ライフサイエンスコーパス: intrarenal

1 To determine whether endogenous intrarenal 5-hydroxytryptamine affects phosphate excreti

2 l insulin (4 mU x kg(-1) x min(-1)) and left intrarenal [6,6-2H]dextrose (14 micromol x kg(-1) x min(

3 l insulin (4 mU x kg(-1) x min(-1)) and left intrarenal [6,6-2H]dextrose (14 micromol x kg(-1) x min(

4 At steady state, intrarenal accumulation of CsA and its secondary metabol

5 The intrarenal accumulation of T cells (CD4(+), CD8(+), CD4(

6 These findings suggest that intrarenal ACE-derived angiotensin II formation, even in

7 cally with losartan suggest that substantive intrarenal actions of Ang II can be maintained even when

8 d with volume homeostasis, particularly with intrarenal actions that influence pressure natriuresis.

9 hritis, CXCR3-/- and CXCL9-/- mice had fewer intrarenal activated T cells and activated macrophages.

10 roximal tubule and intercalated cells, after intrarenal administration of a rAAV vector and provide t

11 Intrarenal administration of angiotensin II receptor typ

12 ovel mechanism, Nrf2-mediated stimulation of intrarenal Agt gene expression and activation of the ren

13 ed, at least in part, via the suppression of intrarenal Agt gene expression in vivo.

14 otion that the loss of systemic AGT, but not intrarenal AGT, is responsible for death in the AGT-/- m

15 The aim of this study was to clarify the intrarenal allograft events associated with the developm

16 -, 140-, and 240-HU renal inserts containing intrarenal and exophytic 7-, 10-, and 15-mm cysts.

17 Increases in intrarenal and interstitial angiotensin (Ang) II levels

18 IL-12 "carrier cells" generated intrarenal and systemic IL-12.

19 AKI associates with intrarenal and systemic inflammation; thus, improved und

20 ty of metabolic/homeostatic processes at the intrarenal and systemic levels and are involved in drug

21 Ang II observed in wild-type mice, including intrarenal Ang II accumulation, sodium and water retenti

22 However, the precise mechanisms by which intrarenal Ang II increases blood pressure have never be

23 The resultant increased intrarenal Ang II levels contribute to the genesis of ch

24 Intrarenal AngII (1 ng) caused a 32% reduction of renal

25 njury observed in association with increased intrarenal AngII accumulation in the absence of APA sugg

26 Intrarenal AngII content, which is greater than can be e

27 produce sustained hypertension and increased intrarenal AngII contents through multiple mechanisms, w

28 It is, likely, however, that the activity of intrarenal AngII is somehow upregulated in the aging kid

29 the nonclipped kidney is renin-depleted, the intrarenal AngII levels are not suppressed, and AngII co

30 levels, thus contributing to the increase in intrarenal AngII levels.

31 nist, it is proposed that there is increased intrarenal AngII production in type 2 diabetes mellitus.

32 AngII-generating system is a major source of intrarenal AngII production, it is here reported that th

33 Simvastatin in RAS enhanced both intrarenal angiogenesis and peri-stenosis arteriogenesis

34 Hyperglycemia and high intrarenal angiotensin II (AngII) levels could contribut

35 was performed to determine whether augmented intrarenal angiotensinogen may contribute to the enhance

36 creases in circulating AngII levels increase intrarenal angiotensinogen mRNA levels, which may contri

37 s point to a potential 20-HETE dependence of intrarenal angiotensinogen production and ANGII receptor

38 hese results indicate that SHR have enhanced intrarenal angiotensinogen production that contributes t

39 Risk genotype was not associated with intrarenal APOL1 mRNA expression levels.

40 We tended to augment PGI2 production by intrarenal arterial Adv-COPI administration with renal v

41 uate gene expression in the rat kidney after intrarenal arterial infusion of a rAAV (serotype 2) vect

42 In rats, intrarenal arterial injection of anti-glomerular endothe

43 An intrarenal arterial resistive index of less than 0.6 was

44 orm grade 3-6) was present in 19 (86%) of 22 intrarenal arteries prior to intervention, as compared w

45 An intrarenal artery injection technique established feasib

46 Blockade of intrarenal AT1 receptors elicited significant increases

47 Intrarenal AT2R activation prevents Na(+) retention and

48 ls of EBV DNA, although only mild persistent intrarenal atypical lymphocytic infiltrates.

