ライフサイエンスコーパス: intramolecular interaction

1 suppressed by its C-terminal portion via an intramolecular interaction.

2 ndicates poorer complementarity for the weak intramolecular interaction.

3 1 and inactivated ("closed") Axin through an intramolecular interaction.

4 or autoinhibition of its function through an intramolecular interaction.

5 ating destabilization of the distal-proximal intramolecular interaction.

6 Most formins are regulated by an intramolecular interaction.

7 vary the effective concentration within this intramolecular interaction.

8 form of ESCRT-III subunit autoinhibition via intramolecular interaction.

9 e proline-rich region, are critical for this intramolecular interaction.

10 ains that regulate actin assembly through an intramolecular interaction.

11 ) and show that phosphorylation regulates an intramolecular interaction.

12 able to activate PKR by interfering with the intramolecular interaction.

13 the participation of oxygen in catalysis or intramolecular interaction.

14 n regulates connecdenn 1 function through an intramolecular interaction.

15 ules formed by subdomain-specific inter- and intramolecular interactions.

16 ll signaling and is under strict control via intramolecular interactions.

17 ion of the effective molarities (EM) for the intramolecular interactions.

18 properties such as atomic charges or inter-/intramolecular interactions.

19 region in the C terminus must be intact for intramolecular interactions.

20 residues 802-990) participates in inhibitory intramolecular interactions.

21 cal for binding, and binding is modulated by intramolecular interactions.

22 replacing amino acid residue was involved in intramolecular interactions.

23 390, suggesting that these residues may form intramolecular interactions.

24 e catalysis and do not become immobilized by intramolecular interactions.

25 cessibility and its potential involvement in intramolecular interactions.

26 the involvement of the histidine residue in intramolecular interactions.

27 ad throughout the structure via a network of intramolecular interactions.

28 a model for autoinhibition of Elf3 involving intramolecular interactions.

29 n of particular sets of receptor-stabilizing intramolecular interactions.

30 irst formin studied that is not regulated by intramolecular interactions.

31 rallel to the betaB strand, eliminating many intramolecular interactions.

32 ce of receptor triggering through inhibitory intramolecular interactions.

33 er shielded by the ligand or involved in new intramolecular interactions.

34 he misfolded UBL is apparently masked by the intramolecular interactions.

35 elieving its autoinhibited state effected by intramolecular interactions.

36 er quantify the nature of various inter- and intramolecular interactions.

37 The conservation of intramolecular interactions across animal species and th

38 ain and phosphorylation of S289 disrupts the intramolecular interaction, allowing the N terminus to b

39 ues in the hydrophobic peptide disrupted the intramolecular interaction and increased p53 binding, pr

40 gomerization of mPar3 is able to relieve the intramolecular interaction and thereby promote microtubu

41 uring activation of NMD and suggest that cis intramolecular interaction and trans self-association ma

42 animals and fungi are autoinhibited through intramolecular interactions and appear to be activated b

43 Here we define the required intramolecular interactions and biochemical properties o

44 show that the Mdm2 C-terminus is involved in intramolecular interactions and can set up a platform fo

45 on of Jak3 at the SH2 domain decreased these intramolecular interactions and facilitated binding of t

46 These mutations disrupt ID-mediated intramolecular interactions and ID-dependent inhibition

47 n of Von Willebrand factor is accelerated by intramolecular interactions and increases GPIbalpha diss

48 y offers insight into the patterns of strong intramolecular interactions and other local determinants

49 nhibitory domain (ID), which participates in intramolecular interactions and prevents cofactor bindin

50 idic domain binds to the RING domain through intramolecular interactions and stimulates the catalytic

51 t the mutations affect regulatory inter- and intramolecular interactions and support the conclusion t

52 ay be auto-inhibited in the resting state by intramolecular interactions and that during signaling, N

53 3 kinase dimers identify specific inter- and intramolecular interactions and were in good agreement w

54 By incorporating the stereochemistry, intramolecular interactions, and solvent effects into th

55 ssembly of membrane proteins for elucidating intramolecular interactions, and they offer the possibil

56 Intramolecular interactions are by far the most common m

57 domains of FhbA, suggesting that long-range intramolecular interactions are involved in the formatio

58 backbones (fewer than five rotatable bonds), intramolecular interactions are not observed, and foldin

59 bstitutions at these positions suggest these intramolecular interactions are not responsible for atte

60 protonated peptide [YAPAA+H](+), where only intramolecular interactions are possible.

