ライフサイエンスコーパス: intrastrand

1 specifically inhibit excision repair of the intrastrand 1,2-d(GpG) and -d(ApG) cross-links.

2 Intrastrand adduct formation by DEB was investigated by

3 However, the protein fails to recognize 1,3-intrastrand adduct produced by trans-diamminedichloropla

4 more efficient at excising the 1,3-d(GpTpG) intrastrand adduct than either the 1,2-d(GpG) or d(ApG)

5 kd(GpG)-N7(1),-N7(2) inverted question mark] intrastrand adduct to domain B of HMG1.

6 d, 1,1/c,c ( n = 4,6) form a 1,2 GG (N7, N7) intrastrand adduct with r(GpG), d(GpG) and d(TGGT).

7 XpG) compared with a 1,2d(GpG) cisplatin-DNA intrastrand adduct, consistent with the difference in th

8 (eta1-O2CCH3)]+ showed that an unprecedented intrastrand adduct, dsII, is formed with the dirhodium u

9 ons at interstrand cross-links or removal of intrastrand adducts and cellular sensitivity.

10 tion experiments indicate that cisplatin 1,2-intrastrand adducts do not form preferentially at G-rich

11 , the structure is similar to that of 1,2 GG intrastrand adducts of 1,1/t,t.

12 Repair of the intrastrand adducts was detected with whole-cell extract

13 nability of 1,1/c,c complexes to form 1,2 GG intrastrand adducts with sterically more demanding doubl

14 dducts in vitro, including cisplatin-induced intrastrand adducts, although the physiological relevanc

15 adduct than either the 1,2-d(GpG) or d(ApG) intrastrand adducts, in agreement with previous experime

16 1,1/c,c complexes do not form 1,2 GG intrastrand adducts, the major adduct of cisplatin, with

17 h smaller amounts of 1,2-interstrand and 1,2-intrastrand adducts.

18 de excision repair (NER) of CDDP-induced DNA intrastrand adducts.

19 CL-induced DNA double strand breaks, but not intrastrand adducts.

20 tides gave rise to comparable numbers of 1,2-intrastrand and 1,3-interstrand bis-N7G-BD cross-links,

21 The distinctive feature of intrastrand and cross-strand pairing of threonine residu

22 The retention of RPA on cisplatin intrastrand and ICL containing DNA affinity columns is c

23 by binding DNA and causing the formation of intrastrand and interstrand (ICL) crosslinks, but the pr

24 ty of DNA lesions, including monoadducts and intrastrand and interstrand crosslinks.

25 rs accurately captures the interplay between intrastrand and interstrand decay channels.

26 latin analogs that interact with DNA forming intrastrand and interstrand DNA cross-links (ICLs).

27 their antiproliferative effects by creating intrastrand and interstrand DNA cross-links, which block

28 ween the various pairings and shows that the intrastrand and interstrand effects are of comparable ma

29 nces in efficiency of photoreduction through intrastrand and interstrand pathways are observed.

30 singly, the resulting replisome is liable to intrastrand and interstrand switches leading to replicat

31 Total numbers of bis-N7G-BD lesions (intrastrand and interstrand) in calf thymus DNA treated

32 We show here that intrastrand annealing following a DNA double-strand brea

33 Structural and functional properties of intrastrand, ANP (N-(4-azido-2-nitrophenyl)-putrescine)

34 e dominated by GG interstrand followed by GU intrastrand base stacking interactions that dictate the

35 The perturbation leads to preferential intrastrand base stacking, disruption of adjacent canoni

36 gations of CT not only demonstrate efficient intrastrand base-base CT in the DNA:RNA hybrids but also

37 Our results suggest that the disruption of intrastrand base-pairing preventing cruciform formation

38 Most cellular RNAs engage in intrastrand base-pairing that gives rise to complex thre

39 e with a near-perfect hairpin could form, by intrastrand base-pairing, on the parental chromosomes.