49 hritis involves antibody binding to multiple intrarenal autoantigens rather than the deposition of ci

50 h histological patterns were associated with intrarenal B cell clonal expansion and ongoing somatic h

51 We identified intrarenal B7-1 and B7-2 expression, restricted to kidne

52 Medullary hypoxia due to intrarenal blood flow redistribution may be one of the f

53 erated and efficacious for the management of intrarenal calculi in multiple-patient populations and i

54 le in the treatment of proximal ureteral and intrarenal calculi with the development of new endoscope

55 , and Tnfr1/2-deficient mice also lacked the intrarenal CaOx deposition and tubular damage observed i

56 In mice, intrarenal CaOx deposition induced tubular damage, cytok

57 These mice had a high frequency of intrarenal CD25(+)Foxp3(+) regulatory T cells and decrea

58 However, the relative contribution of intrarenal cells and extrarenal cells to kidney regenera

59 These results show that intrarenal cells are the main source of renal repair, an

60 Intrarenal changes in cytoplasmic calcium levels have a

61 The focus was on intrarenal chemokine ligand/receptor pairs that were hig

62 in a transcriptional network that regulates intrarenal cholesterol metabolism.

63 allografts in the absence of rejection; (3) intrarenal coexpression of members of each lytic pathway

64 histological severity of acute rejection and intrarenal coexpression of mRNA encoding Fas ligand, Fas

65 ds significantly increased distention of the intrarenal collecting system and proximal ureter (P < .0

66 and overall image quality (P < .001) of the intrarenal collecting system and proximal ureter.

67 lculated on a per-renal unit (defined as the intrarenal collecting system and ureter of one kidney) b

68 instrument being employed to map the entire intrarenal collecting system.

69 portions of the urinary tract--the kidneys, intrarenal collecting systems, ureters, and bladder--and

70 ggest that salt sensitivity is determined by intrarenal collectrin, and increasing the abundance or a

71 rmation and local antibody production add to intrarenal complement activation as renal immunopatholog

72 eased from injured endothelial cells promote intrarenal complement activation.

73 bladder, we evaluated whether measurement of intrarenal concentrations of viral DNA might serve as a

74 Intrarenal control mechanisms play an important role in

75 It has been proposed that excessive intrarenal conversion of cortisol to 6 beta-hydroxycorti

76 Intrarenal crystals trigger inflammation and renal cell

77 affects systemic CsA metabolite exposure and intrarenal CsA accumulation.

78 37), which is suggestive of CYP3A5-dependent intrarenal CsA metabolism.

79 tected in the serum or urine correlates with intrarenal CSF-1 expression and histopathology (increase

80 rine CSF-1 levels correlated with increasing intrarenal CSF-1 expression and histopathology.

81 1 levels correlated with lupus activity, and intrarenal CSF-1 expression correlated with the histopat

82 uggesting that blocking both circulating and intrarenal CSF-1 may be necessary for therapeutic effica

83 r) mice lacking IFN-gamma R, circulating and intrarenal CSF-1 were absent, TNF-alpha was markedly red

84 es and whether systemic CSF-1, as opposed to intrarenal CSF-1, promotes macrophage-dependent lupus ne

85 ong with the csCSF-1 isoform, for increasing intrarenal CSF-1.

86 of cyst diameter, occurred in 34 (38%) of 90 intrarenal cyst measurements.

87 cement is maximal when small (< or = 1.5-cm) intrarenal cysts are scanned during maximal levels of re

88 dy mass index, 31.3 kg/m(2) +/- 6.2) with 34 intrarenal cysts were included.