61 These intramolecular interactions are presumably important for

62 ed size, shape, mass, charge density, but no intramolecular interactions, are ideal model systems to

63 ensity of unfolded chains to form non-random intramolecular interactions as monomers and to self-asse

64 a weaker coupling to the bath (and stronger intramolecular interactions) as the ring size is increas

65 del explicitly takes into account inter- and intramolecular interactions, as well as the finite size

66 erminal tail plays a key role in stabilizing intramolecular interactions at rest.

67 upports the model in which the unique set of intramolecular interactions at the trinucleotide core of

68 pe inhibitor (i.e. the first structure of an intramolecular interaction between a Kunitz and another

69 er DivK, which is modulated by an allosteric intramolecular interaction between adjacent domains.

70 ng that they may both be interfering with an intramolecular interaction between amino acids 4064-4210

71 by which this phosphorylation regulates the intramolecular interaction between CAR's DBD and ligand-

72 he folded domain and eIF1A-CTT; and (iii) an intramolecular interaction between eIF5B-D3 and -D4.

73 osphomimetic mutation of Ser-561 promotes an intramolecular interaction between GK and the nearby Src

74 onformational compaction likely involving an intramolecular interaction between its C-tail and the C2

75 This is because Itch is autoinhibited by an intramolecular interaction between its HECT (homologous

76 ncommon among NRs in that ligand triggers an intramolecular interaction between its N- and C-terminal

77 Dlg is autoinhibited by an intramolecular interaction between its SH3 and GK domain

78 Intramolecular interaction between myosin heads, blockin

79 al analysis was employed to probe an unusual intramolecular interaction between partially buried glut

80 ted in the kinase domain and demonstrated an intramolecular interaction between PBM and dsRNA-binding

81 ylation at threonines 821 and 826 induces an intramolecular interaction between RbC and the Rb pocket

82 of experimental evidence supporting a direct intramolecular interaction between sequences near amino

83 ch receiver phosphorylation destabilizes the intramolecular interaction between SL and receiver domai

84 It has been shown that an intramolecular interaction between the acetylation mark

85 est that activity is switched off through an intramolecular interaction between the actin-binding reg

86 the OFF state is achieved by an asymmetric, intramolecular interaction between the actin-binding reg

87 strated diminished activity in promoting the intramolecular interaction between the AR carboxyl (C) a

88 Autoinhibition involves the intramolecular interaction between the autoinhibitory do

89 ding pocket of GR indirectly by promoting an intramolecular interaction between the C-terminal alpha-

90 Here we identify an intramolecular interaction between the C-terminal domain

91 the other, the origin of which stems from an intramolecular interaction between the carbonyl oxygen o

92 We show that STING is autoinhibited by an intramolecular interaction between the CBD and the C-ter

93 tepwise redox events, indicating significant intramolecular interaction between the cobalt ions acros

94 Intramolecular interaction between the extracellular and

95 We demonstrate that the intramolecular interaction between the FERM and SH2 doma

96 Recent studies identified the dynamic intramolecular interaction between the Gbeta(5) and DEP

97 ding activity of vinculin is inhibited by an intramolecular interaction between the head (D1-D4) and

98 th heads is suppressed due to an asymmetric, intramolecular interaction between the heads.

99 domain that overlaps with the known site of intramolecular interaction between the J domain and the

100 d biophysical approaches, we describe how an intramolecular interaction between the KLC2(TPR) domain

101 y phosphorylates ICAP-1alpha and disrupts an intramolecular interaction between the N- and the C-term

102 s that LEOPARD syndrome mutations weaken the intramolecular interaction between the N-SH2 and phospha

103 on is of interest in view of data indicating intramolecular interaction between the N-terminal extens

104 globular and extended conformations, and an intramolecular interaction between the N-terminal F3 FER

105 Integrin binding is regulated by an intramolecular interaction between the N-terminal head a

106 ese simulations pointed to a key role for an intramolecular interaction between the pseudopilin N-ter