40 nt propeller twisting without an increase in intrastrand base-step distance.

41 The second method was to plot the intrastrand bias of the third codon position from Parity

42 (G--G and A--G denote the intrastrand bifunctional adducts formed between adjacent

43 hat stacks on the purine of the same strand (intrastrand) but has little cross-strand stacking.

44 report evidence for an unusual K+-dependent intrastrand "cinched" tetraplex.

45 g agents and suggest that recognition of 1,2-intrastrand cis-diamminedichloroplatinum(II) adducts by

46 The intrastrand cis-{Pt(NH3)2}(2+) 1,3-d(GpTpG) cross-links

47 ally modified nucleosomes containing defined intrastrand cis-{Pt(NH3)2}(2+) 1,3-d(GpTpG) cross-links.

48 cifically modified nucleosomes containing an intrastrand cis-{Pt(NH3)2}2+ 1,3-d(GpTpG) cross-link, si

49 e N(1) and N(2) are not dG and GG is the 1,2-intrastrand cisplatin adduct in N(1)GGN(2), were previou

50 FACT binds the major 1,2-d(GpG) intrastrand cisplatin adduct, but its isolated SSRP1 sub

51 , site-specific d(GpG), d(ApG), and d(GpXpG) intrastrand cisplatin adducts and a substrate with a sin

52 ocal sequence context on the distribution of intrastrand cisplatin cross-links.

53 induction by forskolin enhanced clearance of intrastrand cisplatin-adducts in melanocytes or MC1R-tra

54 HMG)-domain proteins recognize the major 1,2-intrastrand cisplatin-DNA cross-links and can mediate ci

55 In contrast, centromeric cohesin generates intrastrand cohesion and sister centromeres, while highl

56 ort, stabilized beta-hairpin structure where intrastrand (conformational) and interstrand (SC-SC) inf

57 mall but important differences at inter- and intrastrand contact sites, explaining the inherent insta

58 through its effect on their interstrand and intrastrand contacts.

59 e peptides is caused by both interstrand and intrastrand coupling to (12)C modes.

60 erated in silico the most frequent oxidative intrastrand cross-link adduct, G[8,5-Me]T, embedded in a

61 Both DNA interstrand and intrastrand cross-link adducts, linking two deoxyguanosi

62 ing UV photoproducts or cisplatin 1,2-d(GpG) intrastrand cross-link and mismatch were tested for bind

63 The (GpG) N2G-MMC-N2G intrastrand cross-link appears to be a poor substrate fo

64 markPt(NH(3))(2) inverted question mark(2+) intrastrand cross-link are probed in different sequence

65 rand cross-link at Pu-GAATC-Py sequences, an intrastrand cross-link at both shorter Pu-GATG-Py and lo

66 CAGAGG), containing the cisplatin d(GpG) 1,2-intrastrand cross-link at the position denoted by asteri

67 ase and identified by LC-MS/MS as an unusual intrastrand cross-link between guanine and thymine.

68 tion of repair of a site-specific 1,2-d(GpG) intrastrand cross-link by an HMG-domain protein also occ

69 muM, interferes with repair of cisplatin 1,2-intrastrand cross-link damage by >90% compared to contro

70 10-55-fold faster than that found for 1,2 GG intrastrand cross-link formation by the diaqua form of c

71 tortions in DNA structure following platinum intrastrand cross-link formation.

72 unding a GTG sequence significantly affected intrastrand cross-link formation.

73 s the PT-ACRAMTU-induced damage from the 1,2-intrastrand cross-link formed by cisplatin.

74 or carry a single 1,2-d(GpG) or 1,3-d(GpTpG) intrastrand cross-link formed by either cis-{Pt(NH(3))(2

75 to a site-specific 1,2-d(GpG) cisplatin-DNA intrastrand cross-link in a 20 bp probe were determined.

