ライフサイエンスコーパス: intramyocardial

1 All metastases were intramyocardial.

2 Percutaneous intramyocardial access is safe and feasible by a transve

3 We gained widespread intramyocardial access to the anterior, lateral, septal,

4 s and is apparently exerted through a direct intramyocardial action.

5 Recent studies have demonstrated that intramyocardial adipose tissue (IMAT) may contribute to

6 We investigated the effects of intramyocardial adiposity compared with collagen on elec

7 Intramyocardial adiposity, in association with myocardia

8 infarction model of type 1 diabetic rats by intramyocardial administration of an adenoviral vector e

9 of this study was to investigate the role of intramyocardial administration of chimeric ephrinA1-Fc i

10 Intramyocardial administration of NP12 increased phospho

11 e of Radiology, Saeed et al (1) describe the intramyocardial administration of VM202, a newly constru

12 with hMSCs-alone group in rats 2weeks after intramyocardial administration.

13 rformed with immunocompromised mice by using intramyocardial adoptive transfer injection after infarc

14 myocardial thickness, a diffuse increase in intramyocardial and epicardial fat, little inflammation,

15 Both intramyocardial and intracoronary injection of BM cells

16 -20+/-2% versus -17+/-3%; P<0.01) and showed intramyocardial and pericardial late gadolinium enhancem

17 impairs the survival of endothelial cells in intramyocardial arteries and capillaries in the early po

18 position of VEGF in the endothelium of small intramyocardial arterioles.

19 re-related mortality with tissue disruption, intramyocardial bleeding, and increased cardiac dysfunct

20 dge, we demonstrate NOX5 expression in human intramyocardial blood vessels and cardiomyocytes, with s

21 ed to the endothelium of a limited number of intramyocardial blood vessels and to a limited number of

22 Distally, compressive deformation of intramyocardial blood vessels during systole results in

23 Our results indicate that in AF the intramyocardial blood vessels of the left atrial appenda

24 h manifested as an increase in NOX5-positive intramyocardial blood vessels, as well as in endothelium

25 he oligonucleotide was primarily taken up by intramyocardial blood vessels.

26 supply/demand mismatch or remodeling of the intramyocardial blood vessels; they represent a dynamic

27 ator-dilution methods provide an estimate of intramyocardial blood volume (BV) and perfusion (F), whi

28 Changes in intramyocardial blood volume (IBV) mediate autoregulator

29 Electron-beam CT-based intramyocardial blood volume and perfusion and Doppler u

30 LCx bed intramyocardial blood volume concurrently increased (0.6

31 iology, we used it to relate flow reserve to intramyocardial blood volume in the adjacent bed.

32 ve in the adjacent nonstenotic bed, in which intramyocardial blood volume increases.

33 6+/-0.45 second(-1), P=0.030, respectively); intramyocardial blood volume was unchanged.

34 eta t)), where A, beta, and A x beta reflect intramyocardial blood volume, red cell velocity, and flo

35 Immunohistochemistry demonstrated that intramyocardial BM cell injection formed distinct cell c

36 This study evaluates the effect of repeated intramyocardial bone marrow cell injection in patients w

37 Intramyocardial bone marrow cell injection is associated

38 t ventricular hypertrophy and compression of intramyocardial branches of the epicardial coronary arte

39 2 weeks after cell transplantation indicated intramyocardial calcification in 4 of 14 surviving rats

40 staining confirmed the presence of extensive intramyocardial calcification.

41 infarcted myocardium may induce significant intramyocardial calcification.

42 Although MI induced robust, intramyocardial capillary lymphangiogenesis, adverse rem

43 senchymal stromal cells ex vivo, followed by intramyocardial cell administration in normal and infarc

44 cardiomyopathy and the relationship between intramyocardial cell homing and clinical response.

45 The study evaluated a nonsurgical means of intramyocardial cell introduction using the coronary ven

46 te inflammation and graft death after direct intramyocardial cell transplantation.

47 self-assembling nanofibers can now establish intramyocardial cellular microenvironments by injection.

