ライフサイエンスコーパス: intramembranous

1 (Y/F)G sequence is extracellular rather than intramembranous.

2 xG motifs, I speculate that accumulations of intramembranous Abeta peptides might affect the function

3 of a new type of polytopic protease with an intramembranous active site.

4 Bone wound created in intramembranous alveolar bone heals without the formatio

5 d the role of B cells in osteoblast-mediated intramembranous anabolic bone modeling.

6 Although the latter cleavages are intramembranous and although lipid alterations have been

7 ting callus, the artificial tissue undergoes intramembranous and endochondral ossification and forms

8 Both intramembranous and endochondral ossification of the cra

9 se of osteoblast differentiation during both intramembranous and endochondral ossification.

10 tion is controlled by distinct mechanisms in intramembranous and endochondral ossification.

11 eoblast differentiation and specification of intramembranous and endochondral ossification.

12 asts fail to differentiate leading to severe intramembranous and perichondral ossification defects.

13 In this model, two conserved and apparently intramembranous aspartic acids participate in catalysis.

14 the first identified substrates of a unique intramembranous aspartyl protease that has presenilin as

15 is itself gamma-secretase, an autoactivated intramembranous aspartyl protease.

16 It possesses intramembranous binding sites for haem and cytoplasmic b

17 uated phenotypic changes in the structure of intramembranous bone and dentin mineralization using 3 d

18 Thick intramembranous bone collars develop, but the formation

19 ify a key mechanistic pathway for regulating intramembranous bone development within the skull that i

20 nscriptional regulatory machinery to control intramembranous bone development.

21 creased expression of osteogenic markers and intramembranous bone formation and by decreased expressi

22 uman (rh) BMP-2 increases the rate of normal intramembranous bone formation and enhanced cementum for

23 ult indicating Tgfbr2 has a critical role in intramembranous bone formation as well as endochondral b

24 with ADAS or BMS cells produced significant intramembranous bone formation by 2 weeks and areas of c

25 development that is mainly due to defective intramembranous bone formation by osteoblasts.

26 hat mOSM, a product of macrophages, sustains intramembranous bone formation by signaling through Osmr

27 s an essential role in both endochondral and intramembranous bone formation during skeletal repair.

28 TH-related protein (PTHrP) receptor (PPR) in intramembranous bone formation in the craniofacial regio

29 w that Tbx22 is an important determinant for intramembranous bone formation in the posterior hard pal

30 During intramembranous bone formation in the shafts of long bon

31 mandibular ramus (chondrocyte-derived) with intramembranous bone formation of the mandibular body (n

32 Similarly, intramembranous bone formation on the calvaria was reduc

33 for coordination of chondrocyte maturation, intramembranous bone formation, and chondrogenic condyla

34 rtant roles of VEGF in both endochondral and intramembranous bone formation, as well as some insights

35 Thus, during intramembranous bone formation, EN1 acts both cell auton

36 xpressed very early during in vivo models of intramembranous bone formation, highly enriched in conde

37 t mice demonstrated delayed endochondral and intramembranous bone formation, whereas heterozygous Pkd

38 sufficient for early osteoblastogenesis and intramembranous bone formation, whereas Runx2-II is nece

39 in CNCC-derived osteoprogenitor cells during intramembranous bone formation.

40 ling regulates endochondral, periosteal, and intramembranous bone growth are not known.

41 Taf4b is down-regulated in the CNCC-derived intramembranous bone in Tgfbr2(fl/fl);Wnt1-Cre mice.

42 a-catenin is necessary for fate selection of intramembranous bone progenitors in the skull.

43 ent of functional Runx2 for the formation of intramembranous bone tissues during embryogenesis.

44 formation, and large regions of disorganized intramembranous bone.

45 environment, FCSCs engrafted and regenerated intramembranous bone.

46 well-understood, the development of dermal (intramembranous) bone featured by many craniofacial skel

47 es, such as cartilage, ganglia, and cranial (intramembranous) bone.