76 Together, the formation of intrastrand cross-link in G-quadruplex motifs may accoun

77 cross-link or a single cisplatin 1,3-d(GTG) intrastrand cross-link is a strong block to both polymer

78 HeLa cell extracts which show that the G*CT* intrastrand cross-link is excised with approximately fou

79 The cis-{Pt(NH3)2}2+ 1,2-d(GpG) intrastrand cross-link is the DNA lesion most commonly e

80 oligodeoxyribonucleotide can give rise to an intrastrand cross-link lesion G[8-5]C, where the C8 carb

81 radical can give rise to the predicted novel intrastrand cross-link lesion in dinucleoside monophosph

82 he formation of a guanine-cytosine (G[8-5]C) intrastrand cross-link lesion in HeLa-S3 cells upon expo

83 G[8-5m]mC, whereas the corresponding C[5-8]G intrastrand cross-link lesion was not detectable.

84 G[8-5m]T, a guanine-thymine intrastrand cross-link lesion where the C8 of guanine is

85 It was found that an intrastrand cross-link lesion, in which the methyl carbo

86 y of pure, sufficient and well-characterized intrastrand cross-link lesion-bearing ODN substrates for

87 e formation of single-nucleobase lesions and intrastrand cross-link lesions (i.e. G[8-5]C, C[5-8]G, m

88 These results suggest that oxidative intrastrand cross-link lesions formed at methylated-CpG

89 been structurally characterized, only a few intrastrand cross-link lesions have been identified and

90 hat the formation of this and other types of intrastrand cross-link lesions might have important impl

91 agents was shown to lead to the formation of intrastrand cross-link lesions where the neighboring nuc

92 esults support the conclusion that oxidative intrastrand cross-link lesions, if not repaired, can be

93 uplex DNA carrying three different oxidative intrastrand cross-link lesions, that is, G[8-5]C, G[8-5m

94 Reactive oxygen species can give rise to intrastrand cross-link lesions, where two neighboring nu

95 s were considerably higher than those of the intrastrand cross-link lesions.

96 rucial first step for the formation of a 1,2-intrastrand cross-link of adjacent guanine bases that le

97 pecific cisplatin 1,2-d(GpG) or 1,3-d(GpTpG) intrastrand cross-link or a cisplatin 5'-GC/5'-GC inters

98 d(GpG)-N7(1), -N7(2) inverted question mark] intrastrand cross-link or a putative hSRY target site in

99 We found that a single cisplatin 1,2-d(GG) intrastrand cross-link or a single cisplatin 1,3-d(GTG)

100 The formation of these intrastrand cross-link products and 8-oxo-dG in vivo und

101 s is the first report about the formation of intrastrand cross-link products between cytosine and ade

102 st time, the sequence-dependent formation of intrastrand cross-link products from the UVB irradiation

103 light could lead to the facile formation of intrastrand cross-link products initiated from (Br)dU.

104 ion of d((Br)CA) gave rise to three types of intrastrand cross-link products, that is, d(C[5-N6]A), d

105 radiation of BrdU-treated cells yielded four intrastrand cross-link products, where the C5 of uracil

106 link repair independently from FANCM and (in intrastrand cross-link repair) parallel to MUS81.

107 Taken together, our data show that four DNA intrastrand cross-link subpathways exist in Arabidopsis,

108 bserved when the single cisplatin 1,3-d(GTG) intrastrand cross-link was located in the non-transcribe

109 kd(GpG)-N7(1) -N7(2) inverted question mark] intrastrand cross-link was measured to be 2.5 (+/- 0.1)

110 ciency of the block at a cisplatin 1,2-d(GG) intrastrand cross-link was similar in several different

111 he hSRY-HMG domain recognized the 1,2-d(GpG) intrastrand cross-link with higher affinity [Kd(app) = 4

112 e demonstrated a preference for the extended intrastrand cross-link with Pu-GAATG-Py, which forms mor

113 ts was used to determine that the 1,2-d(ApG) intrastrand cross-link, a prevalent cisplatin-DNA adduct

114 chanical geometry optimization of the 1,2-GG intrastrand cross-link, does not show significant differ

115 se to the efficient formation of the G[8-5]U intrastrand cross-link, where the C8 of guanine in the e

116 gation was completely blocked by a cisplatin intrastrand cross-link.

