ライフサイエンスコーパス: intranuclear inclusion

1 l neurons contained ubiquitin-immunoreactive intranuclear inclusions.

2 Histology showed homogenous intranuclear inclusions.

3 occurred in a subset of huntingtin positive intranuclear inclusions.

4 both grey and white matter and also neuronal intranuclear inclusions.

5 icularly visceral neuropathies with neuronal intranuclear inclusions.

6 rs, including some characterized by neuronal intranuclear inclusions.

7 ith alterations in the formation of neuronal intranuclear inclusions.

8 the proteasome after it is incorporated into intranuclear inclusions.

9 eristic lentiform ub-immunoreactive neuronal intranuclear inclusions.

10 e, particularly in those cases with neuronal intranuclear inclusions.

11 gender-specific motor deficits, and neuronal intranuclear inclusions.

12 transglutaminase 2 and with huntingtin in HD intranuclear inclusions.

13 tologic disease with identifiable adenoviral intranuclear inclusions.

14 he nucleus, despite the presence of abundant intranuclear inclusions.

15 a dorsal to ventral gradient and occasional intranuclear inclusions.

16 a dorsal to ventral gradient and occasional intranuclear inclusions.

17 r neuron loss, with polyQ-AR accumulation in intranuclear inclusions.

18 ton's disease, with the presence of neuronal intranuclear inclusions.

19 ed extensively convoluted nuclear envelopes, intranuclear inclusions and chromatin clumps in cardiomy

20 Neuronal intranuclear inclusions and cytoplasmic aggregates compo

21 Striatal and cortical intranuclear inclusions and cytoplasmic aggregates of mu

22 ve neuronal cytoplasmic inclusions, neuronal intranuclear inclusions and neurites were recorded and f

23 ese abnormalities, diffuse nuclear labeling, intranuclear inclusions and neuritic aggregates, all imm

24 N-terminal fragments are prone to form both intranuclear inclusions and neuritic aggregates.

25 hole mount immunohistochemistry, to identify intranuclear inclusions and quantify subsets of enteric

26 Formation of fibrillar intranuclear inclusions and related neuropathologies of

27 nt of huntingtin has also been found to have intranuclear inclusions and this same fragment can aggre

28 nt huntingtin suppressed its ability to form intranuclear inclusions and to induce neurodegeneration.

29 axia, weight loss, premature death, neuronal intranuclear inclusions, and decreased tyrosine hydroxyl

30 ere distinct and temporally dissociated from intranuclear inclusions, and disappeared rapidly after c

31 Our results support the view that intranuclear inclusions are an integral part of the path

32 Neuronal intranuclear inclusions are found in the brains of patie

33 These ubiquitinated intranuclear inclusions are morphologically similar to t

34 In contrast to other polyQ diseases, intranuclear inclusions are not prominent in SCA2.

35 Intranuclear inclusions are one of the ultrastructural h

36 Neuronal intranuclear inclusions are present in affected mice.

37 We suggest that neuronal intranuclear inclusions are the common neuropathology fo

38 racterized by the presence of ubiquitinated, intranuclear inclusions associated with molecular chaper

39 hich is found in the neuronal and astrocytic intranuclear inclusions associated with the disorder.

40 eliminated the formation of juxtanuclear and intranuclear inclusion bodies by HtEx1.

41 lly leading to deposition of cytoplasmic and intranuclear inclusion bodies containing htt.

42 duct A or 1 (cp-A/1), form intracellular and intranuclear inclusion bodies in the brains of patients

43 c of pan-cellular HD mouse models, including intranuclear inclusion bodies, motor impairment, and cha

44 as truncated fragments forming ubiquitinated intranuclear inclusion bodies.

45 Striatal neuronal intranuclear inclusion burden was similar between HD kno

46 ation) CGG repeat, we have demonstrated that intranuclear inclusions can be formed in both primary ne

47 this patient showed renal tubular cells with intranuclear inclusions characteristic of PV infection,

48 ure death that are characterized by abnormal intranuclear inclusions composed of TDP-43 and fused in

49 essing highly expanded AR form ubiquitinated intranuclear inclusions containing amino-terminal epitop

50 Whether intranuclear inclusions containing DNA damage response (

51 odels have previously been unable to produce intranuclear inclusions containing only a portion of the

52 model mimics the formation of ubiquitinated intranuclear inclusions containing the amino-terminal po

53 SCA3/MJD brain, the proteasome localized to intranuclear inclusions containing the mutant protein, a

54 Neuronal intranuclear inclusion disease (NIID) is a multisystem n

55 mmunolocalized to both nuclear membranes and intranuclear inclusions, fluorescent detection of NADPH-

56 , nuclear mutant huntingtin accumulation and intranuclear inclusion formation.

57 hallmark of FXTAS is the ubiquitin-positive intranuclear inclusion found in neurons and astrocytes i

58 Ubiquitin-positive intranuclear inclusions have also been found in the neur

59 Intranuclear inclusions have also been reported in the n

60 Neuronal intranuclear inclusions have been found in the brain of

61 Because intranuclear inclusions have recently been shown to be a

62 Characteristic smudgy intranuclear inclusions, immunohistochemistry for viral

63 and mSin3a, and CBP to localize to neuronal intranuclear inclusions in a transgenic mouse model of H

64 aining performed in 3 gene carriers revealed intranuclear inclusions in all 3 cases, including 1, wit

65 FTLD with ubiquitin-positive cytoplasmic and intranuclear inclusions in all PGRN mutation carriers.

66 ds to determine the pathological features of intranuclear inclusions in astroglia and neurons.