48 Quantification of percent intramyocardial circumferential segment shortening (%S)

49 Percent intramyocardial circumferential shortening (%S) on a top

50 ass, volumes, ejection fraction and regional intramyocardial circumferential shortening (%S).

51 Change in regional percent intramyocardial circumferential shortening in noninfarct

52 th single-vessel disease demonstrate reduced intramyocardial circumferential shortening throughout th

53 The presence of intramyocardial collateral microvessels was accurately d

54 cy reordering was applied to distinguish new intramyocardial collateral vessels from normal circulati

55 Intramyocardial combination hCSCs/hMSCs (1 million cells

56 involved in promoting adverse remodeling of intramyocardial coronary arteries and arterioles by fibr

57 ed with control hearts but normalized in the intramyocardial coronary arteries and smaller vessels in

58 onuclear cell infiltration and vasculitis of intramyocardial coronary arteries were significantly red

59 linear branching structures consistent with intramyocardial coronary arteries, which were not clearl

60 ad no significant effect on the formation of intramyocardial coronary arteries.

61 ated adventitial/interstitial fibroblasts of intramyocardial coronary arterioles but decreased prolif

62 ings indicate that noninvasive assessment of intramyocardial coronary vasculature and measurement of

63 valuation revealed amyloid deposition in the intramyocardial coronary vessels.

64 identified by TTE; the other patient had an intramyocardial course of the anomalous coronary.

65 ary artery ligation followed by peri-infarct intramyocardial delivery of adenoviral vector expressing

66 Intramyocardial delivery of BMCeP at time of infarction

67 We demonstrated that intramyocardial delivery of BMCs in infarcted mice regul

68 We demonstrated that intramyocardial delivery of BMPCs in infarcted diabetic

69 Pim1 overexpression enhanced the effect of intramyocardial delivery of CSCs to infarcted porcine he

70 Within infarcted hearts in the adult, intramyocardial delivery of iPS yielded progeny that pro

71 Early phase clinical trials suggest that intramyocardial delivery of ixmyelocel-T might improve c

72 Intramyocardial delivery of PDGF by self-assembling pept

73 rat hearts demonstrated that pretreatment by intramyocardial delivery of PDGF-AB promotes angiogenesi

74 We demonstrated that intramyocardial delivery of phEPO by an arginine-grafted

75 Intramyocardial delivery of S-SDF-1(S4V) after myocardia

76 s into cardiac progenitor cells, followed by intramyocardial delivery of the progenitor cells into ne

77 n of Ca2+ oscillations in hCPCs before their intramyocardial delivery to infarcted hearts was associa

78 ate measurement of CDC retention early after intramyocardial delivery.

79 In the subendocardium of HC pigs, the intramyocardial density of microvessels was significantl

80 ast mixture excluded perforation and ensured intramyocardial deployment.

81 radient-echo cine MR sequence was used after intramyocardial deposition of sprodiamide.

82 sence of compromised myocardial function and intramyocardial deposits of Abeta in AD patients.

83 Two-dimensional intramyocardial displacement and strain were measured at

84 ess data transmission system that analyzes 9 intramyocardial electrogram parameters recorded from 4 o

85 cent change from baseline of values for each intramyocardial electrogram.

86 cting rejection is to monitor changes in the intramyocardial electrograms using pacemakers.

87 ECGI can noninvasively estimate the depth of intramyocardial electrophysiological events and provides

88 cells in the mediastinal lymph nodes and the intramyocardial endothelium were both activated in respo

89 Intramyocardial fat detection in ARVD was better with fa

90 Contrast-to-noise ratios (CNRs) of intramyocardial fat in the right ventricle (RV) were com

91 cardial fat thickness, percent fibrosis, and intramyocardial fat infiltration were measured in 16 sec

92 The effect of excess intramyocardial fat on cardiac function in nonobese indi

93 6%) patients on the RV and LV, respectively, intramyocardial fat on multidetector computed tomography

94 Intramyocardial fat was detected in eight of 11 (73%) pa

95 Intramyocardial fat was frequently seen in normal hearts

96 nly LV abnormality detected, the presence of intramyocardial fat, was present in 4 individuals.

