ライフサイエンスコーパス: intramyocellular

1 scle insulin resistance may be aggravated by intramyocellular accumulation of fatty acid-derived meta

2 Intramyocellular accumulation of lipids directly attenua

3 er down-regulation, ceramide diminished both intramyocellular amino acid abundance and the phosphoryl

4 e children and adolescents with prediabetes, intramyocellular and intra-abdominal lipid accumulation

5 se-induced fat oxidation, leading to reduced intramyocellular and liver triglyceride content.

6 Intramyocellular and visceral lipid contents were invers

7 de that obesity is associated with increased intramyocellular ceramide content.

8 We report that both the intramyocellular circadian clock and diurnal variations

9 Intramyocellular content of lipid (IMCL) and fiber-type

10 not attenuate PA-induced increases in total intramyocellular diacylglycerol and ceramide.

11 nsulin resistance in muscle by conversion of intramyocellular fat into thermal energy.

12 However, exercise increases both intramyocellular fat stores and insulin sensitivity, a p

13 The amount of intrahepatic fat and intramyocellular fat was measured with (1)H-magnetic res

14 ffspring is associated with dysregulation of intramyocellular fatty acid metabolism, possibly because

15 diabetes is associated with dysregulation of intramyocellular fatty acid metabolism, possibly because

16 There were no differences between groups in intramyocellular glucose, as measured by biochemical ass

17 Intramyocellular (IMCL) triglyceride stores are an acces

18 Intramyocellular levels of lipid intermediates, includin

19 skeletal muscle as a predisposing factor for intramyocellular lipid (IMCL) accumulation and muscle in

20 To examine the role of intramyocellular lipid (IMCL) accumulation as well as ci

21 Intramyocellular lipid (IMCL) accumulation is postulated

22 Insulin resistance is closely related to intramyocellular lipid (IMCL) accumulation, and both are

23 scle fibers would exhibit similar changes in intramyocellular lipid (IMCL) and extramyocellular lipid

24 resistance correlates more tightly with the intramyocellular lipid (IMCL) concentration than with an

25 This study compared soleus intramyocellular lipid (IMCL) concentrations after consu

26 Intrahepatic lipid (IHL) and intramyocellular lipid (IMCL) concentrations were determ

27 ABSTRACT: Intramyocellular lipid (IMCL) hampers insulin sensitivit

28 Excessive intramyocellular lipid (IMCL) storage exceeds intracellu

29 ydrate and fat as precursors of glycogen and intramyocellular lipid (IMCL) synthesis.

30 The correlations between intramyocellular lipid (IMCL), decreased fatty acid oxid

31 he expression of BMPs, inflammation, HO, and intramyocellular lipid accumulation in both skeletal and

32 function, which predisposes IR offspring to intramyocellular lipid accumulation, which in turn activ

33 rate that burn injury results in a localized intramyocellular lipid accumulation, which in turn is ac

34 ed by etomoxir, in the presence of increased intramyocellular lipid accumulation.

35 In addition, intramyocellular lipid and HTG contents were measured by

36 ectroscopy studies were performed to measure intramyocellular lipid and intrahepatic triglyceride con

37 Increased intramyocellular lipid concentrations are thought to pla

38 s with impaired glucose tolerance had higher intramyocellular lipid content (3.04 [0.43] vs 1.99 [0.1

39 increased intrahepatic lipid content (IHL), intramyocellular lipid content (IMCL), and low circulati

40 me (P = .9), myocardial TG content (P = .9), intramyocellular lipid content (P = .3), or cardiac func

41 increase of approximately 80 percent in the intramyocellular lipid content (P=0.005).

42 es and is strongly associated with increased intramyocellular lipid content and inflammation.