48 that elmo2 originated upon the appearance of intramembranous bones and the jaw in ancestral vertebrat

49 xpansion of the jaw, craniofacial, and other intramembranous bones caused by malformed blood vessels

50 all of the mesodermal skeletal elements and intramembranous bones were essentially conserved.

51 ntaining vascular integrity, specifically in intramembranous bones.

52 Interestingly, formation of an intramembranous bony collar around the diaphysis was not

53 Currents of intramembranous charge movement were recorded, together

54 Activation of Notch signaling requires intramembranous cleavage by gamma-secretase to release t

55 amma-Secretase, which is responsible for the intramembranous cleavage of Alzheimer beta-amyloid precu

56 The intramembranous cleavage of Alzheimer beta-amyloid precu

57 t of gamma-secretase, is responsible for the intramembranous cleavage of amyloid precursor protein an

58 that the DIG fraction is probably where the intramembranous cleavage of APP occurs.

59 amma-secretase protein complex that mediates intramembranous cleavage of betaAPP and Notch proteins.

60 nent of gamma-secretase, responsible for the intramembranous cleavage of substrates that include the

61 l enzymatic step generating beta-amyloid via intramembranous cleavage of the amyloid precursor protei

62 mplex, a protein assembly that catalyzes the intramembranous cleavage of the amyloid precursor protei

63 An unusual intramembranous cleavage of the beta-amyloid precursor p

64 ver, presenilins also mediate the apparently intramembranous cleavage of the Notch receptor, an event

65 This facilitates intramembranous cleavage of the remaining Notch receptor

66 extracellular domain is followed by a second intramembranous cleavage of the residual CD44 fragment,

67 ti-component enzyme complex that performs an intramembranous cleavage, releasing amyloid-beta (Abeta)

68 kely to underlie the regulatory mechanism of intramembranous cleavage.

69 and is therefore unlikely to proceed via an intramembranous cleavage.

70 onsible for this highly unusual, purportedly intramembranous, cleavage has been definitively identifi

71 derived activator of caspase (Smac) from the intramembranous compartment of the mitochondria to the c

72 he linker between M1 and M2 has little or no intramembranous component.

73 st and a series of distinct sites within the intramembranous confluence of helices and extracellular

74 ch BAX death agonist activity may require an intramembranous conformation of this molecule that is no

75 nally, steady-state expression levels of the intramembranous COOH-terminal fragment of cleaved PC1 re

76 ogether, we believe these data indicate that intramembranous cysteines are constrained, possibly via

77 n of C3 convertase and highly electron-dense intramembranous deposits.

78 drug influx, possibly through an increase in intramembranous dipole potential.

79 probe, proof that surface-cleaved TNF has an intramembranous disposition.

80 ghly expressed in neurons, is cleaved in its intramembranous domain by gamma secretase to generate am

81 At extracellular and intramembranous domains, CD44 undergoes sequential metal

82 Widespread endochondral and intramembranous ectopic bone formation is mediated by ex

83 tate the final step in Abeta production, the intramembranous gamma-secretase cleavage of amyloid prec

84 Intramembranous gamma-secretase cleavage of APP plays a

85 omplexes are known to be responsible for the intramembranous gamma-secretase cleavage of the beta-amy

86 eries of sequential proteases, including the intramembranous gamma-secretase complex, which also proc

87 Presenilin (PS) plays an essential role in intramembranous gamma-secretase processing of amyloid pr

88 Intramembranous "gamma-secretase" processing of beta-amy

89 resenilin 1 (PS1) plays an essential role in intramembranous "gamma-secretase" processing of several

90 d2 are subject to presenilin (PS)-dependent, intramembranous "gamma-secretase" processing, resulting

91 PH-1), and PS enhancer 2 (PEN-2) mediate the intramembranous, gamma-secretase cleavage of beta-amyloi

92 hat presenilins (PS) play a critical role in intramembranous, gamma-secretase proteolysis of selected

93 ected to the second loop (residue 204) or to intramembranous helix two (residue 94).