117 DNA and binds the major cisplatin 1,2-d(GpG) intrastrand cross-link.

118 at of the canonical cisplatin-DNA 1,2-d(GpG) intrastrand cross-link.

119 , with the major adduct being the 1,2-d(GpG) intrastrand cross-link.

120 ielded an adduct that contained a 1,3-Pt-GTG intrastrand cross-link.

121 three different types of adducts: inter- and intrastrand cross-linked adducts, and mono-alkylated add

122 y required for resistance to interstrand and intrastrand cross-linking agents, but not alkylating age

123 Intrastrand cross-linking of actin filaments by ANP, N-(

124 of the neighboring bases by way of inter- or intrastrand cross-linking; and (v) the product is a mono

125 ses on the interaction between the cisplatin intrastrand cross-links and human AAG.

126 ines in DNA to form 1,2-Pt-GG and 1,3-Pt-GNG intrastrand cross-links and, to a lesser extent, G-G int

127 Whereas AG 1,2-intrastrand cross-links are commonly observed, the analo

128 atory response, can lead to the formation of intrastrand cross-links between guanine and thymine base

129 r preparation of oligonucleotides containing intrastrand cross-links between the exocyclic amino grou

130 ically shielded cisplatin-modified 1,2-(GpG) intrastrand cross-links from repair.

131 Conversely, intrastrand cross-links generated by Chl are efficiently

132 of proteins that bind cisplatin 1,2- and 1,3-intrastrand cross-links has been identified, much less i

133 DNA damages induced by oxidative intrastrand cross-links have been the subject of intense

134 om the prodrug, which then formed 1,2-d(GpG) intrastrand cross-links in the cell nuclei, as confirmed

135 ative excision repair rates of cisplatin-DNA intrastrand cross-links in the whole cell extracts.

136 duplexes in the asymmetric unit contain 1,2-intrastrand cross-links in which the cyclohexylamine lig

137 e provide evidence that TLS across cisplatin intrastrand cross-links is performed by multiple transle

138 port, we show that Nhp6Ap binds to cisplatin intrastrand cross-links on duplex DNA with a 40-fold gre

139 tosis, and formation of cisplatin 1,2-d(GpG) intrastrand cross-links on nuclear DNA was verified.

140 ave compared the effect of cisplatin-induced intrastrand cross-links on transcription elongation by T

141 leading to the formation of interstrand and intrastrand cross-links that are the critical cytotoxic

142 her radicals to form base sequence-dependent intrastrand cross-links via the nucleophilic addition of

143 tandem DNA lesions G[8,5-Me]T and T[5-Me,8]G intrastrand cross-links was investigated in simian (COS-

144 C incised linear substrates containing these intrastrand cross-links with low efficiency, suggesting

145 ding nucleobase monoadducts, interstrand and intrastrand cross-links, and DNA-protein cross-links (DP

146 he platinum ICL differ from those binding to intrastrand cross-links, indicating different mechanisms

147 utadiene diepoxide-induced N(2)-N(2) guanine intrastrand cross-links, site specifically adducted olig

148 olecule compared to other well characterized intrastrand cross-links, such as cyclobutane pyrimidines

149 xcision repair of cisplatin-DNA adducts, 1,2-intrastrand cross-links, to potentiate the sensitivity o

150 nucleotides containing each of the cisplatin intrastrand cross-links, we found that AAG readily recog

151 DNA containing bulky nucleotide adducts and intrastrand cross-links.

152 event the generation of ICLs, while favoring intrastrand cross-links.

