane proteolysis of substrates.

242 ication within the host cell is regulated by intramembrane proteolysis of TgAMA1.

243 on of Insig-2a in hepatocytes led to reduced intramembrane proteolysis of the newly synthesized SREBP

244 eath via gamma-secretase-dependent regulated intramembrane proteolysis of the p75 neurotrophin recept

245 Subsequent gamma-secretase-mediated intramembrane proteolysis of the remaining membrane-teth

246 -secretase protease and associated regulated intramembrane proteolysis play an important role in cont

247 ithin presenilin is necessary to mediate the intramembrane proteolysis reaction.

248 The discovery of minimal requirements for intramembrane proteolysis should facilitate mechanistic

249 e processes through a mechanism of regulated intramembrane proteolysis that leads to cleavage of Trop

250 e cancer proliferation by blocking regulated intramembrane proteolysis through suppression of S2P cle

251 We propose that IVB regulates intramembrane proteolysis through two proteolytic pathwa

252 hetic genetic system based on ligand-induced intramembrane proteolysis to monitor cell-cell contacts

253 es from the ER to Golgi to undergo regulated intramembrane proteolysis to release a cytosolic domain

254 ol of Transcription) based on ligand-induced intramembrane proteolysis to reveal monosynaptic connect

255 a novel genetic approach N(1)IP-CRE (Notch1 Intramembrane Proteolysis) to follow, at high resolution

256 Regulated intramembrane proteolysis, a highly conserved process em

257 ces the amyloid beta-peptide (Abeta) through intramembrane proteolysis, and >100 presenilin mutations

258 ptor, or the transferrin receptor eliminates intramembrane proteolysis, as does leucine substitution

259 ve been demonstrated to signal via regulated intramembrane proteolysis, in which ectodomain shedding

260 ain that modulates gamma-secretase-dependent intramembrane proteolysis, particularly in differentiati

261 To determine whether intramembrane proteolysis, specifically cleavage by the

262 in shorter than 60 amino acids for efficient intramembrane proteolysis, SPPL3 cleaves mutant FVenv la

263 commonly used for the enzymatic analyses of intramembrane proteolysis, the cleavage rate strongly de

264 y shown to undergo gamma-secretase regulated intramembrane proteolysis, this study examines the effec

265 To elucidate the function of TgAMA1 intramembrane proteolysis, we used a heterologous cleava

266 key step in Notch receptor activation is its intramembrane proteolysis, which releases an intracellul

267 We combined the previously described Notch1 intramembrane proteolysis-Cre (Nip1::Cre) allele with a

268 of a Notch1 activity-trap mouse line, Notch1 intramembrane proteolysis-Cre6MT or N1IP::Cre(LO), that

269 a carboxyl-terminal fragment consistent with intramembrane proteolysis.

270 olytic processing by ectodomain shedding and intramembrane proteolysis.

271 rane-bound proteases that catalyze regulated intramembrane proteolysis.

272 ng TMEFF2 as a novel substrate for regulated intramembrane proteolysis.

273 l substrate entry as a rate-limiting step in intramembrane proteolysis.

274 us membrane-bound proteins undergo regulated intramembrane proteolysis.

275 of the cognate extracellular ligand induces intramembrane proteolysis.

276 which promotes proliferation after regulated intramembrane proteolysis.

277 ity, which leads to suppression of regulated intramembrane proteolysis.

278 of proteins are activated by ligand induced intramembrane proteolysis.

279 ion risk factor TMEM106B undergoes regulated intramembrane proteolysis.

280 These findings also suggest that ionizable intramembrane residues may serve regulatory roles for te

281 l in which the Hrd1p membrane domain employs intramembrane residues to evaluate substrate misfolding,

282 cessing pathway of APP through the mammalian intramembrane rhomboid protease RHBDL4.

283 gamma-secretase mediates proteolysis at the intramembrane S3 site.

284 ss regulation domain located proximal to the intramembrane sequence within the cytoplasmic domain of

285 rotein is a member of the rhomboid family of intramembrane serine proteases and is required for the p

286 rotein is a member of the rhomboid family of intramembrane serine proteases and required for the prod

287 Rhomboids are intramembrane serine proteases conserved in all kingdoms

288 ed subfamily of proteins related to rhomboid intramembrane serine proteases that lack key catalytic r

289 The rhomboids are a well-conserved family of intramembrane serine proteases, which are unrelated to t

290 homboid proteases are evolutionary conserved intramembrane serine proteases.

291 sing domain suggested that PilS may sense an intramembrane signal, possibly PilA.

292 eview highlights the molecular aspects of an intramembrane signaling mechanism in which a signal is p

293 h a substrate that we show is cleaved at two intramembrane sites within the previously defined Spitz

294 Recent work, however, supports an intramembrane topology for the helices with cytosolic or

295 erstanding of the trafficking, activity, and intramembrane topology of this important IFN-induced eff

296 steine at the mIFITM1 C terminus supports an intramembrane topology with mechanistic implications.

297 on in vivo, indicating the essential role of intramembrane trimerization in receptor activity.

298 Biosynthesis of ubiquinones requires the intramembrane UbiA enzyme, an archetypal member of a sup

299 The intramembrane vitamin K epoxide reductase (VKOR) support

300 the higher polarity, and consequently higher intramembrane water concentration, at the protein-lipid