89 ton imaging of CD11c-EYFP mice revealed that intrarenal DCs exhibited increased number and activity o

90 d TGF-beta1 protein expression and increased intrarenal display of TGF-beta1 mRNA.

91 ransduction mechanisms determined, and their intrarenal distribution mapped.

92 activating mutation of c-kit, display normal intrarenal distribution of the c-kit-positive cells at E

93 The intrarenal distribution of these prostanoid receptors ha

94 iminated between the roles of extrarenal and intrarenal dopamine in the overall regulation of renal f

95 rmine the effects of selective inhibition of intrarenal dopamine production, we used mice with proxim

96 Decreasing intrarenal dopamine subjects the kidney to unbuffered re

97 se results demonstrate the importance of the intrarenal dopaminergic system in salt and water homeost

98 y examined the effects of alterations in the intrarenal dopaminergic system on kidney structure and f

99 study demonstrates an important role of the intrarenal dopaminergic system to modulate the developme

100 The kidney has a local intrarenal dopaminergic system, and in the kidney, dopam

101 Intrarenal downstream effector transcripts (IFN-gamma, I

102 Standard intrarenal duplex US parameters (acceleration index [AI]

103 nal blood flow was accompanied by more rapid intrarenal dye transit time and slight increase in renal

104 The diverse intrarenal effects of the prostaglandins (PG) are mediat

105 The intrarenal etiology of lupus nephritis involves antibody

106 We found that intrarenal expression of CL-11 rapidly increases in the

107 Intrarenal expression of csCSF-1 and spCSF-1 increases w

108 ouse model of renal ischemia, an increase in intrarenal expression of CXCR3 and its ligands was obser

109 lymerase chain reaction was used to identify intrarenal expression of Fas antigen, Fas ligand, granzy

110 Our studies demonstrate that: (1) intrarenal expression of Fas ligand mRNA and of granzyme

111 ating GDF-15 levels strongly correlated with intrarenal expression of GDF15 and significantly associa

112 orrelated with early PVN grade 1 and minimal intrarenal expression of SV40-T antigen (P < 0.001).

113 Intrarenal expression of TGF-beta protein was also compa

114 Intrarenal expression of TGF-beta protein was studied by

115 Circulating levels and intrarenal expression of TGF-beta were also significantl

116 Intrarenal expression of TGF-beta, collagen, fibronectin

117 Comparisons were made of intrarenal expression of TGF-beta, collagen, fibronectin

118 Intrarenal expression of TGF-beta, collagen, fibronectin

119 We investigated intrarenal expression of these molecular executors of ce

120 llagen fragments, suggesting accumulation of intrarenal extracellular matrix.

121 With increasing peripheral vasodilatation, intrarenal factors for maintenance of renal perfusion ca

122 A variety of intrarenal factors lead to progressive interstitial fibr

123 Future studies should be directed at intrarenal factors.

124 Our findings show that CD103(+) DCs foster intrarenal FoxP3(+) Treg accumulation, thereby antagoniz

125 GDF-15 levels significantly correlated with intrarenal GDF15 transcript levels (r=0.54, P=0.01).

126 Circulating GDF-15 may be a marker for intrarenal GDF15-related signaling pathways associated w

127 The intrarenal generation of active glucocorticoid by 11beta

128 nificantly slower rate than the rejection of intrarenal grafts.

129 dehydrogenase, and hematocrit levels), acute intrarenal heme loading (cast formation), and BP during

130 Intrarenal hemodynamics and excretory function distal to

131 up, and study changes in concurrent, in vivo intrarenal hemodynamics and segmental tubular function i

132 se to injury, suggesting that a biomarker of intrarenal HO-1 activity may be useful.

133 her plasma or urinary levels of HO-1 reflect intrarenal HO-1 expression.

134 -1 levels may serve as biomarkers of AKI and intrarenal HO-1 gene activity.

135 otection associated with decreased levels of intrarenal IFN-gamma, TNF, and inflammatory chemokines a

136 s nephritis by fostering the accumulation of intrarenal IFN-gamma-secreting T cells, and 2) MRL-Fas(l

137 Although these changes in the intrarenal IGF-1 axis were distinct, it is difficult to

138 nd isotypes (G1,G2b,G3), autoantibodies, and intrarenal IgG deposits.

