ライフサイエンスコーパス: intramitochondrial

1 he outside of mitochondria, SH1 and SUS1 are intramitochondrial.

2 In conclusion, unlike fungi, which have an intramitochondrial acetyl-CoA carboxylase, animals requi

3 ated in neurons after ischemia and to cleave intramitochondrial AIF near its N terminus.

4 The results substantiate the hypothesis that intramitochondrial arginase, presumably the arginase-II

5 re known to bind to VDAC and directly couple intramitochondrial ATP synthesis to glucose metabolism.

6 ricular mitochondria demonstrated negligible intramitochondrial CA activity.

7 e sites, possibly reflecting a high-capacity intramitochondrial Ca storage mechanism.

8 Ca(2+) that entered mitochondria is bound by intramitochondrial Ca(2+) buffering systems.

9 We hypothesized that changes in intramitochondrial Ca(2+) concentration ([Ca(2+)](m)) de

10 a are also Ca(2+)-dependent, suggesting that intramitochondrial Ca(2+) concentration is important for

11 The elevations of cytoplasmic and intramitochondrial Ca(2+) concentrations and mitochondri

12 study is the first to show that NLF inhibits intramitochondrial Ca(2+) flux and protects developing b

13 ental mechanism of post-ischemic cell death: intramitochondrial Ca(2+) overload --> mitochondrial mem

14 ) currents via PTP opening and a decrease in intramitochondrial [Ca(2+)].

15 Intramitochondrial Ca2+ concentration, measured using rh

16 ochondrial Ca2+ ([Ca2+]m) increase regulates intramitochondrial Ca2+-sensitive targets.

17 MCUC dysfunction decreases intramitochondrial calcium ([Ca(2+)]mito), inhibiting py

18 ix-bound soluble adenylyl cyclase) increased intramitochondrial cAMP, but along with membrane-permean

19 Glucocorticoid synthesis requires intramitochondrial cholesterol transport mediated by the

20 In mammalian cells, an intramitochondrial CO2-adenylyl cyclase (AC)-cyclic AMP

21 c mice and that SOD1 displays a very complex intramitochondrial compartmentalization.

22 in vivo could be modulated by changes in the intramitochondrial concentrations of Ca2+ or Mg2+.

23 Overall, the pathway is subject to intramitochondrial control at multiple sites.

24 the redistribution of cytochrome c stored in intramitochondrial cristae.

25 sion are regulated and to what extent direct intramitochondrial cross talk between different processe

26 Intramitochondrial crystals (IMCs) are a well-documented

27 These results indicate that the intramitochondrial crystals characteristic of NASH are h

28 We postulated that intramitochondrial disturbances in NASH are sufficient t

29 e consistent with the hypothesis that normal intramitochondrial dNTP pool asymmetries may contribute

30 the cell nucleus can compensate for loss of intramitochondrial dTMP synthesis in differentiated tiss

31 ial (DeltaPsim), but Ca(2)(+) binding of the intramitochondrial enzymes accelerates oxidative phospho

32 We now show that these same intramitochondrial events that generate signals for leuc

33 and mitochondrial integrity during ischemia, intramitochondrial F(0)F(1) adenosine triphosphate (ATP)

34 ADP(H)-binding 39-kDa subunit is involved in intramitochondrial fatty acid synthesis.

35 We also describe a hitherto unrecognized, intramitochondrial, filamentous structure rich in basic

36 itochondrial superoxide anion (O(2)(.-)) and intramitochondrial free iron released as a result of MOS

37 Intramitochondrial free radicals generated by paraquat o

38 We conclude that an endogenous intramitochondrial H(2)S-producing pathway, governed by

39 Isovaleryl-CoA dehydrogenase (IVD) is an intramitochondrial homotetrameric flavoenzyme that catal

40 The intramitochondrial indo-1 concentration was 0.5-2 mM.

41 resent report shows that tamoxifen increases intramitochondrial ionized Ca(2+) concentration and stim

42 neonatal anemia characterized by pathologic intramitochondrial iron deposits in erythrocytes.