97 sulin and plasma FFA levels can regulate the intramyocardial fate of fatty acids in humans with type

98 ine the relation between regional changes in intramyocardial function and global left ventricular (LV

99 The response of intramyocardial function to low-dose dobutamine after re

100 is a novel noninvasive method that measures intramyocardial function.

101 We investigated whether intramyocardial gene transfer of naked DNA encoding huma

102 Slow, volumetric, and direct intramyocardial heating induces large, deep lesions with

103 uction ( MVO microvascular obstruction ) and intramyocardial hemorrhage ( IMH intramyocardial hemorrh

104 The presence of intramyocardial hemorrhage (IMH) in ST-segment-elevation

105 nd S2, MVO microvascular obstruction and IMH intramyocardial hemorrhage (n = 34).

106 S0, no MVO microvascular obstruction or IMH intramyocardial hemorrhage (n = 68); S1, MVO microvascul

107 ; S1, MVO microvascular obstruction , no IMH intramyocardial hemorrhage (n = 84); and S2, MVO microva

108 ces in microvascular obstruction (p = 0.19), intramyocardial hemorrhage (p = 0.19), or ejection fract

109 ction ) and intramyocardial hemorrhage ( IMH intramyocardial hemorrhage ) helped define three infarct

110 asured myocardial salvage, and the extent of intramyocardial hemorrhage and microvascular obstruction

111 Intramyocardial hemorrhage frequently accompanies large

112 dium at risk, microvascular obstruction, and intramyocardial hemorrhage in both acute setting and lat

113 overy is impaired in infarcted segments with intramyocardial hemorrhage or microvascular obstruction.

114 cardioprotective strategy and the degree of intramyocardial hemorrhage or microvascular obstruction.

115 MVO microvascular obstruction and IMH intramyocardial hemorrhage significantly affect postinfa

116 ion, late gadolinium enhancement, edema, and intramyocardial hemorrhage) and hard events (all-cause m

117 , myocardium at risk, infarct size, salvage, intramyocardial hemorrhage, and microvascular obstructio

118 , myocardium at risk, infarct size, salvage, intramyocardial hemorrhage, and microvascular obstructio

119 nhancement (SEE), microvascular obstruction, intramyocardial hemorrhage, and salvage index (MSI) were

120 Compared with MI with isolated intramyocardial hemorrhage, MI with MVO resulted in sign

121 impaired in MVO areas accompanied by severe intramyocardial hemorrhage.

122 sence of microvascular obstruction (MVO) and intramyocardial hemorrhage.

123 ia-reperfusion injuries, indicated by severe intramyocardial hemorrhage; however, monocyte recruitmen

124 Higher intramyocardial homing is associated with better stem ce

125 o evaluate the associated salutary effect of intramyocardial hydrogel injection on the remodeling res

126 Here we report that a highly local intramyocardial IL-33/ST2 conversation regulates the hea

127 heral blood mononuclear cells (PBMNCs) after intramyocardial (IM), intracoronary (IC), and interstiti

128 ed to probe cell survival or rejection after intramyocardial implantation in mice.

129 he process of cardiac remodeling by reducing intramyocardial inflammation, collagen deposition and ca

130 Intramyocardial infusion-needle catheter ablation is fea

131 domized into three groups, each receiving an intramyocardial injection (IMI) of a single dose at thre

132 idence interval, 3.7 to 14.5), as did direct intramyocardial injection and intravenous infusion, wher

133 Myocytes were isolated 72 hours after intramyocardial injection and stimulation of the ecdyson

134 ice with acute myocardial infarction (MI) by intramyocardial injection exhibited significantly higher

135 Direct intramyocardial injection is useful for local cell deliv

136 Patients again received intramyocardial injection of 100x10(6) autologous bone m

137 trial, 30 patients were randomized (2:1) to intramyocardial injection of 25 million MPCs or medium d

138 underwent myocardial infarction followed by intramyocardial injection of 5x10(5) ASC, MSC, fibroblas

139 Our results show that intramyocardial injection of 6 mug ephrinA1-Fc into the

140 ta-Gal (control) genes was induced by either intramyocardial injection of AAV serotype 2 (AAV2) or sy