94 onegative funnel connects this region to the intramembranous high-affinity ion-binding site and may p

95 We revealed that TMD4 and TMD5 face the intramembranous hydrophilic milieu together with TMD1, T

96 on a specific orientation of desaturase and intramembranous interactions between desaturase and the

97 ATPase regulation of SLN via protein-protein intramembranous interactions between the highly conserve

98 ure GYG sequence (143-145) rather than being intramembranous is extracellular.

99 9(+) population that lead to endochondral or intramembranous-like bone formation.

100 ferences in bone genesis by endochondral and intramembranous mechanisms.

101 t function during anabolic bone modeling via intramembranous mechanisms.

102 om Corti's organ possesses voltage-dependent intramembranous molecular motors evolved from the SLC26

103 mplification relies on an expansive array of intramembranous molecular motors, identified as prestin,

104 n allosteric activation of BAK, inducing its intramembranous oligomerization into a proposed pore for

105 and Notch, might also be cleaved at a third, intramembranous or cytoplasmic site, resulting in the re

106 mote orthotopic bone regeneration via either intramembranous or endochondral ossification, both withi

107 n perichondrial tissues, including excessive intramembranous ossification all along the perichondrial

108 Interestingly, there was excessive intramembranous ossification along the perichondrium, ac

109 Interestingly, there was excessive intramembranous ossification along the perichondrium, ac

110 g cells exhibited a lack of endochondral and intramembranous ossification and a lack of mature osteob

111 ) mice exhibited a delay in endochondral and intramembranous ossification as well as in chondrocyte d

112 e-differentiation of the digit tip occurs by intramembranous ossification forming a trabecular bone n

113 he mechanism of craniosynostosis, we studied intramembranous ossification in Axin2-null mice.

114 indings help us understand the mechanisms of intramembranous ossification in general, which occurs no

115 sses the formation of cartilage and promotes intramembranous ossification in the skull.

116 Premature closure of cranial sutures in intramembranous ossification is a feature of syndromes d

117 vere defects in skeletal development, though intramembranous ossification occurs to some extent.

118 tilage and FGFR2 and FGFR3 have roles during intramembranous ossification of mandibular bones.

119 ibits parietal ossification, suggesting that intramembranous ossification of this mesodermal bone req

120 , and craniofacial bones derived from either intramembranous ossification or mesenchymal cells of the

121 on during normal growth and bone healing via intramembranous ossification proceeded normally in the a

122 esenchyme in the mandibular primordium where intramembranous ossification takes place.

123 ranial connective tissue framework undergoes intramembranous ossification to form skull bones (calvar

124 e majority of the mandible is formed through intramembranous ossification whereas the proximal region

125 l vault and craniofacial complex develop via intramembranous ossification, and are separated by fibro

126 formations that affect both endochondral and intramembranous ossification, and is the basis for sever

127 erated endochondral ossification but delayed intramembranous ossification, as well as skeletal deform

128 of cranial sutures, caused by deficiency in intramembranous ossification, occurs at early postnatal

129 mmalian skull, which forms predominantly via intramembranous ossification, requires precise pre- and

130 Skeletal tissues develop either by intramembranous ossification, where bone is formed withi

131 During the process of intramembranous ossification, which leads to the formati

132 osteogenesis in areas where repair occurs by intramembranous ossification.

133 macrocephaly, which affect endochondral and intramembranous ossification.

134 teoblasts from mesenchymal cells in areas of intramembranous ossification.

135 ferential roles of TRPM7 in endochondral and intramembranous ossification.

136 es of the mammalian skull vault form through intramembranous ossification.

137 ng ectopic cartilage formation and excessive intramembranous ossification.

138 plastic clavicles that result from defective intramembranous ossification.

139 ee-dimensional agent-based model of in vitro intramembranous osteogenic condensation.

140 acture replicas showed strand-like arrays of intramembranous particles in treated cells resembling ru

141 In axons, few intramembranous particles were present outside of these

142 Intramembranous photolabeling shows that (i) protonation

143 to the top of TM5, including portions of the intramembranous pocket as well as the second extracellul

144 attributable to distinct residues lining the intramembranous pocket in the two receptor subtypes.