139 We previously reported that 1) intrarenal IL-12 elicits nephritis by fostering the accu

140 Intrarenal IL-17A mRNA transcription and protein express

141 rvival times, 57 to >100 days) in vivo after intrarenal implant.

142 Furthermore, PSI may decrease intrarenal inflammation through modulation of the NF-kap

143 These include glomerular hypertrophy, intrarenal inflammation, and interstitial fibrosis.

144 ostimulatory effects of histones, suppressed intrarenal inflammation, neutrophil infiltration, and tu

145 espite a similar amount of crystal deposits, intrarenal inflammation, tubular damage, and renal dysfu

146 s was unexpectedly more severe, despite less intrarenal inflammation.

147 nvestigated the renal actions of K201 during intrarenal infusion in normal anesthetized dogs.

148 In hyperdynamic sepsis, intrarenal infusion of a highly selective inducible nitr

149 with RVD not treated (n=7) or 4 weeks after intrarenal infusion of ad-MSC (2.5x10(5) cells/kg; n=6),

150 The present study shows that a single intrarenal infusion of autologous EPCs preserved microva

151 n pigs with RAS, pigs with RAS 4 weeks after intrarenal infusion of autologous EPCs, and controls.

152 We, therefore, examined the effects of intrarenal infusion of selective inducible nitric oxide

153 d and denervated kidneys from CBDL rats, and intrarenal infusion of Zaprinast (10 micrograms/min) cor

154 ction, IL-4-/- mice had significantly higher intrarenal intercellular adhesion molecule-1 mRNA expres

155 idney pathology, loss of renal function, and intrarenal leukocyte infiltrates were increased in each

156 reduced serum autoantibodies, splenomegaly, intrarenal leukocyte trafficking, and end organ disease

157 F-1-deficient mice is not limited to reduced intrarenal leukocytes; circulating Igs and autoantibodie

158 type 2 diabetic nephropathy, we examined the intrarenal localization and expression of the TGF-beta1

159 A are detected in the kidney and its precise intrarenal localization is uncertain, mice with targeted

160 ediators that incite TEC death, and reducing intrarenal M phi during kidney disease diminishes TEC ap

161 The decrease in intrarenal M phi resulted from diminished recruitment an

162 n, resulting in a more rapid accumulation of intrarenal macrophages (CD11b(+)CSF-1R(+) or CD68(+)) th

163 expression increased in both peritoneal and intrarenal macrophages in diabetic wild-type mice.

164 mmatory cytokine and chemokine expression in intrarenal macrophages.

165 ined kidney and urine samples from mice with intrarenal (maleate), prerenal (endotoxemia), or postren

166 The intrarenal mechanisms mediating adaptation to variations

167 S) by restoring angiogenesis and attenuating intrarenal microvascular (IMV) remodeling.

168 (RAS) may impair renal function by inducing intrarenal microvascular injury and remodeling.

169 uent CKD via 2 distinct mechanisms: enhanced intrarenal Mo proliferation and elevated BM myeloid cell

170 se type 2 diabetic nephropathy, only CD68(+) intrarenal monocytes expressed Cat-S mRNA, whereas Cat-S

171 necrotic cell-derived TLR4 agonists activate intrarenal mononuclear cells to secrete IL-22, which acc

172 immunity via the NLRP3/ASC/caspase-1 axis in intrarenal mononuclear phagocytes and directly damage tu

173 There are far fewer intrarenal Mphi and T cells in CSF-1-deficient MRL-Fas(l

174 e prophylaxis group had significantly higher intrarenal mRNA expression of genes involved in fibrogen

175 light microscopy, immunohistochemistry, and intrarenal mRNA expression of proinflammatory and profib

176 g the function and attenuating the damage of intrarenal MV.

177 e renin angiotensin system and inhibition of intrarenal nitric oxide production.

