ライフサイエンスコーパス: intraportal

1 lant outcomes to that of islets transplanted intraportal.

2 Intraportal 5-HT enhances NHGU but blunts nonhepatic glu

3 ive hemophilia B dogs that received a single intraportal administration of AAV2/8 vector have achieve

4 developed in the mice within 7 to 14 days of intraportal administration of adeno-associated virus (AA

5 For a given dose, intraportal administration of rAAV CAGG-FIX resulted in

6 sequently, MHC-mismatched macaques underwent intraportal allogeneic islet transplantation and receive

7 betes with hypoglycemic unawareness received intraportal allogeneic islet transplants.

8 We also evaluated AAV8 against AAV2 in intraportal and tail vein injections.

9 istics of these enzymes in rats subjected to intraportal bacterial endotoxin exposure (lipopolysaccha

10 Conversely, more intense proliferation of intraportal bile duct epithelia was seen with 2-AAF/AA t

11 = 4) by means of imaging-guided transhepatic intraportal catheterization.

12 Intraportal delivery of endothelial cell therapy or sali

13 Three weeks after intraportal delivery of endothelial cells, the swine wer

14 Intraportal delivery of insulin in a constant versus pul

15 let bearing kidneys and were challenged with intraportal donor- or third party-type islets after beco

16 ous shunts was demonstrated by the use of an intraportal dye.

17 e used as recipients to study the effects of intraportal FH transplantation.

18 liver glycogen deposition was stimulated by intraportal fructose infusion in the presence of hypergl

19 upercompensated (SCGly) in two groups (using intraportal fructose infusion) but not in two others (Gl

20 se uptake using hyperglycemia and a low-dose intraportal fructose infusion.

21 = 4]), somatostatin, and glucose, as well as intraportal glucagon (basal).

22 n, fourfold basal intraportal insulin, basal intraportal glucagon, and peripheral glucose (to double

23 During the latter, somatostatin, basal intraportal glucagon, portal glucose (21.3 micromol x kg

24 An intraportal glucose infusion clamp was used in dogs to m

25 a hyperinsulinemic-hyperglycemic clamp with intraportal glucose infusion.

26 The efficiency of islet graft survival after intraportal implantation is compromised by host innate i

27 digital subtraction angiography guidance for intraportal infusion of a 15%, 30%, or 50% by volume lip

28 lating hepatic glucose uptake, the effect of intraportal infusion of a small amount of fructose on ne

29 Furthermore, intraportal infusion of allogeneic islets results in the

30 ered diabetic with streptozocin and given an intraportal infusion of approximately 50 000 islet equiv

31 In contrast, intraportal infusion of collagen or fibronectin-like pol

32 This study examines whether intraportal infusion of GSH can prevent HVOD in the mono

33 Intraportal infusion of GSH protects against monocrotali

34 an animal model of breast cancer metastasis, intraportal infusion of MDA-MB435 cells produced multipl

35 After intraportal infusion of porcine islets in primates, many

36 Intraportal infusion of small amounts of fructose marked

37 ne-partial hepatectomy rat model showed that intraportal infusion of the fibronectin-like polymer bef

38 From 90 to 270 min, an intraportal infusion of the sGC inhibitor 1H-[1,2,4] oxa

39 mbined model was able to reproduce the known intraportal infusion profiles.

40 etion that were then compared with the known intraportal infusion rates.

41 cause the patients had contraindications for intraportal infusion, islets were infused in the BM.

42 Within the first 24 hours after intraportal infusion, we identified greater apoptosis (c

43 t in the liver for a minimum of 1 hour after intraportal infusion.

44 Equimolar intraportal infusions of insulin and C-peptide that are

45 sham-injected animals and in rats receiving intraportal infusions of microbeads.

46 Single tumor cells on the liver arising from intraportal injection also were detectable.

47 anted cells were retained in the liver after intraportal injection and in the liver and spleen after

48 in tumors 30 minutes after intraarterial and intraportal injection and was statistically significantl

49 30 vectors was tested after intramuscular or intraportal injection in female Sprague-Dawley rats with

50 jection, the animals were challenged with an intraportal injection of 106 tumor cells, with subsequen

51 Here we demonstrate that a single intraportal injection of a recombinant adeno-associated

52 Thus, a single intraportal injection of a recombinant adeno-associated

53 iac allografts was induced by intravenous or intraportal injection of graft recipients with donor per

54 After intraportal injection of islets, inferior engraftment an

55 Intraportal injection of the graft recipients with donor

56 After intraportal injection of this vector, high-level, stable

57 After intraportal injection, LSEC were largely in the liver (6

58 nsplanted directly to the recipient liver by intraportal injection.