107 The PFR assay also revealed a second intramolecular interaction between the RING domain and c

108 We also show that there is an intramolecular interaction between the SH3 and GK domain

109 In solution, we uncovered a yet unknown intramolecular interaction between the Spir-2 FYVE-type

110 Allosteric regulation of an intramolecular interaction between the Src homology 3 (S

111 otein interaction domains of Dlg, whereas an intramolecular interaction between the two domains inhib

112 Here we report an intramolecular interaction between the yeast Fab1 kinase

113 two new types of molecular interactions: an intramolecular interaction between these two domains and

114 t in the CD4-unbound prefusion state mediate intramolecular interaction between V2 and the conserved

115 Crystal structures revealed pi-pi intramolecular interactions between a donor and an accep

116 we have determined the relative strengths of intramolecular interactions between a series of monosacc

117 uitination-promoting effect of ASXM requires intramolecular interactions between catalytic and non-ca

118 ast in part, to stronger highly cooperative, intramolecular interactions between consecutive exocycli

119 , in addition to variable domain "matching," intramolecular interactions between constant domains pro

120 Our analysis reveals that intramolecular interactions between DBMs and eight-resid

121 Here we have measured the strength of intramolecular interactions between H-bond donor and acc

122 R tyrosine kinase domain is autoinhibited by intramolecular interactions between its activation loop

123 s function, but vinculin is autoinhibited by intramolecular interactions between its head and tail do

124 ation of vinculin requires a severing of the intramolecular interactions between its N- and C-termina

125 homotrimer in an autoinhibited state due to intramolecular interactions between its pyrin domain (PY

126 The effects of intramolecular interactions between modular domains with

127 hase during concentration of Gag3 into foci, intramolecular interactions between negatively charged S

128 F1 is held in an autoinhibited state through intramolecular interactions between PDZ2 and the CT doma

129 e length of the INO protein, suggesting that intramolecular interactions between regions of INO may c

130 greater burial of residue 105 and heightened intramolecular interactions between residue 105 and resi

131 esult of a subtle balance of many inter- and intramolecular interactions between the Abeta42 and memb

132 kens actin binding by stabilizing inhibitory intramolecular interactions between the actin-binding do

133 an autoinhibited state, which is mediated by intramolecular interactions between the amino-terminal G

134 ether with biochemical evidence for specific intramolecular interactions between the basic and acidic

135 tudy, we provide evidence demonstrating that intramolecular interactions between the DH domain (resid

136 at the R290H mutation alters the strength of intramolecular interactions between the diffuse B-cell l

137 Our results suggest a model whereby intramolecular interactions between the globular tail su

138 es transmembrane signaling instead of direct intramolecular interactions between the input and the ou

139 tion of Sis1 in vitro activity suggests that intramolecular interactions between the J-domain and gly

140 that RAF inhibitors induce the disruption of intramolecular interactions between the kinase domain an

141 The PDZ2CT structure shows weak intramolecular interactions between the largely disorder

142 This process interferes with the intramolecular interactions between the N- and C-termina

143 maintaining the proper protein structure via intramolecular interactions between the protease and bet

144 results in a completely different network of intramolecular interactions between the SCCH and adenyla

145 These results suggest that intramolecular interactions between the SH3 and guanylat

146 eatment with mild denaturants that disrupted intramolecular interactions between the two modules.

147 eric viruses provided evidence for extensive intramolecular interactions between the two RNA-binding

148 embly and disassembly of numerous inter- and intramolecular interactions between transcription factor

149 e phosphomimetic S637D mutation impairs this intramolecular interaction but not Drp1-Drp1 intermolecu

150 leaching that ICP27 undergoes a head-to-tail intramolecular interaction but not head-to-tail or tail-

151 o determine the effective molarities for the intramolecular interactions by comparison with the corre

152 Second, mutations that disrupt Upf1 intramolecular interaction cause loss of Upf1 function.

153 es, and helps define the dynamic networks of intramolecular interactions central to enzyme catalysis.