178 ations in RAP are associated with changes in intrarenal NO, suggesting a direct effect of NO to regul

179 Either intrarenal or systemic administration of C-21 prevented

180 By lowering intrarenal oxygen levels, reduced NO may contribute to s

181 ng) and molecular diagnostic tools to assess intrarenal oxygenation and perfusion, and the molecular

182 sence of a noninvasive technique to estimate intrarenal oxygenation in different zones of the kidney.

183 BOLD MRI can be used to monitor changes in intrarenal oxygenation in humans in a noninvasive fashio

184 These results suggest that marked changes in intrarenal oxygenation occur during acute transplant rej

185 riuretic peptide and overactivity of various intrarenal paracrine systems, including vasodilator and

186 Intrarenal perfusate flows at the same time intervals we

187 ac Death (DCD) in porcine kidneys to measure intrarenal perfusion.

188 uid chromatography analysis showed increased intrarenal polyamine concentrations peaking after 24 h o

189 nal ODC protein expression and localization, intrarenal polyamine levels, and sites of proliferation

190 antly associated with clinical presentation: intrarenal polyomavirus load levels and Banff interstiti

191 al semiquantitative histologic assessment of intrarenal polyomavirus replication/load levels.

192 scular perfusion and histopathology, reduces intrarenal pro-inflammatory mediators and salvages kidne

193 is within 13 weeks, accompanied by increased intrarenal production of angiotensin (Ang) II, fibronect

194 was measured to provide an indication of the intrarenal production of NO.

195 on results from suppressed infiltration, and intrarenal proliferation, but not enhanced apoptosis.

196 Macrophages accumulated because of higher intrarenal proliferation, despite reduced monocyte recru

197 PGE2, the major intrarenal prostaglandin, interacts with at least three

198 Other intrarenal prostanoid receptors include the PGF2 alpha r

199 lation (alpha0.77-0.86) with the severity of intrarenal PV replication and disease grades.

200 of SV40-T-expressing cells as indicators of intrarenal PV replication in corresponding renal allogra

201 dicts PVN disease grades and the severity of intrarenal PV replication.

202 t correlation with disease grades or minimal intrarenal PV replication.

203 suggest that Agt-ASO effectively attenuates intrarenal RAS and therefore can be a novel and effectiv

204 ed the predicted changes in the systemic and intrarenal RAS, while acute BK2A had no consistent effec

205 nitric oxide (NO), and the activation of the intrarenal RAS.

206 nt RAS inhibitors do not adequately suppress intrarenal RAS.

207 In DIO mice, intrarenal RCC tumor challenge in the absence of therapy

208 h advancing nephritis, thereby promoting the intrarenal recruitment of monocytes and expansion of Ly6

209 ease in cell proliferation restricted to the intrarenal region with Mfn2 deletion.

210 Since dopamine produced by the kidney is an intrarenal regulator of sodium transport, an abnormality

211 ed enhanced renal injury and exhibited fewer intrarenal regulatory T cells (Tregs) compared with gene

212 l lines, we detected a reduction of FoxP3(+) intrarenal regulatory T cells (Tregs), which protect aga

213 As a measure of intrarenal renin activity, we have examined renal plasma

214 These were accompanied by blockade of intrarenal renin and Ang II accumulation induced by hype

215 Activation of the intrarenal renin angiotensin system (RAS) is believed to

216 al microvasculature and in expression of the intrarenal renin angiotensin system.

217 masking and perhaps reflecting an activated intrarenal renin system.

218 Activation of the intrarenal renin-angiotensin system (RAS) can elicit hyp

219 The increased activity of intrarenal renin-angiotensin system (RAS) in a setting o

220 al. present further evidence implicating the intrarenal renin-angiotensin system and take us one step

221 h our previous studies, we conclude that the intrarenal renin-angiotensin system located in the proxi

222 The intrarenal renin-angiotensin system plays a critical rol

223 The contribution of the intrarenal renin-angiotensin system to the development o

224 rtant in IFN-gamma-induced activation of the intrarenal renin-angiotensin system.