153 ligands, it can form two isomeric 1,2-d(GpG) intrastrand cross-links.

154 2)-guanine butadiene monoadducts but not the intrastrand cross-links.

155 clusters and GNG motifs probably reflecting intrastrand cross-links.

156 n inhibition by cisplatin and UV-induced 1,2-intrastrand cross-links.

157 values, features characteristic of cisplatin intrastrand cross-links.

158 ntly cis-[Pt(NH(3))(2){d(GpG)-N7(1),-N7(2)}] intrastrand cross-links.

159 s efficiently than bifunctional platinum-DNA intrastrand cross-links.

160 tion with DNA to form DNA adducts, primarily intrastrand crosslink adducts, which activate several si

161 jacent guanine bases to platinum to form the intrastrand crosslink cis-[Pt(NH3)2[d(GpG)-N7(1), -N7(2)

162 the second arm in a position appropriate for intrastrand crosslink formation, while the corresponding

163 nucleotides containing a single 1,2 diguanyl intrastrand crosslink indicate that human cell extracts

164 ted here the sequence-dependent formation of intrastrand crosslink products from the UVB irradiation

165 The formation of intrastrand crosslink products from these halopyrimidine

166 cleoside affected markedly the generation of intrastrand crosslink products.

167 to determine why some types of cisplatin-DNA intrastrand crosslinks are repaired better than others.

168 oxic DNA damage predominantly in the form of intrastrand crosslinks between adjacent purines.

169 orethamine and phosphoramide mustard induced intrastrand crosslinks between the two contiguous Gs in

170 atch repair may be triggered by 1,2 diguanyl intrastrand crosslinks that have undergone replicative b

171 inetics of formation of both interstrand and intrastrand crosslinks were determined.

172 was determined that monoadducts and putative intrastrand crosslinks were preferred targets for the ER

173 effects by cisplatin ICLs but not 1,2-d(GpG) intrastrand crosslinks.

174 ons, are mainly located at sites of putative intrastrand crosslinks.

175 The shallow distance dependence of intrastrand CT in DNA:RNA hybrids correlates with the in

176 complex is strongly blocked by cisplatin 1,2-intrastrand d(GpG) and 1,3-intrastrand d(GpTpG) cross-li

177 isplatin-modified DNA which shield the major intrastrand d(GpG) and d(ApG) cross-links from excision

178 nticancer drug cisplatin, which forms mainly intrastrand d(GpG) and d(ApG) cross-links on DNA.

179 age DNA, with the major adducts formed being intrastrand d(GpG) and d(ApG) crosslinks.

180 oligonucleotide probes containing both a 1,2-intrastrand d(GpG) cisplatin cross-link and a fluorescei

181 ins of HMGB4 to DNA carrying a cisplatin 1,2-intrastrand d(GpG) cross-link are weaker than those of t

182 ) prodrug leads to the cis-{Pt((NH 3) 2} 1,2-intrastrand d(GpG) cross-link in nuclear DNA.

183 HMGB1 protein binds to DNA containing a 1,2-intrastrand d(GpG) cross-link mainly through domain A, a

184 MG) domain into the site of a cisplatin 1, 2-intrastrand d(GpG) cross-link, a series of DNA probes wa

185 roteins that interact with the cisplatin 1,2-intrastrand d(GpG) cross-link.

186 ters the nucleus and targets DNA to form 1,2-intrastrand d(GpG) cross-links characteristic of its own

187 eduction of 1 and formation of cisplatin 1,2-intrastrand d(GpG) cross-links on nuclear DNA was confir

188 Formation of the major cisplatin 1,2-intrastrand d(GpG) cross-links on the nuclear DNA was de

189 o DNA containing site-specific cisplatin 1,2-intrastrand d(GpG) cross-links.