154 Whereas intramolecular interactions confer secondary and tertiar

155 on due to H-bonding with log EM, because the intramolecular interactions contribute fully to the stab

156 These results reveal that multiple intramolecular interactions coordinately regulate arrest

157 This intramolecular interaction could, at least partially, ex

158 The way in which the network of intramolecular interactions determines the cooperative f

159 Here we investigate the LBD as a candidate intramolecular interaction domain.

160 ance-dependent threshold was observed in the intramolecular interaction energies.

161 e one hand, incorporation of F would improve intramolecular interaction, enhance the push-pull effect

162 We propose that intramolecular interactions following tRNA binding remod

163 for primer annealing are initially locked in intramolecular interactions; hence, annealing requires t

164 face between eIF5B and eIF1A; (ii) a dynamic intramolecular interaction in eIF1A between the folded d

165 The intramolecular interaction in Isl1 may provide protectio

166 odel system to assess the role of the SH3-GK intramolecular interaction in MAGUK function.

167 fragment release (PFR) assay, we detected an intramolecular interaction in MDMX that mechanistically

168 ments suggested the presence of an important intramolecular interaction in the active conformation.

169 forces form the basis of intermolecular and intramolecular interactions in chemical and biochemical

170 mined UBL/UBA domain interactions to promote intramolecular interactions in hHR23a that are abrogated

171 These results establish the importance of intramolecular interactions in MDMX regulation, and vali

172 n, and validate a new assay for the study of intramolecular interactions in multidomain proteins with

173 no precedent in TCBD chemistry, results from intramolecular interactions in the excited state between

174 These results show that intramolecular interactions in the folded states of prot

175 aped distortion originating from conflicting intramolecular interactions in the latter case (8-10).

176 coil (NC) segment and its ability to undergo intramolecular interactions in the monomer state versus

177 f Phi values indicated that residues forming intramolecular interactions in the peripheral helices co

178 in TM 6, suggesting that disruption of this intramolecular interaction induces a receptor conformati

179 vides a quantitative glimpse of how specific intramolecular interactions influence protein folding ra

180 NTD mutation, W435L, in a motif involved in intramolecular interaction influenced promoter-selective

181 RNA binding disrupts an assembly inhibitory, intramolecular interaction involving SP and CTD.

182 simplify RNA folding landscapes by weakening intramolecular interactions involving guanosine and expl

183 8C6 is largely controlled by the strength of intramolecular interactions involving lysine residues.

184 es maintain an inactive conformation through intramolecular interactions involving SH3 and SH2 domain

185 used to determine if the NCap contributes to intramolecular interactions involving the Abl SH3 domain

186 in the ground and transition states, namely, intramolecular interactions involving the aromatic rings

187 R) results in destabilization of the domain, intramolecular interactions involving the domain, and th

188 the peptide on or near the droplet surface, intramolecular interactions involving the hydrophilic N-

189 This intramolecular interaction is disrupted by mutation of T

190 The acidic domain-RING domain intramolecular interaction is modulated by ATM-mediated

191 embryonic neuroblasts demonstrates that the intramolecular interaction is not required for Dlg local

192 Disruption of this intramolecular interaction is proposed to enhance the ac

193 Our results also demonstrate that, once this intramolecular interaction is released, the integrin-bou

194 es also demonstrate that an NbSGT1-dependent intramolecular interaction is required for Bs2 function.

195 ude that allosteric regulation of the SH3-GK intramolecular interaction is required for regulation of

196 quence binding site of the SH3.2 domain, the intramolecular interaction is self-inhibitory.

197 activity of the ANK repeat domain through an intramolecular interaction, likely with a groove on the

198 220), forming a fuzzy complex via inter- and intramolecular interactions, mainly through hydrophobici

199 A delicate balance of different types of intramolecular interactions makes the folded states of p

200 sumes a pathological conformation through an intramolecular interaction mediated by Arg-61 in the ami

201 nt domain, LATCH, or coiled coil can perturb intramolecular interactions mediated by multiple REs, su

202 iac troponin I (hcTnI), predicted a possible intramolecular interaction near the basic inhibitory pep

203 analyses demonstrate that these competitive intramolecular interactions negatively regulate Npm hist

204 eptor-ligand intermolecular interactions and intramolecular interaction networks in the human GnRH re

