ライフサイエンスコーパス: intraspinal

1 oven, that this residual 5-HT is produced by intraspinal 5-HT neurons.

2 lts demonstrate that GLT1 overexpression via intraspinal AAV-Gfa2-GLT1 delivery exacerbates neuronal

3 e if it has been exposed to the afferent and intraspinal activation patterns that are associated with

4 Intraspinal administration of an interleukin-converting

5 acy of the remaining synapses and neurons of intraspinal and peripheral afferent (dorsal root ganglio

6 that sensory neurons receive intraganglion, intraspinal, and supraspinal inputs, the latter of which

7 ould be restored by acute systemic E2, or by intraspinal application of the membrane-impermeable E2 (

8 that ephrins affect nerve-muscle matching by intraspinal as well as intramuscular mechanisms.

9 which they were allocated to receive either intraspinal autologous cells derived from olfactory muco

10 dal to the lesion and their integration into intraspinal axonal circuits.

11 otor and visceral inputs and are part of the intraspinal circuit that regulates sexual and voiding fu

12 These studies demonstrate the multisegmental intraspinal circuitry responsible for ejaculatory-like r

13 ections, prompting us to examine whether the intraspinal circuitry that coordinates motor activity li

14 SCI caused pathology, in part by activating intraspinal complement and cells bearing Fc receptors.

15 The intraspinal cues that orchestrate T-cell migration and a

16 Intraspinal delivery of AAV8-Gfa2-GLT1 resulted in trans

17 We used intraspinal delivery of adeno-associated virus type 8 (A

18 f the current study was to determine whether intraspinal delivery of Ch'ase ABC, following T10 hemise

19 r, Shimada histopathology, primary site, and intraspinal extension were significant univariate progno

20 evelop swelling ("nodes") along their entire intraspinal extent and elaborate interstitial collateral

21 s been investigated by using cord dorsum and intraspinal field potential recording.

22 ressing astrocytes in ventral horn and total intraspinal GLT1 protein expression were reduced soon af

23 >/=6 weeks postinjury, as well as increased intraspinal GLT1 protein expression.

24 We observed robust and long-term intraspinal IGF-1 expression and partial rescue of lumba

25 Intraspinal IL-23 reconstitution restored EAE in CCR4(-/

26 tes could also be created in rats by direct, intraspinal immune activation of astrocytes and microgli

27 Strains with marked intraspinal inflammation also developed the most intense

28 the future to reduce the adverse effects of intraspinal inflammation and augment activity-dependent

29 Only in C57BL/6 mice was the magnitude of intraspinal inflammation predictive of secondary neurode

30 We delivered Bcl-2 by intraspinal injection of a DNA plasmid encoding this gen

31 We found that intraspinal injection of chondroitinase-ABC, known to di

32 We treated WT mice with a single intraspinal injection of either full-length or processed

33 s induced more than 1 year previously by the intraspinal injection of ethidium bromide (EB).

34 had been experimentally demyelinated by the intraspinal injection of ethidium bromide.

35 Demyelinating lesions induced by intraspinal injection of gliotoxin have been studied for

36 We conclude that the intraspinal injection of LPS results in inflammation and

37 ype-9 (scAAV-9) in spinal cord tissues after intraspinal injection of mouse embryos (E16).

38 Intraspinal injection of NG2 acutely depressed axonal co

39 ated against neuronal injury produced by the intraspinal injection of NMDA and alpha-amino-3-hydroxy-

40 In gain-of-function studies, intraspinal injection of PAP protein has potent antinoci

41 Previous studies have shown that intraspinal injection of quisqualic acid (QUIS) produces

42 emic injury, in male Sprague-Dawley rats via intraspinal injections of chondroitinase ABC.

43 ection, were quantitated following strategic intraspinal injections of dual retrograde tracers (Fluor

44 cord were demyelinated by x-irradiation and intraspinal injections of ethidium bromide.

45 In this study, we demonstrate that acute intraspinal injections of NG2-Ab prevented an acute bloc

46 ted in 14 male Long-Evans rats that received intraspinal injections of QUIS.

47 y-inhibiting signals in the spinal cord (via intraspinal injections of the enzyme chondroitinase ABC)

48 Macrophages were activated via intraspinal injections of zymosan, a potent inflammatory

49 55 transgenic mice but is evident also after intraspinal inoculation into Cynomolgus monkeys.

50 movements generated via epidural (ES) and/or intraspinal (IS) stimulation.

51 otomy, difficulty in axonal elongation after intraspinal lesion and the lack of target specificity du

52 for the management of complicated as well as intraspinal lesions and peripheral nerve trunk injuries

53 arrival and maximal appearance of activated intraspinal macrophages.