43 ed with an approximately 60% increase in the intramyocellular lipid content as assessed by H magnetic

44 This increase in intramyocellular lipid content was most likely attributa

45 iated with increases in hepatic (HTG) and/or intramyocellular lipid content, little is known about th

46 tion this is avoidable, given that causes of intramyocellular lipid deposition are predominantly life

47 Abdominal adipose tissue volume and intramyocellular lipid levels were comparable between 8-

48 scriptional oxidative phenotype, and altered intramyocellular lipid partitioning and may therefore be

49 KEY POINTS: Intramyocellular lipid storage is negatively associated

50 Intramyocellular lipid was assessed by proton nuclear ma

51 esonance imaging, and intrahepatic lipid and intramyocellular lipid were assessed by proton magnetic

52 magnetic resonance imaging and muscle lipid (intramyocellular lipid) by proton magnetic resonance spe

53 Recent studies have demonstrated increased intramyocellular lipid, decreased mitochondrial ATP synt

54 A levels of regulatory components related to intramyocellular lipid, glucose metabolism and fiber siz

55 ance have been linked to accumulation of the intramyocellular lipid-intermediate diacylglycerol (DAG)

56 taneous (SAT) adipose tissue, liver fat, and intramyocellular lipids (IMCL) in 101 Chinese, 82 Malays

57 one marrow fat content, of soleus muscle for intramyocellular lipids (IMCL), and liver for intrahepat

58 metabolism, resulting in increased levels of intramyocellular lipids (IMCLs) and lipid intermediates,

59 lin resistant, demonstrated higher levels of intramyocellular lipids (IMCLs), and expressed approxima

60 ent understanding of the effects of elevated intramyocellular lipids on insulin signaling and how the

61 ut exercise on skeletal muscle mitochondria, intramyocellular lipids, and insulin sensitivity index (

62 s between BMI and unsaturated fatty acids in intramyocellular lipids, and methylene groups in extramy

63 pecific skeletal muscle proteins involved in intramyocellular lipids, mitochondrial oxidative capacit

64 by a high oxidative capacity, have elevated intramyocellular lipids, yet are highly insulin sensitiv

65 ulin in adipocytes may be inhibited, whereas intramyocellular lipogenesis via the MAP kinase pathway

66 atty acids (NEFA) are trafficked directly to intramyocellular long-chain acylcarnitines (imLCAC) rath

67 Increases in intramyocellular long-chain fatty acyl-CoAs (LCACoA) hav

68 ed circulating fatty acid levels and reduced intramyocellular or liver triglyceride content.

69 PLIN2 overexpression in vitro increased intramyocellular TAG storage paralleled with improved in

70 n of FIT2 (CKF2) had significantly increased intramyocellular triacylglyceride and complete protectio

71 Intramyocellular triacylglycerol (IMTG) accumulation is

72 reased energy metabolism and accumulate more intramyocellular triacylglycerol but have normal glucose

73 Mounting evidence indicates that elevated intramyocellular triacylglycerol concentrations are asso

74 In muscle, diacylglycerol (DAG) and intramyocellular triacylglycerol were increased.

75 To this end, we have determined intramyocellular triglyceride (IMCL-TG) content with pro

76 milar amount of readily accessible energy as intramyocellular triglyceride (imTG).

77 Hepatic, myocardial, and intramyocellular triglyceride (TG) content relative to w

78 bolic response in diabetes, characterized by intramyocellular triglyceride accumulation.

79 Mitochondrial respiration and intramyocellular triglyceride, sphingolipid, and diacylg

80 Intramyocellular triglycerides (imcTG) of skeletal muscl

81 tant muscle and that the association between intramyocellular triglycerides (IMTG) and insulin resist

82 ylcarnitines (imLCAC) rather than transiting intramyocellular triglycerides (imTG) on the way to rest

83 Chronic exercise and obesity both increase intramyocellular triglycerides (IMTGs) despite having op

84 High levels of intramyocellular triglycerides are linked to insulin res

85 ion, glycogen synthesis, and accumulation of intramyocellular triglycerides have all been linked with