145 The distinct conformation of this intramembranous pocket within Y140A CCK1R provides an op

146 racellular loops, E1 and E2, separated by an intramembranous pore-forming segment, H5.

147 panning segments, M1 and M2, connected by an intramembranous pore-forming segment, H5.

148 CTP mechanism due to (i) the presence of two intramembranous positive charges that are essential for

149 e results support the proposal that aberrant intramembranous processing and defective signaling via t

150 in, and presenilin enhancer 2, catalyzes the intramembranous processing of a wide variety of type I m

151 amma-secretase, which is responsible for the intramembranous processing of APP, has never been more e

152 the presenilins (PS) as the executioners of intramembranous processing of APP.

153 milar molecular apparatus is responsible for intramembranous processing of Notch and it's ligands.

154 secretase complexes, in turn, compromise the intramembranous processing of Notch.

155 Our results show that efficient intramembranous processing of Notch1 is indispensable fo

156 sociated with a single point mutation at the intramembranous processing site of Notch1, Val1,744-->Gl

157 lular domain after gamma-secretase-dependent intramembranous processing.

158 e of their intracellular domain (ICD) by the intramembranous protease gamma-secretase.

159 gamma-Secretase is an unusual intramembranous protease that has been reported to cleav

160 gamma-Secretase is an intramembranous protein complex composed of Aph1, Pen2,

161 e first consider hydrophobic matching of the intramembranous proteolipid boundary to explain the conf

162 NTR signalling by the induction of regulated intramembranous proteolysis (RIP) and the release of bot

163 ophic factor administration by 1) initiating intramembranous proteolysis (RIP) of p75(NTR), leading t

164 a-amyloid precursor protein is an apparently intramembranous proteolysis by the elusive gamma-secreta

165 protein (APP) and the Notch receptor undergo intramembranous proteolysis by the Presenilin-dependent

166 Intramembranous proteolysis of amyloid precursor protein

167 ndent signaling pathway, suggesting that the intramembranous proteolysis of APP may play a signaling

168 ctly involved in the pathogenically critical intramembranous proteolysis of APP.

169 a highly regulated manner and catalyzes the intramembranous proteolysis of many type I membrane prot

170 The intramembranous proteolysis of Notch and the amyloid pre

171 Presenilins are required for the putatively intramembranous proteolysis of Notch to release its intr

172 e complex plays a critical role in mediating intramembranous proteolysis of several type I membrane p

173 nteracts with APP in a way that enhances the intramembranous proteolysis of the latter by a gamma-sec

174 se data demonstrate gamma-secretase-mediated intramembranous proteolysis of TREM2 and functionally li

175 strin (NCT), APH-1, and PEN-2, catalyzes the intramembranous proteolysis of truncated beta-amyloid pr

176 are aspartyl proteases that catalyze a novel intramembranous proteolysis.

177 Presenilins mediate an unusual intramembranous proteolytic activity known as gamma-secr

178 mutations within type III NRG1 that disrupt intramembranous proteolytic processing and abolish intra

179 cytosolic, ATP hydrolytic domain (V1) and an intramembranous proton channel, V0.

180 n is structurally specific, dependent on the intramembranous region of the RAMP and TM6 and TM7 of th

181 eting with and compromising the functions of intramembranous segments of membrane-bound proteins that

182 es: one transient Met148-Cys382 site and one intramembranous site formed by trigonal coordination to

183 herence due to exposure of previously buried intramembranous sites of band 3.

184 triazolobenzodiazepinones docked within the intramembranous small molecule allosteric ligand pocket,

185 m); (b) the release of cytochrome c from the intramembranous space to the cytosol; and (c) the releas

186 Freeze fracture reveals that tight junction intramembranous strands are absent in CNS myelin and bet

187 parvum, results in the formation of a unique intramembranous yet extracytoplasmic niche on the apical