141 thermore, cardiac overexpression of Nur77 by intramyocardial injection of Ad-Nur77 substantially inhi

142 Intramyocardial injection of Ad5/iNOS in mice increased

143 Although intramyocardial injection of allogeneic MSCs improves gl

144 Thus, if it is determined that direct intramyocardial injection of angiogenic factors enhances

145 The effect of direct intraoperative intramyocardial injection of angiogenic factors on colla

146 d angiogenesis is being studied after direct intramyocardial injection of angiogenic peptides or plas

147 We tested the hypothesis that intramyocardial injection of autologous bone marrow (ABM

148 7.2+/-13.3 years) received transendocardial, intramyocardial injection of autologous bone marrow prog

149 Intramyocardial injection of autologous cardiospheres am

150 l and early-phase clinical data suggest that intramyocardial injection of autologous CD34+ cells can

151 A randomized trial of intramyocardial injection of autologous CD34+ cells in p

152 Intramyocardial injection of autologous CSCs in a late p

153 Intramyocardial injection of autologous MSCs into akinet

154 Intramyocardial injection of autologous platelet gel ame

155 Mice received an intramyocardial injection of Av3/LacZ (LacZ group) or Av

156 Noticeably, intramyocardial injection of BM cells induced frequent v

157 We previously reported that intramyocardial injection of bone marrow-derived mesench

158 Intramyocardial injection of CACs or CSCs alone improved

159 Furthermore, intramyocardial injection of CCR1-MSCs prevented cardiac

160 modynamic indexes in the mini-pig model, but intramyocardial injection of CDCs or cardiospheres has n

161 The intramyocardial injection of cells or saline did not res

162 Infarcted hearts receiving intramyocardial injection of CPCeA have increased recrui

163 d by repeat thoracotomy for randomization to intramyocardial injection of CSCs (n=13) or vehicle alon

164 zed into 3 groups of 16 rats, each receiving intramyocardial injection of either 7x10(5) DiI-labeled

165 oupled device imaging, rats (n=20) underwent intramyocardial injection of embryonic rat H9c2 cardiomy

166 descending coronary artery and peri-infarct intramyocardial injection of ESA, SDF-1alpha, or saline.

167 The intramyocardial injection of FL into the infarct border

168 erior descending coronary artery followed by intramyocardial injection of FLT3 ligand (FL) or vehicle

169 Intramyocardial injection of genes encoding angiogenic f

170 Intramyocardial injection of HGF enhances Notch1 and Akt

171 rly, using a coronary artery ligation model, intramyocardial injection of IL-18BP MSCs improved LV ej

172 left ventricular function was observed after intramyocardial injection of myoendothelial cells when c

173 t anterior descending artery, catheter-based intramyocardial injection of NIS(pos)-hiPSCs guided by 3

174 ays; intracoronary injection of BM cells and intramyocardial injection of phosphate-buffered saline r

175 sion using naked DNA gene therapy via direct intramyocardial injection of plasmid DNA encoding VEGF (

176 erior descending coronary artery with direct intramyocardial injection of replication-deficient adeno

177 erior descending coronary artery with direct intramyocardial injection of replication-deficient recom

178 Peri-infarct intramyocardial injection of sFRP2-MSCs resulted in enha

179 tation as well as in situ activation through intramyocardial injection of specific growth factors has

180 Intramyocardial injection of sprodiamide caused local an

181 Here we show that intramyocardial injection of synthetic modified RNA (mod

182 The effects of direct intramyocardial injection of the plasmid encoding vascul

183 =8) and control (n=6) athymic rats underwent intramyocardial injection of up to 2x10(9) pfu of Ad-CMV

184 to examine the effect of late autologous CSC intramyocardial injection on long-term cardiac structure

185 Direct intramyocardial injection or coronary artery perfusion w

186 ort, we have tested the feasibility of using intramyocardial injection or intracoronary infusions of

187 = 9), or placebo (n = 10) were delivered by intramyocardial injection to immunosuppressed Yorkshire

188 Failure of intramyocardial injection was confirmed by a brief signa

189 expanded from sheep bone marrow, and direct intramyocardial injection was performed within the borde

190 Rats (n=10) underwent intramyocardial injection with 1x10(9) pfu of adenovirus

191 Intramyocardial injection with ixmyelocel-T reduces majo

192 nce interval, -15.9 to -3.0), whereas direct intramyocardial injection, intravenous infusion, and int

193 After intramyocardial injection, mesenchymal stem cells (MSCs)

194 rotein as a control via AAV6-mediated direct intramyocardial injection.