43 brane potential was significantly increased, intramitochondrial levels of reactive oxygen species and

44 6 for respiratory complex IV biogenesis, its intramitochondrial localization and the presence of the

45 ve of this study was to identify a source of intramitochondrial malonyl-CoA that could be used for de

46 port for the alternative possibility, namely intramitochondrial NAD(+) synthesis, by demonstrating th

47 for moving reducing equivalents between the intramitochondrial [NAD(+) ]/[NADH] pool to molecular ox

48 shold, which can be modulated by the PO2 and intramitochondrial [NAD(+) ]/[NADH].

49 ivity of the PDC in the face of the elevated intramitochondrial NADH/NAD+ ratios associated with anae

50 activity being markedly enhanced by elevated intramitochondrial NADH:NAD+ and acetyl-CoA:CoA ratios.

51 s are known to be mutagenic, we suggest that intramitochondrial nucleotide imbalance could underlie t

52 Last, H2O2 induced intramitochondrial O2-, whereas paraquat produced O2- ou

53 d with Fura-2, and a significant increase in intramitochondrial oxidation of dihydrorhodamine 123, pr

54 ctly couple extramitochondrial glycolysis to intramitochondrial oxidative phosphorylation, and are th

55 Instead, deficits of complex I stimulate intramitochondrial oxidative stress, which, in turn, inc

56 We then elucidated an intramitochondrial pathway in which interaction of JNK a

57 In brief, we found that UCP4 regulates the intramitochondrial pH of astrocytes, which acidifies as

58 ster, and a membrane-permeable base to raise intramitochondrial pH.

59 f BCKD kinase and the activity of an unknown intramitochondrial phosphatase.

60 tes osteogenic differentiation by decreasing intramitochondrial phosphate and ATP synthesis.

61 esult is consistent with a deficiency in the intramitochondrial pool of dTTP relative to dCTP in cell

62 a(2+) uptake by compounds that dissipate the intramitochondrial potential unmasks Ca(2+)-dependent in

63 Emerging evidence has suggested that the intramitochondrial protein apoptosis-inducing factor (AI

64 a specific organellar deposit site we termed intramitochondrial protein quality control compartment (

65 inding protein previously implicated in both intramitochondrial protein synthesis and apoptosis.

66 ber of nuclear genes potentially involved in intramitochondrial protein synthesis, with many not yet

67 embryos, consistent with a role for DAP3 in intramitochondrial protein synthesis.

68 reactive oxygen species production, reduced intramitochondrial protein translation, and increased ce

69 One mechanism - intramitochondrial quality control (IMQC) - is represent

70 network of conserved proteases known as the intramitochondrial quality control (IMQC) system is cent

71 nd integrity by acting in concert with other intramitochondrial quality control components.

72 f conserved mitochondrial proteases known as intramitochondrial quality control represents one of the

73 ate synthetase 1 (CPS1) is a liver-specific, intramitochondrial, rate-limiting enzyme in the urea cyc

74 SA-deficient cells, have increased levels of intramitochondrial reactive oxygen species (ROS), especi

75 Comparative analyses suggest that intramitochondrial recombination and errors in replicati

76 Relative changes in the cortical intramitochondrial redox state of cytochrome aa3 (CYT) a

77 nal types of conversional chimerism, namely, intramitochondrial retroprocessing and interorganellar g

78 bserved, suggesting that the fluorescence of intramitochondrial rhod-2 was responding in a Ca(2+)-sen

79 suggested that LRPPRC may have an additional intramitochondrial role by directly interacting with the

80 In this study, we have further examined the intramitochondrial roles for LRPPRC by creating bacteria

81 or mitochondrial CYP2E1 in the generation of intramitochondrial ROS.

82 the possibility of eNOS association with an intramitochondrial site or inverted mitochondrial partic

83 Moreover, intramitochondrial Smac degradation by XIAP occurs indep

84 ing, membrane depolarization, and release of intramitochondrial solutes.

85 rameric flavoenzyme that catalyzes the first intramitochondrial step in the beta-oxidation of fatty a

86 tabolites that anaerobically generate ATP by intramitochondrial substrate-level phosphorylation and m

87 rements of depolarization-induced changes in intramitochondrial total Ca concentration ([Ca](mito)) o

88 To mimic mt-mRNA species and to optimise intramitochondrial translation, further engineering has

89 teroid hormone biosynthesis by enhancing the intramitochondrial translocation of cholesterol to the c

90 midpiece alterations (swollen mitochondria, intramitochondrial vacuoles, disordered mitochondrial ca