190 everal types of DNA lesion including the 1,2-intrastrand d(GpG) crosslink produced by cis-diamminedic

191 a site-specific cis-diammineplatinum(II)-DNA intrastrand d(GpG) or a d(GpTpG) cross-link.

192 cient and more processive at bypassing a 1,2-intrastrand d(GpG)-cisplatin cross-link than the two-sub

193 to platinated nucleosomes containing the 1,3-intrastrand d(GpTpG) cross-link investigated previously.

194 recombinant nucleosomes containing the same intrastrand d(GpTpG) cross-link.

195 by cisplatin 1,2-intrastrand d(GpG) and 1,3-intrastrand d(GpTpG) cross-links located on the template

196 ing can the interaction of cisplatin-DNA 1,3-intrastrand d(GpTpG) or interstrand cross-links with HMG

197 gher affinity when compared with a cisplatin intrastrand damaged DNA.

198 ctin binding domain of drebrin decreases the intrastrand disulfide cross-linking of Cys-41 (in the DN

199 Intrastrand DNA adducts formed by cisplatin and oxalipla

200 We are now explorin g the stability of intrastrand DNA and RNA pyrimidine motif triplexes at ph

201 reover, RTEL1 is involved in interstrand and intrastrand DNA cross-link repair independently from FAN

202 The N7-Pt-N7 adjacent G,G intrastrand DNA cross-link responsible for cisplatin ant

203 get the nucleosomes of cancer cells and form intrastrand DNA cross-links that are located in the majo

204 t electrophile, forming both interstrand and intrastrand DNA cross-links.

205 ecessary for replicative bypass of cisplatin intrastrand DNA cross-links.

206 In the present work, interstrand and intrastrand DNA-DNA cross-linking by individual DEB ster

207 nterstrand proton transfer (PT) triggered by intrastrand electron transfer (ET) is detected for the f

208 As in longer DNA duplexes, intrastrand electron transfer induced by UV excitation t

209 Intrastrand excimer states with lifetimes of 50-150 ps a

210 suggests either that the ability to adopt an intrastrand folded structure is not sufficient for expan

211 Intrastrand folding by (CAG)(15) in the three-way juncti

212 Evidence is presented for stable intrastrand folding by the CAG/CTG class of triplet repe

213 of adenine with 2-aminopurine, we show that intrastrand folding in repeated CAG trinucleotides is al

214 D binding to the G-rich strand destabilizes intrastrand G-G pairing and that hnRNP D interacts speci

215 mma-irradiation mixture of duplex DNA, a new intrastrand G[8-5]C cross-link lesion, in which the C8 a

216 spacing enables binding of cisplatin via the intrastrand GNG motif (N = A), generating a bend in the

217 used widely in chemotherapy, form adducts on intrastrand guanines (5'GG) in genomic DNA.

218 and alpha7-P180S mutations also formed some intrastrand H bonds along the beta9 strand, although H b

219 tions of CAG or CTG triplets in DNA can form intrastrand hairpin loops with combinations of normal an

220 moval through illegitimate recombination and intrastrand homologous recombination serve as the most i

221 of the base pairs is critical; the yield of intrastrand HT is markedly higher through (A)n compared

222 An intrastrand hydrogen bond is formed from the 2' OH hydro

223 up indicates the presence of internucleotide intrastrand hydrogen bonding between the HmU12C5 hydroxy

224 the cis-5R,6S Tg lesion does not form strong intrastrand hydrogen bonds with the imidazole N7 atom of

225 DNA helix structure caused by the oxidative intrastrand lesions could render them good substrates fo

226 sults from this study suggest that oxidative intrastrand lesions might be substrates for NER enzymes

227 G-BD cross-links, while S,S DEB produced few intrastrand lesions.

228 e assembly at the apex of the loop initiates intrastrand loop formation that extends approximately 25

229 own partner gene from a DNA template with an intrastrand loop schematically shaped like a pan with a

230 unknown 3' sequences from a template with an intrastrand loop schematically shaped like a pan with a

231 her PH domains, the size and position of the intrastrand loops and the presence of an N-terminal alph

232 Intrastrand NMR constraints, obtained from peptides cont

233 ermined, even in the presence of interstrand/intrastrand NOE ambiguity.