67 ebral white matter and (iii) the presence of intranuclear inclusions in both brain and spinal cord.

68 the number of CGG repeats and the numbers of intranuclear inclusions in both neurons and astrocytes,

69 1C2-positive intranuclear inclusions in cerebellar Purkinje and brain

70 The morphology of intranuclear inclusions in CGG KI mice was compared to t

71 st time, de novo formation of ChHV5-positive intranuclear inclusions in cultured green turtle cells,

72 d a severe tubulointerstitial nephritis with intranuclear inclusions in epithelial cells.

73 complete striatal degeneration and rarity of intranuclear inclusions in HD, and the fact that mice ex

74 The discovery last year of neuronal intranuclear inclusions in Huntington's disease and othe

75 rectly relevant to the formation of neuronal intranuclear inclusions in Huntington's disease.

76 a syndrome typically have cerebellar ataxia, intranuclear inclusions in neurons and astrocytes, as we

77 allmark of the disease is ubiquitin-positive intranuclear inclusions in neurons and astrocytes.

78 isease is the presence of ubiquitin-positive intranuclear inclusions in neurons and in astrocytes.

79 FXTAS is the presence of ubiquitin-positive intranuclear inclusions in neurons and in astroglia.

80 The models exhibit the presence of intranuclear inclusions in Purkinje neurons, Purkinje ne

81 tion of FUS but facilitated the formation of intranuclear inclusions in rat hippocampal neurons with

82 logy and by the late development of neuronal intranuclear inclusions in spinal neurons.

83 que pathological feature - appearance of the intranuclear inclusions in the neurons and astrocytes, i

84 weight loss, cerebral atrophy, and neuronal intranuclear inclusions in the R6/2 transgenic mouse mod

85 colytic fibres, containing a large number of intranuclear inclusions (INIs).

86 e, we present evidence that the formation of intranuclear inclusions is a key event in cataract forma

87 However, intranuclear inclusions may reflect a cellular mechanism

88 Neuronal intranuclear inclusion (NII) formation and cell loss is

89 Patient autopsy material reveals neuronal intranuclear inclusions (NII) in affected regions that c

90 mutant huntingtin was localized to neuronal intranuclear inclusions (NIIs) and dystrophic neurites (

91 d hastened both the presentation of neuronal intranuclear inclusions (NIIs) and the onset of behavior

92 arly as 9 weeks of age and striatal neuronal intranuclear inclusions (NIIs) by 20 weeks.

93 Neuronal intranuclear inclusions (NIIs) characteristically occur.

94 lar localization and development of neuronal intranuclear inclusions (NIIs) in cortex and striatum of

95 nsgenic mice described here develop neuronal intranuclear inclusions (NIIs), a hallmark of SBMA and t

96 l dysregulation and accumulation of neuronal intranuclear inclusions (NIIs).

97 other than widespread ubiquitinated neuronal intranuclear inclusions (NIIs).

98 demonstrates widespread ubiquinated neuronal intranuclear inclusions (NIIs).

99 opment of both disease symptoms and neuronal intranuclear inclusions (NIIs).

100 , and in some familial cases UBQ-ir neuronal intranuclear inclusions of a lentiform appearance.

101 All four patients with BKVAN demonstrated intranuclear inclusions on allograft biopsy and a progre

102 active gliosis and the formation of neuronal intranuclear inclusions predominating in the striatum.

103 he neuropathological hallmark of FXTAS is an intranuclear inclusion, present in both neurons and astr

104 clei contained discreet PABP2 immunoreactive intranuclear inclusions, providing the first direct evid

105 rotein ataxin-3 accumulates in ubiquitinated intranuclear inclusions selectively in neurons of affect

106 ippocampus mirror the appearance of neuronal intranuclear inclusions, suggesting a relationship betwe

107 mination showed hypoplastic bone marrow with intranuclear inclusions suggestive of human Parvovirus.

108 models of Huntington's disease with neuronal intranuclear inclusions, the identification of different

109 se carriers demonstrated the presence of the intranuclear inclusions throughout the cerebrum and brai

110 Intranuclear inclusions were absent from Purkinje cells,

111 When CMV intranuclear inclusions were absent within BAL cells of

112 Ubiquitin-positive intranuclear inclusions were also present in protoplasmi

113 clear mutant huntingtin and the formation of intranuclear inclusions were fastest in the C57BL/6 back

114 In CGG KI mice, ubiquitin-positive intranuclear inclusions were found in neurons (e.g., pyr

115 In female CGG KI mice, ubiquitin-positive intranuclear inclusions were found in neurons and astrog

116 in sarcoma-positive neuronal cytoplasmic and intranuclear inclusions were found in the hippocampal gr

117 Intranuclear inclusions were not considered a feature in

118 Intranuclear inclusions were only seen when the polyQ re

119 Eosinophilic, intranuclear inclusions were present in both neuronal an

120 Neuropil aggregates, but no intranuclear inclusions, were observed in the LGP and SN

121 proteins colocalized with viral DNA to form intranuclear inclusions, whereas VP proteins formed holl

122 o induce the formation of ubiquitin-positive intranuclear inclusions, which also stain positive for t

123 its in all the areas examined and widespread intranuclear inclusions, which were particularly numerou