59 omized dogs that were given somatostatin and intraportal insulin (30 pmol x kg(-1) x min(-1)) for 360

60 ol x kg(-1) x min(-1)) was given, along with intraportal insulin (7.2 pmol x kg(-1) x min(-1)) and gl

61 During periods 1 and 2, somatostatin, basal intraportal insulin and glucagon, portal glucose (21.3 m

62 Intraportal insulin infusions (pulsatile, constant, or r

63 imental period, somatostatin, fourfold basal intraportal insulin, basal intraportal glucagon, and per

64 ion and autoimmune recurrence in therapeutic intraportal islet allografts.

65 end-differentiated beta-cell phenotype in 2 intraportal islet allotransplant recipients.

66 ificant prolongation of graft survival after intraportal islet allotransplantation (ITx) in rats: 7.2

67 ant advancement in the clinical relevance of intraportal islet cell transplantation for treatment of

68 In a clinical study, human subjects with an intraportal islet graft (n = 8) underwent two [(11)C]5-H

69 bility and problematic hypoglycemia received intraportal islet grafts under anti-thymocyte globulin-m

70 Each patient had two to three intraportal islet infusions to obtain 10,000 islet equiv

71 BB rats were recipients of Wistar Furth (WF) intraportal islet or islets plus PLNC transplants with c

72 Onset and reversal of liver ischemia due to intraportal islet transplantation are detectable using T

73 liver NK cells significantly increased after intraportal islet transplantation as compared with the c

74 ficantly improves islet graft survival after intraportal islet transplantation by mitigation of coagu

75 essment of liver and islet engraftment after intraportal islet transplantation in a clinical setting.

76 or necrosis factor alpha) are released after intraportal islet transplantation lead to functional sup

77 In intraportal islet transplantation models using mouse and

78 clinical decision-making before entering an intraportal islet transplantation protocol.

79 observed in type 1 diabetic recipients after intraportal islet transplantation raises a question abou

80 ions occurring during radiologic or surgical intraportal islet transplantation significantly impair p

81 Thus, intraportal islet transplantation under conventional imm

82 betic recipients reached normoglycemia after intraportal islet transplantation when they were treated

83 ths and four subjects at 12 months following intraportal islet transplantation who had received compa

84 We report herein a consequence of intraportal islet transplantation, specifically the deve

85 to monitor viable islet mass after clinical intraportal islet transplantation.

86 detected in three patients immediately after intraportal islet transplantation.

87 play a role in early islet graft loss after intraportal islet transplantation.

88 8 nonuremic type 1 diabetic recipients of an intraportal islet-cell graft under maintenance immunosup

89 a first-pass effect, in a large animal (pig) intraportal marginal mass islet autotransplant model.

90 ce that received as few as 50 islets, either intraportal or in the epididymal fat pad, displayed simi

91 may originate from cells derived from either intraportal or periportal ductules.

92 lowed by proliferation of cholangiocytes and intraportal oval cells.

93 Intraportal phlorizin, a competitive inhibitor of glucos

94 Eight diabetic monkeys received intraportal porcine islet transplantation.

95 Ten monkeys underwent intraportal porcine islet transplantation.

96 a pancreatic clamp with glucose unclamped + intraportal propranolol and phentolamine hepatic alpha-

97 argeted to the liver more effectively by the intraportal rather than the intrasplenic route.

98 However, the intraportal route of transplantation is associated with

99 mmunodeficiency mice through intrasplenic or intraportal routes.

100 The -sGC/+NO group also received intraportal SIN-1 (NO donor) to elevate hepatic NO from

101 t, and offers a potential alternative to the intraportal site for islet and future stem cell therapie

102 In rat recipients of intraportal syngeneic transplants, evidence that NO is p

103 er-directed endothelial cell therapy with an intraportal technique for the treatment of cirrhosis in

104 Intraportal thrombolytic infusion, angioplasty, and sten

105 reduced loss of functional islet mass after intraportal transplantation in diabetic mice.

106 nces of IKKbeta knockdown in vitro and after intraportal transplantation in mice.

107 mation and preserves functional islets after intraportal transplantation in mice.

108 vitro by static incubation and in vivo after intraportal transplantation in syngeneic streptozotocin-

109 Intraportal transplantation is associated with procedura

110 (2)), or normoxic (21%O(2)) conditions after intraportal transplantation of 350, 500, 700, or 1,000 s

111 Intraportal transplantation of a marginal mass (50 islet

112 more than 100 d in cynomolgus macaques after intraportal transplantation of cultured islets from gene

113 cific bone marrow is performed together with intraportal transplantation of islets of Langerhans, GVH

114 glycemia was not restored in rats treated by intraportal transplantation of islets.

115 the time needed to restore euglycemia after intraportal transplantation of syngeneic islets in diabe

116 ntrast to the mice that received AAV-hFIX by intraportal vein (IPV) administration.

117 After intraportal vein injection of these vectors in hemophili

118 n the basis of studies that investigated the intraportal versus systemic insulin infusion and transen

119 "), as well as type I cells, are seen in the intraportal zone of the liver within 1 to 2 days after c