225 an infusion of angiotensin II (assessment of intrarenal renin-angiotensin-aldosterone system [RAAS])

226 with stimulation of both the circulating and intrarenal renin-angiotensin-aldosterone system.

227 Despite early-onset hypertension and intrarenal renin/angiotensin II (AngII) activation, angi

228 ry resulted in a significant decrease in the intrarenal resident dendritic cell (DC; CD45(+)MHCII(+)C

229 erfusion conditions were maintained with low intrarenal resistance and normal electrolyte and pH para

230 ctional area suggests that adenosine affects intrarenal resistance blood vessels rather than large co

231 Intrarenal resistance decreased over the course of perfu

232 Increased intrarenal resistance index (RI) has been associated wit

233 During reperfusion, intrarenal resistance was significantly lower in the HMP

234 The intrarenal resistive index is routinely measured in many

235 , these observations suggest that endogenous intrarenal serotonin enhances phosphate reabsorption in

236 Intrarenal signal intensity variations were correlated w

237 lated phosphate metabolism by identifying an intrarenal signaling axis for FGF23.

238 ncy, with flank or back pain associated with intrarenal sludging, and with the classic syndrome of re

239 latter syndrome had radiographic evidence of intrarenal sludging.

240 the kidney cortex processed antigen for the intrarenal stimulation of T helper cells, a function imp

241 ed as a routine option for the management of intrarenal stone disease.

242 ues to improve as a method for management of intrarenal stone disease.

243 f stone fragment retrieval during retrograde intrarenal stone surgery, potentially improving stone-fr

244 ckwave rate improves stone fragmentation for intrarenal stones.

245 mmation, T cell glomerular infiltration, and intrarenal synthesis of TNF-alpha, IL-1beta, and VCAM-1.

246 scular hypertension has been linked to other intrarenal systems, the lipoxygenase pathway, and renin

247 here is an amplification of the frequency of intrarenal T cells generating IFN-gamma and TNF-alpha in

248 termined the relative level of expression of intrarenal TGFbeta protein in transplant biopsies.

249 These findings indicate intrarenal TNFalpha contributes to the development of hy

250 Characterization of the intrarenal transcription profile associated with I/RI wa

251 opsy taken 3 months posttransplantation, the intrarenal transcriptome differed in patients treated wi

252 ective single-center study characterized the intrarenal transcriptome during I/RI as a means of ident

253 ression of APOL1 mRNA levels with a group of intrarenal transcripts that together were associated wit

254 Intrarenal urate crystal deposition was absent in all gr

255 The mechanism does not involve intrarenal uric acid crystal deposition and appears to i

256 mmol/L, overlapping with clinically relevant intrarenal/urinary levels after fluorinated anesthetic u

257 , oxonic acid (OA), results in hypertension, intrarenal vascular disease, and renal injury.

258 hypertrophy may significantly influence the intrarenal vascular resistance measured using Doppler so

259 The intrarenal vasculature was normal in the mutant mice.

260 s and by the thickening and hyalinization of intrarenal vasculature.

261 duction was observed in the glomeruli or the intrarenal vasculature.

262 e (CsA)-induced nephrotoxicity may be due to intrarenal vasoconstriction and glomerular hypoperfusion

263 with chronic tubulointerstitial disease and intrarenal vasoconstriction raised the hypothesis that h

264 n to modify acute cyclosporine (CsA)-induced intrarenal vasoconstriction.

265 stulated to play a major role in the intense intrarenal vasospasm and hypertension provoked by cyclos

266 ominantly in the endothelium of coronary and intrarenal vessels and in renal tubular epithelium.

267 The vascular endothelium of proliferating intrarenal vessels from patients with antiphospholipid s

268 DSA, whereas the visibility of the hilar and intrarenal vessels was significantly worse (P = 0.0001).

269 A in cases that do not require assessment of intrarenal vessels.

270 These observations indicate that intrarenal viral replication in sustained viruria is fre

271 iments were conducted in three tumor models: intrarenal VX2 sarcoma in 27 rabbits, RCC 786-0 human re