54 Deficient CX3CR1 signaling in intraspinal microglia and monocyte-derived macrophages (

55 ontusion of the spinal cord, we synchronized intraspinal microstimulation below the injury with the a

56 excitatory) were evoked after contralateral intraspinal microstimulation in the gray matter (cISMS;

57 tidromic volley evoked in the sural nerve by intraspinal microstimulation in the L4/5 spinal segment

58 the bladder and urethral pressures evoked by intraspinal microstimulation of the sacral segments (S1-

59 sulfate proteoglycans, greatly enhanced the intraspinal migration of caErbB2-expressing SCs, enablin

60 ify the first guidance receptor required for intraspinal migration of pioneering motor axons and impl

61 appears that noncontingent shock induces an intraspinal modification that inhibits the capacity to l

62 nction is required cell non-autonomously for intraspinal motor axon guidance and peripheral branch fo

63 wn about the molecular mechanisms underlying intraspinal motor axon guidance.

64 n via Plexin A3 is a major driving force for intraspinal motor growth cone guidance.

65 omplete neurologic recovery in children with intraspinal NB inversely correlated with the severity of

66 rospective review of children diagnosed with intraspinal NB registered on POG NB Biology Protocol 904

67 May 1990 and January 1998, 83 children with intraspinal NB were entered onto the study.

68 central pattern generator (CPG), which is an intraspinal network of neurons capable of generating a r

69 ons within descending brainstem pathways and intraspinal networks are poorly investigated, despite th

70 ALS subjects receiving 5 unilateral cervical intraspinal neural stem cell injections.

71 The underlying mechanism may be related to intraspinal neuronal processing of noxious convergent in

72 T2-immunoreactive terminals originating from intraspinal neurons were less frequent, or were practica

73 icular glutamate transporters 1 and 2 and by intraspinal neurons.

74 Intraspinal olfactory ensheathing cell transplantation i

75 We conclude that intraspinal olfactory mucosal cell transplantation impro

76 ough either supraspinal structures or direct intraspinal pathways.

77 ngs provide proof-of-principle that subdural intraspinal pressure at the injury site can be measured

78 Intraspinal pressure at the injury site was higher than

79 injury was significantly higher than average intraspinal pressure from 12 subjects without traumatic

80 Average intraspinal pressure from the 18 patients with traumatic

81 Intraspinal pressure monitoring started within 72 hours

82 administration had no significant effect on intraspinal pressure or spinal cord perfusion pressure.

83 nt and laminectomy did not effectively lower intraspinal pressure.

84 Furthermore, significant intraspinal processing is likely to occur between thorac

85 n SCI-Tg mice were associated with increased intraspinal production of proinflammatory cytokine mRNA;

86 pletion of neurogenesis for SDH neurons with intraspinal projections.

87 tor (BDNF), and neurotrophin-3 (NT-3) on the intraspinal regeneration of anterogradely labeled axotom

88 luenced by the presence of radiation-induced intraspinal Schwann cells extend misdirected processes i

89 al gray matter occupied by radiation-induced intraspinal Schwann cells revealed a loss of immunoreact

90 onvergent spinal neurons might contribute to intraspinal sensory transmission for cross-organ afferen

91 umbar sympathetic preganglionic neurons, and intraspinal sprouting of nerve growth factor (NGF)-respo

92 Thus, selective intraspinal sprouting transpires in regions containing i

93 Intraspinal stereotaxic microinjection of MIF resulted i

94 Intraspinal stimuli (typically 1 s, 20 Hz, 100 microA, 1

95 nhibitory postsynaptic potentials (IPSPs) in intraspinal stretch receptor neurons (edge cells).

96 cholinergic actions on Renshaw cells, their intraspinal synaptic targets.

97 Here, we show that chronic intraspinal T-cell accumulation in B10.PL and Tg mice is

98 , greater rubrospinal neuron loss, increased intraspinal T-cell accumulation, and enhanced macrophage

99 PL mice and were associated with accelerated intraspinal T-cell influx and enhanced CNS macrophage ac

100 a a channel-mediated depolarization of their intraspinal terminals which can be recorded extracellula

101 Thus, intraspinal therapy may augment rehabilitative training

102 For instance, we previously showed that intraspinal toll-like receptor 4 macrophage activation i

103 These data indicate that an intraspinal transplant placed into the contused adult ra

104 e I and IIa clinical trials involving direct intraspinal transplantation in humans.

105 Here, we measured the effects of intraspinal transplantation of cells derived from olfact

106 We have previously reported that intraspinal transplantation of mouse NPCs into JHMV-infe

107 e first report of cervical and dual-targeted intraspinal transplantation of neural stem cells in ALS

108 e also tested the antipruritic properties of intraspinal transplantation of precursors of GABAergic i

109 Three months later, intraspinal transplants were analyzed using correlative

110 tration of endogenous BDNF/neurotrophin 4 by intraspinal TrkB-Fc fusion protein administration does n

111 ing a motor task, while measuring the evoked intraspinal unit response to single pulse cortical stimu

112 ministration at C4 elicits long-lasting pMF; intraspinal VEGFA-165 increased integrated phrenic nerve

113 Furthermore, little is known about intraspinal visceroreceptive transmission and processing