205 he ETV1/4/5 subfamily involving a network of intramolecular interactions not present in other ETS fac

206 in the millimolar range, and thus, the weak intramolecular interactions observed here could conceiva

207 The enzyme is negatively regulated by intramolecular interactions occurring between the kinase

208 polarity solvents, there appear to be strong intramolecular interactions occurring, particularly when

209 on and activity of for3p are inhibited by an intramolecular interaction of divergent DAD and DID-like

210 We conclude that the intramolecular interaction of phosphorylated DBD with th

211 odelling revealed that two mutations disrupt intramolecular interaction of PTEN and open its conforma

212 Finally, the intramolecular interaction of pY783 with SH2(C) results

213 he bound transition state by the effectively intramolecular interaction of the cationic side chain of

214 phosphorylation effects are likely due to an intramolecular interaction of the phosphorylated N-termi

215 mation mechanism: Under basal conditions, an intramolecular interaction of the pleckstrin homology (P

216 Also, the intramolecular interaction of the Snf2 bromodomain with

217 nt a monomer in the cell can be regulated by intramolecular interaction of the tail with the head.

218 egion by aurora B kinase interfered with the intramolecular interactions of MyoGEF.

219 unknown but may involve interference in the intramolecular interactions of Prf or to binding of the

220 ation of phosphorylated KID due to favorable intramolecular interactions of the phosphate group of Se

221 The intramolecular interactions of these molecular torsional

222 ic defects resulting from deficiency in Upf1 intramolecular interaction or RNA binding are suppressed

223 t calcium binding, disulfide bond formation, intramolecular interactions, or sites for potential liga

224 xpansivity and revealed how mutations impact intramolecular interaction patterns.

225 model pK(a) values, thus reflecting the weak intramolecular interactions present in the unfolded ense

226 This intramolecular interaction reduces hRpn13's affinity for

227 However, this activity was repressed by an intramolecular interaction relieved by Cdk5 phosphorylat

228 The K465R mutation apparently transforms the intramolecular interactions required for MNB/DYRK1A cata

229 ruption of substrate binding or mildly alter intramolecular interactions result in type 2 AME.

230 by enzyme-substrate interactions and not by intramolecular interactions resulting from the conformat

231 apping, SSB engages in long-range reversible intramolecular interactions resulting in condensation of

232 el in which the SH2C domain is blocked by an intramolecular interaction(s) that is released upon cell

233 roponin switches between alternative sets of intramolecular interactions, similar to previous interme

234 Thus, phosphorylation of the intramolecular interaction site in the PRD is one of the

235 ocesses revealed that phosphorylation of the intramolecular interaction site in the PRD is required f

236 that M phase-specific phosphorylation of the intramolecular interaction site within the proline-rich

237 binding surface overlaps with the inhibitory intramolecular interaction sites in Src.

238 t the single mutation of Cys154-->Gly alters intramolecular interactions so that individual transmemb

239 ited by the central acidic region through an intramolecular interaction that competes for the p53 bin

240 ermini of ICP27 could undergo a head-to-tail intramolecular interaction that exists in open and close

241 rdinates to generate a homology model of the intramolecular interaction that indicates poorer complem

242 ggest that OSM-3 motility is repressed by an intramolecular interaction that involves folding about a

243 ation of GEF activity is achieved through an intramolecular interaction that is controlled by a key r

244 horylation sites of Rgt1 are required for an intramolecular interaction that is thought to regulate i

245 elf, including a requisite A region-P region intramolecular interaction that occurs within the cell p

246 y present in a closed conformation due to an intramolecular interaction that renders ALIX unable to p

247 the extreme amino terminus of GRK2 forms an intramolecular interaction that selectively enhances the

248 ion, and we identify a set of ligand-induced intramolecular interactions that appear to be important

249 ect membrane protein structures by promoting intramolecular interactions that are different from thos

250 and the fourth membrane-spanning helix, has intramolecular interactions that contribute to maintaini

251 Our goal was to define the intramolecular interactions that contribute to quaternar

252 CcdA is driven by a combination of specific intramolecular interactions that favor the final folded

253 ns are designed to provide information about intramolecular interactions that govern the formation (a

254 ligand binding must function to disrupt the intramolecular interactions that keep hNotch intact and

255 These hydrophobic subdomains mediate intramolecular interactions that keep the molecule in a

256 zation sensitivity results from weakening of intramolecular interactions that maintain Env integrity.