234 n NOE-based NMR structure, where interstrand/intrastrand NOEs were treated as ambiguous and where non

235 ing the sugar pucker and mediating 3' --> 5' intrastrand O2'...O4' hydrogen bonds.

236 e base of the terminal GC or UG pair, either intrastrand or cross-strand depending on the orientation

237 rom specific defects in the repair of either intrastrand or interstrand cross-links we measured the e

238 n compared with (T)n bridges, whereas HT via intrastrand pathways is more efficient than through inte

239 erplay among sequence-related base stacking, intrastrand phosphate repulsion, and counterion and wate

240 Furthermore, the intrastrand phosphate separation in the chimeric strand

241 The intrastrand phosphate-phosphate (P-P) distance of the ph

242 ds to O6-methylguanine mismatches but not to intrastrand platinated GG cross-links, explaining why da

243 , N(2) = A, C, G, T and G*G* indicates a 1,2-intrastrand platinum cross-link.

244 rotons, intranucleotide, internucleotide and intrastrand proton-proton distances, and dihedral angle

245 For the high-coverage sensor, formation of intrastrand Pt(II)-AG adducts rigidifies the oligo-AG pr

246 The tandem I.U wobbles show intrastrand purine-pyrimidine stacking but exhibit inter

247 e thus transported preferentially through an intrastrand rather than interstrand pathway.

248 stance dependence is obtained for inter- and intrastrand reactions, while, in B-DNA, a more shallow d

249 analysis provides evidence against a purely intrastrand repulsion-based mechanism and suggests that

250 ys-191 (interstrand) and Gln-41 and Lys-113 (intrastrand), respectively.

251 PR2 is an intrastrand rule where A = T and G = C are expected if t

252 are capable of engaging in cis binding to GG intrastrand sites by establishing N7/O6 bridges that spa

253 Intrastrand stacking between the AFB moiety and the 5' n

254 tifs, can be explained by interstrand versus intrastrand stacking of the central (G or C) deoxyribose

255 n (A.P trans Watson-Crick/Watson-Crick) with intrastrand stacking resembling typical A-form geometry.

256 ismatch-aligned tethered bases preserve good intrastrand stacking with flanking bases.

257 how that this microsatellite is able to form intrastrand structures as well.

258 are not currently known to be, form several intrastrand structures including tetraplexes.

259 The ability to form intrastrand structures is a conserved feature of many hy

260 ught to be a consequence of the formation of intrastrand structures, including hairpins, triplexes an

261 ype of DNA synthesis arrest site might be an intrastrand tetrahelical structure.

262 sis is a sensitive and specific indicator of intrastrand tetraplex formation that can be used, both t

263 ation of secondary structures, in particular intrastrand tetraplexes, is an intrinsic property of som

264 s a hairpin as well as two different unusual intrastrand tetraplexes.

265 nding specificity is partly determined by an intrastrand three-way base-pairing interaction.

266 Potential intrastrand triplex (PIT) element families were found in

267 We term these sequences Potential Intrastrand Triplex (PIT) elements.

268 amily of E. coli PIT elements forms a stable intrastrand triplex at physiological temperature and pH

269 The formation of an intrastrand triplex requires three consecutive sequence

270 If sequences specifying such intrastrand triplexes are encoded in genomes, the potent

271 he potential to form one particular class of intrastrand triplexes in the fully sequenced genomes of

272 Short intrastrand triplexes were observed to form in the pyrim

273 detect sequences with the potential to form intrastrand triplexes.

274 trands can also fold onto themselves to form intrastrand triplexes.

275 ices from disordered strands, involving only intrastrand (vertical) interactions between neighboring