195 ardial infarction induced by mobilization or intramyocardial injection.

196 d in effective catheter guidance and precise intramyocardial injection.

197 es can be found in extracardiac organs after intramyocardial injection.

198 hHO-1) was delivered to normal rat hearts by intramyocardial injection.

199 animals were grouped (n=20/group) to receive intramyocardial injections of 70 microL of basal medium

200 These data suggest that transcatheter, intramyocardial injections of autologous bone marrow pro

201 Patients with refractory angina who received intramyocardial injections of autologous CD34+ cells (10

202 Evaluate the safety and bioactivity of intramyocardial injections of autologous CD34+ cells in

203 nt study demonstrates the relative safety of intramyocardial injections of bone marrow-derived stem c

204 METHODS AND Intramyocardial injections of CPCs overexpressing Pim-1

205 week after the MI, the pigs received direct intramyocardial injections of either a recombinant adeno

206 Thirty days later, they received intramyocardial injections of either MSCs (100x10(6) MSC

207 owing week, swine were randomized to receive intramyocardial injections of PBS control (n=10), circul

208 t left coronary artery ligation and received intramyocardial injections of Sca-1(+)CD31(-) cells gene

209 Afterward, adult FVB mice underwent intramyocardial injections with minicircle vector carryi

210 After intramuscular and intramyocardial injections, in vivo bioluminescence imag

211 of granulocyte colony-stimulating factor or intramyocardial injections.

212 have been reported, including intracoronary, intramyocardial, intravenous, and epicardial.

213 cessfully to conventional CABG because of an intramyocardial LAD and dilated left ventricle.

214 We hypothesized that intramyocardial lipid accumulation is a common feature o

215 Surprisingly, neither intramyocardial lipid accumulation nor lipotoxic hallmar

216 om fatty acid oxidation to glycolysis, while intramyocardial lipid accumulation was prevented.

217 However, whether intramyocardial lipid deposition is a feature of human h

218 Intramyocardial lipid deposition was associated with an

219 Intramyocardial lipid level and fibrosis index were both

220 magnetic resonance imaging (MRI) to measure intramyocardial lipid levels and fibrosis as possible co

221 Intramyocardial lipid levels correlated positively with

222 Intramyocardial lipid levels, myocardial fibrosis, and c

223 Intramyocardial lipid overload in the hearts of ZDF rats

224 Intramyocardial lipid overload was present in 30% of non

225 Intramyocardial lipid staining with oil red O and gene e

226 We determined intramyocardial lipid, gene expression, and contractile

227 atty acid oxidation rates, with no change in intramyocardial lipids.

228 table irrigated needle at the tip capable of intramyocardial mapping and ablation.

229 We investigated intramyocardial mechanics after aortic valve replacement

230 logy allows minimally invasive evaluation of intramyocardial microcirculatory function and permits as

231 f value for quantifying long-term changes in intramyocardial microvascular function.

232 perimental hypercholesterolemia (HC) impairs intramyocardial microvascular function.

233 was used to explore the distribution of the intramyocardial microvessels (group 2, n = 4; three-dime

234 = 6; in-plane resolution, 39 mum) represent intramyocardial microvessels was tested.

235 MR fluoroscopy has the potential to guide intramyocardial MSC injection to desirable targets, such

236 Intramyocardial nerve sprouting after myocardial infarct

237 Intramyocardial neutrophil and T-lymphocyte populations

238 hanced MAO-A activity coupled with increased intramyocardial norepinephrine availability results in a

239 transgenic male rats through either a direct intramyocardial or a retrograde intracoronary route.