257 g conditions, Sos activity is constrained by intramolecular interactions that maintain the protein in

258 nhibitory domain (ID), which participates in intramolecular interactions that prevent cofactor bindin

259 However, the complex intermolecular and intramolecular interactions that regulate FAK activity a

260 Currently, the intramolecular interactions that regulate the active sta

261 eotide binding pocket of Akt kinases enables intramolecular interactions that restrict phosphatase ac

262 cleotides, and characterize broad classes of intramolecular interactions that stabilize RNA.

263 cyclophilin domain and establishes a strong intramolecular interaction, thereby preventing the acces

264 ely stabilize individual EGF repeats through intramolecular interactions, thereby regulating Notch tr

265 Here we show that Nxf1 uses an intramolecular interaction to inhibit its own RNA-bindin

266 cs tRNA, but it uses a very different set of intramolecular interactions to achieve this shape.

267 k (MBS) domain and the motor domain, mediate intramolecular interactions to confer globular protein c

268 we explored the role of kinase activity and intramolecular interactions to further understand ULK fu

269 d information on contributions of inter- and intramolecular interactions to the binding energy and po

270 We confirm the functional relevance of this intramolecular interaction using differential scanning c

271 F497 residue that makes multiple hydrophobic intramolecular interactions was mutated.

272 plication of SMFS to characterize inter- and intramolecular interactions, which change the properties

273 bition of DNA binding potentially through an intramolecular interaction with or close to the HD.

274 e of the first beta-propeller domain through intramolecular interaction with other domains of LRP5 wh

275 rged surface that is partially masked by its intramolecular interaction with R9.

276 ion of the X/Y linker mediates high affinity intramolecular interaction with the C-terminal SH2 domai

277 r loop, the U6 region in ZO-1, forms a novel intramolecular interaction with the core module.

278 M(COD)], in which the metal atoms exhibit an intramolecular interaction with the N-aryl groups of the

279 ex, probably mediated by its highly flexible intramolecular interaction with the NEP C terminus.

280 how beta-CD can improve adduct stability via intramolecular interaction with the O2(*-) adduct.

281 N-terminal domain, which also coordinates an intramolecular interaction with the remainder of the mol

282 reorganization of the benzyl group, to avoid intramolecular interaction with the silyl group, is resp

283 ed that the highly conserved Asn(7.45) makes intramolecular interactions with a highly conserved Cys(

284 e that phosphorylated serines participate in intramolecular interactions with and sequester arginine

285 PknK revealed that PknK is autoregulated via intramolecular interactions with its C-terminal region.

286 ein phosphatase 5 (PP5) is auto-inhibited by intramolecular interactions with its tetratricopeptide r

287 RE1, RE2, and RE3 participate in intramolecular interactions with other CARD11 domains an

288 cular graphics modeling to demonstrate their intramolecular interactions with the catalytic triad and

289 insically disordered, yet utilizes transient intramolecular interactions with the DNA-recognition hel

290 ven-helix bundle head domain (Vh1) displaces intramolecular interactions with the vinculin tail domai

291 e to interact, suggesting the presence of an intramolecular interaction within C-RING1B.

292 osphorylation destabilizes an autoregulatory intramolecular interaction within eIF2alpha; and (ii) th

293 Here we report an interesting intramolecular interaction within Nck that occurs betwee

294 Thus, intramolecular interactions within alphaE-catenin inhibi

295 at the NCap makes in stabilizing the various intramolecular interactions within c-Abl are less clear.

296 The intramolecular interactions within eIF1A and eIF5B inter

297 t specific cleavages are required to disrupt intramolecular interactions within HTT and to cause toxi

298 ficity to MARCKS, suggesting that long-range intramolecular interactions within MARCKS are also possi

299 This study provides important insights into intramolecular interactions within the 7SK snRNP.

300 ER/K alpha-helix reduces the on rate of the intramolecular interaction without significantly affecti