240 Intramyocardial or intravenous injection of FGF23 in wil

241 demonstrate an impaired ability to increase intramyocardial oxygenation during vasodilatory stress,

242 atory stress to index the ability to augment intramyocardial oxygenation in hypertensive hypertrophy,

243 ligation of the coronary artery followed by intramyocardial PBS injections (control group), and LAD

244 The functional significance of the intramyocardial production of TNF-alpha was determined b

245 Connexin 40 immunostaining demonstrated intramyocardial Purkinje fibers at sites of reentry in t

246 ith a consequent reversal of polarity of the intramyocardial QT wave in alternate cycles.

247 Histological intramyocardial quantity of adipose and collagen and deg

248 second, it may lead to the establishment of intramyocardial reentry, at which time the Purkinje syst

249 are consistent with HC-induced impairment of intramyocardial resistance vessel function.

250 hat MR tagging could be used to quantify the intramyocardial response to low-dose dobutamine and rela

251 co-administering a "scaffold" for increasing intramyocardial retention of human MSCs.

252 has a risk of arrhythmia occurrence when the intramyocardial route is used.

253 We found reduced intramyocardial %S throughout the LV in the patient grou

254 MB) is the term for the muscle overlying the intramyocardial segment of the epicardial coronary arter

255 Combination therapy consisting of intramyocardial Shh gene transfer and AMD3100-induced pr

256 stem cells) were identified by MRI as large intramyocardial signal voids that persisted at 3 weeks (

257 rdial structure, cardiomyocyte function, and intramyocardial signaling were shown to be specifically

258 Between the CAD+ and CAD- groups, intramyocardial strain was similar PRE (19+/-10 versus 2

259 -derived regression of LV hypertrophy and LV intramyocardial strain.

260 e resistant to diabetes-induced increases in intramyocardial TAG levels, lipotoxicity, and cardiac dy

261 Intramyocardial-targeted delivery of the vascular endoth

262 A new guidance system for intramyocardial therapy utilizes magnetic fields and cat

263 nditions was also shown to result in de novo intramyocardial TNF-alpha mRNA biosynthesis.

264 nd reperfusion (120 minutes) (n=9) or before intramyocardial TNFalpha injection (n=3).

265 M-MSCs use a different pathway from HSCs for intramyocardial trafficking and engraftment.

266 he total dose of cells was distributed in 10 intramyocardial, transendocardial injections.

267 Intramyocardial transfer of VM202 improved myocardial pe

268 ge future clinical trials of catheter-based, intramyocardial transplantation of autologous CD34+ MNCs

269 We investigated whether catheter-based, intramyocardial transplantation of autologous endothelia

270 Intramyocardial transplantation of genetically modified

271 Intramyocardial transplantation of hBMSCs after myocardi

272 (MI) to investigate the functional impact of intramyocardial transplantation of hiPSC-derived cardiom

273 In a mouse model of myocardial I-R, intramyocardial transplantation of miR-377 silenced hCD3

274 Intramyocardial transplantation of reprogrammed mouse an

275 ght atrial re-entry, which entailed a longer intramyocardial traversal but did not cross the tricuspi

276 c cardiomyopathy is associated with enhanced intramyocardial triacylglycerol (TAG) levels, the role o

277 Intramyocardial triglyceride (TG) turnover is reduced in

278 ion, induced microinfarctions, and increased intramyocardial triglyceride deposition, features sugges

279 ere metabolic dysregulation characterized by intramyocardial triglyceride overload and changes in gen

280 ned to 1 of 4 treatment groups: Combo group, intramyocardial vascular endothelial growth factor (VEGF

281 rt disease had a variable response to single intramyocardial vector administration, ranging from mini

282 arts had a significantly lower percentage of intramyocardial vessel volume and a significantly higher

283 ng study reports the reduction in normalized intramyocardial vessel volume within the aged heart, in

284 ass, which increased with age, the total and intramyocardial vessel volumes were lower, whereas the e

285 Flow through even small intramyocardial vessels can prevent transmural lesion fo

286 easurement of phasic changes in aBV in large intramyocardial vessels using either Definity (group 1;

287 dial endothelial cells, and smooth muscle of intramyocardial vessels.

288 Some intramyocardial VT mapping was possible in 7 patients.